NICHOLAS J contact MANTIS

Summary

Affiliation: Wadsworth Center
Country: USA

Publications

  1. pmc Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit
    Carolyn R McGuinness
    Division of Infectious Disease, Wadsworth Center, 120 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 74:3463-70. 2006
  2. pmc A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles
    Magdia De Jesus
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 9:e91002. 2014
  3. pmc Identification of small molecules that suppress ricin-induced stress-activated signaling pathways
    Paul G Wahome
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 7:e49075. 2012
  4. pmc Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal IgA
    Stephen J Forbes
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA
    MBio 2:e00042-11. 2011
  5. pmc Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies
    Anastasiya Yermakova
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 7:e44317. 2012
  6. doi Mucosal vaccines for biodefense
    N J Mantis
    Division of Infectious Diseases, Wadsworth Center, NYDOH, 120 New Scotland Ave, Albany, NY 12208, USA
    Curr Top Microbiol Immunol 354:181-95. 2012
  7. pmc Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
    N J Mantis
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Mucosal Immunol 4:603-11. 2011
  8. pmc Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region
    Nicholas J Mantis
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 179:3144-52. 2007
  9. pmc Secretory IgA: arresting microbial pathogens at epithelial borders
    Nicholas J Mantis
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, University at Albany School of Public Health, Albany, New York 12208, USA
    Immunol Invest 39:383-406. 2010
  10. pmc Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication
    Nicholas J Mantis
    Division of Infectious Disease, Wadsworth Center, N Y State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 74:3455-62. 2006

Research Grants

  1. IgA-Antigen Uptake by Peyer's Patch M cells
    NICHOLAS MANTIS; Fiscal Year: 2003
  2. Gastrointestinal Immunity to Ricin
    NICHOLAS MANTIS; Fiscal Year: 2004
  3. Epithelial Glycoconjugates as Barriers against Enteric Infections
    NICHOLAS MANTIS; Fiscal Year: 2009
  4. Epithelial Glycoconjugates as Barriers against Enteric Infections
    NICHOLAS J contact MANTIS; Fiscal Year: 2010

Collaborators

  • MARIAN NEUTRA
  • Blaise Corthesy
  • J D Robertus
  • Dennis Burton
  • Paul G Wahome
  • Lori M Neal
  • Stephen J Forbes
  • Magdia De Jesus
  • Anastasiya Yermakova
  • Elizabeth A McCarthy
  • Robert N Brey
  • Joanne M O'Hara
  • Jan Baumann
  • Cassandra D Kelly-Cirino
  • J Marina Yoder
  • Carolyn R McGuinness
  • Tessa V Gonzalez
  • Anna Helander
  • Toni R Bartling
  • Stuart M Levitz
  • Gary R Ostroff
  • Sarita Ahlawat
  • David J Vance
  • Tia Bumpus
  • Jane A Kasten-Jolly
  • Yan Bai
  • Chae Gyu Park
  • Joanne O'Hara
  • Marisa Eschmann
  • Rabia U Aslam
  • Stephanie A Farrant
  • Amy B Hutchings
  • Kartik Chandran
  • Max L Nibert
  • Katherine J Silvey
  • William T Lucas

Detail Information

Publications24

  1. pmc Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit
    Carolyn R McGuinness
    Division of Infectious Disease, Wadsworth Center, 120 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 74:3463-70. 2006
    ..Finally, we demonstrate that R70 and 24B11, when combined, function synergistically to neutralize ricin in vitro, raising the possibility that these two MAbs could serve as a novel immunotherapeutic in vivo...
  2. pmc A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles
    Magdia De Jesus
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 9:e91002. 2014
    ..Future studies will be aimed at defining the role of Langerin in antigen sampling and antigen presentation within the context of the GALT. ..
  3. pmc Identification of small molecules that suppress ricin-induced stress-activated signaling pathways
    Paul G Wahome
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 7:e49075. 2012
    ....
  4. pmc Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal IgA
    Stephen J Forbes
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA
    MBio 2:e00042-11. 2011
    ..Nonetheless, these data suggest a model in which the association of IgA with the O-Ag of S. flexneri partially de-energizes the T3S system and temporarily renders the bacterium incapable of invading intestinal epithelial cells...
  5. pmc Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies
    Anastasiya Yermakova
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 7:e44317. 2012
    ..These data suggest that recognition of RTB's sub-domains 1α and 2γ are critical determinants of antibody neutralizing activity and protective immunity to ricin...
  6. doi Mucosal vaccines for biodefense
    N J Mantis
    Division of Infectious Diseases, Wadsworth Center, NYDOH, 120 New Scotland Ave, Albany, NY 12208, USA
    Curr Top Microbiol Immunol 354:181-95. 2012
    ..For others, however, the respiratory or gastrointestinal mucosa is the primary tissue associated with pathogenesis, and therefore, the tissue for which countermeasures must be developed...
  7. pmc Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
    N J Mantis
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Mucosal Immunol 4:603-11. 2011
    ..This review summarizes the intrinsic biological activities now associated with SIgA and their relationships with immunity and intestinal homeostasis...
  8. pmc Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region
    Nicholas J Mantis
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 179:3144-52. 2007
    ....
  9. pmc Secretory IgA: arresting microbial pathogens at epithelial borders
    Nicholas J Mantis
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, University at Albany School of Public Health, Albany, New York 12208, USA
    Immunol Invest 39:383-406. 2010
    ....
  10. pmc Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication
    Nicholas J Mantis
    Division of Infectious Disease, Wadsworth Center, N Y State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 74:3455-62. 2006
    ..We conclude that IgA antibodies against RTA and RTB can protect mucosal epithelial cells from ricin intoxication...
  11. ncbi Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin
    Nicholas J Mantis
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
    Adv Drug Deliv Rev 57:1424-39. 2005
    ..Our understanding of the mechanisms by which these toxins cross mucosal surfaces, and importance of mucosal immunity in preventing toxin uptake is only rudimentary...
  12. ncbi Oligosaccharide side chains on human secretory IgA serve as receptors for ricin
    Nicholas J Mantis
    Gastrointestinal Cell Biology Laboratory, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:6838-45. 2004
    ..We conclude that sIgA Abs in mucosal secretions may serve as receptor analogues for ricin, thereby reducing the effective dose of toxin capable of gaining access to glycolipid and glycoprotein receptors on epithelial cell surfaces...
  13. pmc Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication
    J Marina Yoder
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 75:1745-50. 2007
    ....
  14. pmc Folding domains within the ricin toxin A subunit as targets of protective antibodies
    Joanne M O'Hara
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
    Vaccine 28:7035-46. 2010
    ..These data offer insights into the immunodominant and structural determinants on RTA that give rise to protective immunity, and for the first time provide an immunological rationale for ricin vaccine design...
  15. pmc A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin
    Lori M Neal
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
    Infect Immun 78:552-61. 2010
    ..The potential of GD12 to serve as a therapeutic following ricin challenge was not explored in this study...
  16. pmc Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen
    Cassandra D Kelly-Cirino
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA
    Infect Immun 77:4859-67. 2009
    ..These results advance our fundamental understanding of the mechanisms by which antibodies neutralize anthrax toxin and may have future application in the evaluation of candidate rPA vaccines...
  17. pmc Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody
    Stephen J Forbes
    Biomedical Sciences Program, University at Albany School of Public Health, Albany, New York 12201, USA
    Infect Immun 76:4137-44. 2008
    ..These results reveal a previously unrecognized capacity of SIgA to "disarm" microbial pathogens on mucosal surfaces and prevent colonization and invasion of the intestinal epithelium...
  18. pmc The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces
    Anna Helander
    GI Cell Biology Laboratory, Enders 1220, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Virol 77:7964-77. 2003
    ....
  19. ncbi Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor
    Nicholas J Mantis
    Department of Pediatrics, Harvard Medical School, and Gastrointestinal Cell Biology Laboratory, Children s Hospital, Boston, MA 02115, USA
    J Immunol 169:1844-51. 2002
    ....
  20. pmc Recognition of secretory IgA by DC-SIGN: implications for immune surveillance in the intestine
    Jan Baumann
    Division of Infectious Diseases, Wadsworth Center, 120 New Scotland Avenue, New York State Department of Health, Albany, NY 12208, USA
    Immunol Lett 131:59-66. 2010
    ..These data identify DC-SIGN as a putative receptor for SIgA, and reveal a mechanism by which DCs could collaborate with M cells in immune surveillance at mucosal surfaces...
  21. pmc Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen
    Paul G Wahome
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Toxicon 56:313-23. 2010
    ..Computer modeling predicted that compound 8 is capable of docking within the ricin active site. In conclusion, we have used a simple high-throughput cell-based method to identify several new small-molecule inhibitors of ricin and Stx...
  22. ncbi Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway
    Tessa V Gonzalez
    Department of Pediatrics, Harvard Medical School, and GI Cell Biology Laboratory, Children s Hospital Boston, Boston, MA 02115, USA
    Mol Immunol 43:1920-3. 2006
    ....
  23. ncbi Analysis of adhesion molecules involved in leukocyte homing into the basolateral pockets of mouse Peyer's patch M cells
    Nicholas J Mantis
    GI Cell Biology Laboratory, Children s Hospital Boston, 300 Longwood Avenue, 02115 Boston, MA, USA
    J Drug Target 12:79-87. 2004
    ....

Research Grants4

  1. IgA-Antigen Uptake by Peyer's Patch M cells
    NICHOLAS MANTIS; Fiscal Year: 2003
    ..The three year KO1 award will provide the applicant with-additional research training and career skills that will greatly facilitate his transition to becoming a successful independent research investigator. ..
  2. Gastrointestinal Immunity to Ricin
    NICHOLAS MANTIS; Fiscal Year: 2004
    ..This information will contribute to the development of a safe and effective mucosal ricin vaccine. ..
  3. Epithelial Glycoconjugates as Barriers against Enteric Infections
    NICHOLAS MANTIS; Fiscal Year: 2009
    ..Aim 3 will specifically test the proposed hypothesis using well-established mouse models of cholera toxin, ricin toxin, reovirus and Salmonella typhimurium infection. ..
  4. Epithelial Glycoconjugates as Barriers against Enteric Infections
    NICHOLAS J contact MANTIS; Fiscal Year: 2010
    ..Aim 3 will specifically test the proposed hypothesis using well-established mouse models of cholera toxin, ricin toxin, reovirus and Salmonella typhimurium infection. ..