Carmen Mannella

Summary

Affiliation: Wadsworth Center
Country: USA

Publications

  1. ncbi request reprint The relevance of mitochondrial membrane topology to mitochondrial function
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201 0509, USA
    Biochim Biophys Acta 1762:140-7. 2006
  2. ncbi request reprint Structure and dynamics of the mitochondrial inner membrane cristae
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201 0509, USA
    Biochim Biophys Acta 1763:542-8. 2006
  3. doi request reprint The connection between inner membrane topology and mitochondrial function
    Carmen A Mannella
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201 0509, USA Electronic address
    J Mol Cell Cardiol 62:51-7. 2013
  4. ncbi request reprint Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications
    C A Mannella
    Resource for the Visualization of Biological Complexity, Division of Molecular Medicine, Wadsworth Center, Albany, New York 12201 0509, USA
    IUBMB Life 52:93-100. 2001
  5. pmc Structural diversity of mitochondria: functional implications
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Albany, NY 12201 0509, USA
    Ann N Y Acad Sci 1147:171-9. 2008
  6. ncbi request reprint Electron tomographic analysis of frozen-hydrated tissue sections
    Chyong Ere Hsieh
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201, USA
    J Struct Biol 138:63-73. 2002
  7. ncbi request reprint Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy
    Michael Marko
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, New York 12201, USA
    Nat Methods 4:215-7. 2007
  8. ncbi request reprint Use of frozen-hydrated axonemes to assess imaging parameters and resolution limits in cryoelectron tomography
    Bruce F McEwen
    Wadsworth Center, New York State Department of Health, P O Box 509, Empire State Plaza, Albany, NY 12201 0509, USA
    J Struct Biol 138:47-57. 2002
  9. pmc Structure of frozen-hydrated triad junctions: a case study in motif searching inside tomograms
    Christian Renken
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    J Struct Biol 165:53-63. 2009
  10. ncbi request reprint Electron tomographic and ultrastructural analysis of the Cryptosporidium parvum relict mitochondrion, its associated membranes, and organelles
    Janet S Keithly
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
    J Eukaryot Microbiol 52:132-40. 2005

Collaborators

  • J Frank
  • Michael Marko
  • TERENCE C WAGENKNECHT
  • Bruce McEwen
  • Janet S Keithly
  • Christian Renken
  • L Li
  • JACQUES G IZARD
  • Chyong Ere Hsieh
  • Takayuki Kanazawa
  • Karolyn F Buttle
  • György Csordás
  • Evgeny Pavlov
  • George B John
  • Yuru Deng
  • Samuel P Mickan
  • Luca Scorrano
  • Ashley P Wright
  • Mauro D Zappaterra
  • Kent McDonald
  • Erin D Newman-Smith
  • Ayako Hasegawa
  • Alexander M van der Bliek
  • David Weaver
  • Peter Varnai
  • Gyorgy Hajnoczky
  • Ludivine Walter
  • Tamas Balla
  • ArDean Leith
  • Linda Rangell
  • Jiping Zha
  • Kathleen W Kinnally
  • Jeanne M L Selker
  • Yonglei Shang
  • Sergey M Grigoriev
  • Michael J Bennett
  • Chaninah L Zweihorn
  • Laurent M Dejean
  • Mona Ashiya
  • Derek Abbott
  • X C Zhang
  • Jesper Munch
  • Haibo Liu
  • Sepp D Kohlwein
  • Abdellah Menikh
  • Solly Weiler
  • Stanley J Korsmeyer
  • Karolyn Buttle
  • Scott A Oakes
  • Robert Maccoll

Detail Information

Publications21

  1. ncbi request reprint The relevance of mitochondrial membrane topology to mitochondrial function
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201 0509, USA
    Biochim Biophys Acta 1762:140-7. 2006
    ..In frozen-hydrated rat-liver mitochondria, the space between the inner and outer membranes contains 10-15 nm particles that may represent macromolecular complexes involved in activities that span the two membranes...
  2. ncbi request reprint Structure and dynamics of the mitochondrial inner membrane cristae
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201 0509, USA
    Biochim Biophys Acta 1763:542-8. 2006
    ..This review summarizes the evidence about how inner membrane shape influences mitochondrial function and, conversely, what is known about the factors that determine this membrane's topology...
  3. doi request reprint The connection between inner membrane topology and mitochondrial function
    Carmen A Mannella
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201 0509, USA Electronic address
    J Mol Cell Cardiol 62:51-7. 2013
    ..This article is part of a Special Issue entitled 'Calcium Signalling in Heart'. ..
  4. ncbi request reprint Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications
    C A Mannella
    Resource for the Visualization of Biological Complexity, Division of Molecular Medicine, Wadsworth Center, Albany, New York 12201 0509, USA
    IUBMB Life 52:93-100. 2001
    ..Simulations indicate that narrow cristae junctions restrict diffusion between intracristal and external compartments, causing depletion of ADP and decreased ATP output inside the cristae...
  5. pmc Structural diversity of mitochondria: functional implications
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Albany, NY 12201 0509, USA
    Ann N Y Acad Sci 1147:171-9. 2008
    ..Progress toward understanding the factors that control mitochondrial inner-membrane curvature and dynamics (fusion and fission) is summarized, with a focus on remodeling events associated with apoptosis and oxidative stress...
  6. ncbi request reprint Electron tomographic analysis of frozen-hydrated tissue sections
    Chyong Ere Hsieh
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, NY 12201, USA
    J Struct Biol 138:63-73. 2002
    ..In rare cases, a 15-nm banding pattern perpendicular to the cutting direction was observed in the interior of the section, most evident in the uniformly dense, protein-rich material of the mitochondrial matrix...
  7. ncbi request reprint Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy
    Michael Marko
    Resource for Visualization of Biological Complexity, Wadsworth Center, Empire State Plaza, Albany, New York 12201, USA
    Nat Methods 4:215-7. 2007
    ..We demonstrate, by cryo-electron tomography of Escherichia coli cells, that a focused ion beam (FIB) can be used to thin whole frozen-hydrated cells in a convenient and essentially artifact-free way...
  8. ncbi request reprint Use of frozen-hydrated axonemes to assess imaging parameters and resolution limits in cryoelectron tomography
    Bruce F McEwen
    Wadsworth Center, New York State Department of Health, P O Box 509, Empire State Plaza, Albany, NY 12201 0509, USA
    J Struct Biol 138:47-57. 2002
    ..Instrumental and computational strategies to circumvent this limitation are discussed...
  9. pmc Structure of frozen-hydrated triad junctions: a case study in motif searching inside tomograms
    Christian Renken
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    J Struct Biol 165:53-63. 2009
    ..In a class average of RyRs with proximal transverse tubules (TT), a cytoplasmic density is observed near the receptor that could represent the most consistent location of tethers observed in tomograms between the SR and TT membranes...
  10. ncbi request reprint Electron tomographic and ultrastructural analysis of the Cryptosporidium parvum relict mitochondrion, its associated membranes, and organelles
    Janet S Keithly
    Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
    J Eukaryot Microbiol 52:132-40. 2005
    ..parvum is a strategy for compartmentalizing away from the cytosol toxic ferrous iron and sulfide, which are needed for iron sulfur cluster biosynthesis, an essential function of mitochondria in all eukaryotes...
  11. ncbi request reprint Three-dimensional imaging of biological complexity
    Joachim Frank
    Howard Hughes Medical Institute, Health Research, Incorporated, Albany, NY 12201 0509, USA
    J Struct Biol 138:85-91. 2002
    ..As techniques of cryo-microtomy are perfected, we hope to be able to apply tomography to high-pressure frozen sections of tissue...
  12. ncbi request reprint Towards high-resolution three-dimensional imaging of native mammalian tissue: electron tomography of frozen-hydrated rat liver sections
    Chyong Ere Hsieh
    Resource for Visualization of Biological Complexity, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, 12201, USA
    J Struct Biol 153:1-13. 2006
    ....
  13. ncbi request reprint Fasting induces cyanide-resistant respiration and oxidative stress in the amoeba Chaos carolinensis: implications for the cubic structural transition in mitochondrial membranes
    Yuru Deng
    Wadsworth Center, New York State Department of Health, Albany, New York, USA
    Protoplasma 219:160-7. 2002
    ....
  14. doi request reprint Reflections on VDAC as a voltage-gated channel and a mitochondrial regulator
    Carmen A Mannella
    Resource for Visualization of Biological Complexity, Wadsworth Center, Albany, NY 12201 0509, USA
    J Bioenerg Biomembr 40:149-55. 2008
    ....
  15. pmc The mitochondrial inner membrane protein mitofilin controls cristae morphology
    George B John
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Mol Biol Cell 16:1543-54. 2005
    ..We propose that mitofilin is a critical organizer of the mitochondrial cristae morphology and thus indispensable for normal mitochondrial function...
  16. pmc Native cellular architecture of Treponema denticola revealed by cryo-electron tomography
    Jacques Izard
    Department of Molecular Genetics, The Forsyth Institute, 140 Fenway, Boston, MA 02135, USA
    J Struct Biol 163:10-7. 2008
    ..Several incompletely characterized structures have been observed in the periplasm between dividing cells, including a cable-like structure linking two cytoplasmic cylinders and complex foil-shaped structures...
  17. pmc The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals
    Takayuki Kanazawa
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 4:e1000022. 2008
    ..We conclude that free radicals contribute to the pathology of C. elegans eat-3 mutants...
  18. pmc Structural and functional features and significance of the physical linkage between ER and mitochondria
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 174:915-21. 2006
    ..These results reveal an unexpected dependence of cell function and survival on the maintenance of proper spacing between the ER and mitochondria...
  19. ncbi request reprint The mitochondrial channel VDAC has a cation-selective open state
    Evgeny Pavlov
    Department of Basic Sciences, New York University, College of Dentistry, 345 East 24th Street, New York, NY 10010, USA
    Biochim Biophys Acta 1710:96-102. 2005
    ....
  20. ncbi request reprint Label-free bioaffinity detection using terahertz technology
    Samuel P Mickan
    Center for Terahertz Research, Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, NY 12180, USA
    Phys Med Biol 47:3789-95. 2002
    ..We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 microg cm(-2) of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation...
  21. ncbi request reprint A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
    Luca Scorrano
    Howard Hughes Medical Institute, Department of Pathology and Medicine, Harvard Medical School, Dana Farber Cancer Institute, 02115, Boston, MA, USA
    Dev Cell 2:55-67. 2002
    ..This reorganization does not require tBID's BH3 domain and is independent of BAK, but is inhibited by CsA. During this process, individual cristae become fused and the junctions between the cristae and the intermembrane space are opened...