Research Topics

Genomes and Genes

Species

Zheng Liu

Summary

Affiliation: Wadsworth Center
Country: USA

Publications

  1. Liu Z, Zhang J, Sharma M, Li P, Chen S, Wagenknecht T. Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus. Proc Natl Acad Sci U S A. 2001;98:6104-9 pubmed
    ..This study describes the 3D reconstruction of a recombinant ryanodine receptor and it demonstrates the potential of this technology for characterizing functional and structural perturbations introduced by site-directed mutagenesis. ..
  2. Liu Z, Zhang J, Wang R, Wayne Chen S, Wagenknecht T. Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor/calcium release channel. J Mol Biol. 2004;338:533-45 pubmed
  3. Liu Z, Zhang J, Li P, Chen S, Wagenknecht T. Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1. J Biol Chem. 2002;277:46712-9 pubmed
    ..This study describes the first internal fusion of a protein into a ryanodine receptor, and it demonstrates the potential of this technology for localizing functional and structural domains on the three-dimensional structure of RyR. ..
  4. Liu Z, Wang R, Zhang J, Chen S, Wagenknecht T. Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor. J Biol Chem. 2005;280:37941-7 pubmed
    ..Moreover, the location of this central mutation site is not close to that of the FKBP12.6-binding site mapped previously by cryoelectron microscopy. ..
  5. Liu Z, Wang R, Tian X, Zhong X, Gangopadhyay J, Cole R, et al. Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J Cell Sci. 2010;123:1775-84 pubmed publisher