JORGE C BLANCO

Summary

Affiliation: Virion Systems
Country: USA

Publications

  1. ncbi Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infection
    Lioubov M Pletneva
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 26:914-21. 2006
  2. pmc Inactivation of respiratory syncytial virus by zinc finger reactive compounds
    Marina S Boukhvalova
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD, USA
    Virol J 7:20. 2010
  3. pmc Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection
    Jorge C G Blanco
    Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
    Virol J 6:57. 2009
  4. ncbi Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats
    Jorge C G Blanco
    Virion Systems, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    J Infect Dis 185:1780-5. 2002
  5. ncbi Prospects of antiviral and anti-inflammatory therapy for respiratory syncytial virus infection
    Jorge C G Blanco
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    Expert Rev Anti Infect Ther 3:945-55. 2005
  6. ncbi The cotton rat: an underutilized animal model for human infectious diseases can now be exploited using specific reagents to cytokines, chemokines, and interferons
    Jorge C G Blanco
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 24:21-8. 2004
  7. ncbi A cotton rat model of human parainfluenza 3 laryngotracheitis: virus growth, pathology, and therapy
    Martin G Ottolini
    Department of Pediatrics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland 20814 4799, USA
    J Infect Dis 186:1713-7. 2002
  8. pmc Induction of type I interferons and interferon-inducible Mx genes during respiratory syncytial virus infection and reinfection in cotton rats
    Lioubov M Pletneva
    Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    J Gen Virol 89:261-70. 2008
  9. pmc Respiratory syncytial virus infects and abortively replicates in the lungs in spite of preexisting immunity
    Marina S Boukhvalova
    Virion Systems, Inc, 9610 Medical Center Dr, Suite 100, Rockville, MD 20850, USA
    J Virol 81:9443-50. 2007
  10. pmc Human metapneumovirus: enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged
    Kevin C Yim
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States
    Vaccine 25:5034-40. 2007

Collaborators

Detail Information

Publications21

  1. ncbi Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infection
    Lioubov M Pletneva
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 26:914-21. 2006
    ....
  2. pmc Inactivation of respiratory syncytial virus by zinc finger reactive compounds
    Marina S Boukhvalova
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD, USA
    Virol J 7:20. 2010
    ..Moreover, inactivation of RSV through modification of an internal protein could yield a safer whole virus vaccine than that produced by RSV inactivation with formalin which modifies surface proteins...
  3. pmc Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infection
    Jorge C G Blanco
    Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
    Virol J 6:57. 2009
    ....
  4. ncbi Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats
    Jorge C G Blanco
    Virion Systems, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    J Infect Dis 185:1780-5. 2002
    ....
  5. ncbi Prospects of antiviral and anti-inflammatory therapy for respiratory syncytial virus infection
    Jorge C G Blanco
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    Expert Rev Anti Infect Ther 3:945-55. 2005
    ..In this review, the current knowledge that has set the rationale for the development of such therapy is summarized...
  6. ncbi The cotton rat: an underutilized animal model for human infectious diseases can now be exploited using specific reagents to cytokines, chemokines, and interferons
    Jorge C G Blanco
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 24:21-8. 2004
    ....
  7. ncbi A cotton rat model of human parainfluenza 3 laryngotracheitis: virus growth, pathology, and therapy
    Martin G Ottolini
    Department of Pediatrics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland 20814 4799, USA
    J Infect Dis 186:1713-7. 2002
    ..Topical glucocorticoid therapy, with or without concurrent topical immunotherapy with antibody to PIV3, did not lead to a rebound of viral replication...
  8. pmc Induction of type I interferons and interferon-inducible Mx genes during respiratory syncytial virus infection and reinfection in cotton rats
    Lioubov M Pletneva
    Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    J Gen Virol 89:261-70. 2008
    ..Virus replication and Mx gene expression became more prominent with increasing intervals between primary infection and reinfection. These results highlight the role of type I IFN in modulation of the immune response to RSV...
  9. pmc Respiratory syncytial virus infects and abortively replicates in the lungs in spite of preexisting immunity
    Marina S Boukhvalova
    Virion Systems, Inc, 9610 Medical Center Dr, Suite 100, Rockville, MD 20850, USA
    J Virol 81:9443-50. 2007
    ..To the best of our knowledge, this is the first evidence of abortive replication of RSV in vivo...
  10. pmc Human metapneumovirus: enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged
    Kevin C Yim
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States
    Vaccine 25:5034-40. 2007
    ..Cytokine profiles were distinctive from those observed during primary infection and re-infection. The data raise safety concerns for hMPV vaccine preparations...
  11. ncbi Age-related differences in pulmonary cytokine response to respiratory syncytial virus infection: modulation by anti-inflammatory and antiviral treatment
    Marina S Boukhvalova
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Infect Dis 195:511-8. 2007
    ..Recently, RSV has also been recognized as a serious health risk in elderly individuals, but the pathogenesis of RSV infection in elderly individuals remains unknown...
  12. ncbi The American cotton rat: a novel model for pulmonary tuberculosis
    Robert L Elwood
    Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Tuberculosis (Edinb) 87:145-54. 2007
    ..Many cytokine genes were more highly expressed in the focal areas of inflammation. Cotton rats provide another valuable tool in future research with tuberculosis...
  13. ncbi The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease
    Marina S Boukhvalova
    Virion Systems, Inc 9610 Medical Center Drive, Suite 100 Rockville, MD 20850, USA
    Vaccine 24:5027-35. 2006
    ..Our data illustrate the complexity of proinflammatory response elicited by FI-RSV vaccination and RSV infection and the potential importance of MPL in modifying this response...
  14. ncbi The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis
    Martin G Ottolini
    Department of Pediatrics, F Edward Hebert School of Medicine, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    J Gen Virol 86:2823-30. 2005
    ..These results indicate that cotton rats will be useful for further studies of influenza pathogenesis and immunity...
  15. pmc Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton rats
    Marie Eve Hamelin
    Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Quebec, and Laval University, Quebec City, Canada
    J Virol 79:8894-903. 2005
    ..Both animal models would be of great value in evaluating different therapeutic agents, as well as vaccine candidates against hMPV...
  16. ncbi Respiratory syncytial virus (RSV) infection induces cyclooxygenase 2: a potential target for RSV therapy
    Joann Y Richardson
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 174:4356-64. 2005
    ..Treatment of cotton rats with indomethacin significantly mitigated lung histopathology produced by RSV. The studies described in this study provide the first evidence that COX-2 is a potential therapeutic target in RSV-induced disease...
  17. ncbi The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus
    Silke Stertz
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Interferon Cytokine Res 27:847-55. 2007
    ..Therefore, cotton rats are a suitable animal model to study experimental infections with FLUAV and other RNA viruses...
  18. ncbi Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children
    Agnes A Awomoyi
    Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
    J Immunol 179:3171-7. 2007
    ....
  19. ncbi Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease
    LoRanee E Braun
    Department of Pediatrics, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Microb Pathog 43:208-16. 2007
    ..aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines...
  20. pmc Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections
    Andrei E Medvedev
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 20101, USA
    J Exp Med 198:521-31. 2003
    ..Thus, IRAK-4 is pivotal in the development of a normal inflammatory response initiated by bacterial or nonbacterial insults...
  21. ncbi The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro
    Shuling Zhang
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
    J Endotoxin Res 8:379-88. 2002
    ..Collectively, these data provide evidence for an important role for IRF-1 in vivo and in vitro and for IRF-2 in vitro in the regulation of COX-2 expression by LPS...

Research Grants11

  1. Establishment fo HIV infection in cotton rats
    Jorge Blanco; Fiscal Year: 2007
    ....
  2. The Role of TLR4 and RSV F Protein in Immunity to RSV
    JORGE C BLANCO; Fiscal Year: 2010
    ..Our proposal seeks to test a new subunit vaccine and to identify new ways to treat RSV infection. ..
  3. The Role of TLR4 and RSV F Protein in Immunity to RSV
    Jorge Blanco; Fiscal Year: 2004
    ..It is expected that at the completion of this grant, we will have determined the molecular basis for primary and vaccine-enhanced RSV disease, and have identified strategies for the development of a human RSV vaccine. ..
  4. The Role of TLR4 and RSV F Protein in Immunity to RSV
    Jorge Blanco; Fiscal Year: 2009
    ..Our proposal seeks to test a new subunit vaccine and to identify new ways to treat RSV infection. ..
  5. The Role of TLR4 and RSV F Protein in Immunity to RSV
    Jorge Blanco; Fiscal Year: 2007
    ..It is expected that at the completion of this grant, we will have determined the molecular basis for primary and vaccine-enhanced RSV disease, and have identified strategies for the development of a human RSV vaccine. ..
  6. Treatment of RSV Bronchiolitis with NSAIDs
    Jorge Blanco; Fiscal Year: 2006
    ..These studies will involve correlating treatment of RSV-infected animals with pulmonary histopathology and inflammation. ..
  7. The Role of TLR4 and RSV F Protein in Immunity to RSV
    Jorge Blanco; Fiscal Year: 2006
    ..It is expected that at the completion of this grant, we will have determined the molecular basis for primary and vaccine-enhanced RSV disease, and have identified strategies for the development of a human RSV vaccine. ..
  8. The Role of TLR4 and RSV F Protein in Immunity to RSV
    Jorge Blanco; Fiscal Year: 2005
    ..It is expected that at the completion of this grant, we will have determined the molecular basis for primary and vaccine-enhanced RSV disease, and have identified strategies for the development of a human RSV vaccine. ..
  9. The Role of TLR4 and RSV F Protein in Immunity to RSV
    JORGE C BLANCO; Fiscal Year: 2010
    ..Our proposal seeks to test a new subunit vaccine and to identify new ways to treat RSV infection. ..