Research Topics
| JORGE C BLANCOSummaryAffiliation: Virion Systems Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infectionLioubov M Pletneva
Virion Systems, Inc, Rockville, MD 20850, USA
J Interferon Cytokine Res 26:914-21. 2006....
Inactivation of respiratory syncytial virus by zinc finger reactive compoundsMarina S Boukhvalova
Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD, USA
Virol J 7:20. 2010..Moreover, inactivation of RSV through modification of an internal protein could yield a safer whole virus vaccine than that produced by RSV inactivation with formalin which modifies surface proteins...- Expression of Human CD4 and chemokine receptors in cotton rat cells confers permissiveness for productive HIV infectionJorge C G Blanco
Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
Virol J 6:57. 2009.... - Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton ratsJorge C G Blanco
Virion Systems, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
J Infect Dis 185:1780-5. 2002.... - Prospects of antiviral and anti-inflammatory therapy for respiratory syncytial virus infectionJorge C G Blanco
Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
Expert Rev Anti Infect Ther 3:945-55. 2005..In this review, the current knowledge that has set the rationale for the development of such therapy is summarized... - The cotton rat: an underutilized animal model for human infectious diseases can now be exploited using specific reagents to cytokines, chemokines, and interferonsJorge C G Blanco
Virion Systems, Inc, Rockville, MD 20850, USA
J Interferon Cytokine Res 24:21-8. 2004.... - A cotton rat model of human parainfluenza 3 laryngotracheitis: virus growth, pathology, and therapyMartin G Ottolini
Department of Pediatrics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland 20814 4799, USA
J Infect Dis 186:1713-7. 2002..Topical glucocorticoid therapy, with or without concurrent topical immunotherapy with antibody to PIV3, did not lead to a rebound of viral replication... - Induction of type I interferons and interferon-inducible Mx genes during respiratory syncytial virus infection and reinfection in cotton ratsLioubov M Pletneva
Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
J Gen Virol 89:261-70. 2008..Virus replication and Mx gene expression became more prominent with increasing intervals between primary infection and reinfection. These results highlight the role of type I IFN in modulation of the immune response to RSV... - Respiratory syncytial virus infects and abortively replicates in the lungs in spite of preexisting immunityMarina S Boukhvalova
Virion Systems, Inc, 9610 Medical Center Dr, Suite 100, Rockville, MD 20850, USA
J Virol 81:9443-50. 2007..To the best of our knowledge, this is the first evidence of abortive replication of RSV in vivo... - Human metapneumovirus: enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challengedKevin C Yim
Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States
Vaccine 25:5034-40. 2007..Cytokine profiles were distinctive from those observed during primary infection and re-infection. The data raise safety concerns for hMPV vaccine preparations... - Age-related differences in pulmonary cytokine response to respiratory syncytial virus infection: modulation by anti-inflammatory and antiviral treatmentMarina S Boukhvalova
Virion Systems, Inc, Rockville, MD 20850, USA
J Infect Dis 195:511-8. 2007..Recently, RSV has also been recognized as a serious health risk in elderly individuals, but the pathogenesis of RSV infection in elderly individuals remains unknown... - The American cotton rat: a novel model for pulmonary tuberculosisRobert L Elwood
Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Tuberculosis (Edinb) 87:145-54. 2007..Many cytokine genes were more highly expressed in the focal areas of inflammation. Cotton rats provide another valuable tool in future research with tuberculosis... - The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced diseaseMarina S Boukhvalova
Virion Systems, Inc. 9610 Medical Center Drive, Suite 100 Rockville, MD 20850, USA
Vaccine 24:5027-35. 2006..Our data illustrate the complexity of proinflammatory response elicited by FI-RSV vaccination and RSV infection and the potential importance of MPL in modifying this response... - The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesisMartin G Ottolini
Department of Pediatrics, F Edward Hebert School of Medicine, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
J Gen Virol 86:2823-30. 2005..These results indicate that cotton rats will be useful for further studies of influenza pathogenesis and immunity... - Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton ratsMarie-Eve Hamelin
, and Laval University, , Canada
J Virol 79:8894-903. 2005..Both animal models would be of great value in evaluating different therapeutic agents, as well as vaccine candidates against hMPV... - Respiratory syncytial virus (RSV) infection induces cyclooxygenase 2: a potential target for RSV therapyJoann Y Richardson
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 174:4356-64. 2005..Treatment of cotton rats with indomethacin significantly mitigated lung histopathology produced by RSV. The studies described in this study provide the first evidence that COX-2 is a potential therapeutic target in RSV-induced disease... - The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirusSilke Stertz
Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
J Interferon Cytokine Res 27:847-55. 2007..Therefore, cotton rats are a suitable animal model to study experimental infections with FLUAV and other RNA viruses... - Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young childrenAgnes A Awomoyi
Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
J Immunol 179:3171-7. 2007.... - Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic diseaseLoRanee E Braun
Department of Pediatrics, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Microb Pathog 43:208-16. 2007..aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines... - Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infectionsAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 20101, USA
J Exp Med 198:521-31. 2003..Thus, IRAK-4 is pivotal in the development of a normal inflammatory response initiated by bacterial or nonbacterial insults... - The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitroShuling Zhang
Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
J Endotoxin Res 8:379-88. 2002..Collectively, these data provide evidence for an important role for IRF-1 in vivo and in vitro and for IRF-2 in vitro in the regulation of COX-2 expression by LPS...
Research Grants
- Establishment fo HIV infection in cotton ratsJorge Blanco; Fiscal Year: 2007....
- The Role of TLR4 and RSV F Protein in Immunity to RSVJORGE C BLANCO; Fiscal Year: 2010..Our proposal seeks to test a new subunit vaccine and to identify new ways to treat RSV infection. ..
- The Role of TLR4 and RSV F Protein in Immunity to RSVJorge Blanco; Fiscal Year: 2007..It is expected that at the completion of this grant, we will have determined the molecular basis for primary and vaccine-enhanced RSV disease, and have identified strategies for the development of a human RSV vaccine. ..
- Treatment of RSV Bronchiolitis with NSAIDsJorge Blanco; Fiscal Year: 2006..These studies will involve correlating treatment of RSV-infected animals with pulmonary histopathology and inflammation. ..
- The Role of TLR4 and RSV F Protein in Immunity to RSVJORGE C BLANCO; Fiscal Year: 2010..Our proposal seeks to test a new subunit vaccine and to identify new ways to treat RSV infection. ..