Zhibing Zhang

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Reprod 79:75-83. 2008
  2. pmc MEIG1 is essential for spermiogenesis in mice
    Zhibing Zhang
    Departments of Obstetrics and Gynecology and Biochemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 106:17055-60. 2009
  3. ncbi request reprint Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cell Motil Cytoskeleton 64:360-76. 2007
  4. ncbi request reprint A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Reprod 77:864-71. 2007
  5. pmc Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles
    Jiannan Wang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e39846. 2012
  6. pmc Spag16, an axonemal central apparatus gene, encodes a male germ cell nuclear speckle protein that regulates SPAG16 mRNA expression
    David R Nagarkatti-Gude
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e20625. 2011
  7. pmc Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5
    Elizabeth Anne Kiselak
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 285:30496-505. 2010
  8. pmc Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males
    David R Nagarkatti-Gude
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    BMC Urol 12:27. 2012
  9. pmc Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival
    Maria Eugenia Teves
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Cell Mol Biol 48:765-72. 2013
  10. pmc Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone
    Celso Silva
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida, USA
    Mol Reprod Dev 76:11-21. 2009

Collaborators

Detail Information

Publications19

  1. pmc Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Reprod 79:75-83. 2008
    ..SPAG16L can be phosphorylated by TSSK2 in vitro. Finally, TSSK2 is absent or markedly reduced from the testes in most of the SPAG16L-null mice. These data support the conclusion that SPAG16L is a TSSK2 substrate...
  2. pmc MEIG1 is essential for spermiogenesis in mice
    Zhibing Zhang
    Departments of Obstetrics and Gynecology and Biochemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 106:17055-60. 2009
    ..Our findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis...
  3. ncbi request reprint Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cell Motil Cytoskeleton 64:360-76. 2007
    ..The findings also demonstrate that SPAG6 and SPAG16L have related roles in controlling the function of cilia in the brain and lung...
  4. ncbi request reprint A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme
    Zhibing Zhang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biol Reprod 77:864-71. 2007
    ....
  5. pmc Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles
    Jiannan Wang
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e39846. 2012
    ..Since RCC1 domains associate with Ran, a small GTPase that regulates molecular trafficking, it is possible that RC/BTB2 plays a role in transporting proteins during acrosome formation...
  6. pmc Spag16, an axonemal central apparatus gene, encodes a male germ cell nuclear speckle protein that regulates SPAG16 mRNA expression
    David R Nagarkatti-Gude
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e20625. 2011
    ..This is a unique example of a highly conserved axonemal protein gene that encodes two protein products with different functions...
  7. pmc Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5
    Elizabeth Anne Kiselak
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 285:30496-505. 2010
    ..The present study demonstrates that SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia...
  8. pmc Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males
    David R Nagarkatti-Gude
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    BMC Urol 12:27. 2012
    ..We have also reported that a heterozygous mutation of the human SPAG16 gene reduces stability of the sperm axonemal central apparatus...
  9. pmc Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival
    Maria Eugenia Teves
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Cell Mol Biol 48:765-72. 2013
    ..We conclude that Spag17 plays a critical role in the function and structure of motile cilia, and that neonatal lethality is likely explained by impaired airway mucociliary clearance...
  10. pmc Expression profile of male germ cell-associated genes in mouse embryonic stem cell cultures treated with all-trans retinoic acid and testosterone
    Celso Silva
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida, USA
    Mol Reprod Dev 76:11-21. 2009
    ..Furthermore, these data represent an important first step in designing a plausible directed differentiation protocol for male germ cells...
  11. ncbi request reprint Deficiency of SPAG16L causes male infertility associated with impaired sperm motility
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Biol Reprod 74:751-9. 2006
    ..The sperm defect is consistent with the motility phenotype of the Pf20 mutants of Chlamydomonas, but morphologically different in that the mutant algal axoneme lacks the central apparatus...
  12. ncbi request reprint Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health and the Department of Ophthalmology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Proteomics 4:914-23. 2005
    ..Thus, PF6, SPAG6, and PF20 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat...
  13. ncbi request reprint Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins
    Eran Horowitz
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mol Hum Reprod 11:307-17. 2005
    ..Collectively, our findings demonstrate a sequential pattern of expression of flagellar component genes, differential times of expression or rates of transcript accumulation within each class and shared promoter features within a class...
  14. pmc Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency
    Bingfang Xu
    Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Dev Biol 319:211-22. 2008
    ....
  15. pmc TSKS concentrates in spermatid centrioles during flagellogenesis
    Bingfang Xu
    Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, VA 22908, USA
    Dev Biol 319:201-10. 2008
    ..Coupled with the infertility due to haploinsufficiency noted in chimeric mice with deletion of Tssk1 and 2 (companion paper) this centriolar kinase/substrate pair is predicted to play an indispensable role during spermiogenesis...
  16. pmc A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health Department of Psychiatry Center for Experimental Therapeutics, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 22:7993-8004. 2002
    ..Our observations provide the first evidence for an association between mammalian orthologues of two Chlamydomonas proteins known to be critical for axoneme structure and function...
  17. pmc Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:12946-51. 2004
    ..The different patterns of expression of the two PF20 proteins suggest the possibility that the Pf20 gene has multiple functions during spermatogenesis...
  18. ncbi request reprint Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism
    Tatsuro Kishida
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:19276-85. 2004
    ..These observations suggest that the Mln64 START domain is largely dispensable for sterol metabolism in mice...
  19. ncbi request reprint COX-2-dependent cardiac failure in Gh/tTG transgenic mice
    Zhibing Zhang
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Circ Res 92:1153-61. 2003
    ..Gh/tTG activation regulates expression of COX-2 and its products may differentially modulate cardiomyocyte commitment to cell death or survival...