Timothy P York

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint The contribution of genetic and environmental factors to the duration of pregnancy
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, VA Electronic address
    Am J Obstet Gynecol 210:398-405. 2014
  2. pmc Fetal and maternal genes' influence on gestational age in a quantitative genetic analysis of 244,000 Swedish births
    Timothy P York
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Epidemiol 178:543-50. 2013
  3. pmc Increased frequency of micronuclei in adults with a history of childhood sexual abuse: a discordant monozygotic twin study
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e55337. 2013
  4. pmc Racial differences in genetic and environmental risk to preterm birth
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 5:e12391. 2010
  5. doi request reprint High-resolution mass spectrometry proteomics for the identification of candidate plasma protein biomarkers for chronic obstructive pulmonary disease
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Biomarkers 15:367-77. 2010
  6. pmc Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 32398 0003, United States of America
    Twin Res Hum Genet 12:333-42. 2009
  7. doi request reprint Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Pharmacogenomics 10:753-67. 2009
  8. ncbi request reprint Multivariate adaptive regression splines: a powerful method for detecting disease-risk relationship differences among subgroups
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980003, Richmond, VA 23298 0003, USA
    Stat Med 25:1355-67. 2006
  9. ncbi request reprint Epistatic and environmental control of genome-wide gene expression
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 8:5-15. 2005
  10. doi request reprint Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD)
    Gaurav S J B Rana
    Health Sciences, Altria Client Services, Research Development and Engineering, 601 E Jackson Street, Richmond, VA 23219, USA
    Anal Bioanal Chem 397:1809-19. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The contribution of genetic and environmental factors to the duration of pregnancy
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, VA Electronic address
    Am J Obstet Gynecol 210:398-405. 2014
    ..A review of the current literature can serve as a guide for future research efforts...
  2. pmc Fetal and maternal genes' influence on gestational age in a quantitative genetic analysis of 244,000 Swedish births
    Timothy P York
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Epidemiol 178:543-50. 2013
    ..Since environmental factors explained most differences in the timing of birth, genetic studies may benefit from understanding the specific effect of fetal and maternal genes in the context of these yet-unidentified factors. ..
  3. pmc Increased frequency of micronuclei in adults with a history of childhood sexual abuse: a discordant monozygotic twin study
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e55337. 2013
    ....
  4. pmc Racial differences in genetic and environmental risk to preterm birth
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 5:e12391. 2010
    ..This study provides a comprehensive description of the relative genetic and environmental contributions to racial differences in gestational age...
  5. doi request reprint High-resolution mass spectrometry proteomics for the identification of candidate plasma protein biomarkers for chronic obstructive pulmonary disease
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Biomarkers 15:367-77. 2010
    ..This research demonstrates the utility of proteomic profiling to improve the understanding of molecular mechanisms involved in cigarette smoking-related COPD by identifying plasma proteins that correlate with decline in lung function...
  6. pmc Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 32398 0003, United States of America
    Twin Res Hum Genet 12:333-42. 2009
    ..We anticipate the flexibility of MCMC methods to handle increasingly complex models to be of particular relevance for the study of birth outcomes...
  7. doi request reprint Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity
    Timothy P York
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Pharmacogenomics 10:753-67. 2009
    ..In this paper, we estimate drug nonresponse in a clinical trial for the asthma drug montelukast as either the result of an inactive genetic variant or the presence of subgroups of patients not responding to the drug...
  8. ncbi request reprint Multivariate adaptive regression splines: a powerful method for detecting disease-risk relationship differences among subgroups
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980003, Richmond, VA 23298 0003, USA
    Stat Med 25:1355-67. 2006
    ..It was shown that power was higher even if the regression curve was linear, that gains increased with the complexity of the curve, and that for highly non-linear curves model-free methods such as MARS might be the only alternative...
  9. ncbi request reprint Epistatic and environmental control of genome-wide gene expression
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 8:5-15. 2005
    ....
  10. doi request reprint Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD)
    Gaurav S J B Rana
    Health Sciences, Altria Client Services, Research Development and Engineering, 601 E Jackson Street, Richmond, VA 23219, USA
    Anal Bioanal Chem 397:1809-19. 2010
    ..Whether these proteins are the cause or result of accelerated decline will require further research...
  11. pmc Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
    Lori D Hill
    Department of Obstetrics and Gynecology and Center on Health Disparities, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    BMC Med Genet 12:64. 2011
    ..Furthermore, ERAP2 expression is altered in first trimester placentas of women destined to develop preeclampsia...
  12. pmc Genetic and environmental influences on spontaneous micronuclei frequencies in children and adults: a twin study
    Kimberly H Jones
    Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298 0662, USA
    Mutagenesis 26:745-52. 2011
    ..Recognition of factors contributing to baseline levels of micronuclei should provide guidance to researchers in designing studies to evaluate agents hypothesised to influence chromosomal instability...
  13. pmc Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome
    Lori D Hill
    Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Mol Cell Endocrinol 350:72-7. 2012
    ..Our findings suggest that common variants and haplotypes of the COMT gene are not major contributors to risk for PCOS, but that COMT genotype may influence prolactin levels...
  14. pmc In silico whole genome association scan for murine prepulse inhibition
    Bradley Todd Webb
    Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA, USA
    PLoS ONE 4:e5246. 2009
    ....
  15. pmc Elevated TRF2 in advanced breast cancers with short telomeres
    Malissa C Diehl
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Breast Cancer Res Treat 127:623-30. 2011
    ..Our findings also reinforce the concept that serially propagated cancer cells, although tumor-derived, may not model all types of authentic tumors especially those demonstrating genetic heterogeneity...
  16. pmc Genetic and environmental effects on diurnal dehydroepiandrosterone sulfate concentrations in middle-aged men
    Elizabeth C Prom-Wormley
    Virginia Institute for Behavioral and Psychiatric Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, United States
    Psychoneuroendocrinology 36:1441-52. 2011
    ..The characterization of the genetic and environmental contributions to daily DHEAS concentrations is thus important for understanding the genetics of health and aging...
  17. pmc The phenotype of persons having mosaicism for trisomy 21/Down syndrome reflects the percentage of trisomic cells present in different tissues
    Paulie Papavassiliou
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    Am J Med Genet A 149:573-83. 2009
    ..The results of this study should enable geneticists and other health care professionals to provide information regarding optimal diagnostic approaches and anticipated clinical outcomes...
  18. pmc Mechanisms leading to the formation of micronuclei containing sex chromosomes differ with age
    Kimberly H Jones
    Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA
    Mutat Res 747:207-17. 2012
    ..Therefore, when analyzing MN frequencies, one may also wish to evaluate the imbalances present in both the binucleates and MN to facilitate the recognition of varying cellular responses to environmental or genotoxic exposures...
  19. pmc Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia
    Lori D Hill
    Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 6:e16681. 2011
    ..341 and P = 0.219, respectively). Our findings demonstrate a role for both maternal and fetal COMT in preeclampsia and highlight the importance of including allelic variation in MTHFR...
  20. pmc Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications
    Aaron R Wolen
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e33575. 2012
    ....
  21. ncbi request reprint Elevated expression of nuclear Hsp90 in invasive breast tumors
    Malissa C Diehl
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Cancer Biol Ther 8:1952-61. 2009
    ..Taken together, our data suggest that blocking nuclear Hsp90 function in advanced breast cancers may be a more targeted approach to treating advanced breast cancers that are refractory to traditional therapy...
  22. doi request reprint Comparison of multivariate adaptive regression splines and logistic regression in detecting SNP-SNP interactions and their application in prostate cancer
    Hui Yi Lin
    Medical Statistics Section, University of Alabama at Birmingham, Birmingham, AL, USA
    J Hum Genet 53:802-11. 2008
    ..The best model with one two-way and one three-way interaction was selected using MARS. The findings supported that MARS may provide a useful tool for exploring SNP-SNP interactions...