J L Wiley

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Ajulemic acid
    Jenny L Wiley
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, 23298, USA
    IDrugs 8:1002-11. 2005
  2. ncbi request reprint Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Pharmacol Exp Ther 301:679-89. 2002
  3. ncbi request reprint Nicotine-like discriminative stimulus effects of bupropion in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Exp Clin Psychopharmacol 10:129-35. 2002
  4. ncbi request reprint Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinity
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virg, USA
    Pharmacology 66:89-99. 2002
  5. ncbi request reprint Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 165:378-85. 2003
  6. ncbi request reprint Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Chem Phys Lipids 121:57-63. 2002
  7. ncbi request reprint Evaluation of toluene dependence and cross-sensitization to diazepam
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Life Sci 72:3023-33. 2003
  8. ncbi request reprint Cannabinoid pharmacological properties common to other centrally acting drugs
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 471:185-93. 2003
  9. ncbi request reprint Pharmacological challenge reveals long-term effects of perinatal phencyclidine on delayed spatial alternation in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:867-73. 2003
  10. ncbi request reprint Sex-dependent effects of delta 9-tetrahydrocannabinol on locomotor activity in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, P O Box 980613, 410 North 12th Street, Richmond, VA 23298 0613, USA
    Neurosci Lett 352:77-80. 2003

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Ajulemic acid
    Jenny L Wiley
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, 23298, USA
    IDrugs 8:1002-11. 2005
    ..Indevus Pharmaceuticals Inc is developing ajulemic acid, a non-steroidal anti-inflammatory drug derived from tetrahydrocannabinol, for the potential treatment of pain, inflammation and cystitis...
  2. ncbi request reprint Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Pharmacol Exp Ther 301:679-89. 2002
    ....
  3. ncbi request reprint Nicotine-like discriminative stimulus effects of bupropion in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Exp Clin Psychopharmacol 10:129-35. 2002
    ..Given bupropion's shared pharmacology with dopamine transport inhibitors, these effects may be produced in part through bupropion's actions on dopaminergic neurotransmission...
  4. ncbi request reprint Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinity
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virg, USA
    Pharmacology 66:89-99. 2002
    ..In addition, some of these analogs may be very low efficacy agonists at CB(1) receptors that act as full agonists in vivo, but lack the ability to displace high affinity and high efficacy binding ligands in vitro...
  5. ncbi request reprint Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 165:378-85. 2003
    ..Recently, a number of low-affinity NMDA channel blockers that exhibit minimal PCP-like effects in humans at therapeutic doses have been developed...
  6. ncbi request reprint Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Chem Phys Lipids 121:57-63. 2002
    ..While not yet conclusive, these results suggest the possibility of additional cannabinoid receptors in the brain and periphery...
  7. ncbi request reprint Evaluation of toluene dependence and cross-sensitization to diazepam
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Life Sci 72:3023-33. 2003
    ..Further, these studies add to increasing evidence that abused inhalants do not have identical pharmacological effects...
  8. ncbi request reprint Cannabinoid pharmacological properties common to other centrally acting drugs
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 471:185-93. 2003
    ....
  9. ncbi request reprint Pharmacological challenge reveals long-term effects of perinatal phencyclidine on delayed spatial alternation in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:867-73. 2003
    ..These results suggest that perinatal administration of PCP may produce long-term alterations in cognition that are revealed by pharmacological challenge and manipulation of task difficulty...
  10. ncbi request reprint Sex-dependent effects of delta 9-tetrahydrocannabinol on locomotor activity in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, P O Box 980613, 410 North 12th Street, Richmond, VA 23298 0613, USA
    Neurosci Lett 352:77-80. 2003
    ..These results are consistent with those of previous studies in which cannabinoids were more potent at producing locomotor suppression and antinociception in female than in male rats...
  11. ncbi request reprint Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Life Sci 75:141-51. 2004
    ..Further, they suggest that similarities between the stimulus properties of GABA(A) agonists and NMDA antagonists are at least as strong as similarities among agonists acting at different sites on GABA(A) receptors...
  12. pmc Progressive ratio performance following challenge with antipsychotics, amphetamine, or NMDA antagonists in adult rats treated perinatally with phencyclidine
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 177:170-7. 2004
    ..In addition to cognitive deficits, schizophrenic patients may also exhibit negative symptoms such as lack of motivation...
  13. ncbi request reprint A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 980613, USA
    Exp Clin Psychopharmacol 12:173-9. 2004
    ..O-1839, a VR(1) agonist, failed to substitute for either cannabinoid. These results suggest that the discriminative stimulus effects of Delta(9)-THC and O-1812 are similar, but subtle differences also exist...
  14. ncbi request reprint Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, Virginia 23298 0613, USA
    Eur J Pharmacol 510:59-68. 2005
    ....
  15. pmc CB1 cannabinoid receptor-mediated modulation of food intake in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Br J Pharmacol 145:293-300. 2005
    ..g., decreased feeding behavior and locomotor stimulation). In either case, these results strongly suggest that CB(1) receptors may play a role in regulation of feeding behavior...
  16. ncbi request reprint Evaluation of the efficacy of antipsychotic attenuation of phencyclidine-disrupted prepulse inhibition in rats
    J L Wiley
    Department of Pharmacology, Virginia Commonwealth University, Richmond 23298 0613, USA
    J Neural Transm 109:523-35. 2002
    ..None of the other antipsychotics nor spermine altered phencyclidine's effects. These results suggest that this model does not reliably differentiate between typical and atypical antipsychotics...
  17. ncbi request reprint Antinociceptive effects of tetrahydrocannabinol side chain analogs: dependence upon route of administration
    J L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 397:319-26. 2000
    ..t. These results suggest that receptor mechanisms for cannabinoid antinociceptive effects differ in brain and spinal cord, although potential pharmacokinetic differences in rate of local distribution cannot be eliminated...
  18. ncbi request reprint Effects of nitric oxide synthase inhibitors on timing and short-term memory in rats
    J L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Behav Pharmacol 11:421-9. 2000
    ..The present results lend further support to the hypothesis that nitric oxide modulation does not affect retention of well-learned tasks, although it may affect acquisition of novel behavior...
  19. ncbi request reprint Evaluation of 1,1,1-trichloroethane and flurothyl locomotor effects following diazepam treatment in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Pharmacol Biochem Behav 71:163-9. 2002
    ..These results suggest that the development of sensitization to TCE involves common mechanisms with those that are affected by repeated dosing with the CNS depressant diazepam...
  20. ncbi request reprint Separation of drug effects on timing and behavioral inhibition by increased stimulus control
    J L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond 23298 0613, USA
    Exp Clin Psychopharmacol 8:451-61. 2000
    ..Collectively, these results suggest that the use of different levels of stimulus control may aid in separation of drug effects on timing and other behavioral processes, including behavioral inhibition...
  21. ncbi request reprint Novel pyrazole cannabinoids: insights into CB(1) receptor recognition and activation
    J L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 296:1013-22. 2001
    ..These results suggest that the structural properties of 1- and 5-substituents are primarily responsible for the antagonist activity of SR141716A...
  22. ncbi request reprint Nitric oxide synthase inhibitors do not substitute in rats trained to discriminate phencyclidine from saline
    J L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Eur J Pharmacol 367:7-11. 1999
    ....
  23. ncbi request reprint Antipunishment activity of diazepam in rats trained to discriminate diazepam from vehicle
    J L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Exp Clin Psychopharmacol 7:13-9. 1999
    ..The potential utility of this new method is that it allows direct comparisons of the antipunishment and discriminative stimulus effects of putative anxiolytic drugs during a single session with the same animals...
  24. ncbi request reprint Effects of modulation of NMDA neurotransmission on response rate and duration in a conflict procedure in rats
    J L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Neuropharmacology 37:1527-34. 1998
    ..Further research is needed to clarify the experimental conditions under which the anxiolytic potential of NMDA antagonists is most evident...
  25. ncbi request reprint Evaluation of cannabimimetic effects of structural analogs of anandamide in rats
    J L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Eur J Pharmacol 355:113-8. 1998
    ..These results support the prediction that the subjective effects of anandamide analogs that have been developed thus far would not be cannabimimetic except at high doses...
  26. ncbi request reprint Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects
    J L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Life Sci 67:1573-83. 2000
    ..These results further suggest that metabolite contribution to anandamide's effects, if any, would occur primarily at later times...
  27. ncbi request reprint Phencyclidine- and diazepam-like discriminative stimulus effects of inhalants in mice
    S E Bowen
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    Exp Clin Psychopharmacol 7:28-37. 1999
    ....
  28. ncbi request reprint Effects of modulation of nitric oxide on acoustic startle responding and prepulse inhibition in rats
    J L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Eur J Pharmacol 328:125-30. 1997
    ....
  29. ncbi request reprint Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects
    M J Wallace
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0599, USA
    Eur J Pharmacol 428:51-7. 2001
    ..This study establishes a role for the cannabinoid CB1 receptor in modulating seizure activity in a whole animal model...
  30. ncbi request reprint Effects of SR 141716A after acute or chronic cannabinoid administration in dogs
    A H Lichtman
    Department of Pharmacology and Toxicology, MCV Campus, Virginia Commonwealth University, Richmond 23298 0613, USA
    Eur J Pharmacol 357:139-48. 1998
    ..This is the first demonstration of a precipitated withdrawal syndrome in a non-rodent species...
  31. ncbi request reprint Interactions between THC and cannabidiol in mouse models of cannabinoid activity
    S A Varvel
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Psychopharmacology (Berl) 186:226-34. 2006
    ..Such interactions may have important implications for understanding the long-term health consequences of chronic marijuana use as well as for attempts to develop therapeutic uses for THC and other CB(1) agonists...
  32. ncbi request reprint Combinations of clozapine and phencyclidine: effects on drug discrimination and behavioral inhibition in rats
    A D Compton
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284-2018, USA
    Neuropharmacology 40:289-97. 2001
    ..Since chronic dosing is required for therapeutic efficacy of antipsychotics, future studies should focus on investigation of chronic dosing effects of these drugs in combination with PCP...
  33. ncbi request reprint Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists
    B R Martin
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    J Pharmacol Exp Ther 290:1065-79. 1999
    ..The finding that manipulations of the side chain produces high- affinity ligands with either antagonist, partial agonist, or full agonist effects reveals a critical structural feature for receptor activation...
  34. ncbi request reprint Effects of phencyclidine-like drugs on punished behavior in rats
    J H Porter
    Department of Psychology, Virginia Commonwealth University, Richmond
    J Pharmacol Exp Ther 248:997-1002. 1989
    ..The concordance between the discriminative stimulus properties and antipunishment effects of PCP-like drugs and actions at the PCP receptor suggests that the PCP receptor may play a role in both behavioral actions of this group of drugs...
  35. pmc Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats
    M Jerry Wright
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613 USA
    Pharmacol Biochem Behav 85:507-13. 2006
    ..Further, they suggest that the role of cholinergic mediation of the behavioral effects of dextrorphan and dextromethorphan related to the abuse properties of nicotine may be minimal...
  36. pmc Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States
    Eur J Pharmacol 615:102-7. 2009
    ..Taken together these studies demonstrate THC's ability to produce discriminative stimulus effects as well as demonstrate its pharmacological specificity and mechanism of action in a two-lever drug discrimination mouse model...
  37. pmc Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 210:275-84. 2010
    ..Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects...
  38. pmc Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice
    K M Tobey
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1217 E Marshall St, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 223:159-68. 2012
    ..Investigating novel compounds selectively targeting α4β2 nAChRs hypothesized to have a key role in the rewarding effects of nicotine may be a useful approach for future treatment...
  39. ncbi request reprint NMDA antagonists produce site-selective impairment of accuracy in a delayed nonmatch-to-sample task in rats
    C B Willmore
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298-0613, USA
    Neuropharmacology 41:916-27. 2001
    ....
  40. ncbi request reprint Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia
    C Wang
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77555-1031, USA
    Neuroscience 107:535-50. 2001
    ..It is postulated that these deficits may model the hypofrontality observed in schizophrenia and that this model may be helpful in designing appropriate pharmacotherapy...
  41. pmc Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure
    James J Burston
    Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA
    Br J Pharmacol 161:103-12. 2010
    ..The aim of this study was to determine whether adolescent and adult rats exhibit differential adaptation of brain cannabinoid (CB(1)) receptors after repeated exposure to Delta(9)-tetrahydrocannabinol (THC)...
  42. ncbi request reprint Behavioral pharmacology of N-methyl-D-aspartate antagonists: implications for the study and pharmacotherapy of anxiety and schizophrenia
    J L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0613, USA
    Exp Clin Psychopharmacol 5:365-74. 1997
    ..Finally, examination of the discriminative stimulus effects of NMDA antagonists may allow prediction of adverse subjective effects of potential medications of this class...
  43. ncbi request reprint Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice
    Cassandra Y Baskfield
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 309:86-91. 2004
    ..In contrast, diazepam did not produce between group differences, suggesting that CB1 receptors are not involved in diazepam-induced disruption of lever press responding...
  44. pmc Enhancement of the behavioral effects of endogenous and exogenous cannabinoid agonists by phenylmethyl sulfonyl fluoride
    R E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, United States
    Neuropharmacology 62:1019-27. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  45. ncbi request reprint Assessment of structural commonality between tetrahydrocannabinol and anandamide
    Billy R Martin
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 435:35-42. 2002
    ....
  46. pmc Pharmacological effects of acute and repeated administration of Delta(9)-tetrahydrocannabinol in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:1097-105. 2007
    ..Despite similarities in pharmacological effects of Delta(9)-THC after repeated use, adolescents and adults may exhibit differences in the pattern of transition from use to abuse...
  47. pmc N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase
    James J Burston
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 327:546-53. 2008
    ..In addition, NAM's unmasking of 2-AG effects that are only partially reversed by SR141716A offers support for the existence of non-CB(1), non-CB(2) cannabinoid receptors...
  48. pmc Addiction epidemiology in adolescents receiving inpatient psychiatric treatment
    Michael F Weaver
    Virginia Commonwealth University, Richmond, VA 23298, USA
    Addict Behav 32:3107-13. 2007
    ..These results suggest that SUD is a major issue in adolescent psychiatric patients. More rigorous screening for SUD and its correlates may facilitate earlier detection of substance use in this vulnerable population...
  49. pmc Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Pharmacol Res 58:240-6. 2008
    ..These results also emphasize the importance of age and sex as determinants of the pharmacological effects of these antipsychotics...
  50. pmc Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 0613, USA
    Addict Biol 13:277-86. 2008
    ..This differential sensitivity may contribute to the different patterns of use that have been noted in adolescent versus adult drug abusers...
  51. pmc Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States
    Drug Alcohol Depend 94:191-8. 2008
    ....
  52. pmc Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
    Diana L McKinney
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980524, 1112 East Clay St, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 324:664-73. 2008
    ..These results reveal that tolerance and CB(1) receptor adaptation exhibit similar dose-dependent development, and they are consistent with previous studies demonstrating less cannabinoid receptor adaptation in striatal circuits...
  53. pmc Cannabimimetic properties of ajulemic acid
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:678-86. 2007
    ..In summary, this study shows that AJA, like Delta(9)-THC, exhibits psychoactive and therapeutic effects at nearly equal doses in preclinical models, suggesting similar limitations in their putative therapeutic profiles...
  54. ncbi request reprint Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology Virginia Commonwealth University Richmond, Virginia 23298 0613, USA
    Life Sci 80:24-35. 2006
    ....
  55. ncbi request reprint Mechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and pain
    Billy R Martin
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond 23298 0613, USA
    J Support Oncol 2:305-14; discussion 314-6. 2004
    ....
  56. pmc Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Pharmacol Exp Ther 334:1087-95. 2010
    ....
  57. ncbi request reprint In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
    ..These results indicate that TMPH may possess unique selectivity for specific nicotinic receptor subtypes...
  58. pmc Chronic Delta9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, Virginia 23298 0613, USA
    Pharmacol Biochem Behav 94:516-23. 2010
    ....
  59. ncbi request reprint Pharmacological characterization of novel water-soluble cannabinoids
    Billy R Martin
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 318:1230-9. 2006
    ..It is now possible to conduct cannabinoid research with agonists that are water-soluble and thus obviating the need of solubilizing agents...
  60. ncbi request reprint Enhancement of the discriminative stimulus effects of phencyclidine by the tetracycline antibiotics doxycycline and minocycline in rats
    Patrik Munzar
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 160:331-6. 2002
    ..Tetracycline antibiotics share some neuroprotective and CNS effects with N-methyl- D-aspartate (NMDA) receptor antagonists...
  61. pmc To breed or not to breed? Empirical evaluation of drug effects in adolescent rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Int J Dev Neurosci 27:9-20. 2009
    ..Further, these results suggest that careful attention to issues related to rodent procurement during adolescence is warranted and may help to account for divergent findings in different labs...
  62. pmc Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Neuropharmacology 55:1183-90. 2008
    ..These findings suggest that modulation of the endocannabinoid system might contribute in a sex- and age-selective manner to differences in motor side effects of clozapine versus haloperidol...
  63. pmc Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    Eur J Pharmacol 578:216-21. 2008
    ..Further, they suggest that, similar to adults, older adolescents may not develop tolerance to the activity suppression induced by these two antipsychotics...
  64. pmc The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific
    Floride Niyuhire
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 191:223-31. 2007
    ..In contrast, CB(1) (-/-) mice exhibited normal extinction rates in an appetitively motivated operant conditioning task...
  65. doi request reprint In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects
    B M Ignatowska-Jankowska
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    Br J Pharmacol 171:1392-407. 2014
    ..Here, we tested the in vivo effects of one such compound, KML29 (1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate)...
  66. doi request reprint How much is too much? Phenotypic consequences of Rai1 overexpression in mice
    Santhosh Girirajan
    Department of Human Genetics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Hum Genet 16:941-54. 2008
    ..2) syndrome or SMS in humans...
  67. pmc In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation
    Amy J Hawkins
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    DNA Repair (Amst) 8:654-63. 2009
    ..Altogether, these results suggest that for 3'-phosphoglycolate overhang lesions, the SCAN1 mutation confers loss of function, while for 3'-phosphotyrosyl lesions, the mutation uniquely stabilizes a reaction intermediate...
  68. pmc Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 16:322-35. 2008
    ..The interactions of these 1-deoxy nontraditional cannabinoids with the CB(2) receptor are discussed...
  69. ncbi request reprint 1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 1905, USA
    Bioorg Med Chem 10:4119-29. 2002
    ....
  70. ncbi request reprint 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, 29634 0973, Clemson, SC, USA
    Bioorg Med Chem 11:539-49. 2003
    ....
  71. pmc Novel, potent THC/anandamide (hybrid) analogs
    Caryl Bourne
    Organix, Inc, Woburn, MA 01801, USA
    Bioorg Med Chem 15:7850-64. 2007
    ..Several such analogs were synthesized and tested for their CB1 and CB2 binding affinities and in vivo activity (tetrad tests). The details of the synthesis and the biological activity of these compounds are described...
  72. ncbi request reprint Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinols
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 11:1397-410. 2003
    ....
  73. pmc The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids
    Peter J Crocker
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem Lett 17:1504-7. 2007
    ..In vitro studies show that substitution by a fluorine has a significant detrimental effect on CB1 binding which is supported by in vivo testing. The implications of these results on the SAR of classical cannabinoids are discussed...
  74. pmc Decreased sensitivity in adolescent vs. adult rats to the locomotor activating effects of toluene
    Scott E Bowen
    Department of Psychology, Wayne State University, Detroit, Michigan, USA
    Neurotoxicol Teratol 29:599-606. 2007
    ....
  75. ncbi request reprint Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 13:89-112. 2005
    ..Docking studies indicated that the CB(1) receptor affinities of these compounds were consistent with their aromatic stacking interactions in the aromatic microdomain of the CB(1) receptor...
  76. pmc New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C N R Pozzuoli Napoli, Italy
    Br J Pharmacol 147:83-91. 2006
    ....
  77. ncbi request reprint Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 14:247-62. 2006
    ..In the 1-deoxy-3-(2'-methylalkyl)-delta8-THC series, the 2'S-methyl compounds in general have greater affinity for the CB2 receptor than the corresponding 2'R isomers...
  78. ncbi request reprint 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem Lett 15:4110-3. 2005
    ..GTPgammaS determinations indicate that both compounds are highly efficacious agonists at the CB1 receptor and partial agonists at the CB2 receptor...
  79. ncbi request reprint 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem Lett 16:5432-5. 2006
    ..The high affinities of these pyrrole derivatives relative to JWH-030 (1, R=C(5)H(11)) support the hypothesis that these pyrroles interact with the CB(1) receptor primarily by aromatic stacking...
  80. ncbi request reprint Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor
    Karla Sue C Marriott
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 14:2386-97. 2006
    ..3 nM. In general, the stereochemistry of the 9-hydroxy group is important and the beta-orientation enhances both CB2 receptor affinity and selectivity...