Research Topics
| Richard P WenzelSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Detail Information
Publications
Comparison of the systemic inflammatory response syndrome between monomicrobial and polymicrobial Pseudomonas aeruginosa nosocomial bloodstream infectionsAlexandre R Marra
Department of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
BMC Infect Dis 5:94. 2005..The purpose of this study was to compare differences in systemic inflammatory response and mortality between monomicrobial and polymicrobial nBSI with Pseudomonas aeruginosa...- Comparison of severity of illness scoring systems for patients with nosocomial bloodstream infection due to Pseudomonas aeruginosaAlexandre R Marra
Division of Infectious Diseases, Universidade Federal de Sao Paulo, Brasil UNIFESP EPM Hospital São Paulo HSP, Brazil
BMC Infect Dis 6:132. 2006..We compared three severity of illness scoring systems for predicting mortality in patients with nBSI due to Pseudomonas aeruginosa... 
Bloodstream infections due to Candida species in the intensive care unit: identifying especially high-risk patients to determine prevention strategiesRichard P Wenzel
Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Clin Infect Dis 41:S389-93. 2005..Use of defined risk factors to select patients who are at high risk for candidemia and treatment with effective antibiotics would be an efficient way to reduce infection-related deaths...- Lessons from severe acute respiratory syndrome (SARS): implications for infection controlRichard P Wenzel
Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA
Arch Med Res 36:610-6. 2005..Herein we relate our perspectives on useful lessons derived from a review of the SARS epidemic... - Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance studyHilmar Wisplinghoff
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
Clin Infect Dis 39:309-17. 2004..CONCLUSION: In this study, one of the largest multicenter studies performed to date, we found that the proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals... 
A crossover trial of antimicrobial scrubs to reduce methicillin-resistant Staphylococcus aureus burden on healthcare worker apparelGonzalo M L Bearman
Epidemiology and Infection Control, Virginia Commonwealth University, Richmond, Virginia WI 53705, USA
Infect Control Hosp Epidemiol 33:268-75. 2012..The impact of antimicrobial scrubs on healthcare worker (HCW) bacterial burden is unknown. Objective. To determine the effectiveness of antimicrobial scrubs on hand and apparel bacterial burden...- A prospective study of outcomes, healthcare resource utilization, and costs associated with postoperative nosocomial infectionsLoreen A Herwaldt
Department of Internal Medicine, University of Iowa College of Public Health, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Infect Control Hosp Epidemiol 27:1291-8. 2006..We evaluated 4 important outcomes associated with postoperative nosocomial infection: costs, mortality, excess length of stay, and utilization of healthcare resources... - A controlled trial of universal gloving versus contact precautions for preventing the transmission of multidrug-resistant organismsGonzalo M L Bearman
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
Am J Infect Control 35:650-5. 2007..Contact precautions are recommended to reduce the transmission of multidrug-resistant organisms. However, the optimal method for control of multidrug-resistant organisms remains unclear... - Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communitiesRonald E Polk
School of Pharmacy, Department of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
Clin Infect Dis 39:497-503. 2004..aeruginosa. Levofloxacin was associated with resistance, but ciprofloxacin was not. Most of the variability in resistance rates is explained by volume of fluoroquinolone use, both in the hospital and the surrounding community... - Screening for MRSA: a flawed hospital infection control interventionRichard P Wenzel
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
Infect Control Hosp Epidemiol 29:1012-8. 2008.... - Community-acquired methicillin-resistant Staphylococcus aureus (MRSA): new issues for infection controlRichard P Wenzel
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, and Medical College of Virginia Hospitals, 1101 East Broad Street, P O Box 980663, Richmond, VA 23298, USA
Int J Antimicrob Agents 30:210-2. 2007..Questions about changing prophylactic and empirical therapy as well as the use of intravenous immunoglobulin for life-threatening infections are addressed... - Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infectionAlexandre R Marra
A D Williams Clinic, 1201 East Marshall Street, 6th Floor, Room 6 602, P O Box 980019, Richmond, VA 23298, USA
J Clin Microbiol 44:1342-6. 2006..aureus (OR, 9.3; 95% CI, 1.45 to 59.23), and TTPs of </=12 h (OR, 6.9; 95% CI, 1.07 to 44.66). In this historical cohort study of BSIs due to S. aureus, a TTP of </=12 h was a predictor of the clinical outcome... - Health care-associated infections: major issues in the early years of the 21st centuryRichard P Wenzel
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
Clin Infect Dis 45:S85-8. 2007..Increasing levels of antibiotic resistance and the problems associated with biofilms surrounding prostheses and vascular catheters pose special challenges. These issues and potential solutions are addressed in the present article... - Antibiotic options for treating community-acquired MRSAJ Patrick Powell
Department of Pharmacy, VCU Health System, 401 N 12th Street, Box 980042, Richmond, VA 23298 0042, USA
Expert Rev Anti Infect Ther 6:299-307. 2008..Clinical trials directly comparing antibiotic options in both out-patient and in-patient settings are needed to enhance recommendations for empiric therapy algorithms... - Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infections due to enterococciKatharine Bar
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
BMC Infect Dis 6:145. 2006..This study analyzed the inflammatory response of Enterococcal BSI, contrasting infections from vancomycin-resistant and vancomycin-susceptible isolates... - Preoperative risk factors for nasal carriage of Staphylococcus aureusLoreen A Herwaldt
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242-1081, USA
Infect Control Hosp Epidemiol 25:481-4. 2004..aureus nasal carriage. It remains to be seen whether preoperative weight loss would reduce the rate of nasal carriage. In addition, the value of screening this patient population for S. aureus nasal carriage merits further investigation... - Managing SARS amidst uncertaintyRichard P Wenzel
Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
N Engl J Med 348:1947-8. 2003 - Nasal carriage of inducible dormant and community-associated methicillin-resistant Staphylococcus aureus in an ambulatory population of predominantly university studentsGonzalo M L Bearman
Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0019, USA
Int J Infect Dis 14:e18-24. 2010..We studied risk factors for nasal colonization with inducible dormant methicillin-resistant Staphylococcus aureus (ID-MRSA) and community-associated MRSA (CA-MRSA) in a cohort of predominantly university students... - Bacteremias: a leading cause of deathGonzalo M L Bearman
Internal Medicine, Epidemiology and Community Medicine, Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0019, USA
Arch Med Res 36:646-59. 2005..Regrettably, despite advances in treatment and intensive care facilities, mortality remains high... - Infection control: the case for horizontal rather than vertical interventional programsRichard P Wenzel
Department of Internal Medicine, Virginia Commonwealth University, 1101 East Broad Street, PO Box 980663, Richmond, VA 23298, USA
Int J Infect Dis 14:S3-5. 2010..We suggest that horizontal programs should form the platform of all infection control programs and the key question should be, what is the incremental value of a new vertical program?.. - Infection control and the prevention of nosocomial infections in the intensive care unitGonzalo M L Bearman
Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
Semin Respir Crit Care Med 27:310-24. 2006..For greatest risk reduction, multifaceted programs ensuring maximal adherence with evidence-based infection control guidelines are needed... - Using theater to teach clinical empathy: a pilot studyAlan W Dow
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0102, USA
J Gen Intern Med 22:1114-8. 2007..Clinical empathy, a critical skill for the doctor-patient relationship, is infrequently taught in graduate medical education. No study has tested if clinical empathy can be taught effectively... - In vitro susceptibilities of gram-negative bacteria isolated from hospitalized patients in four European countries, Canada, and the United States in 2000-2001 to expanded-spectrum cephalosporins and comparator antimicrobials: implications for therapyRichard P Wenzel
Virginia Commonwealth University, Richmond. Focus Technologies, Herndon, Virginia 20171, USA
Antimicrob Agents Chemother 47:3089-98. 2003..The present study demonstrated that established parenteral expanded-spectrum cephalosporin antimicrobial agents retain significant in vitro activity against many clinically important gram-negative pathogens... - The antibiotic pipeline--challenges, costs, and valuesRichard P Wenzel
Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
N Engl J Med 351:523-6. 2004 - Antibiotic Prevention of Acute Exacerbations of COPDRichard P Wenzel
From the Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond
N Engl J Med 367:340-7. 2012..A 55-year-old man with COPD presents with recurrent acute exacerbations despite compliance with appropriate therapy. Azithromycin prophylaxis is recommended since the drug has been shown to prevent acute exacerbations in such patients... - Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infectionsSandra M Tallent
Department of Internal Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Clin Microbiol 40:2249-50. 2002..Only one isolate exhibiting heterotypic resistance was detected. Thus, vancomycin heteroresistance in clinical bloodstream isolates remains rare in the United States... - Treating sepsisRichard P Wenzel
Virginia Commonwealth University, Richmond, VA 23298, USA
N Engl J Med 347:966-7. 2002 - Voriconazole: a broad-spectrum triazole for the treatment of invasive fungal infectionsJane A Cecil
Virginia Commonwealth University, MCV Campus, 1101 East Marshall Street, Richmond, VA 23298 0049, USA
Expert Rev Hematol 2:237-54. 2009..Although it has the potential for some unique and interesting side effects, as well as important drug-drug interactions, the use of therapeutic drug monitoring can be used to optimize its efficacy and safety... - Clinical practice. Acute bronchitisRichard P Wenzel
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
N Engl J Med 355:2125-30. 2006 - John E. Bennett Forum on Deep Mycoses Study Design 2004: Candidiasis and salvage therapy for aspergillosisRichard P Wenzel
Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
Clin Infect Dis 41:S369-70. 2005 - Ramoplanin: a topical lipoglycodepsipeptide antibacterial agentPatricia Fulco
Virginia Commonwealth University, Department of Internal Medicine, Richmond, VA, USA
Expert Rev Anti Infect Ther 4:939-45. 2006..difficile colitis. The clinical value and place in therapy of ramoplanin is dependent upon the results of Phase III trials addressing its utility in suppressing carriage of target organisms in the gastrointestinal tract or in the nares... - Intranasal mupirocin to prevent postoperative Staphylococcus aureus infectionsTrish M Perl
University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
N Engl J Med 346:1871-7. 2002..aureus surgical-site infections overall, but it did significantly decrease the rate of all nosocomial S. aureus infections among the patients who were S. aureus carriers... - Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosaAlexandre R Marra
Division of Infectious Diseases, Brazil UNIFESP EPM Hospital São Paulo HSP, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Infect 53:30-5. 2006..To evaluate relationships between the inflammatory response, clinical course, and outcome of nosocomial BSI due to Pseudomonas aeruginosa... - Listening to SARS: lessons for infection controlRichard P Wenzel
Ann Intern Med 139:592-3. 2003 - Team-based prevention of catheter-related infectionsRichard P Wenzel
N Engl J Med 355:2781-3. 2006 - Systemic inflammatory response syndrome in nosocomial bloodstream infections with Pseudomonas aeruginosa and Enterococcus Species: comparison of elderly and nonelderly patientsAlexandre R Marra
Division of Infectious Diseases, Universidade Federal de São Paulo Hospital São Paulo, Sao Paulo, Brazil
J Am Geriatr Soc 54:804-8. 2006..is different in elderly patients than in younger patients... - Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United StatesHilmar Wisplinghoff
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
Clin Infect Dis 36:1103-10. 2003..The source of BSI was not determined for 57% of patients. The crude mortality rate was 36% for neutropenic patients and 31% for nonneutropenic patients... - Hospital-acquired Clostridium difficile-associated disease in the intensive care unit setting: epidemiology, clinical course and outcomeAlexandre R Marra
Department of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
BMC Infect Dis 7:42. 2007..We evaluated the epidemiology, clinical course and outcome of hospital-acquired CDAD in the critical care setting... - Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilitiesHilmar Wisplinghoff
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Germany
Pediatr Infect Dis J 22:686-91. 2003..CONCLUSION: Nosocomial BSI occurred predominantly in very young and/or critically ill children. Gram-positive pathogens predominated across all ages, and increasing antimicrobial resistance was observed in pediatric patients... - Intranasal mupirocin for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic reviewMiranda M L Van Rijen
Laboratory for Microbiology and Infection Control, Amphia Hospital, Location Molengracht, PO Box 90158, 4800 RK Breda, The Netherlands
J Antimicrob Chemother 61:254-61. 2008..The objective of this review was to assess whether intranasal mupirocin treatment of nasal S. aureus carriers before surgery results in a reduction of the post-operative S. aureus infection rate... - Patient-to-patient transmission of hepatitis C virusRichard P Wenzel
Ann Intern Med 142:940-1. 2005