Richard P Wenzel

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Comparison of the systemic inflammatory response syndrome between monomicrobial and polymicrobial Pseudomonas aeruginosa nosocomial bloodstream infections
    Alexandre R Marra
    Department of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    BMC Infect Dis 5:94. 2005
  2. pmc Comparison of severity of illness scoring systems for patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa
    Alexandre R Marra
    Division of Infectious Diseases, Universidade Federal de Sao Paulo, Brasil UNIFESP EPM Hospital São Paulo HSP, Brazil
    BMC Infect Dis 6:132. 2006
  3. ncbi request reprint Lessons from severe acute respiratory syndrome (SARS): implications for infection control
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA
    Arch Med Res 36:610-6. 2005
  4. ncbi request reprint Bloodstream infections due to Candida species in the intensive care unit: identifying especially high-risk patients to determine prevention strategies
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Clin Infect Dis 41:S389-93. 2005
  5. ncbi request reprint Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
  6. doi request reprint A crossover trial of antimicrobial scrubs to reduce methicillin-resistant Staphylococcus aureus burden on healthcare worker apparel
    Gonzalo M L Bearman
    Epidemiology and Infection Control, Virginia Commonwealth University, Richmond, Virginia WI 53705, USA
    Infect Control Hosp Epidemiol 33:268-75. 2012
  7. ncbi request reprint A controlled trial of universal gloving versus contact precautions for preventing the transmission of multidrug-resistant organisms
    Gonzalo M L Bearman
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    Am J Infect Control 35:650-5. 2007
  8. ncbi request reprint Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities
    Ronald E Polk
    School of Pharmacy, Department of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
    Clin Infect Dis 39:497-503. 2004
  9. ncbi request reprint A prospective study of outcomes, healthcare resource utilization, and costs associated with postoperative nosocomial infections
    Loreen A Herwaldt
    Department of Internal Medicine, University of Iowa College of Public Health, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Infect Control Hosp Epidemiol 27:1291-8. 2006
  10. ncbi request reprint Community-acquired methicillin-resistant Staphylococcus aureus (MRSA): new issues for infection control
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, and Medical College of Virginia Hospitals, 1101 East Broad Street, P O Box 980663, Richmond, VA 23298, USA
    Int J Antimicrob Agents 30:210-2. 2007

Detail Information

Publications42

  1. pmc Comparison of the systemic inflammatory response syndrome between monomicrobial and polymicrobial Pseudomonas aeruginosa nosocomial bloodstream infections
    Alexandre R Marra
    Department of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    BMC Infect Dis 5:94. 2005
    ..The purpose of this study was to compare differences in systemic inflammatory response and mortality between monomicrobial and polymicrobial nBSI with Pseudomonas aeruginosa...
  2. pmc Comparison of severity of illness scoring systems for patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa
    Alexandre R Marra
    Division of Infectious Diseases, Universidade Federal de Sao Paulo, Brasil UNIFESP EPM Hospital São Paulo HSP, Brazil
    BMC Infect Dis 6:132. 2006
    ..We compared three severity of illness scoring systems for predicting mortality in patients with nBSI due to Pseudomonas aeruginosa...
  3. ncbi request reprint Lessons from severe acute respiratory syndrome (SARS): implications for infection control
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA
    Arch Med Res 36:610-6. 2005
    ..Herein we relate our perspectives on useful lessons derived from a review of the SARS epidemic...
  4. ncbi request reprint Bloodstream infections due to Candida species in the intensive care unit: identifying especially high-risk patients to determine prevention strategies
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Clin Infect Dis 41:S389-93. 2005
    ..Use of defined risk factors to select patients who are at high risk for candidemia and treatment with effective antibiotics would be an efficient way to reduce infection-related deaths...
  5. ncbi request reprint Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  6. doi request reprint A crossover trial of antimicrobial scrubs to reduce methicillin-resistant Staphylococcus aureus burden on healthcare worker apparel
    Gonzalo M L Bearman
    Epidemiology and Infection Control, Virginia Commonwealth University, Richmond, Virginia WI 53705, USA
    Infect Control Hosp Epidemiol 33:268-75. 2012
    ..The impact of antimicrobial scrubs on healthcare worker (HCW) bacterial burden is unknown. Objective. To determine the effectiveness of antimicrobial scrubs on hand and apparel bacterial burden...
  7. ncbi request reprint A controlled trial of universal gloving versus contact precautions for preventing the transmission of multidrug-resistant organisms
    Gonzalo M L Bearman
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    Am J Infect Control 35:650-5. 2007
    ..Contact precautions are recommended to reduce the transmission of multidrug-resistant organisms. However, the optimal method for control of multidrug-resistant organisms remains unclear...
  8. ncbi request reprint Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities
    Ronald E Polk
    School of Pharmacy, Department of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
    Clin Infect Dis 39:497-503. 2004
    ..aeruginosa. Levofloxacin was associated with resistance, but ciprofloxacin was not. Most of the variability in resistance rates is explained by volume of fluoroquinolone use, both in the hospital and the surrounding community...
  9. ncbi request reprint A prospective study of outcomes, healthcare resource utilization, and costs associated with postoperative nosocomial infections
    Loreen A Herwaldt
    Department of Internal Medicine, University of Iowa College of Public Health, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Infect Control Hosp Epidemiol 27:1291-8. 2006
    ..We evaluated 4 important outcomes associated with postoperative nosocomial infection: costs, mortality, excess length of stay, and utilization of healthcare resources...
  10. ncbi request reprint Community-acquired methicillin-resistant Staphylococcus aureus (MRSA): new issues for infection control
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, and Medical College of Virginia Hospitals, 1101 East Broad Street, P O Box 980663, Richmond, VA 23298, USA
    Int J Antimicrob Agents 30:210-2. 2007
    ..Questions about changing prophylactic and empirical therapy as well as the use of intravenous immunoglobulin for life-threatening infections are addressed...
  11. doi request reprint Screening for MRSA: a flawed hospital infection control intervention
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    Infect Control Hosp Epidemiol 29:1012-8. 2008
    ....
  12. doi request reprint Antibiotic options for treating community-acquired MRSA
    J Patrick Powell
    Department of Pharmacy, VCU Health System, 401 N 12th Street, Box 980042, Richmond, VA 23298 0042, USA
    Expert Rev Anti Infect Ther 6:299-307. 2008
    ..Clinical trials directly comparing antibiotic options in both out-patient and in-patient settings are needed to enhance recommendations for empiric therapy algorithms...
  13. pmc Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infections due to enterococci
    Katharine Bar
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    BMC Infect Dis 6:145. 2006
    ..This study analyzed the inflammatory response of Enterococcal BSI, contrasting infections from vancomycin-resistant and vancomycin-susceptible isolates...
  14. pmc Time to blood culture positivity as a predictor of clinical outcome of Staphylococcus aureus bloodstream infection
    Alexandre R Marra
    A D Williams Clinic, 1201 East Marshall Street, 6th Floor, Room 6 602, P O Box 980019, Richmond, VA 23298, USA
    J Clin Microbiol 44:1342-6. 2006
    ..aureus (OR, 9.3; 95% CI, 1.45 to 59.23), and TTPs of </=12 h (OR, 6.9; 95% CI, 1.07 to 44.66). In this historical cohort study of BSIs due to S. aureus, a TTP of </=12 h was a predictor of the clinical outcome...
  15. ncbi request reprint Health care-associated infections: major issues in the early years of the 21st century
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Infect Dis 45:S85-8. 2007
    ..Increasing levels of antibiotic resistance and the problems associated with biofilms surrounding prostheses and vascular catheters pose special challenges. These issues and potential solutions are addressed in the present article...
  16. ncbi request reprint Preoperative risk factors for nasal carriage of Staphylococcus aureus
    Loreen A Herwaldt
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1081, USA
    Infect Control Hosp Epidemiol 25:481-4. 2004
    ..aureus, and eradication of carriage reduces postoperative nosocomial infections caused by it. No study has compared large groups of preoperative carriers and non-carriers to identify factors that are linked to S. aureus nasal carriage...
  17. doi request reprint Infection control: the case for horizontal rather than vertical interventional programs
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University, 1101 East Broad Street, PO Box 980663, Richmond, VA 23298, USA
    Int J Infect Dis 14:S3-5. 2010
    ..We suggest that horizontal programs should form the platform of all infection control programs and the key question should be, what is the incremental value of a new vertical program?..
  18. ncbi request reprint Infection control and the prevention of nosocomial infections in the intensive care unit
    Gonzalo M L Bearman
    Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
    Semin Respir Crit Care Med 27:310-24. 2006
    ..For greatest risk reduction, multifaceted programs ensuring maximal adherence with evidence-based infection control guidelines are needed...
  19. ncbi request reprint Managing SARS amidst uncertainty
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    N Engl J Med 348:1947-8. 2003
  20. ncbi request reprint Bacteremias: a leading cause of death
    Gonzalo M L Bearman
    Internal Medicine, Epidemiology and Community Medicine, Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
    Arch Med Res 36:646-59. 2005
    ..Regrettably, despite advances in treatment and intensive care facilities, mortality remains high...
  21. doi request reprint Nasal carriage of inducible dormant and community-associated methicillin-resistant Staphylococcus aureus in an ambulatory population of predominantly university students
    Gonzalo M L Bearman
    Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0019, USA
    Int J Infect Dis 14:e18-24. 2010
    ..We studied risk factors for nasal colonization with inducible dormant methicillin-resistant Staphylococcus aureus (ID-MRSA) and community-associated MRSA (CA-MRSA) in a cohort of predominantly university students...
  22. pmc Using theater to teach clinical empathy: a pilot study
    Alan W Dow
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0102, USA
    J Gen Intern Med 22:1114-8. 2007
    ..Clinical empathy, a critical skill for the doctor-patient relationship, is infrequently taught in graduate medical education. No study has tested if clinical empathy can be taught effectively...
  23. doi request reprint Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities
    Hilmar Wisplinghoff
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University, Medical Center Box 980019, Richmond, VA 23298 0019, USA
    Int J Antimicrob Agents 43:78-81. 2014
    ..tropicalis were non-susceptible to voriconazole. All echinocandins showed good activity against most Candida spp., including the majority of C. parapsilosis isolates, but only 38.1% of C. glabrata tested susceptible to caspofungin. ..
  24. ncbi request reprint The antibiotic pipeline--challenges, costs, and values
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    N Engl J Med 351:523-6. 2004
  25. pmc In vitro susceptibilities of gram-negative bacteria isolated from hospitalized patients in four European countries, Canada, and the United States in 2000-2001 to expanded-spectrum cephalosporins and comparator antimicrobials: implications for therapy
    Richard P Wenzel
    Virginia Commonwealth University, Richmond Focus Technologies, Herndon, Virginia 20171, USA
    Antimicrob Agents Chemother 47:3089-98. 2003
    ..The present study demonstrated that established parenteral expanded-spectrum cephalosporin antimicrobial agents retain significant in vitro activity against many clinically important gram-negative pathogens...
  26. ncbi request reprint Antibiotic Prevention of Acute Exacerbations of COPD
    Richard P Wenzel
    From the Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond
    N Engl J Med 367:340-7. 2012
    ..A 55-year-old man with COPD presents with recurrent acute exacerbations despite compliance with appropriate therapy. Azithromycin prophylaxis is recommended since the drug has been shown to prevent acute exacerbations in such patients...
  27. doi request reprint Voriconazole: a broad-spectrum triazole for the treatment of invasive fungal infections
    Jane A Cecil
    Virginia Commonwealth University, MCV Campus, 1101 East Marshall Street, Richmond, VA 23298 0049, USA
    Expert Rev Hematol 2:237-54. 2009
    ..Although it has the potential for some unique and interesting side effects, as well as important drug-drug interactions, the use of therapeutic drug monitoring can be used to optimize its efficacy and safety...
  28. pmc Vancomycin susceptibility of oxacillin-resistant Staphylococcus aureus isolates causing nosocomial bloodstream infections
    Sandra M Tallent
    Department of Internal Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Clin Microbiol 40:2249-50. 2002
    ..Only one isolate exhibiting heterotypic resistance was detected. Thus, vancomycin heteroresistance in clinical bloodstream isolates remains rare in the United States...
  29. ncbi request reprint John E. Bennett Forum on Deep Mycoses Study Design 2004: Candidiasis and salvage therapy for aspergillosis
    Richard P Wenzel
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Clin Infect Dis 41:S369-70. 2005
  30. ncbi request reprint Treating sepsis
    Richard P Wenzel
    Virginia Commonwealth University, Richmond, VA 23298, USA
    N Engl J Med 347:966-7. 2002
  31. ncbi request reprint Clinical practice. Acute bronchitis
    Richard P Wenzel
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    N Engl J Med 355:2125-30. 2006
  32. ncbi request reprint Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent
    Patricia Fulco
    Virginia Commonwealth University, Department of Internal Medicine, Richmond, VA, USA
    Expert Rev Anti Infect Ther 4:939-45. 2006
    ..difficile colitis. The clinical value and place in therapy of ramoplanin is dependent upon the results of Phase III trials addressing its utility in suppressing carriage of target organisms in the gastrointestinal tract or in the nares...
  33. ncbi request reprint Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States
    Hilmar Wisplinghoff
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
    Clin Infect Dis 36:1103-10. 2003
    ..The source of BSI was not determined for 57% of patients. The crude mortality rate was 36% for neutropenic patients and 31% for nonneutropenic patients...
  34. ncbi request reprint Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections
    Trish M Perl
    University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
    N Engl J Med 346:1871-7. 2002
    ..Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections...
  35. ncbi request reprint Listening to SARS: lessons for infection control
    Richard P Wenzel
    Ann Intern Med 139:592-3. 2003
  36. pmc Hospital-acquired Clostridium difficile-associated disease in the intensive care unit setting: epidemiology, clinical course and outcome
    Alexandre R Marra
    Department of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    BMC Infect Dis 7:42. 2007
    ..We evaluated the epidemiology, clinical course and outcome of hospital-acquired CDAD in the critical care setting...
  37. ncbi request reprint Team-based prevention of catheter-related infections
    Richard P Wenzel
    N Engl J Med 355:2781-3. 2006
  38. ncbi request reprint Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities
    Hilmar Wisplinghoff
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Germany
    Pediatr Infect Dis J 22:686-91. 2003
    ....
  39. ncbi request reprint Systemic inflammatory response syndrome in nosocomial bloodstream infections with Pseudomonas aeruginosa and Enterococcus Species: comparison of elderly and nonelderly patients
    Alexandre R Marra
    Division of Infectious Diseases, Universidade Federal de São Paulo Hospital São Paulo, Sao Paulo, Brazil
    J Am Geriatr Soc 54:804-8. 2006
    ..is different in elderly patients than in younger patients...
  40. ncbi request reprint Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Pseudomonas aeruginosa
    Alexandre R Marra
    Division of Infectious Diseases, Brazil UNIFESP EPM Hospital São Paulo HSP, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    J Infect 53:30-5. 2006
    ..To evaluate relationships between the inflammatory response, clinical course, and outcome of nosocomial BSI due to Pseudomonas aeruginosa...
  41. doi request reprint Intranasal mupirocin for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic review
    Miranda M L Van Rijen
    Laboratory for Microbiology and Infection Control, Amphia Hospital, Location Molengracht, PO Box 90158, 4800 RK Breda, The Netherlands
    J Antimicrob Chemother 61:254-61. 2008
    ..The objective of this review was to assess whether intranasal mupirocin treatment of nasal S. aureus carriers before surgery results in a reduction of the post-operative S. aureus infection rate...
  42. ncbi request reprint Patient-to-patient transmission of hepatitis C virus
    Richard P Wenzel
    Ann Intern Med 142:940-1. 2005