Scott W Walsh

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites
    Mohammad A Alzoghaibi
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0034, USA
    Am J Physiol Gastrointest Liver Physiol 286:G528-37. 2004
  2. ncbi request reprint Systemic activation and vascular infiltration of neutrophils with term labor
    Courtney E Leik
    Departments of Obstetrics and Gynecology and Physiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0034, USA
    J Soc Gynecol Investig 13:425-9. 2006
  3. pmc Plasma from preeclamptic women stimulates transendothelial migration of neutrophils
    Scott W Walsh
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Reprod Sci 16:320-5. 2009
  4. ncbi request reprint Obesity: a risk factor for preeclampsia
    Scott W Walsh
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0034, USA
    Trends Endocrinol Metab 18:365-70. 2007
  5. pmc What causes endothelial cell activation in preeclamptic women?
    Scott W Walsh
    Virginia Commonwealth University, Dept of Obstetrics and Gynecology, 1101 E Marshall St, PO Box 980034, Richmond, VA 23298 0034, USA
    Am J Pathol 169:1104-6. 2006
  6. pmc Neutrophil infiltration and systemic vascular inflammation in obese women
    Tanvi J Shah
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Reprod Sci 17:116-24. 2010
  7. pmc DNA methylation is altered in maternal blood vessels of women with preeclampsia
    Ahmad A Mousa
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Reprod Sci 19:1332-42. 2012
  8. pmc Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism
    Ahmad A Mousa
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298 0034, USA
    Am J Pathol 181:1455-63. 2012
  9. ncbi request reprint Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress
    Courtney E Leik
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0034, USA
    J Soc Gynecol Investig 12:593-8. 2005
  10. pmc Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia
    Ahmad A Mousa
    Departments of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA23298 0034, USA
    Hypertension 59:1249-55. 2012

Research Grants

  1. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2003
  2. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2006
  3. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2007
  4. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites
    Mohammad A Alzoghaibi
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0034, USA
    Am J Physiol Gastrointest Liver Physiol 286:G528-37. 2004
    ..We speculate that AA metabolites increased IL-8 production by enhancing NF-kappaB-dependent transcription of IL-8...
  2. ncbi request reprint Systemic activation and vascular infiltration of neutrophils with term labor
    Courtney E Leik
    Departments of Obstetrics and Gynecology and Physiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0034, USA
    J Soc Gynecol Investig 13:425-9. 2006
    ..The purpose of the current study was to determine if neutrophils infiltrate maternal systemic vascular tissue at the time of term labor...
  3. pmc Plasma from preeclamptic women stimulates transendothelial migration of neutrophils
    Scott W Walsh
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Reprod Sci 16:320-5. 2009
    ..Compared to medium control or LA, OxLA stimulated IL-8 and neutrophil migration which was inhibited by vitamins E and C or IL-8 antibody...
  4. ncbi request reprint Obesity: a risk factor for preeclampsia
    Scott W Walsh
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0034, USA
    Trends Endocrinol Metab 18:365-70. 2007
    ..Therefore, if the vasculature of obese women is inflamed, they could be at increased risk of developing preeclampsia when they become pregnant and are exposed to the additional burdens of pregnancy...
  5. pmc What causes endothelial cell activation in preeclamptic women?
    Scott W Walsh
    Virginia Commonwealth University, Dept of Obstetrics and Gynecology, 1101 E Marshall St, PO Box 980034, Richmond, VA 23298 0034, USA
    Am J Pathol 169:1104-6. 2006
  6. pmc Neutrophil infiltration and systemic vascular inflammation in obese women
    Tanvi J Shah
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Reprod Sci 17:116-24. 2010
    ..These data may help explain the relationship between obesity and hypertensive disorders...
  7. pmc DNA methylation is altered in maternal blood vessels of women with preeclampsia
    Ahmad A Mousa
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Reprod Sci 19:1332-42. 2012
    ..We speculate that reduced methylation may contribute to the pathogenesis of preeclampsia and that alterations in DNA methylation resulting from preeclampsia may increase maternal risk of cardiovascular disease later in life...
  8. pmc Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism
    Ahmad A Mousa
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298 0034, USA
    Am J Pathol 181:1455-63. 2012
    ..Our findings suggest that epigenetic regulation contributes to the imbalance in genes involved in collagen metabolism in blood vessels of preeclamptic women...
  9. ncbi request reprint Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress
    Courtney E Leik
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0034, USA
    J Soc Gynecol Investig 12:593-8. 2005
    ..We also hypothesized that oleic acid (OA), which is not metabolized to AA metabolites, would not increase IL-8 under conditions of oxidative stress...
  10. pmc Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia
    Ahmad A Mousa
    Departments of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA23298 0034, USA
    Hypertension 59:1249-55. 2012
    ....
  11. ncbi request reprint Thromboxane mediates neutrophil superoxide production in pregnancy
    John E Vaughan
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0034, USA
    Am J Obstet Gynecol 195:1415-20. 2006
    ..In this study, we tested the possibility that thromboxane plays a role in neutrophil superoxide generation in pregnancy via cyclooxygenase-2 by inhibiting key enzymes in the pathway leading to its synthesis...
  12. pmc Application of human placental villous tissue explants to study ABC transporter mediated efflux of 2,4-dinitrophenyl-S-glutathione
    Soniya S Vaidya
    Department of Pharmaceutics, Virginia Commonwealth University, MCV Campus, 410 N 12 Street, PO Box 980533, Richmond, VA 23298 0533, USA
    Curr Pharm Biotechnol 12:814-23. 2011
    ....
  13. ncbi request reprint Neutrophils infiltrate resistance-sized vessels of subcutaneous fat in women with preeclampsia
    Courtney E Leik
    Department of Obstetrics and Gynecology, PO Box 980034, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0034, USA
    Hypertension 44:72-7. 2004
    ..Neutrophil infiltration provides a reasonable explanation for endothelial and vascular smooth muscle dysfunction in preeclampsia because neutrophils produce toxic substances, which may explain clinical symptoms...
  14. pmc Mechanisms of enhanced vascular reactivity in preeclampsia
    Nikita Mishra
    Virginia Commonwealth University Medical Center, Department of Obstetrics and Gynecology, Richmond, VA 23298 0034, USA
    Hypertension 58:867-73. 2011
    ..We speculate that neutrophil infiltration into systemic vasculature of preeclamptic women is an important mechanism for hypertension...
  15. ncbi request reprint Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress
    John E Vaughan
    Departments of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Am J Obstet Gynecol 193:830-5. 2005
    ..In this study we evaluated whether linoleic acid under conditions of oxidative stress would stimulate neutrophil production of thromboxane and tumor necrosis factor-alpha...
  16. pmc Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia
    Kristen A Cadden
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0034, USA
    Hypertens Pregnancy 27:396-405. 2008
    ..Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known...
  17. pmc Activation of NF-κB in placentas of women with preeclampsia
    John E Vaughan
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0034, USA
    Hypertens Pregnancy 31:243-51. 2012
    ..We measured the levels of activated NF-κB in normal and preeclamptic placentas and determined whether oxidative stress activates NF-κB in a trophoblast-like cell line...
  18. ncbi request reprint Activation of NF-kappaB and expression of COX-2 in association with neutrophil infiltration in systemic vascular tissue of women with preeclampsia
    Tanvi J Shah
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0034, USA
    Am J Obstet Gynecol 196:48.e1-8. 2007
    ..The purpose of this study was to determine whether activation of NF-kappaB and expression of COX-2 are associated with neutrophil infiltration in systemic vascular tissue of women with preeclampsia...
  19. ncbi request reprint Induction of labor using a foley balloon, with and without extra-amniotic saline infusion
    Nicole W Karjane
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, 23298, USA
    Obstet Gynecol 107:234-9. 2006
    ..To compare transcervical Foley bulb with and without extra-amniotic saline infusion for induction of labor in patients with an unfavorable cervix...
  20. ncbi request reprint Isolation and culture of arterial smooth muscle cells from human placenta
    Courtney E Leik
    Virginia Commonwealth University Medical Center, Department of Obstetrics and Gynecology, Richmond, VA 23298 0034, USA
    Hypertension 43:837-40. 2004
    ..This technique provides a simple method to obtain normal human arterial smooth muscle cells for in vitro studies of physiology and pathophysiology...
  21. pmc Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction
    Guadalupe Estrada-Gutierrez
    Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0034, USA
    Am J Pathol 178:451-60. 2011
    ..Collectively, these findings disclose a novel role for MMP-1 as a mediator of vasoconstriction and vascular dysfunction in preeclampsia...
  22. doi request reprint Formation and efflux of ATP-binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments
    Soniya S Vaidya
    Departments of Pharmaceutics and Obstetrics and Gynecology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia 23298 0533, USA
    Mol Pharm 6:1689-702. 2009
    ....
  23. ncbi request reprint Eicosanoids in preeclampsia
    Scott W Walsh
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, 1101 E Marshall St, PO Box 980034, Richmond, VA 23298 0034, USA
    Prostaglandins Leukot Essent Fatty Acids 70:223-32. 2004
    ..Low-dose aspirin therapy should not yet be dismissed for the prevention of preeclampsia, but be reconsidered with emphasis on compliance using doses of aspirin in the range of 100-150 mg/day combined with antioxidants...
  24. pmc Neutrophil expression of cyclooxygenase 2 in preeclampsia
    Teddi Bachawaty
    Departments of Obstetrics and Gynecology, and Physiology and Biophysics, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Reprod Sci 17:465-70. 2010
    ..These data demonstrate that COX-2 is expressed in neutrophils of preeclamptic women and that COX-2 mediates IL-8 production by activated neutrophils...
  25. ncbi request reprint Placental tissue levels of nonesterified polyunsaturated fatty acids in normal and preeclamptic pregnancies
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Hypertens Pregnancy 24:235-45. 2005
    ..Polyunsaturated fatty acids of the n-6 and n-3 families are essential dietary fatty acids. The n-6 polyunsaturated fatty acids are involved in inflammatory reactions, whereas n-3 polyunsaturated fatty acids protect against inflammation...
  26. ncbi request reprint A prospective study of early-pregnancy plasma malondialdehyde concentration and risk of preeclampsia
    Carole B Rudra
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA
    Clin Biochem 39:722-6. 2006
    ..Preeclampsia is associated with elevated plasma malondialdehyde concentration, but prospective data are scarce. We examined the relation between early-pregnancy plasma malondialdehyde and subsequent preeclampsia risk...
  27. pmc Maternal erythrocyte omega-3 and omega-6 fatty acids, and plasma lipid concentrations, are associated with habitual dietary fish consumption in early pregnancy
    Michelle A Williams
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA
    Clin Biochem 39:1063-70. 2006
    ..We investigated the relationship between selected maternal erythrocyte omega-3 and omega-6 polyunsaturated fatty acids (PUFA) and plasma lipids in early pregnancy and reported habitual fish consumption during the periconceptional period...
  28. doi request reprint Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes
    Hongyan Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University School of Life Science, Shanghai 200433, China
    Hum Mol Genet 17:1087-96. 2008
    ..We conclude that in addition to genetic variation, DNA methylation plays a role in controlling MMP1 expression and risk of an adverse obstetrical outcome...
  29. ncbi request reprint A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia
    Chunfang Qiu
    Center for Perinatal Studies, Swedish Medical Center, 747 Broadway, Suite 449 North, Seattle, WA 98122, USA
    Am J Hypertens 17:154-60. 2004
    ..We measured C-reactive protein (CRP), a clinical marker of systemic inflammation, in maternal serum collected at 13 weeks gestation on average, to determine whether elevations precede the clinical manifestation of preeclampsia...

Research Grants6

  1. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2003
    ..A novel transendothelial migration assay will be used to measure the migration of 51Cr-labeled neutrophils across endothelial cells in culture. ..
  2. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2006
    ..A novel transendothelial migration assay will be used to measure the migration of 51Cr-labeled neutrophils across endothelial cells in culture. ..
  3. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2007
    ..A novel transendothelial migration assay will be used to measure the migration of SlCr-labeled neutrophils across endothelial cells in culture. ..
  4. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2010
    ....