Norbert Voelkel

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
    Norbert F Voelkel
    Department of Biochemistry and Molecular Biology, Victorial Johnson Center for Obstructive Pulmonary Disease Research, Virginia Commonwealth University, Richmond, 23298, USA
    Immunol Cell Biol 87:601-5. 2009
  2. ncbi Pathobiology of pulmonary arterial hypertension and right ventricular failure
    Norbert F Voelkel
    Dept of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur Respir J 40:1555-65. 2012
  3. ncbi Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization
    Shiro Mizuno
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Cell Mol Biol 47:679-87. 2012
  4. ncbi Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension
    Lori Sweeney
    Endocrinology and Metabolism Division, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Eur J Med Res 14:433-42. 2009
  5. ncbi A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
    Jose Gomez-Arroyo
    Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA 23298, USA
    Am J Physiol Lung Cell Mol Physiol 302:L977-91. 2012
  6. ncbi The monocrotaline model of pulmonary hypertension in perspective
    Jose G Gomez-Arroyo
    Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, Richmond, 23298, USA
    Am J Physiol Lung Cell Mol Physiol 302:L363-9. 2012
  7. ncbi Immunomodulatory strategies prevent the development of autoimmune emphysema
    Masayuki Hanaoka
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Respir Res 11:179. 2010
  8. ncbi Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study
    Silvia Ulrich
    Department of Internal Medicine, Pulmonary Hypertension Clinic, University Hospital of Zurich, Zurich, Switzerland
    Respir Res 9:20. 2008
  9. ncbi Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways
    Shiro Mizuno
    Third Department of Internal Medicine, University of Fukui, Yoshida gun, Fukui, Japan
    Respir Res 10:17. 2009
  10. ncbi Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation
    Seiichiro Sakao
    Department of Respirology B2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Respir Res 10:95. 2009

Research Grants

  1. PROSTACYCLIN SYNTHESIS IN PULMONARY HYPERTENSION
    Norbert Voelkel; Fiscal Year: 2001
  2. Exhaled Air Biomarkers in COPD
    Norbert Voelkel; Fiscal Year: 2005
  3. PROSTACYCLIN IN SYNTHESIS PULMONARY HYPERTENSION
    Norbert Voelkel; Fiscal Year: 1993

Collaborators

  • Antonio Abbate
  • Catherine I Dumur
  • Sarah Spiegel
  • Mark Geraci
  • Laimute Taraseviciene-Stewart
  • T M Bull
  • C D Cool
  • M Kasper
  • Takeshi Ishizaki
  • Ivor Douglas
  • Shiro Mizuno
  • Donatas Kraskauskas
  • Harm J Bogaard
  • Herman J Bogaard
  • Ramesh Natarajan
  • Jose Gomez-Arroyo
  • Mark R Nicolls
  • Daniela Farkas
  • Laszlo Farkas
  • Jose G Gomez-Arroyo
  • M Yasuo
  • Jennifer I Drake
  • Masayuki Hanaoka
  • Lori Sweeney
  • Seiichiro Sakao
  • Silvia Ulrich
  • Wen Feng Fang
  • Ashok N Babu
  • Sheinei J Saleem
  • Aysar A Alhussaini
  • Daniel H Conrad
  • Aamer A Syed
  • Aysar Al Husseini
  • Yon Sung
  • Ayser A Al Hussaini
  • H J Bogaard
  • S Mizuno
  • Aysar Alhussaini
  • Paul Fawcett
  • Berrick Clifton
  • D Kraskauskas
  • R Natarajan
  • Stefano Toldo
  • Bin Xie
  • Yuan Gao
  • Masanori Yasuo
  • M Zamora
  • Nana Burns
  • Vita Kraskauskiene
  • Fadi N Salloum
  • Jonas Salys
  • Adelheid Kratzer
  • Andrew P Fontenot
  • Philip J Chang
  • Vinh Q Chau
  • Nicholas N Hoke
  • Douglas G Mack
  • Scott C Henderson
  • Lisa Smithson
  • Isamu Miyamori
  • Koichiro Tatsumi
  • Maiko Kadowaki
  • Shingo Ameshima
  • Yukihiro Umeda
  • Ramzi Ockaili
  • Joe M McCord
  • Carlin S Long
  • Lars C Huber
  • Rudolf Speich
  • Peter M Henson
  • Chao Chien Wu
  • Wen-Feng Fang
  • Martin R Zamora
  • Meng-Chih Lin
  • Edmund J Miller
  • Qianbin He
  • Jae Hwa Cho
  • Tomohiro Murakawa
  • Joshua M Thurman
  • Chao-Chien Wu
  • Meng Chih Lin

Detail Information

Publications26

  1. ncbi Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
    Norbert F Voelkel
    Department of Biochemistry and Molecular Biology, Victorial Johnson Center for Obstructive Pulmonary Disease Research, Virginia Commonwealth University, Richmond, 23298, USA
    Immunol Cell Biol 87:601-5. 2009
    ....
  2. ncbi Pathobiology of pulmonary arterial hypertension and right ventricular failure
    Norbert F Voelkel
    Dept of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur Respir J 40:1555-65. 2012
    ....
  3. ncbi Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization
    Shiro Mizuno
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Cell Mol Biol 47:679-87. 2012
    ..Our results also suggest that the increased expression of hypoxia-induced factor-1α and IL-6 induced by the allergic lung inflammation may be a component of the pathogenesis of PAH...
  4. ncbi Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension
    Lori Sweeney
    Endocrinology and Metabolism Division, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Eur J Med Res 14:433-42. 2009
    ....
  5. ncbi A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
    Jose Gomez-Arroyo
    Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA 23298, USA
    Am J Physiol Lung Cell Mol Physiol 302:L977-91. 2012
    ..Anatomical, cellular, and genetic differences distinguish mice and rats, and pharmacogenomics may explain the degree of PH and the particular mode of pulmonary vascular adaptation and also the response of the right ventricle...
  6. ncbi The monocrotaline model of pulmonary hypertension in perspective
    Jose G Gomez-Arroyo
    Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, Richmond, 23298, USA
    Am J Physiol Lung Cell Mol Physiol 302:L363-9. 2012
    ..Here we review pertinent publications that either have been forgotten or ignored, and we reexamine the monocrotaline model in the context of human forms of PAH...
  7. ncbi Immunomodulatory strategies prevent the development of autoimmune emphysema
    Masayuki Hanaoka
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Respir Res 11:179. 2010
    ..Whether immune modulatory strategies can protect against the development of emphysema is not known...
  8. ncbi Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study
    Silvia Ulrich
    Department of Internal Medicine, Pulmonary Hypertension Clinic, University Hospital of Zurich, Zurich, Switzerland
    Respir Res 9:20. 2008
    ..The purpose of the present work was therefore to comparatively analyze peripheral blood B lymphocyte RNA expression characteristics in IPAH and healthy controls...
  9. ncbi Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways
    Shiro Mizuno
    Third Department of Internal Medicine, University of Fukui, Yoshida gun, Fukui, Japan
    Respir Res 10:17. 2009
    ..Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and cyclin-dependent kinase inhibitors p21 and p27 remain unclear...
  10. ncbi Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation
    Seiichiro Sakao
    Department of Respirology B2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Respir Res 10:95. 2009
    ..e., apoptosis, proliferation, interaction with smooth muscle cells and transdifferentiation...
  11. ncbi Molecular signature of a right heart failure program in chronic severe pulmonary hypertension
    Jennifer I Drake
    Department of Microbiology, Virginia Commonwealth University, Richmond, USA
    Am J Respir Cell Mol Biol 45:1239-47. 2011
    ....
  12. ncbi Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Conference summary
    Norbert F Voelkel
    Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Proc Am Thorac Soc 5:354-7. 2008
  13. ncbi Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure
    Harm J Bogaard
    Divisions of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, VA 23298 0281, USA
    Circulation 120:1951-60. 2009
    ....
  14. ncbi Gene expression profiling in pulmonary hypertension
    Todd M Bull
    Pulmonary and Critical Care Medicine Division, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Proc Am Thorac Soc 4:117-20. 2007
    ..As will be discussed in this article, the investigation of pulmonary hypertension has already benefited greatly from the application of this technology...
  15. ncbi Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats
    Harm J Bogaard
    Director of the Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 East Broad Street, Richmond, VA 23298, USA
    Am J Respir Crit Care Med 182:652-60. 2010
    ..Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH...
  16. ncbi Inhibition of histone deacetylase causes emphysema
    Shiro Mizuno
    Pulmonary and Critical Care Medicine Division, Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth Univ, Richmond, VA 23284, USA
    Am J Physiol Lung Cell Mol Physiol 300:L402-13. 2011
    ..Our results also suggest that the increase in apoptosis, as a consequence of HDAC inhibition, is associated with decreased VEGF and HIF-1α expression...
  17. ncbi Hypoxia inducible factor-1α in human emphysema lung tissue
    M Yasuo
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 37:775-83. 2011
    ..In conclusion, reduced expression of HIF-1α protein in severe COPD is consistent with the concept of a lung structure maintenance programme which is impaired on a molecular level...
  18. ncbi Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats
    Harm J Bogaard
    Division of Pulmonary and Critical Care, Department of Medicine and Victoria Johnson Center for Lung Research, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Crit Care Med 183:1402-10. 2011
    ..Inhibitors of histone deacetylases (HDACs) reduce pressure-overload-induced left ventricular hypertrophy and dysfunction, but their effects on right ventricular (RV) adaptation to pressure overload are unknown...
  19. ncbi p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice
    Shiro Mizuno
    Third Department of Internal Medicine, University of Fukui, Fukui, Japan
    Am J Physiol Lung Cell Mol Physiol 300:L753-61. 2011
    ..By interacting with p21 and HIF-1α, p53 may suppress hypoxic pulmonary arterial remodeling and pulmonary arterial smooth muscle cell proliferation under hypoxia...
  20. ncbi Molecular pathogenesis of emphysema
    Laimute Taraseviciene-Stewart
    Pulmonary and Critical Care Medicine Division, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:394-402. 2008
    ....
  21. ncbi From viral infection to pulmonary arterial hypertension: a role for viral proteins?
    Norbert F Voelkel
    Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA, USA
    AIDS 22:S49-53. 2008
    ..In this article we discuss recent studies on a potential role for Nef in HIV-PAH, with special reference to the knowledge gained from the SIV model of HIV infection...
  22. ncbi Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
    ..Here we provide a comprehensive overview of the rapidly expanding literature...
  23. ncbi Angiogenesis in chronic lung disease
    Norbert F Voelkel
    University of Colorado at Denver Health Sciences Center, COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, 4200 E Ninth Ave, Box C272, Denver, CO 80220, USA
    Chest 131:874-9. 2007
    ..This review will therefore discuss angiogenesis in several chronic lung diseases and will speculate on how altered vascular homeostasis may contribute to lung disease development...
  24. ncbi Lipid A fraction of LPS induces a discrete MAPK activation in acute lung injury
    Wen Feng Fang
    Divisio of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver, Health Sciences Center, Denver, CO 80204, USA
    Am J Physiol Lung Cell Mol Physiol 293:L336-44. 2007
    ..Compared with whole LPS, the lipid A fraction is associated with amplified whole lung MPO and ERK activation 6 h after intratracheal instillation in mice...
  25. ncbi Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
    Ashok N Babu
    Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 117:3774-85. 2007
    ..One implication of this study is that bronchial artery revascularization at the time of lung transplantation may decrease the risk of subsequent airway fibrosis...
  26. ncbi Beta-catenin in the fibroproliferative response to acute lung injury
    Ivor S Douglas
    Department of Medicine, Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 34:274-85. 2006
    ..The noncanonical cadherin-beta-catenin axis is associated with fibroproliferative repair after BHT/hyperoxia exposure and may regulate epithelial proliferation and lung matrix remodeling and repair in response to lung injury...

Research Grants11

  1. PROSTACYCLIN SYNTHESIS IN PULMONARY HYPERTENSION
    Norbert Voelkel; Fiscal Year: 2001
    ..Lung endothelial cells and airway cells of rats also will be transfected with the PGI2 synthase gene and their response to hypoxia examined. ..
  2. Exhaled Air Biomarkers in COPD
    Norbert Voelkel; Fiscal Year: 2005
    ..abstract_text> ..
  3. PROSTACYCLIN IN SYNTHESIS PULMONARY HYPERTENSION
    Norbert Voelkel; Fiscal Year: 1993
    ..We also want to examine whether simple mechanical perturbations (vascular ring contraction, stretch, shear stress) cause impairment of PGI2 synthesis by suicide inactivation of the enzyme...