Robert E Vann

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Drug Alcohol Depend 103:124-30. 2009
  2. pmc Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States
    Drug Alcohol Depend 94:191-8. 2008
  3. pmc Cannabimimetic properties of ajulemic acid
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:678-86. 2007
  4. ncbi request reprint Neurochemical and behavioral effects of bupropion and mecamylamine in the presence of nicotine
    Robert E Vann
    Department of Pharmacology, Virginia Commonwealth University, Richmond, PO Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 1117:18-24. 2006
  5. ncbi request reprint Nicotinic receptor inactivation after acute and repeated in vivo nicotine exposures in rats
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, 23298, USA
    Brain Res 1086:98-103. 2006
  6. pmc Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Pharmacol Exp Ther 334:1087-95. 2010
  7. ncbi request reprint Cellular nicotinic receptor desensitization correlates with nicotine-induced acute behavioral tolerance in rats
    Susan E Robinson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 192:71-8. 2007
  8. ncbi request reprint Differential behavioral responses to nicotine in Lewis and Fischer-344 rats
    Scott D Philibin
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
    Pharmacol Biochem Behav 80:87-92. 2005
  9. pmc Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 210:275-84. 2010
  10. ncbi request reprint Evidence of cellular nicotinic receptor desensitization in rats exhibiting nicotine-induced acute tolerance
    Susan E Robinson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 184:306-13. 2006

Collaborators

Detail Information

Publications24

  1. pmc Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Drug Alcohol Depend 103:124-30. 2009
    ..Taken together, these results suggest that methadone's shared subjective effects with abused opioids, as well as its unique metabolic properties contribute to its efficacy in opioid maintenance therapy...
  2. pmc Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States
    Drug Alcohol Depend 94:191-8. 2008
    ....
  3. pmc Cannabimimetic properties of ajulemic acid
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:678-86. 2007
    ..In summary, this study shows that AJA, like Delta(9)-THC, exhibits psychoactive and therapeutic effects at nearly equal doses in preclinical models, suggesting similar limitations in their putative therapeutic profiles...
  4. ncbi request reprint Neurochemical and behavioral effects of bupropion and mecamylamine in the presence of nicotine
    Robert E Vann
    Department of Pharmacology, Virginia Commonwealth University, Richmond, PO Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 1117:18-24. 2006
    ..Taken together these results demonstrate that when administered in the presence of nicotine, bupropion elicits unique pharmacological differences such that it exhibits both nAChR agonist- and antagonistic-like effects...
  5. ncbi request reprint Nicotinic receptor inactivation after acute and repeated in vivo nicotine exposures in rats
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, 23298, USA
    Brain Res 1086:98-103. 2006
    ..Overall, these data suggest that neuronal adaptations underlying nicotine tolerance may begin upon initial exposure then persist following repeated exposures...
  6. pmc Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Pharmacol Exp Ther 334:1087-95. 2010
    ....
  7. ncbi request reprint Cellular nicotinic receptor desensitization correlates with nicotine-induced acute behavioral tolerance in rats
    Susan E Robinson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 192:71-8. 2007
    ..Individuals vary in their susceptibility to nicotine addiction. However, there is little evidence that behavioral sensitivity to nicotine is dependent upon the functional state of nicotinic cholinergic receptors (nAChRs)...
  8. ncbi request reprint Differential behavioral responses to nicotine in Lewis and Fischer-344 rats
    Scott D Philibin
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
    Pharmacol Biochem Behav 80:87-92. 2005
    ..These findings support previous research by demonstrating that the F-344 rat is less sensitive to nicotine compared to the LEW rat...
  9. pmc Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 210:275-84. 2010
    ..Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects...
  10. ncbi request reprint Evidence of cellular nicotinic receptor desensitization in rats exhibiting nicotine-induced acute tolerance
    Susan E Robinson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 184:306-13. 2006
    ..Individuals vary in their susceptibility to nicotine addiction. However, there is little evidence that behavioral sensitivity to nicotine is dependent upon the functional state of nicotinic cholinergic receptors (nAChRs)...
  11. pmc The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States
    Eur J Pharmacol 656:63-7. 2011
    ..These findings suggest that, in the absence of FAAH, AEA produces intoxication comparable to THC, and consequently to marijuana...
  12. pmc Removal of continuous nicotine infusion produces somatic but not behavioral signs of withdrawal in mice
    Andrew J Kwilasz
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    Pharmacol Biochem Behav 94:114-8. 2009
    ..e. disruptions in operant response rates) were not observed, these findings suggest the importance of considering differences in the apparent manifestations of withdrawal syndromes while evaluating nicotine dependence...
  13. pmc Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States
    Eur J Pharmacol 615:102-7. 2009
    ..Taken together these studies demonstrate THC's ability to produce discriminative stimulus effects as well as demonstrate its pharmacological specificity and mechanism of action in a two-lever drug discrimination mouse model...
  14. ncbi request reprint Dose, duration, and pattern of nicotine administration as determinants of behavioral dependence in rats
    Robert E Vann
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298, USA
    Psychopharmacology (Berl) 184:482-93. 2006
    ..Disruption of learned behavior during antagonist-precipitated withdrawal can be a sensitive, quantitative measure of behavioral dependence...
  15. ncbi request reprint Endocannabinoid contribution to Δ(9)-tetrahydrocannabinol discrimination in rodents
    Jenny L Wiley
    RTI International, Research Triangle Park, NC 27709 2194, USA Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA Electronic address
    Eur J Pharmacol 737:97-105. 2014
    ..The present results highlight the complex interplay between anandamide and 2-AG and suggest that endogenous increases of both endocannabinoids are most effective in elicitation of THC-like discriminative stimulus effects. ..
  16. doi request reprint The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: analysis of brain area epibatidine binding and cotinine levels
    Alan L Pehrson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacol Biochem Behav 89:424-31. 2008
    ..However, a relationship between [(3)H] epibatidine and spontaneous activity on the final test day is suggested...
  17. pmc Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats
    M Jerry Wright
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613 USA
    Pharmacol Biochem Behav 85:507-13. 2006
    ..Further, they suggest that the role of cholinergic mediation of the behavioral effects of dextrorphan and dextromethorphan related to the abuse properties of nicotine may be minimal...
  18. ncbi request reprint Perinatal nicotine exposure eliminates peak in nicotinic acetylcholine receptor response in adolescent rats
    Angela F Britton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:871-6. 2007
    ....
  19. pmc Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist
    Jenny L Wiley
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, VA, USA
    Eur J Pharmacol 651:96-105. 2011
    ..Together, these results suggest that O-2050 is not a viable candidate for classification as a neutral cannabinoid CB(1) receptor antagonist...
  20. ncbi request reprint Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats
    Joseph H Porter
    Department of Psychology, Virginia Commonwealth University, PO Box 842018, 808 West Franklin Street, Richmond, VA 23284 2018, USA
    Psychopharmacology (Berl) 178:67-77. 2005
    ..The atypical antipsychotic drug (APD) clozapine elicits a robust discriminative cue that is generally selective for other atypical APDS in two-choice drug discrimination (DD) procedures...
  21. pmc Inhalation exposure to smoke from synthetic "marijuana" produces potent cannabimimetic effects in mice
    Jason M Wiebelhaus
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
    Drug Alcohol Depend 126:316-23. 2012
    ....
  22. ncbi request reprint Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats
    Jennifer L Newman
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 164:108-14. 2002
    ..Few studies have reported on the pharmacology of acetylmethadol's other isomers and most of these have focused on their potential analgesic activity...
  23. pmc Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia
    Joseph L McClay
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
    Neuropsychopharmacology 36:616-26. 2011
    ..This study has generated several novel candidate genes for antipsychotic response. However, our findings will require replication and functional validation. To facilitate replication efforts, we provide all GWAS p-values for download...
  24. pmc Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA
    Pharmacol Biochem Behav 91:150-4. 2008
    ..These results further clarify the behavioral sensitivity of the LEW strain of rat to nicotine exposure and lend credence to the role of genetics in the individual susceptibility to nicotine dependence...