Kristoffer Valerie

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Regulation and mechanisms of mammalian double-strand break repair
    Kristoffer Valerie
    Department of Radiation Oncology, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Oncogene 22:5792-812. 2003
  2. pmc Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
    Cell Cycle 11:1167-73. 2012
  3. ncbi request reprint Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity
    Guido Lammering
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Clin Cancer Res 10:6732-43. 2004
  4. ncbi request reprint Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cancer Res 67:1046-53. 2007
  5. pmc Mutations in the BRCT binding site of BRCA1 result in hyper-recombination
    Seth M Dever
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, 23298, USA
    Aging (Albany NY) 3:515-32. 2011
  6. pmc Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks
    Tong Zhou
    Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    DNA Repair (Amst) 8:901-11. 2009
  7. pmc ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks
    Ashraf Khalil
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
    Cell Cycle 10:481-91. 2011
  8. pmc ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells
    Bret R Adams
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Aging (Albany NY) 2:582-96. 2010
  9. ncbi request reprint ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells
    Joseph N Contessa
    Department of Radiation Oncology, Medical College of Virginia Virginia Commonwealth University, Richmond VA, USA
    Int J Radiat Oncol Biol Phys 65:851-8. 2006
  10. pmc Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Mol Cancer Ther 8:2894-902. 2009

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Regulation and mechanisms of mammalian double-strand break repair
    Kristoffer Valerie
    Department of Radiation Oncology, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Oncogene 22:5792-812. 2003
    ....
  2. pmc Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
    Cell Cycle 11:1167-73. 2012
    ..Thus, inter-fraction growth inhibition could perhaps be achieved in vivo with minor adverse effects to the brain...
  3. ncbi request reprint Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity
    Guido Lammering
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Clin Cancer Res 10:6732-43. 2004
    ....
  4. ncbi request reprint Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cancer Res 67:1046-53. 2007
    ..More specifically, ATM-dependent signaling through the RAF/MEK/ERK pathway is critical for efficient HRR and for radiation-induced ATM activation, suggestive of a regulatory feedback loop between ERK and ATM...
  5. pmc Mutations in the BRCT binding site of BRCA1 result in hyper-recombination
    Seth M Dever
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, 23298, USA
    Aging (Albany NY) 3:515-32. 2011
    ..Thus, certain BRCA1 mutations that cause hyper-recombination instead of reduced DSB repair might lead to breast cancer...
  6. pmc Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks
    Tong Zhou
    Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    DNA Repair (Amst) 8:901-11. 2009
    ..This chromosomal hypersensitivity, as well as a small but reproducible enhancement of calicheamicin cytotoxicity following siRNA-mediated TDP1 knockdown, suggests a role for TDP1 in repair of 3'-PG double-strand breaks in vivo...
  7. pmc ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks
    Ashraf Khalil
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
    Cell Cycle 10:481-91. 2011
    ....
  8. pmc ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells
    Bret R Adams
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Aging (Albany NY) 2:582-96. 2010
    ..Altogether, we conclude that NHEJ in hESCs is largely independent of ATM, DNA-PKcs, and PARP but dependent on XRCC4 with repair fidelity several-fold greater than in astrocytes...
  9. ncbi request reprint ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells
    Joseph N Contessa
    Department of Radiation Oncology, Medical College of Virginia Virginia Commonwealth University, Richmond VA, USA
    Int J Radiat Oncol Biol Phys 65:851-8. 2006
    ..In this study, the effects of EGFR-CD533 on other ErbB receptor tyrosine kinase (RTK) family members were quantified to better understand the mechanism of EGFR-CD533-mediated radiosensitization...
  10. pmc Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Mol Cancer Ther 8:2894-902. 2009
    ..Altogether, KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells...
  11. ncbi request reprint Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2
    Lisa Marie Sturla
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    J Biol Chem 280:14597-604. 2005
    ....
  12. pmc Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts
    Konstantin Akopiants
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Nucleic Acids Res 37:4055-62. 2009
    ..Thus, Cernunnos is essential for gap filling by either polymerase during nonhomologous end joining, suggesting that it plays a major role in aligning the two DNA ends in the repair complex...
  13. ncbi request reprint Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells
    Sarah E Golding
    Department of Radiation Oncology, Pharmacology and Toxicology, Medical College of Virginia, Virginia 23298, USA
    J Biol Chem 279:15402-10. 2004
    ..Altogether, these results demonstrate that HRR contributes substantially to DSB repair in human glioma cells, and, importantly, ATM plays a critical role in regulating HRR but not NHEJ throughout the cell cycle...
  14. pmc DNA double-strand break - induced pro-survival signaling
    Amy J Hawkins
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Radiother Oncol 101:13-7. 2011
    ..Our findings suggest that clinically relevant radiation doses, which are intended to halt tumor growth and induce cell death, are unable to inhibit tumor pro-survival signaling via ERK dephosphorylation...
  15. ncbi request reprint Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation
    Joseph N Contessa
    The Department of Radiation Oncology, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
    Breast Cancer Res Treat 95:17-27. 2006
    ..In summary, these studies identify a novel ErbB3/c-Src survival signal and point to ErbB3 expression levels as an important variable in therapeutic targeting of ErbB receptors in breast carcinoma cells...
  16. pmc Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
    Sarah E Golding
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
    Cancer Biol Ther 8:730-8. 2009
    ..Altogether, signaling from EGFR and EGFRvIII promotes both HRR and NHEJ that is likely a contributing factor towards the radioresistance of malignant gliomas...
  17. pmc Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
    Lawrence F Povirk
    Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Nucleic Acids Res 35:3869-78. 2007
    ....
  18. ncbi request reprint Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression
    Mohiuddin M Taher
    Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA
    Mol Cell Biochem 254:289-97. 2003
    ..We conclude that the mechanism by which curcumin modulates UV activation of HIV-LTR gene expression mainly involves the inhibition of NF-kappaB activation...
  19. pmc Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants
    Bret R Adams
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 5:e10001. 2010
    ..Altogether, our results show that hESCs have efficient DSB repair that is largely ATR-dependent HRR, whereas astrocytes critically depend on ATM for NHEJ, which, in part, is DNA-PKcs-independent...
  20. pmc In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation
    Amy J Hawkins
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    DNA Repair (Amst) 8:654-63. 2009
    ..Altogether, these results suggest that for 3'-phosphoglycolate overhang lesions, the SCAN1 mutation confers loss of function, while for 3'-phosphotyrosyl lesions, the mutation uniquely stabilizes a reaction intermediate...
  21. ncbi request reprint Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein
    Kara R Jones
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980230, Richmond, VA 23298, USA
    Mol Cancer Ther 4:1541-7. 2005
    ..These studies support the potential clinical utility of combining radiation therapy with agents that inhibit DNA double-strand break repair...
  22. ncbi request reprint Radiation-induced cell signaling: inside-out and outside-in
    Kristoffer Valerie
    Department of Biochemistry, Virginia Commonwealth University, 401 College Street, Box 980035, Richmond, VA 23298, USA
    Mol Cancer Ther 6:789-801. 2007
    ..Thus, tumor cells are dynamic with respect to their reliance on specific cell signaling pathways to exist and rapidly adapt to repeated toxic challenges in an attempt to maintain tumor cell survival...
  23. pmc BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies
    Seth M Dever
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
    Cell Cycle 11:687-94. 2012
    ..Herein, we review recent findings of how altered functions of these domains might lead to cancer through a mechanism of increased aberrant homologous recombination and possible implications for the development of BRCA1 inhibitors...
  24. ncbi request reprint Triggering of apoptosis is not sufficient to induce human immunodeficiency virus gene expression
    Jacqueline D Oakley
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    IUBMB Life 55:415-27. 2003
    ..Most importantly, the apoptotic and HIV gene expression responses elicited by UV are different to some extent and can be separated...
  25. pmc Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)
    Zao Zhong Su
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:20906-11. 2008
    ..These findings uncover a novel mode of IFN-induced anti-tumor growth suppression and suggest potential gene therapy applications for SARI...
  26. pmc Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
    Tong Zhou
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0230, USA
    Nucleic Acids Res 33:289-97. 2005
    ..However, the lack of severe radiosensitivity suggests that there must be alternative, TDP1-independent pathways for repair of 3'-PG DSBs...
  27. ncbi request reprint Stress and radiation-induced activation of multiple intracellular signaling pathways
    Paul Dent
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Radiat Res 159:283-300. 2003
    ..The impact on radiation-induced signaling of other autocrine and paracrine ligands such as TGFbeta and interleukin 6 is likely to be as complicated as described above for the ERBB receptors...
  28. pmc ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation
    Laura Biddlestone-Thorpe
    Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23112, USA
    Clin Cancer Res 19:3189-200. 2013
    ..As a first step toward this goal, we recently showed that the novel ATM kinase inhibitor KU-60019 reduced migration, invasion, and growth, and potently radiosensitized human glioma cells in vitro...
  29. pmc The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
    Rachel W Goehe
    Departments of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    J Pharmacol Exp Ther 343:763-78. 2012
    ..However, these responses are not inexorably linked or interdependent, as senescence can occur when autophagy is abrogated...
  30. ncbi request reprint Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance
    Guido Lammering
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Radiother Oncol 72:267-73. 2004
    ..In the current study, we have extended our investigations of EGFRvIII to human tumor cells in vitro and in vivo and further verified the important role of EGFRvIII in modulating radiosensitivity...
  31. pmc Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells
    George P Amorino
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Biol Cell 13:2233-44. 2002
    ..These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling...
  32. ncbi request reprint MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Cancer Ther 2:623-32. 2003
    ..Collectively, these findings demonstrate that MDA-7 protein, in combination with agents that generate free radicals, may have potential in the treatment of RCC...
  33. pmc Nuclear factor I isoforms regulate gene expression during the differentiation of human neural progenitors to astrocytes
    Katarzyna M Wilczynska
    Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Stem Cells 27:1173-81. 2009
    ..We conclude that an expression program of NFIs is executed during the differentiation of astrocytes, with NFI-X and -C controlling the expression of astrocytic markers at late stages of differentiation...
  34. ncbi request reprint Dominant-negative cAMP-responsive element-binding protein inhibits proliferating cell nuclear antigen and DNA repair, leading to increased cellular radiosensitivity
    George P Amorino
    Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 278:29394-9. 2003
    ..These data demonstrate that genetic disruption of CREB results in radiosensitization, and that this effect can be explained by a mechanism involving decreased PCNA expression and inhibition of DNA repair...
  35. pmc Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
    Liang Qiao
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Cell Biol 23:3052-66. 2003
    ..Collectively, these data demonstrate that multiple DCA-induced signaling pathways and transcription factors control hepatocyte survival...
  36. pmc UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53
    Nadine Chouinard
    Unité de BioTechnologie, Centre de recherche de l Hôpital St François d Assise de Québec, 10 rue de l Espinay, Quebec G1L 3L5, Canada
    Biochem J 365:133-45. 2002
    ..We conclude that the p38/p53 pathway plays a key role in the adaptive response of normal human keratinocytes against UV stress...
  37. pmc mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:10054-9. 2002
    ..These results support the hypothesis that Ad.mda-7 mediates induction of the GADD family of genes by means of the p38 MAPK pathway, thereby resulting in the selective induction of apoptosis in human melanoma cells...
  38. pmc BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination
    Sagar Sengupta
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 22:1210-22. 2003
    ..These results indicate that p53 and BLM functionally interact during resolution of stalled DNA replication forks and provide insight into the mechanism of genomic fidelity maintenance by these nuclear proteins...
  39. ncbi request reprint EGFRvIII-mediated radioresistance through a strong cytoprotective response
    Guido Lammering
    Department of Radiation Oncology, Heinrich Heine University, Duesseldorf, Germany
    Oncogene 22:5545-53. 2003
    ..Therefore, disabling EGFRvIII in addition to EGFRwt needs to be considered in any therapeutic approach aimed at targeting EGFR for tumor cell radiosensitization...
  40. ncbi request reprint Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
    Joseph N Contessa
    The Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Oncogene 21:4032-41. 2002
    ..Together this work demonstrates that the Erb-B receptor tyrosine kinase network stimulates cytoprotective p70 S6 kinase and Akt activity in response to clinically relevant doses of ionizing radiation...
  41. ncbi request reprint Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy
    Zhimin Tong
    Department of Biology, McMaster University, Hamilton, ON, Canada L8S 4K1
    J Photochem Photobiol B 71:77-85. 2003
    ..These data suggest that although Photofrin-mediated PDT is able to induce JNK1 and p38 in human cells, the p38 pathway alone does not play a major role in the sensitivity of LFS cells to Photofrin-mediated PDT...
  42. ncbi request reprint Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways
    Moira Sauane
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 64:2988-93. 2004
    ..Our results indicate that mda-7/IL-24-mediated apoptosis can be triggered through a combination of intracellular as well as secretory mechanisms and can occur efficiently in the absence of protein secretion...
  43. ncbi request reprint Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis
    Luni Emdad
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 66:1509-16. 2006
    ..Our findings suggest that activation of NF-kappaB by AEG-1 could represent a key molecular mechanism by which AEG-1 promotes anchorage-independent growth and invasion, two central features of the neoplastic phenotype...
  44. pmc Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter
    Zhao Zhong Su
    Department of Pathology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:1059-64. 2005
    ....
  45. ncbi request reprint Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment
    Adly Yacoub
    Department of Biochemistry, 401 College St, Massey Cancer Center, Room 2 108, Box 980035, Virginia Commonwealth University, Richmond VA 23298 0035, USA
    Mol Pharmacol 71:259-75. 2007
    ..Thus, hCG, in combination with radiation and lovastatin, may represent a novel approach to kill prostate cancer cells...
  46. ncbi request reprint Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner
    Zao Zhong Su
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 22:1164-80. 2003
    ..mda-7 may, in many instances, prove more beneficial for the gene-based therapy of malignant gliomas than administration of wild-type p53...
  47. pmc Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles
    Marshonna Forgues
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Mol Cell Biol 23:5282-92. 2003
    ..Based on this evidence, we suggest that Crm1 is actively involved in maintaining centrosome integrity and that HBx disrupts this process by inactivating Crm1 and thus contributes to HBV-mediated carcinogenesis...
  48. ncbi request reprint BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis
    Pankaj Gupta
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Res 66:8182-91. 2006
    ....
  49. ncbi request reprint Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression
    Isaac Chan
    College of Physicians and Surgeons, Columbia University Medical School, New York, New York, USA
    J Cell Physiol 215:401-9. 2008
    ....
  50. ncbi request reprint mda-9/Syntenin: a positive regulator of melanoma metastasis
    Habib Boukerche
    Department of Pathology, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 65:10901-11. 2005
    ..Based on its ability to directly alter metastasis, mda-9/syntenin provides a promising new focus for melanoma cancer research with potential therapeutic applications for metastatic diseases...
  51. ncbi request reprint Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene
    Dong Chul Kang
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 23:1789-800. 2004
    ..The conserved genomic and protein structure of mda-5 in human and mouse will permit analysis of the evolution and developmental aspects of this gene...
  52. pmc Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
    Steven M Yannone
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Nucleic Acids Res 36:3354-65. 2008
    ..Such processing could account for the very small deletions often found at DNA double-strand break repair sites...
  53. ncbi request reprint Molecular target-based therapy of pancreatic cancer
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 66:2403-13. 2006
    ..Our study provides support for a "dual molecular targeted therapy" involving oncogene inhibition and selective cancer apoptosis-inducing gene expression with potential for effectively treating an invariably fatal cancer...
  54. pmc Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence
    Devanand Sarkar
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 25:7333-43. 2005
    ....
  55. ncbi request reprint Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude mice
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 65:9056-63. 2005
    ..The CTV provides a novel reagent for treating pancreatic and other human cancers with potential for eliminating both primary tumors and metastatic disease...
  56. ncbi request reprint N-glycosylation of MDA-7/IL-24 is dispensable for tumor cell-specific apoptosis and "bystander" antitumor activity
    Moira Sauane
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 66:11869-77. 2006
    ....