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Genomes and Genes | Kristoffer ValerieSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Publications
Regulation and mechanisms of mammalian double-strand break repairKristoffer Valerie
Department of Radiation Oncology, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Oncogene 22:5792-812. 2003....
Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth controlSarah E Golding
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
Cell Cycle 11:1167-73. 2012..Thus, inter-fraction growth inhibition could perhaps be achieved in vivo with minor adverse effects to the brain...- Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivityGuido Lammering
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0058, USA
Clin Cancer Res 10:6732-43. 2004..These data affirm the broad potential of EGFR-CD533 to radiosensitize human malignant glioma cells... - Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage responseSarah E Golding
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA
Cancer Res 67:1046-53. 2007..More specifically, ATM-dependent signaling through the RAF/MEK/ERK pathway is critical for efficient HRR and for radiation-induced ATM activation, suggestive of a regulatory feedback loop between ERK and ATM... - Mutations in the BRCT binding site of BRCA1 result in hyper-recombinationSeth M Dever
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, 23298, USA
Aging (Albany NY) 3:515-32. 2011..Thus, certain BRCA1 mutations that cause hyper-recombination instead of reduced DSB repair might lead to breast cancer... - Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaksTong Zhou
Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
DNA Repair (Amst) 8:901-11. 2009..This chromosomal hypersensitivity, as well as a small but reproducible enhancement of calicheamicin cytotoxicity following siRNA-mediated TDP1 knockdown, suggests a role for TDP1 in repair of 3'-PG double-strand breaks in vivo... - ATM-dependent ERK signaling via AKT in response to DNA double-strand breaksAshraf Khalil
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
Cell Cycle 10:481-91. 2011.... - ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cellsJoseph N Contessa
Department of Radiation Oncology, Medical College of Virginia Virginia Commonwealth University, Richmond VA, USA
Int J Radiat Oncol Biol Phys 65:851-8. 2006..In this study, the effects of EGFR-CD533 on other ErbB receptor tyrosine kinase (RTK) family members were quantified to better understand the mechanism of EGFR-CD533-mediated radiosensitization... - Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionSarah E Golding
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Mol Cancer Ther 8:2894-902. 2009..Altogether, KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells... - ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cellsBret R Adams
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Aging (Albany NY) 2:582-96. 2010..Altogether, we conclude that NHEJ in hESCs is largely independent of ATM, DNA-PKcs, and PARP but dependent on XRCC4 with repair fidelity several-fold greater than in astrocytes... - Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2Lisa Marie Sturla
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
J Biol Chem 280:14597-604. 2005.... - Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extractsKonstantin Akopiants
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
Nucleic Acids Res 37:4055-62. 2009..Thus, Cernunnos is essential for gap filling by either polymerase during nonhomologous end joining, suggesting that it plays a major role in aligning the two DNA ends in the repair complex... - Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cellsSarah E Golding
Department of Radiation Oncology, Pharmacology and Toxicology, Medical College of Virginia, Virginia 23298, USA
J Biol Chem 279:15402-10. 2004..Altogether, these results demonstrate that HRR contributes substantially to DSB repair in human glioma cells, and, importantly, ATM plays a critical role in regulating HRR but not NHEJ throughout the cell cycle... - DNA double-strand break - induced pro-survival signalingAmy J Hawkins
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Radiother Oncol 101:13-7. 2011..Our findings suggest that clinically relevant radiation doses, which are intended to halt tumor growth and induce cell death, are unable to inhibit tumor pro-survival signaling via ERK dephosphorylation... - Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cellsSarah E Golding
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298 0058, USA
Cancer Biol Ther 8:730-8. 2009..Altogether, signaling from EGFR and EGFRvIII promotes both HRR and NHEJ that is likely a contributing factor towards the radioresistance of malignant gliomas... - Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiationJoseph N Contessa
The Department of Radiation Oncology, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
Breast Cancer Res Treat 95:17-27. 2006..In summary, these studies identify a novel ErbB3/c-Src survival signal and point to ErbB3 expression levels as an important variable in therapeutic targeting of ErbB receptors in breast carcinoma cells... - Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendantsBret R Adams
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
PLoS ONE 5:e10001. 2010..Altogether, our results show that hESCs have efficient DSB repair that is largely ATR-dependent HRR, whereas astrocytes critically depend on ATM for NHEJ, which, in part, is DNA-PKcs-independent... - Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extractsLawrence F Povirk
Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
Nucleic Acids Res 35:3869-78. 2007.... - Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expressionMohiuddin M Taher
Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA
Mol Cell Biochem 254:289-97. 2003..We conclude that the mechanism by which curcumin modulates UV activation of HIV-LTR gene expression mainly involves the inhibition of NF-kappaB activation... - In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutationAmy J Hawkins
Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
DNA Repair (Amst) 8:654-63. 2009..Altogether, these results suggest that for 3'-phosphoglycolate overhang lesions, the SCAN1 mutation confers loss of function, while for 3'-phosphotyrosyl lesions, the mutation uniquely stabilizes a reaction intermediate... - Radiation-induced cell signaling: inside-out and outside-inKristoffer Valerie
Department of Biochemistry, Virginia Commonwealth University, 401 College Street, Box 980035, Richmond, VA 23298, USA
Mol Cancer Ther 6:789-801. 2007..Thus, tumor cells are dynamic with respect to their reliance on specific cell signaling pathways to exist and rapidly adapt to repeated toxic challenges in an attempt to maintain tumor cell survival... - Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 proteinKara R Jones
Department of Pharmacology and Toxicology, Virginia Commonwealth University, P.O. Box 980230, Richmond, VA 23298, USA
Mol Cancer Ther 4:1541-7. 2005..These studies support the potential clinical utility of combining radiation therapy with agents that inhibit DNA double-strand break repair... - BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategiesSeth M Dever
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA
Cell Cycle 11:687-94. 2012..Herein, we review recent findings of how altered functions of these domains might lead to cancer through a mechanism of increased aberrant homologous recombination and possible implications for the development of BRCA1 inhibitors... - Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN)Zao Zhong Su
Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
Proc Natl Acad Sci U S A 105:20906-11. 2008..These findings uncover a novel mode of IFN-induced anti-tumor growth suppression and suggest potential gene therapy applications for SARI... - Triggering of apoptosis is not sufficient to induce human immunodeficiency virus gene expressionJacqueline D Oakley
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
IUBMB Life 55:415-27. 2003..Most importantly, the apoptotic and HIV gene expression responses elicited by UV are different to some extent and can be separated... - Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Tong Zhou
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0230, USA
Nucleic Acids Res 33:289-97. 2005..However, the lack of severe radiosensitivity suggests that there must be alternative, TDP1-independent pathways for repair of 3'-PG DSBs... - Stress and radiation-induced activation of multiple intracellular signaling pathwaysPaul Dent
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
Radiat Res 159:283-300. 2003..The impact on radiation-induced signaling of other autocrine and paracrine ligands such as TGFbeta and interleukin 6 is likely to be as complicated as described above for the ERBB receptors... - Radiation-induced activation of a common variant of EGFR confers enhanced radioresistanceGuido Lammering
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Radiother Oncol 72:267-73. 2004.... - Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cellsGeorge P Amorino
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Mol Biol Cell 13:2233-44. 2002..These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling... - MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacityAdly Yacoub
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Mol Cancer Ther 2:623-32. 2003..Collectively, these findings demonstrate that MDA-7 protein, in combination with agents that generate free radicals, may have potential in the treatment of RCC... - Nuclear factor I isoforms regulate gene expression during the differentiation of human neural progenitors to astrocytesKatarzyna M Wilczynska
Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
Stem Cells 27:1173-81. 2009..We conclude that an expression program of NFIs is executed during the differentiation of astrocytes, with NFI-X and -C controlling the expression of astrocytic markers at late stages of differentiation... - Dominant-negative cAMP-responsive element-binding protein inhibits proliferating cell nuclear antigen and DNA repair, leading to increased cellular radiosensitivityGeorge P Amorino
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Biol Chem 278:29394-9. 2003..These data demonstrate that genetic disruption of CREB results in radiosensitization, and that this effect can be explained by a mechanism involving decreased PCNA expression and inhibition of DNA repair... - Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytesLiang Qiao
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Mol Cell Biol 23:3052-66. 2003..Collectively, these data demonstrate that multiple DCA-induced signaling pathways and transcription factors control hepatocyte survival... - UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53Nadine Chouinard
Unité de BioTechnologie, Centre de recherche de l Hôpital St François d Assise de Québec, 10 rue de l Espinay, Quebec G1L 3L5, Canada
Biochem J 365:133-45. 2002..We conclude that the p38/p53 pathway plays a key role in the adaptive response of normal human keratinocytes against UV stress... - Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapyZhimin Tong
Department of Biology, McMaster University, Hamilton, ON, Canada L8S 4K1
J Photochem Photobiol B 71:77-85. 2003..These data suggest that although Photofrin-mediated PDT is able to induce JNK1 and p38 in human cells, the p38 pathway alone does not play a major role in the sensitivity of LFS cells to Photofrin-mediated PDT... - Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cellsJoseph N Contessa
The Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
Oncogene 21:4032-41. 2002..Together this work demonstrates that the Erb-B receptor tyrosine kinase network stimulates cytoprotective p70 S6 kinase and Akt activity in response to clinically relevant doses of ionizing radiation... - Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathwaysMoira Sauane
Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
Cancer Res 64:2988-93. 2004..Our results indicate that mda-7/IL-24-mediated apoptosis can be triggered through a combination of intracellular as well as secretory mechanisms and can occur efficiently in the absence of protein secretion... - EGFRvIII-mediated radioresistance through a strong cytoprotective responseGuido Lammering
Department of Radiation Oncology, Heinrich-Heine University, Duesseldorf, Germany
Oncogene 22:5545-53. 2003..Therefore, disabling EGFRvIII in addition to EGFRwt needs to be considered in any therapeutic approach aimed at targeting EGFR for tumor cell radiosensitization... - BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombinationSagar Sengupta
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
EMBO J 22:1210-22. 2003..These results indicate that p53 and BLM functionally interact during resolution of stalled DNA replication forks and provide insight into the mechanism of genomic fidelity maintenance by these nuclear proteins... - mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPKDevanand Sarkar
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 99:10054-9. 2002..These results support the hypothesis that Ad.mda-7 mediates induction of the GADD family of genes by means of the p38 MAPK pathway, thereby resulting in the selective induction of apoptosis in human melanoma cells... - Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindlesMarshonna Forgues
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
Mol Cell Biol 23:5282-92. 2003..Based on this evidence, we suggest that Crm1 is actively involved in maintaining centrosome integrity and that HBx disrupts this process by inactivating Crm1 and thus contributes to HBV-mediated carcinogenesis... - Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoterZhao-Zhong Su
Department of Pathology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:1059-64. 2005.... - Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing geneDong Chul Kang
Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Oncogene 23:1789-800. 2004..The conserved genomic and protein structure of mda-5 in human and mouse will permit analysis of the evolution and developmental aspects of this gene... - Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent mannerZao Zhong Su
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Oncogene 22:1164-80. 2003..mda-7 may, in many instances, prove more beneficial for the gene-based therapy of malignant gliomas than administration of wild-type p53... - Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescenceDevanand Sarkar
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Cell Biol 25:7333-43. 2005.... - N-glycosylation of MDA-7/IL-24 is dispensable for tumor cell-specific apoptosis and "bystander" antitumor activityMoira Sauane
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
Cancer Res 66:11869-77. 2006.... - BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosisPankaj Gupta
Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
Cancer Res 66:8182-91. 2006.... - Molecular target-based therapy of pancreatic cancerIrina V Lebedeva
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Cancer Res 66:2403-13. 2006..Our study provides support for a "dual molecular targeted therapy" involving oncogene inhibition and selective cancer apoptosis-inducing gene expression with potential for effectively treating an invariably fatal cancer... - Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasisLuni Emdad
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Cancer Res 66:1509-16. 2006..Our findings suggest that activation of NF-kappaB by AEG-1 could represent a key molecular mechanism by which AEG-1 promotes anchorage-independent growth and invasion, two central features of the neoplastic phenotype... - Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppressionIsaac Chan
College of Physicians and Surgeons, Columbia University Medical School, New York, New York, USA
J Cell Physiol 215:401-9. 2008.... - Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinaseSteven M Yannone
Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Nucleic Acids Res 36:3354-65. 2008..Such processing could account for the very small deletions often found at DNA double-strand break repair sites... - mda-9/Syntenin: a positive regulator of melanoma metastasisHabib Boukerche
Department of Pathology, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
Cancer Res 65:10901-11. 2005..Based on its ability to directly alter metastasis, mda-9/syntenin provides a promising new focus for melanoma cancer research with potential therapeutic applications for metastatic diseases... - Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude miceDevanand Sarkar
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
Cancer Res 65:9056-63. 2005..The CTV provides a novel reagent for treating pancreatic and other human cancers with potential for eliminating both primary tumors and metastatic disease... - Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatmentAdly Yacoub
Department of Biochemistry, 401 College St, Massey Cancer Center, Room 2 108, Box 980035, Virginia Commonwealth University, Richmond VA 23298 0035, USA
Mol Pharmacol 71:259-75. 2007..Thus, hCG, in combination with radiation and lovastatin, may represent a novel approach to kill prostate cancer cells...