Brett M Tyler

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. ncbi request reprint The Avr1b locus of Phytophthora sojae encodes an elicitor and a regulator required for avirulence on soybean plants carrying resistance gene Rps1b
    Weixing Shan
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Mol Plant Microbe Interact 17:394-403. 2004
  2. ncbi request reprint Comparative analysis of Phytophthora genes encoding secreted proteins reveals conserved synteny and lineage-specific gene duplications and deletions
    Rays H Y Jiang
    Laboratory of Phytopathology, Plant Sciences Group, Wageningen University, Binnenhaven 5, NL 6709 PD Wageningen, The Netherlands
    Mol Plant Microbe Interact 19:1311-21. 2006
  3. ncbi request reprint Extensive variation in nuclear mitochondrial DNA content between the genomes of Phytophthora sojae and Phytophthora ramorum
    Konstantinos Krampis
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0477, USA
    Mol Plant Microbe Interact 19:1329-36. 2006
  4. pmc VMD: a community annotation database for oomycetes and microbial genomes
    Sucheta Tripathy
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Nucleic Acids Res 34:D379-81. 2006
  5. pmc Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire
    C André Lévesque
    Agriculture and Agri Food Canada, 960 Carling Ave, Ottawa, ON, K1A 0C6, Canada
    Genome Biol 11:R73. 2010
  6. ncbi request reprint Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Science 313:1261-6. 2006
  7. doi request reprint Entering and breaking: virulence effector proteins of oomycete plant pathogens
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, One Washington Street, Blacksburg, VA 24061 0477, USA
    Cell Microbiol 11:13-20. 2009
  8. ncbi request reprint Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry
    Furong Sun
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA
    Mol Plant Microbe Interact 26:330-44. 2013
  9. doi request reprint Different domains of Phytophthora sojae effector Avr4/6 are recognized by soybean resistance genes Rps4 and Rps6
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University Blacksburg 24061, USA
    Mol Plant Microbe Interact 23:425-35. 2010
  10. pmc RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1930-47. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The Avr1b locus of Phytophthora sojae encodes an elicitor and a regulator required for avirulence on soybean plants carrying resistance gene Rps1b
    Weixing Shan
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Mol Plant Microbe Interact 17:394-403. 2004
    ..Avr1b-2 was genetically mapped to the same BAC contig as Avr1b-1, using a cross between P7064 (race 7) and P6497. The Avr1k gene, required for avirulence on soybean cultivars containing Rps1k, was mapped to the same interval as Avr1b-1...
  2. ncbi request reprint Comparative analysis of Phytophthora genes encoding secreted proteins reveals conserved synteny and lineage-specific gene duplications and deletions
    Rays H Y Jiang
    Laboratory of Phytopathology, Plant Sciences Group, Wageningen University, Binnenhaven 5, NL 6709 PD Wageningen, The Netherlands
    Mol Plant Microbe Interact 19:1311-21. 2006
    ..These different evolutionary patterns may shed light on the functions of these secreted proteins in the biology and pathology of the two Phytophthora spp...
  3. ncbi request reprint Extensive variation in nuclear mitochondrial DNA content between the genomes of Phytophthora sojae and Phytophthora ramorum
    Konstantinos Krampis
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0477, USA
    Mol Plant Microbe Interact 19:1329-36. 2006
    ..No clear examples were found of NUMTs forming functional nuclear genes or of NUMTs inserted into exons or introns of any nuclear gene...
  4. pmc VMD: a community annotation database for oomycetes and microbial genomes
    Sucheta Tripathy
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Nucleic Acids Res 34:D379-81. 2006
    ..ramorum that have already been manually curated. A toolkit is provided as an additional resource for users to perform a variety of sequence analysis jobs. The database is publicly available at http://phytophthora.vbi.vt.edu/...
  5. pmc Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire
    C André Lévesque
    Agriculture and Agri Food Canada, 960 Carling Ave, Ottawa, ON, K1A 0C6, Canada
    Genome Biol 11:R73. 2010
    ..Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species...
  6. ncbi request reprint Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Science 313:1261-6. 2006
    ....
  7. doi request reprint Entering and breaking: virulence effector proteins of oomycete plant pathogens
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, One Washington Street, Blacksburg, VA 24061 0477, USA
    Cell Microbiol 11:13-20. 2009
    ..The mechanisms by which the effector enter host cells, and by which they suppress host defences, remain to be elucidated...
  8. ncbi request reprint Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry
    Furong Sun
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA
    Mol Plant Microbe Interact 26:330-44. 2013
    ..Based on these findings, we propose a model where Avh5 interacts with PtdIns(3)P through its C terminus, and by binding of the RFLR motif, which promotes host cell entry...
  9. doi request reprint Different domains of Phytophthora sojae effector Avr4/6 are recognized by soybean resistance genes Rps4 and Rps6
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University Blacksburg 24061, USA
    Mol Plant Microbe Interact 23:425-35. 2010
    ..Compared with alleles from avirulent races, alleles of Avr4/6 from virulent races possess nucleotide substitutions in the 5' untranslated region of the gene but not in the protein-coding region...
  10. pmc RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1930-47. 2008
    ..Mutational analysis of the RXLR motif shows that the required residues are very similar in the motifs of Plasmodium and Phytophthora. Thus, the machinery of the hosts (soybean and human) targeted by the effectors may be very ancient...
  11. pmc Unifying themes in microbial associations with animal and plant hosts described using the gene ontology
    Trudy Torto-Alalibo
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, Blacksburg, VA 24061 0477, USA
    Microbiol Mol Biol Rev 74:479-503. 2010
    ..We also highlight areas where new terms need to be developed, an ongoing process that should involve the whole community...
  12. pmc Programmed cell death in host-symbiont associations, viewed through the Gene Ontology
    Marcus C Chibucos
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Microbiol 9:S5. 2009
    ....
  13. doi request reprint Entry of oomycete and fungal effectors into plant and animal host cells
    Shiv D Kale
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061 0477, USA
    Cell Microbiol 13:1839-48. 2011
    ..Reagents that can block PI-3-P-mediated entry have been identified, suggesting new therapeutic strategies...
  14. pmc Infection and genotype remodel the entire soybean transcriptome
    Lecong Zhou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Genomics 10:49. 2009
    ....
  15. pmc RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members
    Rays H Y Jiang
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:4874-9. 2008
    ..The superfamily includes all experimentally identified oomycete effector and avirulence genes, and its rapid pace of evolution is consistent with a role for Avh proteins in interaction with plant hosts...
  16. pmc Common themes in nutrient acquisition by plant symbiotic microbes, described by the Gene Ontology
    Marcus C Chibucos
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Microbiol 9:S6. 2009
    ..Where appropriate, parallels found among animal symbionts are also highlighted...
  17. ncbi request reprint External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells
    Shiv D Kale
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Cell 142:284-95. 2010
    ..Entry into both plant and animal cells involves lipid raft-mediated endocytosis. Blocking PI3P binding inhibited effector entry, suggesting new therapeutic avenues...
  18. pmc Common and contrasting themes in host cell-targeted effectors from bacterial, fungal, oomycete and nematode plant symbionts described using the Gene Ontology
    Trudy Torto-Alalibo
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Microbiol 9:S3. 2009
    ....
  19. pmc Oomycete Transcriptomics Database: a resource for oomycete transcriptomes
    Sucheta Tripathy
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA
    BMC Genomics 13:303. 2012
    ....
  20. doi request reprint Identification of lipid-binding effectors
    Shiv D Kale
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    Methods Mol Biol 835:393-414. 2012
    ..We describe in detail how to perform lipid filter and liposome-binding assays and provide suggestions for troubleshooting potential problems with these assays...
  21. pmc Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1118-33. 2008
    ....
  22. pmc Sequence verification of synthetic DNA by assembly of sequencing reads
    Mandy L Wilson
    Virginia Bioinformatics Institute, Virginia Tech, Washington Street MC 0477, Blacksburg, VA 24061, USA
    Nucleic Acids Res 41:e25. 2013
    ..Comparing GenoREAD results with those from manual analysis of the sequencing data demonstrates that GenoREAD tends to be conservative in its diagnostic. GenoREAD is available at www.genoread.org...
  23. pmc Zoospore interspecific signaling promotes plant infection by Phytophthora
    Ping Kong
    Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Virginia Beach, VA 23455 3363, USA
    BMC Microbiol 10:313. 2010
    ..It is unclear whether these molecules are shared among related species and what their chemistries are...
  24. ncbi request reprint Expressed sequence tags from phytophthora sojae reveal genes specific to development and infection
    Trudy A Torto-Alalibo
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Mol Plant Microbe Interact 20:781-93. 2007
    ..Sequences identified with putative roles in pathogenesis included avirulence homologs possessing the RxLR motif, elicitins, and hydrolytic enzymes. This large collection of P. sojae ESTs will serve as a valuable public genomic resource...
  25. doi request reprint Assaying effector function in planta using double-barreled particle bombardment
    Shiv D Kale
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA
    Methods Mol Biol 712:153-72. 2011
    ....
  26. ncbi request reprint An integrated BAC and genome sequence physical map of Phytophthora sojae
    Xuemin Zhang
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0477, USA
    Mol Plant Microbe Interact 19:1302-10. 2006
    ..sojae and other Phytophthora spp. In one illustration of this value, we have placed the 350 members of a superfamily of putative pathogenicity effector genes onto the map, revealing extensive clustering of these genes...
  27. pmc Sensitive detection of pathway perturbations in cancers
    Corban G Rivera
    Department of Computer Science, Virginia Tech, Blacksburg, VA, USA
    BMC Bioinformatics 13:S9. 2012
    ..Associations detected between diseases and perturbations in well-defined pathways within such interaction networks have the potential to illuminate the molecular mechanisms underlying disease progression and response to treatment...
  28. ncbi request reprint Molecular basis of recognition between phytophthora pathogens and their hosts
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Annu Rev Phytopathol 40:137-67. 2002
    ..One Phytophthora Avr gene, Avr1b from P. sojae, has been cloned and characterized. It encodes a secreted elicitor that triggers a system-wide defense response in soybean plants carrying the cognate R gene, Rps1b...
  29. ncbi request reprint The repertoire of transfer RNA genes is tuned to codon usage bias in the genomes of Phytophthora sojae and Phytophthora ramorum
    Sucheta Tripathy
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Mol Plant Microbe Interact 19:1322-8. 2006
    ..99), as were tRNA gene frequencies (0.77). Approximately 60% of orthologous tRNA gene pairs in P sojae and P. ramorum are located in regions that have conserved synteny in the two species...
  30. pmc Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology
    Tsai Tien Tseng
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Microbiol 9:S2. 2009
    ....
  31. pmc Using interpolation to estimate system uncertainty in gene expression experiments
    Lee J Falin
    Virginia Bioinformatics Institute, Virginia Polytechnic and State University, Blacksburg, Virginia, United States of America
    PLoS ONE 6:e22071. 2011
    ..e. non-categorical) treatments. In principle, the method could also be applied to combinations of treatments, in which case it could greatly simplify the task of exploring the large combinatorial space of future possible measurements...
  32. pmc Network-based prediction and analysis of HIV dependency factors
    T M Murali
    Department of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
    PLoS Comput Biol 7:e1002164. 2011
    ....
  33. ncbi request reprint Mitochondrial genome sequences and comparative genomics of Phytophthora ramorum and P. sojae
    Frank N Martin
    U S Department of Agriculture ARS, Salinas, CA 93905, USA
    Curr Genet 51:285-96. 2007
    ....
  34. ncbi request reprint Ancient origin of elicitin gene clusters in Phytophthora genomes
    Rays H Y Jiang
    Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands
    Mol Biol Evol 23:338-51. 2006
    ..Overall, eli and ell genes are expressed at different levels and in different life cycle stages but those sharing the same phylogenetic clade appear to have similar expression patterns...
  35. ncbi request reprint Spatial and temporal expression patterns of Avr1b-1 and defense-related genes in soybean plants upon infection with Phytophthora sojae
    Karina Valer
    Department Biologie I Botanik, Ludwig Maximilians Universitat, Menzinger Strasse 67, D 80638 Munich, Germany
    FEMS Microbiol Lett 265:60-8. 2006
    ..In contrast, the PsojNIP gene encoding a proposed virulence factor was expressed only during the necrotrophic phase in the compatible interaction...
  36. pmc Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1 resistance genes from two Arabidopsis lines
    Anne P Rehmany
    Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Cell 17:1839-50. 2005
    ..The presence of the motif in additional secreted proteins from plant pathogenic oomycetes and its similarity to a host-targeting signal from malaria parasites suggest a conserved role in pathogenicity...