P F Sullivan

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples
    P F Sullivan
    Virginia Commonwealth University Medical College of Virginia, Richmond, USA
    Am J Psychiatry 155:98-101. 1998
  2. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
  3. ncbi request reprint Genetic epidemiology of major depression: review and meta-analysis
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 157:1552-62. 2000
  4. ncbi request reprint Genetic case-control association studies in neuropsychiatry
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, PO Box 980126, Richmond, VA 23298 0126
    Arch Gen Psychiatry 58:1015-24. 2001
  5. ncbi request reprint Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:479-84. 2001
  6. ncbi request reprint The genetic epidemiology of smoking
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University, Richmond 23298 0126, USA
    Nicotine Tob Res 1:S51-7; discussion S69-70. 1999
  7. ncbi request reprint The subtypes of major depression in a twin registry
    Patrick F Sullivan
    Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
    J Affect Disord 68:273-84. 2002
  8. ncbi request reprint Latent class analysis of lifetime depressive symptoms in the national comorbidity survey
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1398-406. 1998
  9. ncbi request reprint Outcome of anorexia nervosa: a case-control study
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:939-46. 1998
  10. ncbi request reprint Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:266-70. 2001

Collaborators

Detail Information

Publications85

  1. ncbi request reprint No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples
    P F Sullivan
    Virginia Commonwealth University Medical College of Virginia, Richmond, USA
    Am J Psychiatry 155:98-101. 1998
    ..The authors' objective was to investigate this association in two New Zealand samples...
  2. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
    ..These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors...
  3. ncbi request reprint Genetic epidemiology of major depression: review and meta-analysis
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 157:1552-62. 2000
    ..The authors conducted a meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression...
  4. ncbi request reprint Genetic case-control association studies in neuropsychiatry
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, PO Box 980126, Richmond, VA 23298 0126
    Arch Gen Psychiatry 58:1015-24. 2001
    ..If conducted with care and mindfulness of the potential pitfalls, case-control association studies can be an important tool for psychiatric genetic research...
  5. ncbi request reprint Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:479-84. 2001
    ..If these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of TPH in the biosynthesis of serotonin...
  6. ncbi request reprint The genetic epidemiology of smoking
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University, Richmond 23298 0126, USA
    Nicotine Tob Res 1:S51-7; discussion S69-70. 1999
    ..nicotine or are they also involved in dependence on other licit and illicit psychoactive substances? Are there different mechanisms in men and women? What are the specific environmental factors and how do genes and environment interact?..
  7. ncbi request reprint The subtypes of major depression in a twin registry
    Patrick F Sullivan
    Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
    J Affect Disord 68:273-84. 2002
    ..The subtypes of major depression (MD) remain incompletely understood. While there is consensus about the existence of MD with 'typical' vegetative features, further data are required to evaluate the existence of MD with atypical features...
  8. ncbi request reprint Latent class analysis of lifetime depressive symptoms in the national comorbidity survey
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1398-406. 1998
    ..In a prior report, the authors used latent class analysis (LCA) to identify a distinctive atypical depressive subtype; they sought to replicate that finding in the current study...
  9. ncbi request reprint Outcome of anorexia nervosa: a case-control study
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:939-46. 1998
    ..Although there have been many studies of the outcome of anorexia nervosa, methodological weaknesses limit their interpretation. The authors used a case-control design to try to improve knowledge about the outcome of anorexia nervosa...
  10. ncbi request reprint Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:266-70. 2001
    ..No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF...
  11. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
    ....
  12. ncbi request reprint Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample
    B P Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 11:1025-31. 2006
    ....
  13. ncbi request reprint Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence
    M A Silverman
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219 1534, USA
    Am J Med Genet 96:646-53. 2000
    ..None of the four polymorphisms we tested, nor their estimated haplotypes, were associated with smoking initiation or progression to nicotine dependence...
  14. ncbi request reprint Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families
    E J C G van den Oord
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 8:499-510. 2003
    ..Implications of these findings for follow-up and replication studies are discussed...
  15. pmc Genome-wide association study of antipsychotic-induced QTc interval prolongation
    K Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacogenomics J 12:165-72. 2012
    ..However, some genes may also be unique for drug-induced prolongation. This study demonstrates the potential of GWAS to discover genes and pathways that mediate antipsychotic-induced QT prolongation...
  16. pmc Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs
    D E Adkins
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23223, USA
    Mol Psychiatry 16:321-32. 2011
    ..Although our findings require replication and functional validation, this study shows the potential of GWAS to discover genes and pathways that potentially mediate adverse effects of antipsychotic medication...
  17. ncbi request reprint Outcome of anorexia nervosa: eating attitudes, personality, and parental bonding
    C M Bulik
    Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298 0126, USA
    Int J Eat Disord 28:139-47. 2000
    ..We were interested in the distinguishing characteristics of recovery and of chronic anorexia nervosa...
  18. ncbi request reprint Fertility and reproduction in women with anorexia nervosa: a controlled study
    C M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, 23298, USA
    J Clin Psychiatry 60:130-5; quiz 135-7. 1999
    ..Women who have anorexia nervosa may experience difficulties with fertility and reproduction...
  19. pmc GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
    X Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 16:1117-29. 2011
    ..On the basis of these results, we concluded that CMYA5 is associated with schizophrenia and further investigation of the gene is warranted...
  20. ncbi request reprint Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4
    C A Prescott
    Department of Psychology, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA
    Mol Psychiatry 11:603-11. 2006
    ..The results of this study suggest the importance of genetic variation in chromosome 4 in the etiology and severity of alcoholism in Caucasian populations...
  21. ncbi request reprint Twin studies of eating disorders: a review
    C M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Int J Eat Disord 27:1-20. 2000
    ..Although twin studies are powerful tools, their methodology can be arcane and their implications easily misinterpreted...
  22. ncbi request reprint Fatigue in a community sample of twins
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 33:263-81. 2003
    ..Fatigue is a complex symptom associated with many physiological, psychological and pathological processes. Its correlates and typology remain inadequately understood...
  23. ncbi request reprint Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput
    X Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298 0424, USA
    Pharmacogenomics J 3:77-96. 2003
    ..Finally, we describe some popular techniques and the applications that are suitable for these techniques...
  24. ncbi request reprint Predictors of rapid and sustained response to cognitive-behavioral therapy for bulimia nervosa
    C M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond 23298 0126, USA
    Int J Eat Disord 26:137-44. 1999
    ..To examine characteristics of individuals who show a rapid and sustained response to cognitive-behavioral therapy (CBT) for bulimia nervosa (BN)...
  25. pmc Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics
    J L McClay
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Psychiatry 16:76-85. 2011
    ..This study demonstrates the potential of genome-wide association studies to discover novel genes that mediate the effects of antipsychotics, which could eventually help to tailor drug treatment to schizophrenic patients...
  26. ncbi request reprint Latent class analysis of symptoms associated with chronic fatigue syndrome and fibromyalgia
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Psychol Med 32:881-8. 2002
    ..Aetiological and symptomatic heterogeneity is likely and the distinctiveness of these disorders remains unclear. Our aims were to investigate empirically symptomatic heterogeneity in chronic fatigue syndrome and fibromyalgia...
  27. ncbi request reprint Model-based gene selection shows engrailed 1 is associated with antipsychotic response
    Bradley Todd Webb
    Center for Biomarker Research and Personalized Medicine, Department of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacogenet Genomics 18:751-9. 2008
    ..We sought to find genes that may influence treatment response in a less biased manner, after integrating heterogeneous data sources related to schizophrenia...
  28. pmc Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biol Psychiatry 63:32-41. 2008
    ..The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses...
  29. ncbi request reprint AKT1 and neurocognition in schizophrenia
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
    Aust N Z J Psychiatry 41:169-77. 2007
    ..Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia...
  30. ncbi request reprint The genetics of anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Annu Rev Nutr 27:263-75. 2007
    ..With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research...
  31. ncbi request reprint Spurious genetic associations
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:1121-6. 2007
    ..I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication...
  32. ncbi request reprint Anxiety and comorbid measures associated with PLXNA2
    Naomi R Wray
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
    Arch Gen Psychiatry 64:318-26. 2007
    ..Common genetic liabilities have been reported between psychiatric and psychological measures, but few examples exist of common genetic variants...
  33. ncbi request reprint The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  34. pmc Feeling bad in more ways than one: comorbidity patterns of medically unexplained and psychiatric conditions
    Ellen A Schur
    Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    J Gen Intern Med 22:818-21. 2007
    ....
  35. ncbi request reprint NCAM1 and neurocognition in schizophrenia
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:902-10. 2007
    ..Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings...
  36. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  37. ncbi request reprint Premorbid predictors of chronic fatigue
    Kenji Kato
    Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Arch Gen Psychiatry 63:1267-72. 2006
    ..Moreover, subjects with chronic fatiguing illness may have distinctive personality traits, although this finding could reflect confounding by other mechanisms...
  38. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  39. ncbi request reprint Simulating association studies: a data-based resampling method for candidate regions or whole genome scans
    Fred A Wright
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioinformatics 23:2581-8. 2007
    ..Improvements in study design and analytic techniques will require the simulation of datasets with realistic patterns of linkage disequilibrium and allele frequencies for typed SNPs...
  40. ncbi request reprint Irritable bowel syndrome: a co-twin control analysis
    Mary K Wojczynski
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Gastroenterol 102:2220-9. 2007
    ..Therefore, we aimed to examine if there is a genetic component to the co-occurrence of MDD and IBS in participants from the population-based Swedish Twin Registry...
  41. pmc Current developments in the genetics of autism: from phenome to genome
    Molly Losh
    Department of Allied Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7190, USA
    J Neuropathol Exp Neurol 67:829-37. 2008
    ....
  42. pmc Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands
    Naomi R Wray
    Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
    Arch Gen Psychiatry 65:649-58. 2008
    ..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders...
  43. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  44. pmc The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
    ..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition...
  45. pmc Association of RGS2 and RGS5 variants with schizophrenia symptom severity
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Schizophr Res 101:67-75. 2008
    ..3-1q31. Due to overlapping cellular functions and chromosomal proximity, we hypothesized that multiple RGS genes may contribute to schizophrenia severity and treatment responsiveness...
  46. pmc Comment on a simple and improved correction for population stratification
    Seunggeun Lee
    Am J Hum Genet 82:524-6; author reply 526-8. 2008
  47. doi request reprint Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects
    Dorret I Boomsma
    Netherlands Twin Register, Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands
    Eur J Hum Genet 16:335-42. 2008
    ..Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007...
  48. ncbi request reprint An empirical study of the typology of bulimic symptoms in young Portuguese women
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina, USA
    Int J Eat Disord 41:251-8. 2008
    ..To investigate whether clusters of bulimic symptoms exist in a community sample of young Portuguese women...
  49. pmc Genomewide linkage survey of nicotine dependence phenotypes
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Drug Alcohol Depend 93:210-6. 2008
    ..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses...
  50. pmc Twin analyses of fatigue
    Ellen Schur
    1 Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Twin Res Hum Genet 10:729-33. 2007
    ..About half the variance for both prolonged and chronic fatigue in males was due to genetic effects, and half due to individual-specific environmental effects. For females, most variance was due to individual environmental effects...
  51. ncbi request reprint Genetic and phenotypic stability of measures of neuroticism over 22 years
    Naomi R Wray
    Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:695-702. 2007
    ..33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism...
  52. ncbi request reprint Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA
    Hum Mol Genet 15:3329-42. 2006
    ..However, due to the extended high LD in this region, we were unable to distinguish whether the association signals came from one or more of these genes...
  53. pmc Cigarettes and oral snuff use in Sweden: Prevalence and transitions
    Helena Furberg
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
    Addiction 101:1509-15. 2006
    ..To investigate the prevalence and patterns of transitions between cigarette and snus use...
  54. ncbi request reprint Bipolar II disorder: personality and outcome in two clinical samples
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Aust N Z J Psychiatry 38:433-8. 2004
    ..To compare the personality traits and disorders of patients with bipolar II disorder and major depression and to examine the impact on treatment outcome of a bipolar II diagnosis...
  55. ncbi request reprint Psychiatric and medical symptoms in binge eating in the absence of compensatory behaviors
    Ted Reichborn-Kjennerud
    Division of Epidemiology, The Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    Obes Res 12:1445-54. 2004
    ..To explore the extent to which binge eating in the absence of compensatory behaviors (BE) is associated with psychiatric and medical symptoms in men and women and to control for the independent effects of BMI...
  56. ncbi request reprint A genome scan of neuroticism in nicotine dependent smokers
    Benjamin M Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 132:65-9. 2005
    ..52 and 1.97 (P-value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P-value of 0.0014)...
  57. ncbi request reprint Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics
    Patrick F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA, USA
    Am J Med Genet B Neuropsychiatr Genet 126:23-36. 2004
    ..Although the hypotheses resulting from these linkage and bioinformatic analyses are plausible and intriguing, their ultimate worth depends on replication in additional linkage samples and in future experimental studies...
  58. ncbi request reprint A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations
    Edwin J C G van den Oord
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Hum Hered 56:188-99. 2003
    ..To develop a method for designing studies to find disease mutations that can achieve a set of goals with respect to proportions of false and true discoveries with the minimum amount of genotyping...
  59. ncbi request reprint Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 60:1187-92. 2003
    ....
  60. ncbi request reprint Temperament, childhood environment and psychopathology as risk factors for avoidant and borderline personality disorders
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Aust N Z J Psychiatry 37:756-64. 2003
    ..To evaluate childhood experiences (neglect and abuse), temperament and childhood and adolescent psychopathology as risk factors for avoidant and borderline personality disorders in depressed outpatients...
  61. ncbi request reprint False discoveries and models for gene discovery
    Edwin J C G van den Oord
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Trends Genet 19:537-42. 2003
    ..This raises the question of whether current models for gene discovery are shaped excessively by a fear of false discoveries...
  62. ncbi request reprint Multipoint and single point non-parametric linkage analysis with imperfect data
    Patrick F Sullivan
    Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 121:89-94. 2003
    ..The absence of parental genotypes in the presence of 1% genotype error led to marked degradation of linkage signal, particularly for multipoint analyses...
  63. ncbi request reprint Genetic and environmental contributions to obesity and binge eating
    Cynthia M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Int J Eat Disord 33:293-8. 2003
    ..The purpose of this article was to determine the extent of overlap between genetic and environmental factors that contribute to the liability to obesity and binge eating...
  64. ncbi request reprint The relation between eating disorders and components of perfectionism
    Cynthia M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, USA
    Am J Psychiatry 160:366-8. 2003
    ..The authors' goal was to explore the relation between perfectionism and psychopathology, including eating disorders...
  65. ncbi request reprint Medical and psychiatric morbidity in obese women with and without binge eating
    Cynthia M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Int J Eat Disord 32:72-8. 2002
    ....
  66. ncbi request reprint Evaluation of analyses of univariate discrete twin data
    Patrick F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, 23298 0126, USA
    Behav Genet 32:221-7. 2002
    ..These results suggest that the use of AIC to guide twin modeling for univariate discrete traits should either be abandoned or used with great caution...
  67. ncbi request reprint Melancholia: definitions, risk factors, personality, neuroendocrine markers and differential antidepressant response
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Aust N Z J Psychiatry 36:376-83. 2002
    ....
  68. ncbi request reprint Evaluation of genetic substructure in the Irish Study of High-Density Schizophrenia Families
    Patrick F Sullivan
    University of North Carolina at Chapel Hill, Department of Genetics, 27599 7264, USA
    Psychiatr Genet 14:187-9. 2004
    ..We found no evidence for the presence of genetic substructure in this sample...
  69. ncbi request reprint A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004
    ..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary...
  70. ncbi request reprint The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history
    Carol A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 29:417-29. 2005
    ....
  71. ncbi request reprint [Genetics in eating disorders: extending the boundaries of research]
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA
    Rev Bras Psiquiatr 28:218-25. 2006
    ..To review the recent literature relevant to genetic research in eating disorders and to discuss unique issues which are crucial for the development of a genetic research project in eating disorders in Brazil...
  72. ncbi request reprint Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, United States of America
    Twin Res Hum Genet 9:600-2. 2006
    ..30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses...
  73. ncbi request reprint Extensions to the modeling of initiation and progression: applications to substance use and abuse
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 980126, Richmond, VA, 23298 0126, USA
    Behav Genet 36:507-24. 2006
    ..Other suitable applications include the relationship between symptoms and diagnosis, such as fears and the progression to phobia...
  74. ncbi request reprint A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Psychol Med 36:807-13. 2006
    ..We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD...
  75. ncbi request reprint Prevalence, heritability, and prospective risk factors for anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, School of Public Health, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 63:305-12. 2006
    ..Anorexia nervosa (AN) is a serious mental illness with marked morbidity and mortality...
  76. ncbi request reprint Genetic, developmental and personality correlates of self-mutilation in depressed patients
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
    Aust N Z J Psychiatry 40:225-9. 2006
    ..To examine whether the T allele of G protein beta3 (GNbeta3) is associated with self-mutilation in depressed patients...
  77. ncbi request reprint Six months of treatment for depression: outcome and predictors of the course of illness
    Roger T Mulder
    Department of Psychological Medicine, Christchurch School of Medicine and Health Science, P O Box 4345, Christchurch, New Zealand
    Am J Psychiatry 163:95-100. 2006
    ..The goals of this study were to determine the course of illness in a cohort of depressed patients undergoing treatment for 6 months and whether there are clinically useful predictors of their course of illness...
  78. ncbi request reprint Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression
    A Leo Beem
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Behav Genet 36:127-36. 2006
    ..However, the association occurred in the absence of evidence for linkage in this region on chromosome 2...
  79. ncbi request reprint Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings
    Christel M Middeldorp
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
    Twin Res Hum Genet 8:609-15. 2005
    ..Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found...
  80. pmc The prevalence of self-reported chronic fatigue in a U.S. twin registry
    Helena Furberg
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    J Psychosom Res 59:283-90. 2005
    ..To investigate the prevalence and correlates of various definitions of self-reported lifetime fatiguing illness in a U.S. twin registry...
  81. ncbi request reprint Epidemiology of cancer-related fatigue in the Swedish twin registry
    Michael J Forlenza
    Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Cancer 104:2022-31. 2005
    ..However, most studies examining the prevalence of CRF have been hospital-based or clinic-based studies, which often are subject to bias...
  82. pmc The genetics of schizophrenia
    Patrick F Sullivan
    Department of Genetics, Psychiatry, and Epidemiology, University of North Carolina, Chapel Hill, USA
    PLoS Med 2:e212. 2005
  83. ncbi request reprint Mania in the Swedish Twin Registry: criterion validity and prevalence
    Federico Soldani
    Department of Psychiatry, Harvard University, Boston, MA, USA
    Aust N Z J Psychiatry 39:235-43. 2005
    ..We examined the criterion validity and prevalence of lifetime mania in a survey of Swedish twins conducted with interview methodology usually applied in psychiatric epidemiology...
  84. pmc Nonpaternity in linkage studies of extremely discordant sib pairs
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Hum Genet 70:526-9. 2002
    ..The proportion in discordant pairs may be much higher. The present article explores this potential inflation as a function of the resemblance of sib pairs and the criteria for discordance used for selection...