Research Topics
| R Todd StravitzSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Publications
Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study GroupR Todd Stravitz
Section of Hepatology, Virginia Commonwealth University, Richmond, USA
Crit Care Med 35:2498-508. 2007..To provide a uniform platform from which to study acute liver failure, the U.S. Acute Liver Failure Study Group has sought to standardize the management of patients with acute liver failure within participating centers...- Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantationR Todd Stravitz
Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Liver Transpl 10:850-8. 2004..In conclusion, interferon treatment of recurrent hepatitis C does not consistently improve histologic disease after virologic response, and it may increase the risk of allograft rejection... 
Critical management decisions in patients with acute liver failureR Todd Stravitz
Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Chest 134:1092-102. 2008..New data on the administration of N-acetylcysteine to patients with non-acetaminophen ALF, the treatment of ICH, and assessment of the need for liver transplantation will also be presented...- Therapeutic hypothermia for acute liver failure: toward a randomized, controlled trial in patients with advanced hepatic encephalopathyR Todd Stravitz
Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Neurocrit Care 9:90-6. 2008..Herein, we consider the many difficulties which will be encountered in the design of such a trial in patients with ALF at high risk of developing cerebral edema... - Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcomeRichard Todd Stravitz
Section of Hepatology, Hume Lee Transplant Center of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Am J Med 121:119-26. 2008..We hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation... - Drug-induced steatohepatitisR Todd Stravitz
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, 1200 East Broad Street, Room 1496, Richmond, VA 23298, USA
Clin Liver Dis 7:435-51. 2003..Further research should determine the mechanisms by which drug-induced steatosis, a benign lesion, evolves to steatohepatitis and progressive fibrosis... - A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantationNevin Yilmaz
Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Liver Transpl 13:975-83. 2007..However, complications associated with sepsis, not recurrent cirrhosis, was the most common cause of death in patients with recurrent HCV and this was similar in patients with or without advanced fibrosis... - Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epoetin alphaMitchell L Shiffman
Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Hepatology 46:371-9. 2007..In contrast, a higher starting dose of RVN was associated with a lower relapse rate and higher rate of SVR... - Driving simulation can improve insight into impaired driving skills in cirrhosisJasmohan S Bajaj
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
Dig Dis Sci 57:554-60. 2012..Minimal hepatic encephalopathy (MHE) is associated with poor driving skills and insight. Increasing insight may improve receptiveness for therapy or driving restrictions... - Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantationR Todd Stravitz
Section of Hepatology, Division of Gastroenterology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Liver Int 32:1138-45. 2012..However, the use of HBIg has many disadvantages... - Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantationMitchell L Shiffman
Hepatology Section, Division of Surgical Pathology, Virginia Commonwealth University Medical Center, Richmond, VA, 23298, USA
Liver Transpl 10:1248-55. 2004..9, compared with 59% with fibrosis and a mean score of.9 after LDLT. In conclusion, these data strongly suggest that fibrosis progression from recurrent HCV is not more severe in patients after LDLT... 
Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathyJasmohan S Bajaj
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
Gastroenterology 140:478-487.e1. 2011..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...- Similar progression of fibrosis between HIV/HCV-infected and HCV-infected patients: Analysis of paired liver biopsy samplesRichard K Sterling
Virginia Commonwealth University Health System, Richmond, USA
Clin Gastroenterol Hepatol 8:1070-6. 2010..However, no studies have directly compared fibrosis progression by paired liver biopsy between patients infected with HIV and HCV versus those infected with only HCV... - Treatment of chronic hepatitis C virus in African Americans with genotypes 2 and 3Mitchell L Shiffman
Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
Am J Gastroenterol 102:761-6. 2007..These results suggest that African Americans have a global defect in their ability to eradicate HCV infection following treatment with interferon and ribavirin which transcends across all genotypes... - The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregiversJasmohan S Bajaj
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
Am J Gastroenterol 106:1646-53. 2011..The aim was to study the emotional and socioeconomic burden of cirrhosis and HE on patients and informal caregivers... - Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfectionRichard K Sterling
Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
Clin Gastroenterol Hepatol 2:432-9. 2004.... - A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African AmericansRichard K Sterling
Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
Clin Gastroenterol Hepatol 2:469-73. 2004..Differences in hepatitis C virus (HCV)-related liver disease between Caucasians and African Americans remain controversial... - Incidence of prolonged length of stay after orthotopic liver transplantation and its influence on outcomesJenny O Smith
Hepatology Section and Liver Transplant Program, Virginia Commonwealth University Medical Center, Richmond, VA, USA
Liver Transpl 15:273-9. 2009..Efforts to modify those factors that contribute to PLOS may reduce this event, improve survival, and reduce OLT-associated costs... - Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfectionRichard K Sterling
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
Hepatology 47:1118-27. 2008..Although we did identify genotype 3, increased BMI, and diabetes as risk factors, we found no independent association with antiretroviral therapy... - A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitisJonathan T Hlivko
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
Clin Gastroenterol Hepatol 6:1036-40. 2008..Although this regimen achieves remission in approximately 80%, some patients are intolerant or do not respond. Mycophenolate mofetil (MMF) is a potent immunosuppressant. However, its utility in AIH is not well-defined... - Persistence of cognitive impairment after resolution of overt hepatic encephalopathyJasmohan S Bajaj
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
Gastroenterology 138:2332-40. 2010..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)... - Is hepatic transplantation justified for primary liver cancer?Robert A Fisher
Department of Surgery, Division of Transplant Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
J Surg Oncol 95:674-9. 2007..The pertinent medical literature and update of an ongoing intent-to-treat HCC with transplant single center randomized control trial are reviewed... - Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndromeArun J Sanyal
Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
Am J Gastroenterol 98:2064-71. 2003..Advanced fibrosis in such patients is related to weight, presence of diabetes, and presence and degree of cytological ballooning... - The clinical spectrum of hepatitis C virus in HIV coinfectionRichard K Sterling
Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Richmond, Virginia, USA
J Acquir Immune Defic Syndr 32:30-7. 2003..The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity... - Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: A prospective studyJasmohan S Bajaj
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA
Liver Transpl 18:1179-87. 2012..SSRI use is associated with better cognitive performance and a reduced likelihood of developing HE. Liver Transpl 18:1179-1187, 2012. © 2012 AASLD... - Comparison of three commercially available assays for HCV RNA using the international unit standard: implications for management of patients with chronic hepatitis C virus infection in clinical practiceMitchell L Shiffman
Hepatology Section, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
Am J Gastroenterol 98:1159-66. 2003..The present study was performed to evaluate the impact of the international unit standard for measuring HCV RNA in the management of patients with chronic hepatitis C virus (HCV) infection... - MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapyDouglas M Heuman
Virginia Commonwealth University Health System, Richmond, VA, USA
Liver Transpl 13:30-7. 2007..In patients treated with oral anticoagulants, substitution of MELD-XI for MELD may permit more accurate assessment of risk and more rational assignment of "sickest first" priority for LT... - Hepatocellular carcinoma: strategy for optimizing surgical resection, transplantation and palliationRobert A Fisher
Division of Transplant Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
Clin Transplant 16:52-8. 2002..No incidental HCC group post-OLT patient has died or had HCC recurrence at mean follow-up of 24 +/- 14 months. This neoadjuvant protocol is safe and effective in reducing HCC recurrence prior to and after OLT and resection... - Therapeutic hypothermia for acute liver failureR Todd Stravitz
Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia, USA
Crit Care Med 37:S258-64. 2009.... - Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early deathDouglas M Heuman
Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
Hepatology 40:802-10. 2004.... - Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastographyR Todd Stravitz
Section of Hepatology and Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
J Hepatol 56:129-36. 2012..We hypothesized that patients with ALI/ALF have normal hemostasis despite elevated INR... - A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitisArun J Sanyal
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
Clin Gastroenterol Hepatol 2:1107-15. 2004.... - Calcineurin inhibitor-induced chronic nephrotoxicity in liver transplant patients is reversible using rapamycin as the primary immunosuppressive agentAdrian H Cotterell
Division of Transplantation Surgery, Department of Surgery, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
Clin Transplant 16:49-51. 2002..Rapamycin is an effective replacement agent as primary immunosuppressive therapy following withdrawal of CNIs in liver transplant patients with CNI-induced chronic nephrotoxicity... - Impact of the donor risk index on the outcome of hepatitis C virus-positive liver transplant recipientsDaniel G Maluf
Division of Transplantation Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
Liver Transpl 15:592-9. 2009..In conclusion, a synergistic interaction between donor DRI and recipient HCV status exists, such that an allograft from a high-DRI donor more adversely affects the outcome of an HCV(+) recipient than that of an HCV(-) recipient... - Antibody-mediated pure red cell aplasia due to epoetin alfa during antiviral therapy of chronic hepatitis CR Todd Stravitz
Section of Hepatology, Division of Gastroenterology and the Division of Hematology/Oncology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0341, USA
Am J Gastroenterol 100:1415-9. 2005..PRCA caused by the development of erythropoietin antibodies is a potentially life-threatening complication of administering epoetin alfa to prevent the anemia associated with antiviral therapy in patients with chronic hepatitis C... - Autoimmune acute liver failure: proposed clinical and histological criteriaR Todd Stravitz
Section of Hepatology, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Hepatology 53:517-26. 2011..In contrast to classical autoimmune hepatitis, histological features of AI-ALF predominate in the centrilobular zone... - Living donor liver transplant with clinical tolerance, laboratory evidence of chimerism, and spontaneous clearance of HBVJames J Stone
Department of Surgery, Division of Transplantation, Hepatology Section, Medical College of Virginia Hospitals, Commonwealth University Health Care Systems, Richmond, VA 23298, USA
Liver Transpl 10:1432-5. 2004..MLC and cytokine elaboration were used to show recipient hyporeactivity towards donor antigen. He also has clinical evidence of clearing his HBV without continued use of HBIG... - Management of acute liver failureR Todd Stravitz
Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, P O Box 980341, Richmond, VA 23298 0341, USA
Nat Rev Gastroenterol Hepatol 6:542-53. 2009..Finally, we summarize the role of orthotopic liver transplantation in salvage of the most severely affected patients... - Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving testJasmohan S Bajaj
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
Hepatology 50:1175-83. 2009..ICT, but not SPT performance is significantly associated with prior and future crashes and violations. There was an excellent agreement between self- and DOT-reports... - Adult living donor versus deceased donor liver transplantation: a 10-year prospective single center experienceRobert A Fisher
Division of Transplantation, Department of Surgery, Virginia Commonwealth, University Health System, Richmond, VA, USA
Ann Hepatol 8:298-307. 2009..Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx... - Medical management of the liver transplant recipientR Todd Stravitz
Section of Hepatology, Division of Gastroenterology, Hepatology, and Nutrition, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Clin Liver Dis 15:821-43. 2011.... - Hepatitis C virus recurrence after liver transplantation: biomarkers of disease and fibrosis progressionDaniel G Maluf
Transplant Division, Virginia Commonwealth University Medical Center, Medical College of Virginia Hospitals, 1200 East Broad Street, West Hospital, 9th Fl, South Wing, PO Box 980254, Richmond, VA 23298, USA
Expert Rev Gastroenterol Hepatol 4:445-58. 2010..The mechanisms responsible for the accelerated liver damage in HCV-infected orthotopic liver transplantation recipients remain largely unknown... - Adult living donor versus deceased donor liver transplantation: a 6-year single center experienceDaniel G Maluf
Division of Transplantation, Department of Surgery, Virginia Commonwealth University Health System, Richmon, VA, USA
Am J Transplant 5:149-56. 2005..Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx...