R Todd Stravitz

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi request reprint Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure
    R Todd Stravitz
    Section of Hepatology and Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 58:304-13. 2013
  2. doi request reprint Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantation
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Int 32:1138-45. 2012
  3. doi request reprint Therapeutic hypothermia for acute liver failure
    R Todd Stravitz
    Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Crit Care Med 37:S258-64. 2009
  4. doi request reprint Medical management of the liver transplant recipient
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology, Hepatology, and Nutrition, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Clin Liver Dis 15:821-43. 2011
  5. pmc Autoimmune acute liver failure: proposed clinical and histological criteria
    R Todd Stravitz
    Section of Hepatology, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Hepatology 53:517-26. 2011
  6. doi request reprint Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography
    R Todd Stravitz
    Section of Hepatology and Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    J Hepatol 56:129-36. 2012
  7. ncbi request reprint A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantation
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Transpl 13:975-83. 2007
  8. ncbi request reprint Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
    R Todd Stravitz
    Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Transpl 10:850-8. 2004
  9. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
  10. ncbi request reprint Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epoetin alpha
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:371-9. 2007

Detail Information

Publications45

  1. doi request reprint Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure
    R Todd Stravitz
    Section of Hepatology and Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 58:304-13. 2013
    ..Conclusion: Highly procoagulant MPs of specific size ranges are associated with the SIRS, systemic complications, and adverse outcome of ALI/ALF. MPs may contribute to the multiorgan system failure and high mortality of ALF...
  2. doi request reprint Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantation
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Int 32:1138-45. 2012
    ..However, the use of HBIg has many disadvantages...
  3. doi request reprint Therapeutic hypothermia for acute liver failure
    R Todd Stravitz
    Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Crit Care Med 37:S258-64. 2009
    ....
  4. doi request reprint Medical management of the liver transplant recipient
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology, Hepatology, and Nutrition, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Clin Liver Dis 15:821-43. 2011
    ....
  5. pmc Autoimmune acute liver failure: proposed clinical and histological criteria
    R Todd Stravitz
    Section of Hepatology, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Hepatology 53:517-26. 2011
    ..9 ± 0.2 g/dL versus 3.0 ± 0.2 g/dL; P < 0.005], and higher incidence of chronic hepatitis in long-term follow-up [67% versus 17%, P = 0.019]) compared to the population without concordant AI-ALF histology and autoantibodies...
  6. doi request reprint Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography
    R Todd Stravitz
    Section of Hepatology and Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    J Hepatol 56:129-36. 2012
    ..We hypothesized that patients with ALI/ALF have normal hemostasis despite elevated INR...
  7. ncbi request reprint A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantation
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Transpl 13:975-83. 2007
    ..However, complications associated with sepsis, not recurrent cirrhosis, was the most common cause of death in patients with recurrent HCV and this was similar in patients with or without advanced fibrosis...
  8. ncbi request reprint Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
    R Todd Stravitz
    Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Transpl 10:850-8. 2004
    ..In conclusion, interferon treatment of recurrent hepatitis C does not consistently improve histologic disease after virologic response, and it may increase the risk of allograft rejection...
  9. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
    ..In conclusion, cognitive tests (particularly the ICT) remain valid predictors of HE in the face of psychiatric diseases and medications. SSRI use is associated with better cognitive performance and a reduced likelihood of developing HE...
  10. ncbi request reprint Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epoetin alpha
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:371-9. 2007
    ..SVR was significantly greater (P < 0.05) in group 3 patients (49%). This resulted from a significant decline (P < 0.05) in relapse rate; only 8% versus 38% for groups 1 and 2...
  11. ncbi request reprint The spectrum of chronic hepatitis C virus infection in the Virginia Correctional System: development of a strategy for the evaluation and treatment of inmates with HCV
    Richard K Sterling
    Hepatology Section and Division of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia
    Am J Gastroenterol 100:313-21. 2005
    ..Our objective was to develop an economic strategy for evaluation and treatment of inmates with chronic HCV...
  12. ncbi request reprint Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantation
    Mitchell L Shiffman
    Hepatology Section, Division of Surgical Pathology, Virginia Commonwealth University Medical Center, Richmond, VA, 23298, USA
    Liver Transpl 10:1248-55. 2004
    ..9, compared with 59% with fibrosis and a mean score of.9 after LDLT. In conclusion, these data strongly suggest that fibrosis progression from recurrent HCV is not more severe in patients after LDLT...
  13. doi request reprint The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 106:1646-53. 2011
    ..The aim was to study the emotional and socioeconomic burden of cirrhosis and HE on patients and informal caregivers...
  14. doi request reprint Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
    ..Minimal hepatic encephalopathy (MHE) is associated with poor driving skills and insight. Increasing insight may improve receptiveness for therapy or driving restrictions...
  15. pmc Similar progression of fibrosis between HIV/HCV-infected and HCV-infected patients: Analysis of paired liver biopsy samples
    Richard K Sterling
    Virginia Commonwealth University Health System, Richmond, USA
    Clin Gastroenterol Hepatol 8:1070-6. 2010
    ..However, no studies have directly compared fibrosis progression by paired liver biopsy between patients infected with HIV and HCV versus those infected with only HCV...
  16. ncbi request reprint Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfection
    Richard K Sterling
    Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
    Clin Gastroenterol Hepatol 2:432-9. 2004
    ....
  17. pmc Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  18. ncbi request reprint Treatment of chronic hepatitis C virus in African Americans with genotypes 2 and 3
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Am J Gastroenterol 102:761-6. 2007
    ..These results suggest that African Americans have a global defect in their ability to eradicate HCV infection following treatment with interferon and ribavirin which transcends across all genotypes...
  19. ncbi request reprint A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African Americans
    Richard K Sterling
    Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
    Clin Gastroenterol Hepatol 2:469-73. 2004
    ..Differences in hepatitis C virus (HCV)-related liver disease between Caucasians and African Americans remain controversial...
  20. pmc Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Hepatology 47:1118-27. 2008
    ..Although we did identify genotype 3, increased BMI, and diabetes as risk factors, we found no independent association with antiretroviral therapy...
  21. doi request reprint Incidence of prolonged length of stay after orthotopic liver transplantation and its influence on outcomes
    Jenny O Smith
    Hepatology Section and Liver Transplant Program, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Transpl 15:273-9. 2009
    ..Efforts to modify those factors that contribute to PLOS may reduce this event, improve survival, and reduce OLT-associated costs...
  22. pmc Association between high-normal levels of alanine aminotransferase and risk factors for atherogenesis
    M Shadab Siddiqui
    Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia Electronic address
    Gastroenterology 145:1271-9.e1-3. 2013
    ..We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of cardiovascular risk factors among individuals with no known diseases in a primary care setting...
  23. pmc Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
    PLoS ONE 8:e60042. 2013
    ..Aim To perform a systems biology analysis of the microbiome, metabolome and cognitive change after rifaximin in MHE...
  24. ncbi request reprint MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapy
    Douglas M Heuman
    Virginia Commonwealth University Health System, Richmond, VA, USA
    Liver Transpl 13:30-7. 2007
    ..In patients treated with oral anticoagulants, substitution of MELD-XI for MELD may permit more accurate assessment of risk and more rational assignment of "sickest first" priority for LT...
  25. pmc Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  26. doi request reprint A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitis
    Jonathan T Hlivko
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Clin Gastroenterol Hepatol 6:1036-40. 2008
    ..Although this regimen achieves remission in approximately 80%, some patients are intolerant or do not respond. Mycophenolate mofetil (MMF) is a potent immunosuppressant. However, its utility in AIH is not well-defined...
  27. ncbi request reprint Is hepatic transplantation justified for primary liver cancer?
    Robert A Fisher
    Department of Surgery, Division of Transplant Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Surg Oncol 95:674-9. 2007
    ..The pertinent medical literature and update of an ongoing intent-to-treat HCC with transplant single center randomized control trial are reviewed...
  28. ncbi request reprint Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome
    Arun J Sanyal
    Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Am J Gastroenterol 98:2064-71. 2003
    ....
  29. ncbi request reprint Calcineurin inhibitor-induced chronic nephrotoxicity in liver transplant patients is reversible using rapamycin as the primary immunosuppressive agent
    Adrian H Cotterell
    Division of Transplantation Surgery, Department of Surgery, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Clin Transplant 16:49-51. 2002
    ..Rapamycin is an effective replacement agent as primary immunosuppressive therapy following withdrawal of CNIs in liver transplant patients with CNI-induced chronic nephrotoxicity...
  30. ncbi request reprint Comparison of three commercially available assays for HCV RNA using the international unit standard: implications for management of patients with chronic hepatitis C virus infection in clinical practice
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
    Am J Gastroenterol 98:1159-66. 2003
    ..The present study was performed to evaluate the impact of the international unit standard for measuring HCV RNA in the management of patients with chronic hepatitis C virus (HCV) infection...
  31. doi request reprint Therapeutic hypothermia for acute liver failure: toward a randomized, controlled trial in patients with advanced hepatic encephalopathy
    R Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Neurocrit Care 9:90-6. 2008
    ..Herein, we consider the many difficulties which will be encountered in the design of such a trial in patients with ALF at high risk of developing cerebral edema...
  32. doi request reprint Impact of the donor risk index on the outcome of hepatitis C virus-positive liver transplant recipients
    Daniel G Maluf
    Division of Transplantation Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Liver Transpl 15:592-9. 2009
    ..In conclusion, a synergistic interaction between donor DRI and recipient HCV status exists, such that an allograft from a high-DRI donor more adversely affects the outcome of an HCV(+) recipient than that of an HCV(-) recipient...
  33. ncbi request reprint A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
    Clin Gastroenterol Hepatol 2:1107-15. 2004
    ....
  34. ncbi request reprint Antibody-mediated pure red cell aplasia due to epoetin alfa during antiviral therapy of chronic hepatitis C
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology and the Division of Hematology Oncology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
    Am J Gastroenterol 100:1415-9. 2005
    ..PRCA caused by the development of erythropoietin antibodies is a potentially life-threatening complication of administering epoetin alfa to prevent the anemia associated with antiviral therapy in patients with chronic hepatitis C...
  35. ncbi request reprint Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
    ....
  36. pmc Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis
    Vishwadeep Ahluwalia
    Radiology, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    J Hepatol 59:467-73. 2013
    ..We aimed at studying the effect of hyponatremia on cognition, HRQOL, and brain MR spectroscopy (MRS) independent of HE...
  37. ncbi request reprint Living donor liver transplant with clinical tolerance, laboratory evidence of chimerism, and spontaneous clearance of HBV
    James J Stone
    Department of Surgery, Division of Transplantation, Hepatology Section, Medical College of Virginia Hospitals, Commonwealth University Health Care Systems, Richmond, VA 23298, USA
    Liver Transpl 10:1432-5. 2004
    ..MLC and cytokine elaboration were used to show recipient hyporeactivity towards donor antigen. He also has clinical evidence of clearing his HBV without continued use of HBIG...
  38. ncbi request reprint The clinical spectrum of hepatitis C virus in HIV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Richmond, Virginia, USA
    J Acquir Immune Defic Syndr 32:30-7. 2003
    ..The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity...
  39. ncbi request reprint Hepatocellular carcinoma: strategy for optimizing surgical resection, transplantation and palliation
    Robert A Fisher
    Division of Transplant Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Transplant 16:52-8. 2002
    ..No incidental HCC group post-OLT patient has died or had HCC recurrence at mean follow-up of 24 +/- 14 months. This neoadjuvant protocol is safe and effective in reducing HCC recurrence prior to and after OLT and resection...
  40. ncbi request reprint Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group
    R Todd Stravitz
    Section of Hepatology, Virginia Commonwealth University, Richmond, USA
    Crit Care Med 35:2498-508. 2007
    ..To provide a uniform platform from which to study acute liver failure, the U.S. Acute Liver Failure Study Group has sought to standardize the management of patients with acute liver failure within participating centers...
  41. pmc Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
    ..03) but MHESPT did not. MHEICT (Odds ratio: 4.51) and prior year crash/violation (Odds ratio: 2.96) were significantly associated with future crash/violation occurrence...
  42. doi request reprint Management of acute liver failure
    R Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, P O Box 980341, Richmond, VA 23298 0341, USA
    Nat Rev Gastroenterol Hepatol 6:542-53. 2009
    ..Finally, we summarize the role of orthotopic liver transplantation in salvage of the most severely affected patients...
  43. doi request reprint Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology, Hepatology and Nutrition and the Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
    Liver Int 33:1324-31. 2013
    ..N-Acetylcysteine (NAC) improves transplant-free survival in patients with non-acetaminophen acute liver failure (ALF) when administered in early stages of hepatic encephalopathy. The mechanisms of this benefit are unknown...
  44. doi request reprint Critical management decisions in patients with acute liver failure
    R Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Chest 134:1092-102. 2008
    ..New data on the administration of N-acetylcysteine to patients with non-acetaminophen ALF, the treatment of ICH, and assessment of the need for liver transplantation will also be presented...
  45. ncbi request reprint Drug-induced steatohepatitis
    R Todd Stravitz
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, 1200 East Broad Street, Room 1496, Richmond, VA 23298, USA
    Clin Liver Dis 7:435-51. 2003
    ..Further research should determine the mechanisms by which drug-induced steatosis, a benign lesion, evolves to steatohepatitis and progressive fibrosis...