R E Straub

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint A schizophrenia locus may be located in region 10p15-p11
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond 23219 1534, USA
    Am J Med Genet 81:296-301. 1998
  2. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
  3. ncbi request reprint Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes
    R E Straub
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 7:542-59. 2002
  4. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
  5. pmc The trimmed-haplotype test for linkage disequilibrium
    C J MacLean
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Am J Hum Genet 66:1062-75. 2000
  6. ncbi request reprint Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Med Genet 88:29-33. 1999
  7. pmc Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Am J Hum Genet 67:652-63. 2000
  8. ncbi request reprint Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia families
    D E Ross
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0710, USA
    Am J Psychiatry 157:1071-6. 2000
  9. ncbi request reprint Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:402-8. 2000
  10. ncbi request reprint Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families
    R E Straub
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
    Mol Psychiatry 2:148-55. 1997

Collaborators

Detail Information

Publications27

  1. ncbi request reprint A schizophrenia locus may be located in region 10p15-p11
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond 23219 1534, USA
    Am J Med Genet 81:296-301. 1998
    ..When evaluated in the context of our genome scan results, the evidence suggests the possibility of a fourth vulnerability locus for schizophrenia in these Irish families, in region 10p15-p11...
  2. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
    ....
  3. ncbi request reprint Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes
    R E Straub
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 7:542-59. 2002
    ..However, our internal replications, when considered along with the positive results obtained in multiple other samples, suggests that most of these six regions are likely to contain genes that influence liability to schizophrenia...
  4. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
    ..These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors...
  5. pmc The trimmed-haplotype test for linkage disequilibrium
    C J MacLean
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Am J Hum Genet 66:1062-75. 2000
    ..We present a method for summarizing the LD evidence, in any pedigree, that can be employed in trimmed-haplotype analysis as well as in other methods...
  6. ncbi request reprint Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Med Genet 88:29-33. 1999
    ..Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM...
  7. pmc Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Am J Hum Genet 67:652-63. 2000
    ..0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P=. 045 and with significant evidence for intersample heterogeneity (empirical P=.0096)...
  8. ncbi request reprint Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia families
    D E Ross
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0710, USA
    Am J Psychiatry 157:1071-6. 2000
    ..Little is known about the familial or genetic aspects of the deficit syndrome. The purpose of this study was to determine whether deficit versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia...
  9. ncbi request reprint Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0710, USA
    Am J Psychiatry 157:402-8. 2000
    ..Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity...
  10. ncbi request reprint Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families
    R E Straub
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
    Mol Psychiatry 2:148-55. 1997
    ..Comparison of individual family multipoint H-LOD scores at the regions of interest on chromosomes 6p, 8p and 5q showed that only a minority of families yield high lod scores in two or three regions...
  11. ncbi request reprint Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond 23298 0126, USA
    Am J Psychiatry 154:191-8. 1997
    ..The authors sought to determine whether the clinical manifestations of schizophrenia and other psychotic disorders are correlated in affected sibling pairs...
  12. ncbi request reprint Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:479-84. 2001
    ..If these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of TPH in the biosynthesis of serotonin...
  13. ncbi request reprint Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence
    M A Silverman
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219 1534, USA
    Am J Med Genet 96:646-53. 2000
    ..None of the four polymorphisms we tested, nor their estimated haplotypes, were associated with smoking initiation or progression to nicotine dependence...
  14. ncbi request reprint Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:266-70. 2001
    ..No correlation reached our a priori level of statistical significance. Using this statistical approach, we did not find evidence of important epistatic effects among these six regions in the ISHDSF...
  15. ncbi request reprint Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families
    K S Kendler
    Departments of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 153:1534-40. 1996
    ..This study was an attempt to replicate evidence for a vulnerability locus for schizophrenia and associated disorders in the 8p22-21 region reported by Pulver and colleagues...
  16. ncbi request reprint Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  17. pmc GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
    X Chen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 16:1117-29. 2011
    ..On the basis of these results, we concluded that CMYA5 is associated with schizophrenia and further investigation of the gene is warranted...
  18. pmc Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
    M F Egan
    Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:6917-22. 2001
    ..These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia...
  19. ncbi request reprint Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
    A H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
    Mol Psychiatry 12:958-65. 2007
    ..Power may therefore be increased in molecular genetic studies of schizophrenia if they incorporate measures of schizotypy in non-psychotic relatives...
  20. ncbi request reprint Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls
    K K Nicodemus
    Mol Psychiatry 11:1062-5. 2006
  21. ncbi request reprint Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
    R E Straub
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD 20892 1379, USA
    Mol Psychiatry 12:854-69. 2007
    ..These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function...
  22. ncbi request reprint GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
    A M Addington
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 10:581-8. 2005
    ..These observations, when taken together with the positive results reported recently in two independent adult-onset schizophrenia pedigree samples, suggest that the gene encoding GAD67 may be a common risk factor for schizophrenia...
  23. ncbi request reprint Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)
    M C Gornick
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    J Autism Dev Disord 35:831-8. 2005
    ..Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment...
  24. ncbi request reprint Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia
    R Hashimoto
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Mol Psychiatry 9:299-307. 2004
    ..Subtle abnormalities in the expression patterns of NRG-1 mRNA isoforms in DLPFC may be associated with schizophrenia...
  25. ncbi request reprint SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins
    S C Borinstein
    Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Signal 12:769-79. 2000
    ..Evidence that SETA binds to the CD2 protein, the proto-oncogene c-Cbl, and the signal transduction molecule Grb2, and can dimerize via its C-terminal coiled coil (CC) domain is also presented...
  26. pmc Linkage of Niemann-Pick disease type C to human chromosome 18
    E D Carstea
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:2002-4. 1993
    ..84. Analysis of meiotic chromosomal breakpoint patterns among the affected individuals indicated that the NPC gene is pericentromerically localized on human chromosome 18...
  27. pmc Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor
    R E Straub
    Department of Medicine, Cornell University Medical College, New York, NY 10021
    Proc Natl Acad Sci U S A 87:9514-8. 1990
    ..The 3.8-kilobase mouse TRH-R cDNA encodes a protein of 393 amino acids that shows similarities to other guanine nucleotide-binding regulatory protein-coupled receptors...