R K Sterling

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
    Herbert L Bonkovsky
    Liver Biliary Pancreatic Center and the Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Hepatol 46:420-31. 2007
  2. ncbi request reprint Percutaneous liver biopsy in adult haemophiliacs with hepatitis C virus: safety of outpatient procedure and impact of human immunodeficiency virus coinfection on the spectrum of liver disease
    R K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, VA 23298, USA
    Haemophilia 13:164-71. 2007
  3. ncbi request reprint Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfection
    Richard K Sterling
    Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
    Clin Gastroenterol Hepatol 2:432-9. 2004
  4. ncbi request reprint A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African Americans
    Richard K Sterling
    Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
    Clin Gastroenterol Hepatol 2:469-73. 2004
  5. ncbi request reprint Hepatitis C virus in the setting of HIV or hepatitis B virus coinfection
    Richard K Sterling
    Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
    Semin Liver Dis 24:61-8. 2004
  6. ncbi request reprint A prospective, randomized-controlled pilot study of ursodeoxycholic acid combined with mycophenolate mofetil in the treatment of primary sclerosing cholangitis
    R K Sterling
    Division of Gastroenterology and Hepatology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Aliment Pharmacol Ther 20:943-9. 2004
  7. ncbi request reprint Role of liver biopsy in the evaluation of hepatitis C virus infection in HIV coinfection
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Clin Infect Dis 40:S270-5. 2005
  8. pmc The prevalence and risk factors for abnormal liver enzymes in HIV-positive patients without hepatitis B or C coinfections
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Dig Dis Sci 53:1375-82. 2008
  9. ncbi request reprint Extrahepatic manifestations of hepatitis C virus
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, 1200 E Broad Street, West Hospital, Room 1492, Richmond, VA 23298, USA
    Curr Gastroenterol Rep 8:53-9. 2006
  10. ncbi request reprint Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006

Research Grants

Detail Information

Publications79

  1. pmc Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
    Herbert L Bonkovsky
    Liver Biliary Pancreatic Center and the Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Hepatol 46:420-31. 2007
    ..This study assessed HRQOL and sexual health in patients with advanced fibrosis or cirrhosis in the HALT-C Trial...
  2. ncbi request reprint Percutaneous liver biopsy in adult haemophiliacs with hepatitis C virus: safety of outpatient procedure and impact of human immunodeficiency virus coinfection on the spectrum of liver disease
    R K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, VA 23298, USA
    Haemophilia 13:164-71. 2007
    ..These data support the hypothesis that HIV accelerates fibrosis progression in those coinfected with HCV and highlights the importance of liver histology in this population...
  3. ncbi request reprint Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfection
    Richard K Sterling
    Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
    Clin Gastroenterol Hepatol 2:432-9. 2004
    ....
  4. ncbi request reprint A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African Americans
    Richard K Sterling
    Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
    Clin Gastroenterol Hepatol 2:469-73. 2004
    ..Differences in hepatitis C virus (HCV)-related liver disease between Caucasians and African Americans remain controversial...
  5. ncbi request reprint Hepatitis C virus in the setting of HIV or hepatitis B virus coinfection
    Richard K Sterling
    Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
    Semin Liver Dis 24:61-8. 2004
    ....
  6. ncbi request reprint A prospective, randomized-controlled pilot study of ursodeoxycholic acid combined with mycophenolate mofetil in the treatment of primary sclerosing cholangitis
    R K Sterling
    Division of Gastroenterology and Hepatology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Aliment Pharmacol Ther 20:943-9. 2004
    ..Mycophenolate mofetil is a potent immunosuppressant that is now widely used in organ transplantation...
  7. ncbi request reprint Role of liver biopsy in the evaluation of hepatitis C virus infection in HIV coinfection
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Clin Infect Dis 40:S270-5. 2005
    ..However, there remain important questions and controversies related to adequately determining the histological severity of liver disease and the role of liver biopsy in HIV-HCV-coinfected patients...
  8. pmc The prevalence and risk factors for abnormal liver enzymes in HIV-positive patients without hepatitis B or C coinfections
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Dig Dis Sci 53:1375-82. 2008
    ..Abnormal liver enzymes (LFTs) are frequently seen in HIV patients. Because HCV and HBV overshadow other possible variables, little is known about the prevalence and predictive factors of abnormal LFTs in the absence of viral hepatitis...
  9. ncbi request reprint Extrahepatic manifestations of hepatitis C virus
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, 1200 E Broad Street, West Hospital, Room 1492, Richmond, VA 23298, USA
    Curr Gastroenterol Rep 8:53-9. 2006
    ..This article highlights the pathophysiology and clinical manifestations of these disorders...
  10. ncbi request reprint Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006
    ..In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV-coinfected patients...
  11. ncbi request reprint The clinical spectrum of hepatitis C virus in HIV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Richmond, Virginia, USA
    J Acquir Immune Defic Syndr 32:30-7. 2003
    ..The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity...
  12. ncbi request reprint Are TIPS tops in the treatment of portal hypertension? A review on the use and misuse of transjugular intrahepatic portosystemic shunts
    R K Sterling
    Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0341, USA
    Can J Gastroenterol 14:122D-128D. 2000
    ..Until further clinical trials become available, TIPS should be considered as a therapeutic option for the treatment of refractory variceal hemorrhage and refractory ascites in selected patients...
  13. ncbi request reprint Management of gastrointestinal disease in liver transplant recipients
    R K Sterling
    Section of Hepatology and Liver Transplantation, Medical College of Virginia Commonwealth University, Richmond, Virginia 23298 0341, USA
    Gastrointest Endosc Clin N Am 11:185-97. 2001
    ..The most frequent disorders encountered are related to medications, infections, and exacerbations of pre-existing gastrointestinal pathology...
  14. ncbi request reprint Liver transplantation. Living donor, hepatocyte, and xenotransplantation
    R K Sterling
    Section of Hepatology, Division of Transplantation, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Liver Dis 5:431-60, vii. 2001
    ..Several novel approaches have been developed to address the growing disparity between the limited supply and excessive demand for suitable organs...
  15. ncbi request reprint A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia
    M L Shiffman
    Hepatology Section, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA
    Gastroenterology 117:1164-72. 1999
    ..Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histological progression in this subset of nonresponders...
  16. ncbi request reprint Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy
    M L Shiffman
    Hepatology Section, Medical College of Virginia Commonwealth University, Richmond, VA 23298, USA
    J Infect Dis 182:1595-601. 2000
    ..Persons with chronic HCV infection and persistently normal serum ALT levels have milder liver disease than, and respond to IFN therapy similarly to, persons with elevated ALT levels...
  17. ncbi request reprint Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis
    M J Contos
    Department of Pathology, Division of Gastroenterology/Hepatology/Nutrition, Virginia Commonwealth University-Medical College of Virginia, Richmond, VA, USA
    Liver Transpl 7:363-73. 2001
    ..Despite the frequent histological recurrence of disease, clinical outcomes are similar to those of other groups of patients undergoing OLT...
  18. pmc Modified-orientation log to assess hepatic encephalopathy
    M Salam
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, USA
    Aliment Pharmacol Ther 35:913-20. 2012
    ..The new HE classification has emphasised assessment of orientation. The modified-orientation log (MO-log, eight questions, scores 0-24; 24 normal) is adapted from a validated brain injury measure...
  19. pmc Quantitative tests of liver function measure hepatic improvement after sustained virological response: results from the HALT-C trial
    G T Everson
    Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Aliment Pharmacol Ther 29:589-601. 2009
    ..The impact of virologic response on hepatic function has not been previously defined...
  20. ncbi request reprint Adult living donor versus deceased donor liver transplantation: a 6-year single center experience
    Daniel G Maluf
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University Health System, Richmon, VA, USA
    Am J Transplant 5:149-56. 2005
    ..Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx...
  21. ncbi request reprint A randomized, controlled trial to determine whether continued ribavirin monotherapy in hepatitis C virus-infected patients who responded to interferon-ribavirin combination therapy will enhance sustained virologic response
    M L Shiffman
    Hepatology Section, Medical College of Virginia Commonwealth University, Richmond, VA 23298, USA
    J Infect Dis 184:405-9. 2001
    ..56%) and in patients with a virus titer < 2 x 10(6) copies/mL (93% vs. 43%). The results indicate that continuing ribavirin monotherapy after achieving a virologic response does not improve sustained virologic response...
  22. pmc Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    N Engl J Med 359:2429-41. 2008
    ..Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain...
  23. ncbi request reprint Primary sclerosing cholangitis: evaluation with MR cholangiography-a case-control study
    A S Fulcher
    Department of Radiology, Medical College of Virginia of Virginia Commonwealth University, Main Hospital, Richmond, VA 23298, USA
    Radiology 215:71-80. 2000
    ..To determine the accuracy of magnetic resonance (MR) cholangiography for detection of primary sclerosing cholangitis (PSC) and localization of PSC in the biliary tract...
  24. ncbi request reprint Treatment of chronic hepatitis C virus in the virginia department of corrections: can compliance overcome racial differences to response?
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298 0341, USA
    Am J Gastroenterol 99:866-72. 2004
    ..The present study describes our experience of treating HCV in the inmate population of the Virginia Department of Corrections...
  25. ncbi request reprint A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantation
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Transpl 13:975-83. 2007
    ..However, complications associated with sepsis, not recurrent cirrhosis, was the most common cause of death in patients with recurrent HCV and this was similar in patients with or without advanced fibrosis...
  26. ncbi request reprint DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial
    Timothy R Morgan
    Division of Gastroenterology, University of California Irvine, Irvine, CA, USA
    J Hepatol 49:548-56. 2008
    ..As part of the HALT-C trial we evaluated genetic associations among patients infected with HCV genotype 1 who had failed previous interferon treatment...
  27. doi request reprint The spectrum of hepatic functional impairment in compensated chronic hepatitis C: results from the Hepatitis C Anti-viral Long-term Treatment against Cirrhosis Trial
    G T Everson
    Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Aliment Pharmacol Ther 27:798-809. 2008
    ..The spectrum of functional impairment in patients with compensated chronic hepatitis C is incompletely defined...
  28. ncbi request reprint The spectrum of chronic hepatitis C virus infection in the Virginia Correctional System: development of a strategy for the evaluation and treatment of inmates with HCV
    Richard K Sterling
    Hepatology Section and Division of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia
    Am J Gastroenterol 100:313-21. 2005
    ..Our objective was to develop an economic strategy for evaluation and treatment of inmates with chronic HCV...
  29. ncbi request reprint Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome
    Arun J Sanyal
    Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Am J Gastroenterol 98:2064-71. 2003
    ....
  30. ncbi request reprint Clinical utility of AFP-L3% measurement in North American patients with HCV-related cirrhosis
    Richard K Sterling
    Virginia Commonwealth University Health Systems, Richmond, Virginia, USA
    Am J Gastroenterol 102:2196-205. 2007
    ..The aim of this prospective study was to compare the clinical utility of AFP-L3% with that of total AFP in North American patients...
  31. ncbi request reprint Treatment of chronic hepatitis C virus in African Americans with genotypes 2 and 3
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Am J Gastroenterol 102:761-6. 2007
    ..These results suggest that African Americans have a global defect in their ability to eradicate HCV infection following treatment with interferon and ribavirin which transcends across all genotypes...
  32. ncbi request reprint Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48210, USA
    Hepatology 42:282-92. 2005
    ..In conclusion, a model based on standard laboratory test results can be used to predict histological cirrhosis with a high degree of accuracy in 50% of patients with CHC...
  33. ncbi request reprint Triple infection with human immunodeficiency virus, hepatitis C virus, and hepatitis B virus: a clinical challenge
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Medical College of Virginia, and Section of Hepatology, West Hospital, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Gastroenterol 98:2130-4. 2003
  34. pmc Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Hepatology 49:1828-37. 2009
    ....
  35. ncbi request reprint Prophylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 years
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Int 28:72-8. 2008
    ..Maintaining a serum anti-HB surface level above a minimum arbitrary titre of 200 pg/mL did not appear to be necessary for effective HBIG prophylaxis...
  36. pmc Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gastroenterology 136:138-48. 2009
    ..We evaluated the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) cohort for the incidence of HCC and associated risk factors...
  37. ncbi request reprint Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VAMC, Richmond, VA, USA
    Aliment Pharmacol Ther 39:1113-25. 2014
    ..Safety of individual probiotic strains approved under Investigational New Drug (IND) policies in cirrhosis with minimal hepatic encephalopathy (MHE) is not clear...
  38. ncbi request reprint Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    A J Sanyal
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia 23298 0711, USA
    Gastroenterology 120:1183-92. 2001
    ....
  39. doi request reprint Systematic review: non-invasive methods of fibrosis analysis in chronic hepatitis C
    J O Smith
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Aliment Pharmacol Ther 30:557-76. 2009
    ..Non-invasive methods of assessing fibrosis have been developed to reduce the need for biopsy...
  40. doi request reprint A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitis
    Jonathan T Hlivko
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Clin Gastroenterol Hepatol 6:1036-40. 2008
    ..Although this regimen achieves remission in approximately 80%, some patients are intolerant or do not respond. Mycophenolate mofetil (MMF) is a potent immunosuppressant. However, its utility in AIH is not well-defined...
  41. pmc Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma
    Anna S Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Gastroenterology 138:493-502. 2010
    ..The aim of this study was to compare the accuracy of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) in the early diagnosis of HCC...
  42. ncbi request reprint Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 43:434-41. 2005
    ..We assessed serum AFP among patients with chronic hepatitis C and advanced fibrosis to establish predictors of AFP elevations and changes with antiviral therapy...
  43. ncbi request reprint The impact of fat distribution on the severity of nonalcoholic fatty liver disease and metabolic syndrome
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Richmond, VA 23298, USA
    Hepatology 46:1091-100. 2007
    ..However, DCL is most strongly associated with severity of steatohepatitis. WC and BMI added modestly to the contribution of DCL to severity of nonalcoholic steatohepatitis...
  44. ncbi request reprint Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: results from the National Hemochromatosis Transplant Registry
    Cynthia Ko
    Division of Gastroenterology, University of Washington Medical Center, Seattle, WA, USA
    Liver Int 27:1394-401. 2007
    ..This study examined the association between hepatic iron grade and hepatocellular carcinoma in patients with end-stage liver disease of diverse aetiologies...
  45. ncbi request reprint Portal-systemic shunting in patients with fibrosis or cirrhosis due to chronic hepatitis C: the minimal model for measuring cholate clearances and shunt
    G T Everson
    Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO, USA
    Aliment Pharmacol Ther 26:401-10. 2007
    ..Measurement of portal inflow and portal-systemic shunt using cholate clearances could be useful in monitoring patients with liver disease...
  46. ncbi request reprint Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantation
    Mitchell L Shiffman
    Hepatology Section, Division of Surgical Pathology, Virginia Commonwealth University Medical Center, Richmond, VA, 23298, USA
    Liver Transpl 10:1248-55. 2004
    ..9, compared with 59% with fibrosis and a mean score of.9 after LDLT. In conclusion, these data strongly suggest that fibrosis progression from recurrent HCV is not more severe in patients after LDLT...
  47. pmc Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Hepatology 47:1118-27. 2008
    ..Although we did identify genotype 3, increased BMI, and diabetes as risk factors, we found no independent association with antiretroviral therapy...
  48. ncbi request reprint Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
    R Todd Stravitz
    Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Transpl 10:850-8. 2004
    ..In conclusion, interferon treatment of recurrent hepatitis C does not consistently improve histologic disease after virologic response, and it may increase the risk of allograft rejection...
  49. doi request reprint Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma
    Richard K Sterling
    Virginia Commonwealth University Health Systems, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:104-13. 2009
    ..This study evaluated their utility, alone or in combination, in a North American population...
  50. ncbi request reprint Four-year follow-up of a prospective randomized trial of mycophenolate mofetil with cyclosporine microemulsion or tacrolimus following liver transplantation
    Robert A Fisher
    Department of Surgery, Division of Transplantation, Virginia Commonwealth University Health Systems at Medical College of Virginia Hospitals, Richmond, 23298 0254, USA
    Clin Transplant 18:463-72. 2004
    ..The goal of this study was to evaluate a multidrug approach that would reduce both early and long-term morbidity related to immunosuppression while maintaining an acceptable freedom from rejection...
  51. ncbi request reprint Adult living donor versus deceased donor liver transplantation: a 10-year prospective single center experience
    Robert A Fisher
    Division of Transplantation, Department of Surgery, Virginia Commonwealth, University Health System, Richmond, VA, USA
    Ann Hepatol 8:298-307. 2009
    ..Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx...
  52. ncbi request reprint Comparison of three commercially available assays for HCV RNA using the international unit standard: implications for management of patients with chronic hepatitis C virus infection in clinical practice
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
    Am J Gastroenterol 98:1159-66. 2003
    ..The present study was performed to evaluate the impact of the international unit standard for measuring HCV RNA in the management of patients with chronic hepatitis C virus (HCV) infection...
  53. doi request reprint Response to hepatitis A and B vaccine alone or in combination in patients with chronic hepatitis C virus and advanced fibrosis
    Erik Seth Kramer
    Department of Epidemiology and Community Health, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Dig Dis Sci 54:2016-25. 2009
    ....
  54. doi request reprint Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome
    Richard Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Am J Med 121:119-26. 2008
    ..We hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation...
  55. pmc Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  56. ncbi request reprint A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
    Clin Gastroenterol Hepatol 2:1107-15. 2004
    ....
  57. ncbi request reprint Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    Arun J Sanyal
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Hepatology 43:682-9. 2006
    ..It is also associated with a lower rate of development of ascites, hyperbilirubinemia, and hepatocellular carcinoma. However, cardiovascular mortality is greater in patients with NASH...
  58. ncbi request reprint Hepatitis C virus infection and kidney transplantation: predictors of patient and graft survival
    Daniel G Maluf
    Department of Surgery, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 83:853-7. 2007
    ..This study aimed to evaluate the outcomes of our HCV+/end-stage renal disease (ESRD) patient population based on the therapeutic option including KTx or continuation in dialysis...
  59. ncbi request reprint Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epoetin alpha
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:371-9. 2007
    ..SVR was significantly greater (P < 0.05) in group 3 patients (49%). This resulted from a significant decline (P < 0.05) in relapse rate; only 8% versus 38% for groups 1 and 2...
  60. pmc Autoimmune acute liver failure: proposed clinical and histological criteria
    R Todd Stravitz
    Section of Hepatology, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Hepatology 53:517-26. 2011
    ..9 ± 0.2 g/dL versus 3.0 ± 0.2 g/dL; P < 0.005], and higher incidence of chronic hepatitis in long-term follow-up [67% versus 17%, P = 0.019]) compared to the population without concordant AI-ALF histology and autoantibodies...
  61. pmc Similar progression of fibrosis between HIV/HCV-infected and HCV-infected patients: Analysis of paired liver biopsy samples
    Richard K Sterling
    Virginia Commonwealth University Health System, Richmond, USA
    Clin Gastroenterol Hepatol 8:1070-6. 2010
    ..However, no studies have directly compared fibrosis progression by paired liver biopsy between patients infected with HIV and HCV versus those infected with only HCV...
  62. pmc Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  63. doi request reprint PROMIS computerised adaptive tests are dynamic instruments to measure health-related quality of life in patients with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, 23249, USA
    Aliment Pharmacol Ther 34:1123-32. 2011
    ..CAT presents five to seven questions/domain depending on the patient's response, from large validated question banks. This provides brevity and precision equivalent to the entire question bank...
  64. pmc Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
    ..03) but MHESPT did not. MHEICT (Odds ratio: 4.51) and prior year crash/violation (Odds ratio: 2.96) were significantly associated with future crash/violation occurrence...
  65. ncbi request reprint Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ....
  66. ncbi request reprint Hepatitis C and HIV
    Jenny O Smith
    Section of Hepatology, Virginia Commonwealth University Medical Center, 1200 East Broad Street, Room 1492, Box 908341, Richmond, VA 23298 0341, USA
    Curr Gastroenterol Rep 9:83-90. 2007
    ..This increase in progression of liver disease and its subsequent increased mortality have spurred research into the optimization of evaluation and management of the HIV-HCV coinfected patient...
  67. doi request reprint Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
    ..Aims: To assess impact of pretransplant hyponatraemia on post-transplant outcomes...
  68. doi request reprint The plasma lipidomic signature of nonalcoholic steatohepatitis
    Puneet Puri
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 50:1827-38. 2009
    ..Conclusions: Although increased lipogenesis, desaturases, and LOX activities characterize NAFL and NASH, impaired peroxisomal polyunsaturated fatty acid (PUFA) metabolism and nonenzymatic oxidation is associated with progression to NASH...
  69. ncbi request reprint Hepatocellular carcinoma: strategy for optimizing surgical resection, transplantation and palliation
    Robert A Fisher
    Division of Transplant Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Transplant 16:52-8. 2002
    ..No incidental HCC group post-OLT patient has died or had HCC recurrence at mean follow-up of 24 +/- 14 months. This neoadjuvant protocol is safe and effective in reducing HCC recurrence prior to and after OLT and resection...
  70. ncbi request reprint Incidence of prolonged length of stay after orthotopic liver transplantation and its influence on outcomes
    Jenny O Smith
    Hepatology Section and Liver Transplant Program, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Transpl 15:273-9. 2009
    ..Efforts to modify those factors that contribute to PLOS may reduce this event, improve survival, and reduce OLT-associated costs...
  71. ncbi request reprint Acute liver failure
    R Q Gill
    Division of Gastroenterology, Section of Hepatology and Liver Transplantation, Medical College of Virginia, Commonwealth University, Richmond, Virginia 23298-0341, USA
    J Clin Gastroenterol 33:191-8. 2001
    ..The only proven therapy for those who are unlikely to recover is liver transplantation. Therefore, recognition of ALF is paramount, and urgent referral to a transplant center is critical to assess transplantation status...
  72. ncbi request reprint Review article: Drug therapy for non-alcoholic fatty liver disease
    K M Comar
    Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Aliment Pharmacol Ther 23:207-15. 2006
    ..However, without larger randomized studies, no pharmacological treatments can be recommended at this time...
  73. ncbi request reprint Calcineurin inhibitor-induced chronic nephrotoxicity in liver transplant patients is reversible using rapamycin as the primary immunosuppressive agent
    Adrian H Cotterell
    Division of Transplantation Surgery, Department of Surgery, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Clin Transplant 16:49-51. 2002
    ..Rapamycin is an effective replacement agent as primary immunosuppressive therapy following withdrawal of CNIs in liver transplant patients with CNI-induced chronic nephrotoxicity...
  74. ncbi request reprint Antibody-mediated pure red cell aplasia due to epoetin alfa during antiviral therapy of chronic hepatitis C
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology and the Division of Hematology Oncology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
    Am J Gastroenterol 100:1415-9. 2005
    ..PRCA caused by the development of erythropoietin antibodies is a potentially life-threatening complication of administering epoetin alfa to prevent the anemia associated with antiviral therapy in patients with chronic hepatitis C...
  75. ncbi request reprint Intensive interferon therapy does not increase virological response rates in African Americans with chronic hepatitis C
    Dickens Theodore
    University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Dig Dis Sci 48:140-5. 2003
    ..Nelson-Aalen cumulative hazard estimates for the different race and dose combinations revealed that Caucasians who received daily interferon were most likely to have an initial response (logrank, P < 0.001)...
  76. ncbi request reprint Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a U.S.-Canadian multicenter study
    Norbert Brau
    Bronx Veterans Affairs VA Medical Center, Infectious Disease Section 111F, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    J Hepatol 47:527-37. 2007
    ..HIV-infected patients now live longer and often have complications of liver disease, especially with hepatitis B or C virus coinfection. Limited data are available on those with hepatocellular carcinoma (HCC)...
  77. doi request reprint Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C
    Robert J Fontana
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Hepatology 47:789-98. 2008
    ..79). Multivariate analysis demonstrated that the serum fibrosis markers correlated substantially better with Ishak fibrosis scores than with the log hepatic collagen content (AUROC 0.84 versus 0.72)...
  78. ncbi request reprint Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C
    Herbert L Bonkovsky
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 131:1440-51. 2006
    ....
  79. ncbi request reprint Predicting outcome of critically ill patients with cirrhosis admitted to the intensive care unit: who's keeping score?
    Patrick D Hung
    J Clin Gastroenterol 37:203-5. 2003

Research Grants3

  1. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2007
    ..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. ..
  2. HCV-HIV Coinfection: Impact of Immune Dysfunction
    Richard Sterling; Fiscal Year: 2007
    ..The K-23 award will protect this candidates time and help him mature into a senior investigator in Hepatology. ..