B D Spiess

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Basic mechanisms of gas transport and past research using perfluorocarbons
    Bruce D Spiess
    Professor of Anesthesiology and Emergency Medicine and Director of VCURES at Virginia Commonwealth University Medical Center, 1101 East Marshal Street, Sanger Hall B1 007, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0695, USA, E mail
    Diving Hyperb Med 40:23-8. 2010
  2. ncbi request reprint The potential role of perfluorocarbon emulsions in decompression illness
    Bruce D Spiess
    Professor of Anesthesiology and Emergency Medicine and Director of VCURES at Virginia Commonwealth University Medical Center, 1101 East Marshal Street, Sanger Hall B1 007, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0695, USA, E mail
    Diving Hyperb Med 40:28-33. 2010
  3. ncbi request reprint Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, Virginia 23298 0695, USA
    Transfusion 44:1143-8. 2004
  4. ncbi request reprint Risks of transfusion: outcome focus
    Bruce D Spiess
    Department of Anesthesiology, VCUMC, Richmond, Virginia 23298 0695, USA
    Transfusion 44:4S-14S. 2004
  5. ncbi request reprint Blood conservation: why bother?
    Bruce D Spiess
    Department of Anesthesiology, VCUHS, Richmond, VA 23298, USA
    J Cardiothorac Vasc Anesth 18:1S-5S. 2004
  6. ncbi request reprint Update on heparin-induced thrombocytopenia and cardiovascular interventions
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0695, USA
    Semin Hematol 42:S22-7. 2005
  7. ncbi request reprint Case 1-2006: off-pump coronary artery bypass graft surgery anticoagulation with bivalirudin: a patient with heparin-induced thrombocytopenia syndrome type II and renal failure
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Health System, Richmond, VA 23298 0695, USA
    J Cardiothorac Vasc Anesth 20:106-11. 2006
  8. ncbi request reprint Con: continuation of aspirin/clopidogrel for cardiac surgery
    Bruce D Spiess
    VCURES Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0695, USA
    J Cardiothorac Vasc Anesth 21:606-9. 2007
  9. ncbi request reprint Platelet transfusions: the science behind safety, risks and appropriate applications
    Bruce D Spiess
    Virginia Commonwealth University Medical Center, Sanger Hall 81 007, 1101 East Marshall Street, Richmond, Virginia 23298 0695, USA
    Best Pract Res Clin Anaesthesiol 24:65-83. 2010
  10. doi request reprint Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics
    Bruce D Spiess
    Department of Anesthesiology and Emergency Medicine, Virginia Commonwealth University Reanimation Engineering Shock Center, Richmond, Virginia, USA
    J Appl Physiol 106:1444-52. 2009

Detail Information

Publications44

  1. ncbi request reprint Basic mechanisms of gas transport and past research using perfluorocarbons
    Bruce D Spiess
    Professor of Anesthesiology and Emergency Medicine and Director of VCURES at Virginia Commonwealth University Medical Center, 1101 East Marshal Street, Sanger Hall B1 007, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0695, USA, E mail
    Diving Hyperb Med 40:23-8. 2010
    ..It is clear they should not simply be viewed as 'blood substitutes' but rather as enhanced gas transport pharmaceuticals...
  2. ncbi request reprint The potential role of perfluorocarbon emulsions in decompression illness
    Bruce D Spiess
    Professor of Anesthesiology and Emergency Medicine and Director of VCURES at Virginia Commonwealth University Medical Center, 1101 East Marshal Street, Sanger Hall B1 007, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0695, USA, E mail
    Diving Hyperb Med 40:28-33. 2010
    ..This review examines approximately 30 years of research regarding the utilization of PFCs in gas embolism as well as experimental DCI. To date, no humans have been treated with PFCs for DCI...
  3. ncbi request reprint Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, Virginia 23298 0695, USA
    Transfusion 44:1143-8. 2004
    ..The current analysis investigates the hypothesis that PLT transfusion is associated with adverse outcomes associated with coronary artery bypass graft surgery (CABG)...
  4. ncbi request reprint Risks of transfusion: outcome focus
    Bruce D Spiess
    Department of Anesthesiology, VCUMC, Richmond, Virginia 23298 0695, USA
    Transfusion 44:4S-14S. 2004
  5. ncbi request reprint Blood conservation: why bother?
    Bruce D Spiess
    Department of Anesthesiology, VCUHS, Richmond, VA 23298, USA
    J Cardiothorac Vasc Anesth 18:1S-5S. 2004
  6. ncbi request reprint Update on heparin-induced thrombocytopenia and cardiovascular interventions
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0695, USA
    Semin Hematol 42:S22-7. 2005
    ..The direct thrombin inhibitor bivalirudin offers promise in this area and is currently being evaluated in multicenter trials as an alternative for heparin/protamine in patients with HIT undergoing cardiac surgery...
  7. ncbi request reprint Case 1-2006: off-pump coronary artery bypass graft surgery anticoagulation with bivalirudin: a patient with heparin-induced thrombocytopenia syndrome type II and renal failure
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Health System, Richmond, VA 23298 0695, USA
    J Cardiothorac Vasc Anesth 20:106-11. 2006
  8. ncbi request reprint Con: continuation of aspirin/clopidogrel for cardiac surgery
    Bruce D Spiess
    VCURES Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0695, USA
    J Cardiothorac Vasc Anesth 21:606-9. 2007
  9. ncbi request reprint Platelet transfusions: the science behind safety, risks and appropriate applications
    Bruce D Spiess
    Virginia Commonwealth University Medical Center, Sanger Hall 81 007, 1101 East Marshall Street, Richmond, Virginia 23298 0695, USA
    Best Pract Res Clin Anaesthesiol 24:65-83. 2010
    ..Platelets are administered in the surgical arena often due to 'clinical judgement', which errs on the side of, perhaps, too frequent use...
  10. doi request reprint Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics
    Bruce D Spiess
    Department of Anesthesiology and Emergency Medicine, Virginia Commonwealth University Reanimation Engineering Shock Center, Richmond, Virginia, USA
    J Appl Physiol 106:1444-52. 2009
    ..This review will stress the fundamental knowledge we now have regarding how respiratory gas movements are changed when intravenous PFC is present...
  11. doi request reprint Effects of perfluorocarbon infusion in an anesthetized swine decompression model
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Reanimation Engineering Shock Center VCURES, Richmond, Virginia 23298 0695, USA
    J Surg Res 153:83-94. 2009
    ..Perfluorocarbon emulsions (PFC) increase both oxygen and nitrogen solubility when infused into the blood stream. This study hypothesized that PFC would increase N(2) removal as well as O(2) delivery to tissues...
  12. ncbi request reprint Blood transfusion: the silent epidemic
    B D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical College of Virginia, Richmond 23298 0695, USA
    Ann Thorac Surg 72:S1832-7. 2001
    ..Therefore, in an evidence-based medical practice the physician should regard transfusion with a skewed risk/benefit ratio. The following article examines that risk/benefit ratio in the post-AIDS era...
  13. ncbi request reprint Transfusion of blood products affects outcome in cardiac surgery
    Bruce D Spiess
    Department of Anesthesiology and the Reanimation Engineering Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0695, USA
    Semin Cardiothorac Vasc Anesth 8:267-81. 2004
    ....
  14. ncbi request reprint Bivalirudin anticoagulation for a patient with hypercoagulable immune syndromes undergoing mitral valve surgery
    Rebecca L Cain
    Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0695, USA
    Ann Thorac Surg 81:2308-10. 2006
    ..Our patient did not experience perioperative thrombotic or bleeding complications. The possible cross-reactivity between heparin induced thrombocytopenia type II and antiphospholipid syndrome has not been investigated...
  15. ncbi request reprint Onset of force development as a marker of thrombin generation in whole blood: the thrombin generation time (TGT)
    M E Carr
    Coagulation Special Studies Laboratory, Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0230, USA
    J Thromb Haemost 1:1977-83. 2003
    ..TGT is short in thrombophilic states such as coronary artery disease, diabetes and thromboangiitis obliterans and prolongs toward normal with oral and intravenous anticoagulants...
  16. ncbi request reprint Experimental analysis of critical oxygen delivery
    Ivo P Torres Filho
    Department of Anesthesiology, Virginia Commonwealth University Reanimation Engineering Shock Center, Virginia Commonwealth University, Richmond, Virginia 23298 0695, USA
    Am J Physiol Heart Circ Physiol 288:H1071-9. 2005
    ..This may assist in finding therapeutic triggers on an individual basis using systemic markers of the transition from aerobic to anaerobic metabolism...
  17. doi request reprint A novel noninvasive impedance-based technique for central venous pressure measurement
    Kevin R Ward
    Virginia Commonwealth University, Department of Emergency Medicine, 1201 East Marshall St, P O Box 980401, Richmond, VA 23298, USA
    Shock 33:269-73. 2010
    ..0001). Noninvasive CVP as determined in this study may be a clinically useful substitute for traditional CVP measurement and may offer a tool for early diagnosis and treatment of acute states in which knowledge of CVP would be helpful...
  18. ncbi request reprint A new noninvasive method to determine central venous pressure
    Kevin R Ward
    Virginia Commonwealth University Reanimation Engineering Shock Center VCURES, 1201 East Marshall Street, P O Box 980401, Richmond, VA 23298, United States
    Resuscitation 70:238-46. 2006
    ..Knowledge of central venous pressure (CVP) is considered valuable in the assessment and treatment of various states of critical illness and injury...
  19. ncbi request reprint Current status of antifibrinolytics in cardiopulmonary bypass and elective deep hypothermic circulatory arrest
    Jeffrey A Green
    Department of Anesthesiology, Virginia Commonwealth University, Medical College of Virginia Campus, 1200 East Broad Street, PO Box 980695, Richmond, VA 23209, USA
    Anesthesiol Clin North America 21:527-51. viii. 2003
    ..Prophylactic antifibrinolytic therapy can attenuate the response to this insult by restoring the delicate balance within these systems, potentially reducing the complication rate and improving patient outcomes...
  20. ncbi request reprint Critical oxygen delivery: the crux of bypass with a special look at the microcirculation
    Bruce D Spiess
    Anaesthesiology and Emergency Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0662, USA
    J Extra Corpor Technol 43:P10-6. 2011
    ..We, as yet, do not understand all the mechanisms involved in the changes of the microcirculation so thoughts regarding future areas for research are discussed...
  21. doi request reprint Treating heparin resistance with antithrombin or fresh frozen plasma
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Reanimation Engineering Shock Center, Richmond, Virginia 23219, USA
    Ann Thorac Surg 85:2153-60. 2008
    ....
  22. ncbi request reprint Human error in medicine: change in cardiac operating rooms through the FOCUS initiative
    Bruce D Spiess
    Anaesthesiology and Emergency Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0662, USA
    J Extra Corpor Technol 43:P33-8. 2011
    ..The first FOCUS data is sobering and shows tremendous possibility for improvement...
  23. ncbi request reprint Blood management-issues: the panic of coagulopathic bleeding--is there a rational approach?
    Bruce D Spiess
    Anaesthesiology and Emergency Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0662, USA
    J Extra Corpor Technol 43:P58-64. 2011
    ..When a therapy produces no advantage all that it leaves the patient with is the side effects or adverse outcomes. Adverse outcomes from coagulation products are real and sobering...
  24. ncbi request reprint Intravenous perfluorocarbon emulsion increases nitrogen washout after venous gas emboli in rabbits
    J Zhu
    Department of Anesthesiology, Virginia Commonwealth University Reanimation Engineering Shock Center, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
    Undersea Hyperb Med 34:7-20. 2007
    ..The use of IV-PFC promises to be a breakthrough non-recompression therapy for gas embolism in the treatment of Decompression Sickness (DCS) and in surgery...
  25. ncbi request reprint Systemic responses to hemodilution after transfusion with stored blood and with a hemoglobin-based oxygen carrier
    Ivo P Torres Filho
    Department of Anesthesiology, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Anesth Analg 100:912-20. 2005
    ..The data suggest that tolerance to Do(2)crit is not altered by 50% replacement of native Hb by stored blood or Hb raffimer...
  26. doi request reprint Perfluorocarbon emulsions improve cognitive recovery after lateral fluid percussion brain injury in rats
    Zhengwen Zhou
    Department of Neurosurgery, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    Neurosurgery 63:799-806; discussion 806-7. 2008
    ..Costa Mesa, CA) treatment on cognitive recovery and mitochondrial oxygen consumption after a moderate lateral fluid percussion injury (LFPI)...
  27. ncbi request reprint Perfluorocarbon emulsion improves cerebral oxygenation and mitochondrial function after fluid percussion brain injury in rats
    Wilson P Daugherty
    Departments of Neurosurgery and Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Neurosurgery 54:1223-30; discussion 1230. 2004
    ..San Diego, CA) on cerebral oxygenation, mitochondrial redox potential, and free radical formation after lateral fluid percussion injury...
  28. ncbi request reprint Comparison of bioimpedance versus thermodilution cardiac output during cardiac surgery: evaluation of a second-generation bioimpedance device
    B D Spiess
    Department of Anesthesiology, University of Washington, Seattle, WA, USA
    J Cardiothorac Vasc Anesth 15:567-73. 2001
    ..CONCLUSION: TEB reporting of cardiac index during coronary artery surgery generally agreed with TD-PAC cardiac index except at the end of the case (time 4)...
  29. ncbi request reprint Retinal angiography: noninvasive, real-time bubble assessment from the ocular fundus
    J Travis Parsons
    Department of Anesthesiology, Virginia Commonwealth University, Richmond, Virginia, USA
    Undersea Hyperb Med 36:169-81. 2009
    ..This study also presents for the first time images of bubbles in the retinal circulation associated with DCS captured by a fundus camera...
  30. ncbi request reprint Red cell transfusions and guidelines: a work in progress
    Bruce D Spiess
    Department of Anesthesiology, Virginia Commonwealth University Medical Center, 1200 East Broad Street, Richmond, VA 23298 0695, USA
    Hematol Oncol Clin North Am 21:185-200. 2007
    ..Outcome data from retrospective data bases are sobering, calling to question the present practices of red cell transfusion...
  31. ncbi request reprint Blood transfusion for cardiopulmonary bypass: the need to answer a basic question
    Bruce D Spiess
    J Cardiothorac Vasc Anesth 16:535-8. 2002
  32. ncbi request reprint Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass
    Andreas Koster
    Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany
    Anesth Analg 96:383-6, table of contents. 2003
  33. ncbi request reprint Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study
    Nicholas G Smedira
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:686-92. 2006
    ..This trial was performed to evaluate the safety and efficacy of bivalirudin in off-pump coronary artery bypass grafting...
  34. ncbi request reprint Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies
    Cornelius M Dyke
    Department of Cardiovascular and Thoracic Surgery, Gaston Memorial Hospital, Gastonia, North Carolina 28054, USA
    Ann Thorac Surg 84:836-9. 2007
    ....
  35. ncbi request reprint Argatroban for off-pump coronary artery bypass surgery
    Jeffrey A Green
    Anesth Analg 97:1201; author reply 1201-2. 2003
  36. ncbi request reprint Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline
    Victor A Ferraris
    Ann Thorac Surg 83:S27-86. 2007
    ..Blood must be viewed as a scarce resource that carries risks and benefits. A careful review of available evidence can provide guidelines to allocate this valuable resource and improve patient outcomes...
  37. ncbi request reprint Full-dose aprotinin use in coronary artery bypass graft surgery: an analysis of perioperative pharmacotherapy and patient outcomes
    David Royston
    Department of Anaesthesia and Critical Care, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK
    Anesth Analg 103:1082-8. 2006
    ..In this retrospective analysis, we evaluated the relationship of aprotinin therapy with organ dysfunction in humans undergoing coronary artery bypass graft surgery (CABG)...
  38. ncbi request reprint An assessment of different filter systems for extracorporeal elimination of bivalirudin: an in vitro study
    Andreas Koster
    Department for Anesthesia, Deutsches Herzzentrum Berlin, Germany
    Anesth Analg 96:1316-9, table of contents. 2003
    ..Our data show that bivalirudin can be effectively eliminated via hemofiltration and plasmapheresis, although there were significant differences in the elimination rates among the filter systems investigated...
  39. ncbi request reprint A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study
    Cornelius M Dyke
    Carolina Cardiovascular and Thoracic Surgery Associates, Gaston Memorial Hospital, Gastonia, NC 28056, USA
    J Thorac Cardiovasc Surg 131:533-9. 2006
    ..This trial was performed to evaluate the safety and efficacy of bivalirudin as an alternative to heparin with protamine reversal in on-pump cardiac surgery...
  40. ncbi request reprint Choose one: damned if you do/damned if you don't!
    Bruce D Spiess
    Crit Care Med 33:1871-4. 2005
  41. ncbi request reprint Effect of perfluorocarbons on brain oxygenation and ischemic damage in an acute subdural hematoma model in rats
    Taek Hyun Kwon
    Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea
    J Neurosurg 103:724-30. 2005
    ..This study was conducted to determine whether perfluorocarbons (PFCs) improve brain oxygenation and reduce ischemic brain damage in an acute subdural hematoma (SDH) model in rats...
  42. doi request reprint Case 1-2008. One institution's decreasing use of aprotinin during cardiac surgery in 2006
    Zaneta Y Strouch
    Department of Anesthesia and Critical Care, University of Chicago Medical Center, Chicago, IL 60637, USA
    J Cardiothorac Vasc Anesth 22:139-46. 2008
  43. ncbi request reprint Developing a blood conservation program in cardiac surgery
    Abe Deanda
    Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Med Qual 21:230-7. 2006
    ..The success of the program is believed to be a result of the multidisciplinary approach taken, with a commitment from all members of the blood reduction team being the key component of this success...
  44. ncbi request reprint Equivalence of bioimpedance and thermodilution in measuring cardiac index after cardiac surgery
    W Scott Sageman
    Pulmonary Medicine, Monterey, CA, USA
    J Cardiothorac Vasc Anesth 16:8-14. 2002
    ..To compare thoracic electrical bioimpedance (TEB) cardiography versus pulmonary artery thermodilution (TD) derived cardiac index in patients after cardiopulmonary bypass...