F L Smith

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Involvement of phospholipid signal transduction pathways in morphine tolerance in mice
    F L Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, P O Box 980613, Richmond, Virginia, VA 23298 0613, USA
    Br J Pharmacol 128:220-6. 1999
  2. ncbi request reprint Influence of Voltage-sensitive Ca(++) channel drugs on bupivacaine infiltration anesthesia in mice
    F L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    Anesthesiology 95:1189-97. 2001
  3. ncbi request reprint Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, PO Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 958:28-35. 2002
  4. ncbi request reprint Paradoxical enhancement of bupivacaine anesthesia in mice by drugs that open sodium channels
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Pharmacology 67:90-8. 2003
  5. ncbi request reprint Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice
    Forrest L Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus of Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pain 8:153-61. 2004
  6. ncbi request reprint The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, P O Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 985:78-88. 2003
  7. pmc The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy
    L C Hull
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Pharmacol Exp Ther 332:1127-35. 2010
  8. pmc Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance
    L J Sim-Selley
    Department of Pharmacology and Toxicology, Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Medical College of Virginia Campus, 1112 East Clay Street, Richmond, VA 23298, USA
    Br J Pharmacol 151:1324-33. 2007
  9. ncbi request reprint Regional cutaneous differences in the duration of bupivacaine local anesthesia in mice
    F L Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia Virginia Commonwealth University, Richmond 23298 0613, USA
    Life Sci 60:1613-21. 1997
  10. ncbi request reprint Buprenorphine substitution ameliorates spontaneous withdrawal in fentanyl-dependent rat pups
    A B Lohmann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0613, USA
    Pediatr Res 49:50-5. 2001

Collaborators

Detail Information

Publications31

  1. pmc Involvement of phospholipid signal transduction pathways in morphine tolerance in mice
    F L Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, P O Box 980613, Richmond, Virginia, VA 23298 0613, USA
    Br J Pharmacol 128:220-6. 1999
    ..Evidence is accumulating that opioid tolerance disrupts the homeostatic balance of several important signal transduction pathways...
  2. ncbi request reprint Influence of Voltage-sensitive Ca(++) channel drugs on bupivacaine infiltration anesthesia in mice
    F L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, 23298 0613, USA
    Anesthesiology 95:1189-97. 2001
    ..The current study examines the influence of voltage-sensitive Ca(++) channels in bupivacaine infiltration anesthesia...
  3. ncbi request reprint Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, PO Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 958:28-35. 2002
    ..Finally, the use of persistent PKC inhibitors that lasted for 24 h demonstrated that the neuronal systems in these animals did not adapt by increasing the activity of other protein kinase cascades to re-establish morphine tolerance...
  4. ncbi request reprint Paradoxical enhancement of bupivacaine anesthesia in mice by drugs that open sodium channels
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Pharmacology 67:90-8. 2003
    ..In conclusion, veratridine and ATXII may have increased the stimulus-dependent binding of bupivacaine to Na(+) channels, thereby increasing the anesthetic effects of bupivacaine...
  5. ncbi request reprint Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice
    Forrest L Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus of Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pain 8:153-61. 2004
    ..This provides the first evidence that RyR channels might affect bupivacaine anesthesia in some fashion...
  6. ncbi request reprint The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, P O Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 985:78-88. 2003
    ....
  7. pmc The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy
    L C Hull
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Pharmacol Exp Ther 332:1127-35. 2010
    ..These results suggest that tolerance induced by low- and moderate-efficacy mu-opioid receptor agonists is dependent on PKC, whereas tolerance induced by the high-efficacy agonist DAMGO is dependent on GRK...
  8. pmc Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance
    L J Sim-Selley
    Department of Pharmacology and Toxicology, Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Medical College of Virginia Campus, 1112 East Clay Street, Richmond, VA 23298, USA
    Br J Pharmacol 151:1324-33. 2007
    ..The present study examined MOR-mediated G-protein activation in the CNS of mice with different levels of morphine tolerance...
  9. ncbi request reprint Regional cutaneous differences in the duration of bupivacaine local anesthesia in mice
    F L Smith
    Department of Pharmacology and Toxicology, Medical College of Virginia Virginia Commonwealth University, Richmond 23298 0613, USA
    Life Sci 60:1613-21. 1997
    ..5% concentration. These results provide evidence of regional differences in cutaneous sensitivity to local anesthetics, and the ability of EPI to extend the duration of anesthesia...
  10. ncbi request reprint Buprenorphine substitution ameliorates spontaneous withdrawal in fentanyl-dependent rat pups
    A B Lohmann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0613, USA
    Pediatr Res 49:50-5. 2001
    ..Surprisingly, p.o. buprenorphine was nearly as efficacious as the s.c. route of administration. These results indicate that buprenorphine substitution therapy may be effective in fentanyl-dependent human infants...
  11. ncbi request reprint The role of several kinases in mice tolerant to delta 9-tetrahydrocannabinol
    Matthew C Lee
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 305:593-9. 2003
    ..In addition, inhibition of PKA reversed a decrease in dynorphin release shown to accompany THC tolerance in rats. These data support a role for PKA and Src tyrosine kinase in phosphorylation events in delta(9)-THC-tolerant mice...
  12. ncbi request reprint How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?
    Chris P Bailey
    Department of Pharmacology, University of Bristol, Bristol BS8 1TD, UK
    Trends Pharmacol Sci 27:558-65. 2006
    ..Here, we propose that protein kinase C could have a crucial role in the desensitization of mu-opioid receptors by morphine and that this cellular process could contribute to the development and maintenance of morphine tolerance in vivo...
  13. ncbi request reprint PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0524, United States
    Pharmacol Res 54:474-80. 2006
    ..Our results provide the first evidence on the ability of PKC and PKA inhibitors to reinstate the behavioral and physiological effects of morphine in non-challenged morphine-tolerant animals...
  14. pmc Role of kappa and delta opioid receptors in mediating morphine-induced antinociception in morphine-tolerant infant rats
    Dawn C Stoller
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, PO Box 980613, Richmond, VA 23298 0613, USA
    Brain Res 1142:28-36. 2007
    ..Furthermore, [(3)H]naloxone binding indicated a lack of mu receptor downregulation in morphine-tolerant rat pups...
  15. ncbi request reprint Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia
    Bichoy H Gabra
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298 0613
    J Pharmacol Exp Ther 322:186-94. 2007
    ..Taken together, our results suggest the hypothesis that mGluRs are coupled to the NMDAR channels through the NR2B subunit in the spinal cord and that this coupling involves the activation of protein kinase C and protein kinase A...
  16. pmc Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance
    Bichoy H Gabra
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298 0524, USA
    Brain Res 1159:86-93. 2007
    ..Further studies will be directed towards a better understanding of the role of different phosphatase isoforms in morphine tolerance...
  17. pmc mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo
    Bichoy H Gabra
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298, USA
    Brain Res 1187:58-66. 2008
    ..These results are in agreement with our previous study in which we demonstrated that the same active mGluR5 antagonists blocked glutamate-mediated mobilization of internal calcium in a selective mGluR5 in vitro efficacy assay...
  18. pmc Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice
    Bichoy H Gabra
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Brain Res 1217:70-7. 2008
    ..However, it appears that tolerance can be dissociated from physical dependence, indicating a role for PKC and PKA to affect antinociception but not those signs mediated through the complex physiological processes of withdrawal...
  19. ncbi request reprint Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0524, USA
    Pain 127:129-39. 2007
    ..The PKC beta(I), beta(II), delta, theta, epsilon, eta and xi inhibitors were inactive. Thus, PKC alpha, gamma and epsilon appear to contribute to the expression of morphine tolerance in mice...
  20. ncbi request reprint Enhancement of bupivacaine local anesthesia with the potassium channel blocker ibutilide
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980524, Richmond, VA 23298 0524, USA
    Eur J Pain 11:551-6. 2007
    ..Epinephrine augmented the enhancement by ibutilide of bupivacaine's potency by 6.8-fold. In summary, ibutilide may enhance the effects of bupivacaine by blocking K(+) channels on sensory nociceptive nerves...
  21. ncbi request reprint Pharmacological characterization of novel water-soluble cannabinoids
    Billy R Martin
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 318:1230-9. 2006
    ..It is now possible to conduct cannabinoid research with agonists that are water-soluble and thus obviating the need of solubilizing agents...
  22. ncbi request reprint Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice
    Forrest L Smith
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 492:137-42. 2004
    ..Thus, greater mGlu(1) and mGlu(5) receptor stimulation during morphine tolerance may lead to persistent activation of the phosphatidylinositol cascade...
  23. ncbi request reprint PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice
    Ruby R Javed
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 492:149-57. 2004
    ..However, co-administration of bisinolylmaleimide I with KT-5720 or Gö-7874 with KT-5720 completely reversed the tolerance. This demonstrates that tolerance in a non-behavioral system involves the actions of PKC and PKA...
  24. ncbi request reprint Buprenorphine blocks withdrawal in morphine-dependent rat pups
    Dawn C Stoller
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Paediatr Anaesth 14:642-9. 2004
    ..Buprenorphine effectively blocks abstinence in dependent adults, and in infants it could accelerate or eliminate the tapering schedule, thereby enabling earlier hospital dismissals...
  25. ncbi request reprint Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, Virginia 23298 0613, USA
    Eur J Pharmacol 510:59-68. 2005
    ....
  26. ncbi request reprint Chronic Delta9-tetrahydrocannabinol treatment produces antinociceptive tolerance in mice without altering protein kinase A activity in mouse brain and spinal cord
    George D Dalton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, 1112 E Clay Street McGuire Hall, Box 980613, Richmond, VA 23298, USA
    Biochem Pharmacol 70:152-60. 2005
    ..Future work is needed to determine the role of PKA in cannabinoid tolerance in mice...
  27. ncbi request reprint Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI)
    George D Dalton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, 3298 0613, USA
    Neuropharmacology 48:648-57. 2005
    ..Moreover, the inhibition of PKA activity in specific brain regions and LSC from morphine-tolerant mice by PKI analogs administered i.c.v. is evidence that PKA plays a role in morphine tolerance...
  28. ncbi request reprint Loss of antinociceptive efficacy in rat pups infused with morphine from osmotic minipumps
    Dawn C Stoller
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Pharmacology 66:11-8. 2002
    ..However, this effect cannot be attributed to changes in mu-opioid receptor number or affinity...
  29. ncbi request reprint Protein Kinase A activity is increased in mouse lumbar spinal cord but not brain following morphine antinociceptive tolerance for 15 days
    George D Dalton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298, USA
    Pharmacol Res 52:204-10. 2005
    ..Thus, neurons in mouse brain and LSC that comprise the pain pathway descending from the brainstem and ending in the spinal cord respond differently to chronic morphine treatment...
  30. ncbi request reprint Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal delta9-tetrahydrocannabinol
    Diana L Cichewicz
    Philip Morris, U S A, Richmond, VA 23261, United States
    Eur J Pharmacol 525:74-82. 2005
    ..2-fold at 2-h and 7.2-fold at 4-h when co-administered with THC. These results indicate that the enhancement of transdermal opioids by THC could lead to the design of an effective combination analgesic patch...
  31. ncbi request reprint Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine
    F Ivy Carroll
    Center for Organic and Medicinal Chemistry, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709, USA
    J Med Chem 50:3388-91. 2007
    ..The most potent compounds were 3-(3-methylphenylethynyl)-5-methyl[1,2,4]triazine (6b), 5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine (6c), and 3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine (6d)...