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Domenic A Sica
Virginia Commonwealth University
Sica D, Gehr T, Fernandez A. Risk-benefit ratio of angiotensin antagonists versus ACE inhibitors in end-stage renal disease. Drug Saf. 2000;22:350-60
Sica D, Struthers A, Cushman W, Wood M, Banas J, Epstein M. Importance of potassium in cardiovascular disease. J Clin Hypertens (Greenwich). 2002;4:198-206
..Because of the complexity of this topic, issues of hyperkalemia will be addressed in a forthcoming manuscript. ..
Sica D. Metolazone and its role in edema management. Congest Heart Fail. 2003;9:100-5
..The temptation should be avoided to simply reduce the doses of either metolazone or the loop diuretic as a means to controlling an active diuresis. ..
Sica D. Minoxidil: an underused vasodilator for resistant or severe hypertension. J Clin Hypertens (Greenwich). 2004;6:283-7
..There is, however, a place for minoxidil in the treatment of resistant hypertension especially in patients with advanced renal disease. ..
Sica D. Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Fail Rev. 2005;10:23-9
..This is more apt to occur with spironolactone due to the very long half-life of several of its active metabolites. ..
Sica D, Grubbs R. Transdermal clonidine: therapeutic considerations. J Clin Hypertens (Greenwich). 2005;7:558-62
..The not infrequent development of a dermatitis, together with a substantially greater cost than oral clonidine, have been the major undoings for transdermal clonidine. ..
Sica D. Centrally acting antihypertensive agents: an update. J Clin Hypertens (Greenwich). 2007;9:399-405
..Escalating doses of drugs in this class often give rise to salt and water retention, in which case diuretic therapy becomes a valuable adjunctive therapy...
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