K L Shelton

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Effects of naltrexone and Ro 15-4513 on a multiple schedule of ethanol and Tang self-administration
    K L Shelton
    Department of Pharmacology and Toxicology KLS, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    Alcohol Clin Exp Res 25:1576-85. 2001
  2. doi request reprint Effect of drug-paired exteroceptive stimulus presentations on methamphetamine reinstatement in rats
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond VA 23298 0613, United States
    Pharmacol Biochem Behav 90:434-40. 2008
  3. ncbi request reprint Substitution profiles of N-methyl-D-aspartate antagonists in ethanol-discriminating inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, PO Box 980613, Richmond, VA 23298 0613, USA
    Alcohol 34:165-75. 2004
  4. ncbi request reprint Effects of abused inhalants and GABA-positive modulators in dizocilpine discriminating inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, P O Box 980613, Richmond, VA 23298 0613, USA
    Pharmacol Biochem Behav 79:219-28. 2004
  5. ncbi request reprint Effect of 5-HT3 receptor over-expression on the discriminative stimulus effects of ethanol
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    Alcohol Clin Exp Res 28:1161-71. 2004
  6. ncbi request reprint Interaction of noncontingent cocaine and contingent drug-paired stimuli on cocaine reinstatement
    Keith L Shelton
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 497:35-40. 2004
  7. ncbi request reprint Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Alcohol Clin Exp Res 26:747-57. 2002
  8. ncbi request reprint A multiple schedule model of limited access drinking in the cynomolgus macaque
    K L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Behav Pharmacol 12:559-73. 2001
  9. pmc Inhaled toluene vapor as a discriminative stimulus
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    Behav Pharmacol 18:219-29. 2007
  10. pmc Pharmacological characterization of the discriminative stimulus of inhaled 1,1,1-trichloroethane
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 333:612-20. 2010

Research Grants

  1. Ethanol Discrimination in Transgenic Mice
    KEITH SHELTON; Fiscal Year: 2002
  2. Discriminative stimulus effects of abused inhalants
    KEITH SHELTON; Fiscal Year: 2007

Detail Information

Publications19

  1. ncbi request reprint Effects of naltrexone and Ro 15-4513 on a multiple schedule of ethanol and Tang self-administration
    K L Shelton
    Department of Pharmacology and Toxicology KLS, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    Alcohol Clin Exp Res 25:1576-85. 2001
    ....
  2. doi request reprint Effect of drug-paired exteroceptive stimulus presentations on methamphetamine reinstatement in rats
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond VA 23298 0613, United States
    Pharmacol Biochem Behav 90:434-40. 2008
    ..These data show that methamphetamine priming produces a robust reinstatement effect which can be influenced by drug-paired cues...
  3. ncbi request reprint Substitution profiles of N-methyl-D-aspartate antagonists in ethanol-discriminating inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, PO Box 980613, Richmond, VA 23298 0613, USA
    Alcohol 34:165-75. 2004
    ..Taken together, these findings seem to indicate that the behavioral effects of NMDA antagonists differ between strains, but that the NMDA-mediated component of the discriminative stimulus effects of ethanol is similar in B6 and D2 mice...
  4. ncbi request reprint Effects of abused inhalants and GABA-positive modulators in dizocilpine discriminating inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, P O Box 980613, Richmond, VA 23298 0613, USA
    Pharmacol Biochem Behav 79:219-28. 2004
    ....
  5. ncbi request reprint Effect of 5-HT3 receptor over-expression on the discriminative stimulus effects of ethanol
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    Alcohol Clin Exp Res 28:1161-71. 2004
    ..The present study utilized transgenic mice that over-express 5-HT3 receptors in conjunction with traditional pharmacological techniques to examine the contribution of 5-HT3 receptors to ethanol's discriminative stimulus...
  6. ncbi request reprint Interaction of noncontingent cocaine and contingent drug-paired stimuli on cocaine reinstatement
    Keith L Shelton
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 497:35-40. 2004
    ..The results highlight the important interaction between drug administration and drug-paired environmental stimuli in the reinstatement model...
  7. ncbi request reprint Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Alcohol Clin Exp Res 26:747-57. 2002
    ..Examination of the discriminative stimulus effects of ethanol in B6 and D2 mouse strains may enhance our understanding of the relationship between the subjective effects of ethanol and other ethanol-induced behavioral effects...
  8. ncbi request reprint A multiple schedule model of limited access drinking in the cynomolgus macaque
    K L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Behav Pharmacol 12:559-73. 2001
    ..The results suggest that ethanol self-administration under a multiple schedule is insensitive to alteration by acute ethanol pretreatment, but can be decreased by more prolonged chronic ethanol pretreatment...
  9. pmc Inhaled toluene vapor as a discriminative stimulus
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    Behav Pharmacol 18:219-29. 2007
    ..The results also suggest that the discrimination was likely to have been based primarily on interoceptive rather than exteroceptive stimulus effects...
  10. pmc Pharmacological characterization of the discriminative stimulus of inhaled 1,1,1-trichloroethane
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 333:612-20. 2010
    ....
  11. pmc The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse
    Patrick M Beardsley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 3298 0613, USA
    Eur J Pharmacol 637:102-8. 2010
    ..These results thus reinforce interest in atypical neurobiological mechanisms which could be exploited for developing novel medications for treating drug abuse disorders...
  12. pmc Characterization of an inhaled toluene drug discrimination in mice: effect of exposure conditions and route of administration
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Pharmacol Biochem Behav 92:614-20. 2009
    ..These results indicate that the discriminative stimulus effects of inhaled toluene vapor are likely mediated by CNS effects rather than by its pronounced peripheral stimulus effects...
  13. pmc Discriminative stimulus effects of inhaled 1,1,1-trichloroethane in mice: comparison to other hydrocarbon vapors and volatile anesthetics
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 203:431-40. 2009
    ..Because the toxicity of many inhalants precludes evaluation in humans, drug discrimination, an animal model of subjective effects, can be used to gain insights on their poorly understood abuse-related effects...
  14. ncbi request reprint Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
    Patrick M Beardsley
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Psychopharmacology (Berl) 183:118-26. 2005
    ..Antagonism of the kappa opioid receptor (KOR) has been reported to attenuate some effects of stressors, and antagonism of the KOR has been reported to have antidepressant-like properties...
  15. ncbi request reprint Chronic ethanol consumption transiently reduces adult neural progenitor cell proliferation
    Ann C Rice
    Department of Neurosurgery, Virginia Commonwealth University, 8th floor West Hospital Box 980631, 1200 E Broad St, Richmond, VA 23298 0613, USA
    Brain Res 1011:94-8. 2004
    ..Thus, the progenitor cell proliferation rate is transiently decreased by chronic ethanol usage. This data suggests that chronic alcohol use results in a compensatory response that restores the progenitor cell proliferation rate...
  16. pmc GABA(A) positive modulator and NMDA antagonist-like discriminative stimulus effects of isoflurane vapor in mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 212:559-69. 2010
    ..Drug discrimination may represent a novel procedure to explore the neurochemical systems underlying the sub-anesthetic behavioral effects of these compounds...
  17. pmc Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice
    Rahul T Khisti
    Department of Pharmacology Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol 40:119-26. 2006
    ..A reliable behavioral model to study EDE in inbred C57BL/6NCrl mice could greatly facilitate further studies on molecular mechanisms of ethanol craving behavior...
  18. ncbi request reprint Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination
    Clyde W Hodge
    Department of Psychiatry and Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 5679, USA
    Alcohol Clin Exp Res 30:203-13. 2006
    ....
  19. ncbi request reprint Discriminative stimulus effects of ethanol in mice lacking the gamma-aminobutyric acid type A receptor delta subunit
    Erin E Shannon
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 28:906-13. 2004
    ....

Research Grants2

  1. Ethanol Discrimination in Transgenic Mice
    KEITH SHELTON; Fiscal Year: 2002
    ..background to the ethanol's discriminative ctimnlnc effects. ..
  2. Discriminative stimulus effects of abused inhalants
    KEITH SHELTON; Fiscal Year: 2007
    ....