D Sarkar

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 22:8758-73. 2003
  2. doi request reprint Human polynucleotide phosphorylase (hPNPase(old-35)): an evolutionary conserved gene with an expanding repertoire of RNA degradation functions
    S K Das
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298 0033, USA
    Oncogene 30:1733-43. 2011
  3. doi request reprint Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells
    Michelle R Staudt
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    J Cell Physiol 218:304-14. 2009
  4. pmc PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Autophagy 4:513-5. 2008
  5. ncbi request reprint Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems
    Devanand Sarkar
    Department of Human Genetics and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Biol Ther 7:109-12. 2008
  6. pmc AEG-1/MTDH/LYRIC: clinical significance
    Devanand Sarkar
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    Adv Cancer Res 120:39-74. 2013
  7. pmc AEG-1/MTDH/LYRIC in liver cancer
    Devanand Sarkar
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    Adv Cancer Res 120:193-221. 2013
  8. doi request reprint A cancer terminator virus eradicates both primary and distant human melanomas
    D Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
    Cancer Gene Ther 15:293-302. 2008
  9. doi request reprint Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
  10. pmc Evolution of MDA-5/RIG-I-dependent innate immunity: independent evolution by domain grafting
    Devanand Sarkar
    Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:17040-5. 2008

Research Grants

Collaborators

Detail Information

Publications95

  1. ncbi request reprint Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 22:8758-73. 2003
    ..The mda-7/IL-24 gene represents a new class of cancer-specific apoptosis-inducing genes with obvious potential for the targeted gene-based therapy of human prostate cancer...
  2. doi request reprint Human polynucleotide phosphorylase (hPNPase(old-35)): an evolutionary conserved gene with an expanding repertoire of RNA degradation functions
    S K Das
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298 0033, USA
    Oncogene 30:1733-43. 2011
    ..In these contexts, targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions...
  3. doi request reprint Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells
    Michelle R Staudt
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    J Cell Physiol 218:304-14. 2009
    ....
  4. pmc PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Autophagy 4:513-5. 2008
    ....
  5. ncbi request reprint Acquired and innate resistance to the cancer-specific apoptosis-inducing cytokine, mda-7/IL-24: not insurmountable therapeutic problems
    Devanand Sarkar
    Department of Human Genetics and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Biol Ther 7:109-12. 2008
    ..In these contexts, should resistance to monotherapy with mda-7/IL-24 occur, combinatorial therapies with this cytokine might provide a viable path for potentially curing patients of primary and metastatic cancer...
  6. pmc AEG-1/MTDH/LYRIC: clinical significance
    Devanand Sarkar
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    Adv Cancer Res 120:39-74. 2013
    ..This chapter provides a comprehensive analysis of the existing literature to emphasize the common and conflicting findings relative to the clinical significance of AEG-1/MTDH/LYRIC in cancer. ..
  7. pmc AEG-1/MTDH/LYRIC in liver cancer
    Devanand Sarkar
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, USA
    Adv Cancer Res 120:193-221. 2013
    ....
  8. doi request reprint A cancer terminator virus eradicates both primary and distant human melanomas
    D Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
    Cancer Gene Ther 15:293-302. 2008
    ..These provocative findings advocate potential therapeutic applications of this novel virus for treating patients with advanced melanomas with metastases...
  9. doi request reprint Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
    ..In these contexts, AEG-1 represents a viable potential target for the therapy of malignant glioma...
  10. pmc Evolution of MDA-5/RIG-I-dependent innate immunity: independent evolution by domain grafting
    Devanand Sarkar
    Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:17040-5. 2008
    ....
  11. pmc Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes
    Devanand Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Cancer Res 69:8529-35. 2009
    ..The present review critically evaluates what is currently known about AEG-1 and provides new perspectives relative to this intriguing molecule that may provide a rational target for intervening in the cancer phenotype...
  12. doi request reprint mda-9/Syntenin: more than just a simple adapter protein when it comes to cancer metastasis
    Devanand Sarkar
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Sanger Hall Building, Room 11 015, 1101 East Marshall Street, Richmond, VA 23298, USA
    Cancer Res 68:3087-93. 2008
    ....
  13. ncbi request reprint Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells
    R Dash
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cancer Gene Ther 17:447-56. 2010
    ..Considering the fact that Ad.5-mda-7 has shown significant objective responses in a phase I clinical trial for solid tumors, Ad.5/3-mda-7 is predicted to exert enhanced therapeutic benefit in patients with prostate cancer...
  14. doi request reprint Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1
    R Dash
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Oncogene 29:4412-23. 2010
    ..In these contexts, transformed cells 'addicted' to AP-1 activity are rendered susceptible to SARI-mediated inhibition of expression of the transformed phenotype...
  15. ncbi request reprint Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells
    I V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 26:733-44. 2007
    ..mda-7. These findings support an effective dual-combinatorial approach for the therapy of colorectal cancers that employs a unique cancer-specific suppressor gene (mda-7/IL-24) with targeted inhibition of oncogene (ras) expression...
  16. ncbi request reprint Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma
    S G Lee
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Oncogene 28:2476-84. 2009
    ..These provocative results indicate that AEG-1 may play a crucial role in the pathogenesis of neuroblastoma and could represent a potential target for therapeutic intervention...
  17. ncbi request reprint Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    S G Lee
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 27:1114-21. 2008
    ..Activation of survival pathways may be one mechanism by which AEG-1 exerts its oncogenic properties...
  18. ncbi request reprint Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus
    S Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, P O Box 980678, Richmond, VA 23298 067, USA
    Curr Mol Med 14:125-40. 2014
    ..5/3-CTV-M7 plus POH in PDAC treatment, where all other current treatment strategies in clinical settings show minimal efficacy. ..
  19. ncbi request reprint Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis
    L Lin
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Cell Death Differ 13:1982-93. 2006
    ....
  20. ncbi request reprint Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner
    Zao Zhong Su
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 22:1164-80. 2003
    ..mda-7 may, in many instances, prove more beneficial for the gene-based therapy of malignant gliomas than administration of wild-type p53...
  21. pmc Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB
    H Boukerche
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Oncogene 29:3054-66. 2010
    ..These findings underscore PDZ domains of MDA-9/syntenin as promising potential therapeutic targets for intervening in a decisive component of cancer progression, namely, metastatic tumor spread...
  22. ncbi request reprint Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
    Clin Cancer Res 9:3272-81. 2003
    ..Despite therapeutic interventions including surgery, chemotherapy, and radiotherapy, glioblastoma multiforme (GBM) has a very poor prognosis and novel therapies are required...
  23. ncbi request reprint Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis
    Luni Emdad
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 66:1509-16. 2006
    ..Our findings suggest that activation of NF-kappaB by AEG-1 could represent a key molecular mechanism by which AEG-1 promotes anchorage-independent growth and invasion, two central features of the neoplastic phenotype...
  24. ncbi request reprint mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB
    Habib Boukerche
    Departments of Urology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 67:1812-22. 2007
    ..These results highlight the importance of mda-9/syntenin as a key component of melanoma metastasis providing a rational molecular target for potentially intervening in the metastatic process...
  25. ncbi request reprint Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy
    Luni Emdad
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 210:549-59. 2007
    ..Our findings indicate that a combinatorial treatment with Ad.mda-7 and gefitinib may provide benefit in the treatment of NSCLC, especially in patients displaying resistance to clinically used EGFR inhibitors...
  26. pmc Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration
    Luni Emdad
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Pharmacol Ther 114:155-70. 2007
    ..In this review, we discuss the cloning, structure and function(s) of AEG-1 and provide recent insights into the diverse actions and intriguing properties of this molecule...
  27. ncbi request reprint Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells
    Zhaozhong Su
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 24:7552-66. 2005
    ....
  28. ncbi request reprint Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2
    Z Z Su
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 25:2339-48. 2006
    ....
  29. pmc Astrocyte elevated gene-1: a novel target for human glioma therapy
    Luni Emdad
    Departments of Neurosurgery and Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Mol Cancer Ther 9:79-88. 2010
    ..Taken together, these provocative results indicate that AEG-1 may play a crucial role in the pathogenesis of glioma and that AEG-1 could represent a viable potential target for malignant glioma therapy...
  30. ncbi request reprint mda-7 (IL-24): signaling and functional roles
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Biotechniques . 2002
    ..The present review examines the biological properties of mda-7 and the signaling pathways that contribute to its unique cancer-specific apoptosis-inducing properties...
  31. ncbi request reprint Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Semin Cancer Biol 13:169-78. 2003
    ..Although these approaches represent works in progress, future refinements will in all likelihood result in the next generation of cancer therapies...
  32. ncbi request reprint MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity
    Adly Yacoub
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Cancer Ther 2:623-32. 2003
    ..Collectively, these findings demonstrate that MDA-7 protein, in combination with agents that generate free radicals, may have potential in the treatment of RCC...
  33. ncbi request reprint Chemoprevention gene therapy (CGT): novel combinatorial approach for preventing and treating pancreatic cancer
    S Sarkar
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Curr Mol Med 13:1140-59. 2013
    ..This novel chemoprevention gene therapy (CGT) strategy holds promise for both prevention and treatment of pancreatic cancers where all other strategies have proven ineffective. ..
  34. ncbi request reprint Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35)
    D Sarkar
    Department of Pathology, Herbert Irving Comprehensive Caner Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Cell Death Differ 13:1541-53. 2006
    ..In these contexts, targeted overexpression of hPNPase(old-35) might be a novel therapeutic strategy for c-myc-overexpressing and IFN-resistant tumors, such as melanomas...
  35. ncbi request reprint Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways
    Moira Sauane
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    J Cell Physiol 196:334-45. 2003
    ..mda-7 induced apoptosis, might be tyrosine kinase independent and can thus be distinguished from its cytokine function related properties mediated by the IL-20/IL-22 receptor complexes that require JAK/STAT kinase activity...
  36. pmc MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism
    Margaret A Park
    Department of Biochemistry and Molecular Biology, Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Mol Cancer Ther 8:1280-91. 2009
    ..Our data show that in kidney cancer cells GST-MDA-7 induces ceramide-dependent activation of CD95, which is causal in promoting an endoplasmic reticulum stress response that activates multiple proapoptotic pathways to decrease survival...
  37. ncbi request reprint MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine
    Moira Sauane
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, BB 1501, 630 West 168th Street, New York, NY 10032, USA
    Cytokine Growth Factor Rev 14:35-51. 2003
    ..Various aspects of this intriguing molecule including its cytokine and anti-tumoral effects are described and discussed...
  38. ncbi request reprint Searching for a cure: gene therapy for glioblastoma
    Paul Dent
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:1335-40. 2008
    ..The concerted use of established and novel signal transduction modulatory agents on GBM survival may have potential to lower the apoptotic threshold and facilitate killing in this lethal malignancy...
  39. pmc Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity
    Paola M Barral
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA
    Pharmacol Ther 124:219-34. 2009
    ..We also consider the function of these cytoplasmic sensors in apoptosis, development and differentiation, and diabetes...
  40. pmc Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma
    Tom Van Maerken
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
    J Cell Physiol 219:707-15. 2009
    ..J. Cell. Physiol. 219: 707-715, 2009. (c) 2009 Wiley-Liss, Inc...
  41. pmc Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma
    Hossein A Hamed
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298 0035, USA
    Mol Ther 18:1130-42. 2010
    ..5/3-mda-7. Ad.5/3-mda-7 more effectively infected and killed GBM cells in vitro and in vivo than Ad.5-mda-7. Future combinations of these approaches hold promise for developing an effective therapy for GBM...
  42. pmc Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:14034-9. 2005
    ..Additionally, these studies support the potential use of mda-7/IL-24 in the therapy of malignant cancers...
  43. ncbi request reprint mda-9/Syntenin: a positive regulator of melanoma metastasis
    Habib Boukerche
    Department of Pathology, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 65:10901-11. 2005
    ..Based on its ability to directly alter metastasis, mda-9/syntenin provides a promising new focus for melanoma cancer research with potential therapeutic applications for metastatic diseases...
  44. pmc MDA-7/IL-24 as a cancer therapeutic: from bench to bedside
    Paul Dent
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, 23298 0035, USA
    Anticancer Drugs 21:725-31. 2010
    ..This review describes what is known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications...
  45. pmc The development of MDA-7/IL-24 as a cancer therapeutic
    Paul Dent
    Department of Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Pharmacol Ther 128:375-84. 2010
    ..This review describes what is presently known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications...
  46. pmc Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:7439-47. 2008
    ..Because both POH and Ad.mda-7 are being evaluated in clinical trials, combining a dietary agent and a virally delivered therapeutic cytokine provides an innovative approach for potentially treating human pancreatic cancer...
  47. ncbi request reprint Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic
    Rupesh Dash
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
    Discov Med 11:46-56. 2011
    ..These unique strategies for enhancing the efficacy of gene therapy provide a direct path to translation from the laboratory into the clinic for developing an effective gene therapy of prostate cancer...
  48. ncbi request reprint Eradication of therapy-resistant human prostate tumors using a cancer terminator virus
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 67:5434-42. 2007
    ..These provocative findings advocate potential therapeutic applications of this novel virus for advanced prostate cancer patients with metastatic disease...
  49. ncbi request reprint MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
    Cancer Biol Ther 7:917-33. 2008
    ....
  50. doi request reprint Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Mol Cancer Ther 7:2042-50. 2008
    ..This novel and innovative approach combining a dietary agent and a virally delivered therapeutic cytokine provides a means of both preventing and treating human pancreatic cancer with significant clinical translational potential...
  51. pmc mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src
    Habib Boukerche
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 105:15914-9. 2008
    ..These provocative findings highlight mda-9/syntenin and its interacting partners as promising therapeutic targets for intervention of metastasis...
  52. ncbi request reprint mda-7/IL-24: exploiting cancer's Achilles' heel
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Mol Ther 11:4-18. 2005
    ....
  53. pmc Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter
    Zhao Zhong Su
    Department of Pathology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:1059-64. 2005
    ....
  54. ncbi request reprint Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 63:8138-44. 2003
    ..mda-7 action. These studies present definitive evidence that changes in mitochondrial function and ROS production are key components associated with selective killing of prostate cancer cells by mda-7/IL-24...
  55. pmc mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine
    Pankaj Gupta
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, United States
    Pharmacol Ther 111:596-628. 2006
    ..This review highlights our current understanding of the diverse activities and properties of this novel cytokine, with potential to become a prominent gene therapy for cancer...
  56. ncbi request reprint Molecular target-based therapy of pancreatic cancer
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 66:2403-13. 2006
    ..Our study provides support for a "dual molecular targeted therapy" involving oncogene inhibition and selective cancer apoptosis-inducing gene expression with potential for effectively treating an invariably fatal cancer...
  57. ncbi request reprint Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?
    Devanand Sarkar
    Columbia University Medical Center, Department of Urology, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Expert Opin Biol Ther 7:577-86. 2007
    ..This review elaborates on the pleiotropic properties of mda-7/IL-24 and unravels novel aspects of the molecule mandating future studies and expanded clinical applications...
  58. ncbi request reprint BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis
    Pankaj Gupta
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Res 66:8182-91. 2006
    ....
  59. pmc Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
    Zao Zhong Su
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:1955-60. 2003
    ....
  60. pmc Molecular mechanism of chemoresistance by astrocyte elevated gene-1
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, and VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 70:3249-58. 2010
    ..e., translational and posttranslational regulation of proteins). Inhibition of AEG-1 might provide a means of more effectively using chemotherapy to treat HCC, which displays inherent chemoresistance with aggressive pathology...
  61. pmc Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Clin Invest 119:465-77. 2009
    ..Targeted inhibition of AEG1 might lead to the shutdown of key elemental characteristics of HCC and could lead to an effective therapeutic strategy for HCC...
  62. pmc Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Pharmacol 77:298-310. 2010
    ..Collectively, our data demonstrate that MDA-7/IL-24 induces an endoplasmic reticulum stress response that activates multiple proapoptotic pathways, culminating in decreased ovarian tumor cell survival...
  63. pmc Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24
    Sujit K Bhutia
    Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Cancer Res 70:3667-76. 2010
    ....
  64. pmc mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:10054-9. 2002
    ..These results support the hypothesis that Ad.mda-7 mediates induction of the GADD family of genes by means of the p38 MAPK pathway, thereby resulting in the selective induction of apoptosis in human melanoma cells...
  65. pmc PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells
    Adly Yacoub
    Department of Biochemistry and Molecular Biology, VCU Institute of Molecular Medicine, Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298 0035, USA
    Cancer Res 70:1120-9. 2010
    ..Our findings indicate that mda-7/IL-24 induces an endoplasmic reticulum stress response that triggers production of ceramide, Ca(2+), and ROS, which in turn promote glioma cell autophagy and cell death...
  66. pmc Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis
    Luni Emdad
    Department of Neurosurgery and Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 106:21300-5. 2009
    ..These findings suggest that AEG-1 may provide a viable target for directly suppressing the cancer phenotype...
  67. pmc Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis
    Moira Sauane
    Departments of Urology, Pathology, and Neurosurgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:9763-8. 2008
    ..Thus, our results clarify the molecular mechanism by which secreted MDA-7/IL-24 protein (generated from Ad.mda-7-infected cells) exerts cancer-specific killing...
  68. ncbi request reprint Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis
    Irina V Lebedeva
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 24:585-96. 2005
    ..These findings suggest a promising combinatorial approach for safely promoting cell death in pancreatic tumors that provides a rational framework for developing a selective and effective therapy for this invariably fatal cancer...
  69. ncbi request reprint Molecular mechanisms of aging-associated inflammation
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Lett 236:13-23. 2006
    ..In these contexts, inhibition of hPNPase(old-35) may represent a novel molecular target for intervening in aging-associated chronic diseases...
  70. pmc Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence
    Devanand Sarkar
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 25:7333-43. 2005
    ....
  71. pmc Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer
    Luni Emdad
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 208:298-306. 2006
    ..The present studies support the use of IR in combination with mda-7/IL-24 as a means of augmenting the therapeutic benefit of this gene in ovarian cancer, particularly in the context of tumors displaying resistance to radiation therapy...
  72. pmc Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
    Seok Geun Lee
    Department of Urology, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17390-5. 2006
    ....
  73. pmc Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma
    Paul B Fisher
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:300-7. 2007
    ..These results provide an impetus for further clinical studies and document a central paradigm of cancer therapy, namely translation of basic science from the "bench to the bedside."..
  74. pmc Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:3484-9. 2007
    ..These provocative findings suggest that this combinatorial strategy might provide a platform for developing effective treatments for therapy-resistant cancers...
  75. ncbi request reprint Unique conditionally replication competent bipartite adenoviruses-cancer terminator viruses (CTV): efficacious reagents for cancer gene therapy
    Devanand Sarkar
    Department of Pathology, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Cycle 5:1531-6. 2006
    ..These findings suggest that CTVs might prove efficacious for the therapy of primary and advanced neoplastic diseases...
  76. doi request reprint Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva
    Pankaj Gupta
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 215:827-36. 2008
    ..This approach highlights a potential new combinatorial strategy, which may prove beneficial for NSCLC patients with acquired resistance to EGFR inhibitors...
  77. pmc Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:297-313. 2008
    ....
  78. ncbi request reprint Melanoma differentiation associated gene-7/interleukin-24 reverses multidrug resistance in human colorectal cancer cells
    Luni Emdad
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Cancer Ther 6:2985-94. 2007
    ....
  79. ncbi request reprint mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review)
    Irina V Lebedeva
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Oncol 31:985-1007. 2007
    ..Additionally, an overview of the phase I clinical trial is provided. These studies affirm that mda-7/IL-24 has promise for the management of diverse cancers...
  80. ncbi request reprint Expression regulation and genomic organization of human polynucleotide phosphorylase, hPNPase(old-35), a Type I interferon inducible early response gene
    Magdalena Leszczyniecka
    Department of Pathology, College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Gene 316:143-56. 2003
    ....
  81. ncbi request reprint A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells
    Luiz F Zerbini
    BIDMC Genomics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 66:11922-31. 2006
    ..Our results establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells...
  82. ncbi request reprint Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude mice
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 65:9056-63. 2005
    ..The CTV provides a novel reagent for treating pancreatic and other human cancers with potential for eliminating both primary tumors and metastatic disease...
  83. ncbi request reprint Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1
    Dong Chul Kang
    Hallym University, Ilsong Institute of Life Science, 1605 4, Kwanyang dong, Anyang, Kyeonggi Do, Republic of Korea
    Gene 353:8-15. 2005
    ..In these contexts, an HIV-1-inducible gene, AEG-1, may contribute to multiple brain abnormalities, including HAD and tumor formation, by both common and distinct mechanisms...
  84. ncbi request reprint mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling
    Adly Yacoub
    Department of Radiatin Oncology, Virginia Commonwealth University Richmond, Virginia USA
    Cancer Biol Ther 2:347-53. 2003
    ..mda-7, whereas combined inhibition of both pathways enhanced cell killing, suggesting that ERK and PI3K signaling can be protective against MDA-7 lethality...
  85. ncbi request reprint Progression elevated gene-3 (PEG-3) induces pleiotropic effects on tumor progression: modulation of genomic stability and invasion
    Luni Emdad
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 202:135-46. 2005
    ..These findings demonstrate that PEG-3 plays a central role in augmenting tumor progression by modulating several critical parameters of the carcinogenic process, such as genomic stability and local tumor cell invasion...
  86. ncbi request reprint Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 64:7473-8. 2004
    ..Understanding the relationship between hPNPase(old-35) and inflammation and aging provides a unique opportunity to mechanistically comprehend and potentially intervene in these physiologically important processes...
  87. ncbi request reprint Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:24542-51. 2003
    ..Inhibition of hPNPaseold-35 by an antisense approach provided partial but significant protection against interferon-beta-mediated growth inhibition, thus demonstrating the biological significance of hPNPaseold-35 in interferon action...
  88. pmc Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes
    Seok Geun Lee
    Department of Urology, Neurosurgery, and Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 283:13116-23. 2008
    ..These findings suggest a mechanism for ceftriaxone modulation of glutamate transport and for its potential effects on ameliorating specific neurodegenerative diseases through modulation of extracellular glutamate...
  89. doi request reprint Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:314-29. 2008
    ....
  90. ncbi request reprint Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms
    Evan J Ryer
    Department of Surgery, Division of Vascular Surgery, New York Presbyterian Hospital and Weill Medical College, Cornell University, New York, New York 10021, USA
    J Biol Chem 280:35310-7. 2005
    ..Together, our data suggest that SMC apoptosis proceeds through a pathway that involves PKCdelta, the intermediary p38 MAPK, and the downstream target tumor suppressor p53...
  91. ncbi request reprint Human polynucleotide phosphorylase (hPNPase old-35): an RNA degradation enzyme with pleiotrophic biological effects
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Caner Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Cycle 5:1080-4. 2006
    ..The present review recaps these findings and provides a framework for the future understanding of the versatile functions of this interesting molecule...
  92. ncbi request reprint N-glycosylation of MDA-7/IL-24 is dispensable for tumor cell-specific apoptosis and "bystander" antitumor activity
    Moira Sauane
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer Res 66:11869-77. 2006
    ....
  93. doi request reprint Reciprocal subtraction differential RNA display (RSDD): an efficient technology for cloning differentially expressed genes
    Devanand Sarkar
    Department of Urology, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY, USA
    Methods Mol Biol 383:1-14. 2007
    ....
  94. ncbi request reprint Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression
    Isaac Chan
    College of Physicians and Surgeons, Columbia University Medical School, New York, New York, USA
    J Cell Physiol 215:401-9. 2008
    ....
  95. pmc Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence
    Magdalena Leszczyniecka
    Departments of Pathology, Urology, and Neurosurgery, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:16636-41. 2002
    ....

Research Grants2

  1. Analysis of a novel regulator of hepatocellular carcinoma
    Devanand Sarkar; Fiscal Year: 2010
    ..The proposed studies aim at understanding AEG-1 function by using a transgenic mouse model and analyzing AEG-1 interacting proteins and establishing AEG-1 as a diagnostic and prognostic marker for HCC. ..