A Sanyal

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint The impact of fat distribution on the severity of nonalcoholic fatty liver disease and metabolic syndrome
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Richmond, VA 23298, USA
    Hepatology 46:1091-100. 2007
  2. pmc Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 48:1810-20. 2008
  3. doi request reprint The etiology of hepatocellular carcinoma and consequences for treatment
    Arun J Sanyal
    Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Oncologist 15:14-22. 2010
  4. doi request reprint Population-based risk factors and resource utilization for HCC: US perspective
    A Sanyal
    Virginia Commonwealth University Healthcare System, Richmond, VA 23298 0341, USA
    Curr Med Res Opin 26:2183-91. 2010
  5. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
  6. doi request reprint Endpoints and clinical trial design for nonalcoholic steatohepatitis
    Arun J Sanyal
    Department of Gastroenterology, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 54:344-53. 2011
  7. ncbi request reprint A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
    Clin Gastroenterol Hepatol 2:1107-15. 2004
  8. ncbi request reprint The management of hepatorenal syndrome
    D E Carl
    Department of Medicine, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298 0160, USA
    Minerva Gastroenterol Dietol 55:207-26. 2009
  9. doi request reprint Abnormalities of lipid metabolism in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Semin Liver Dis 28:351-9. 2008
  10. ncbi request reprint Recent advances in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
    Curr Opin Gastroenterol 25:230-7. 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint The impact of fat distribution on the severity of nonalcoholic fatty liver disease and metabolic syndrome
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Richmond, VA 23298, USA
    Hepatology 46:1091-100. 2007
    ..However, DCL is most strongly associated with severity of steatohepatitis. WC and BMI added modestly to the contribution of DCL to severity of nonalcoholic steatohepatitis...
  2. pmc Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 48:1810-20. 2008
    ..Conclusions: NASH is associated with altered hepatic microRNA expression. Underexpression of miR-122 potentially contributes to altered lipid metabolism implicated in the pathogenesis of NASH...
  3. doi request reprint The etiology of hepatocellular carcinoma and consequences for treatment
    Arun J Sanyal
    Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Oncologist 15:14-22. 2010
    ....
  4. doi request reprint Population-based risk factors and resource utilization for HCC: US perspective
    A Sanyal
    Virginia Commonwealth University Healthcare System, Richmond, VA 23298 0341, USA
    Curr Med Res Opin 26:2183-91. 2010
    ..HCC cases in the United States (US) were identified from a claims database to analyze the risk factors, the health care provider referral patterns, and treatment options in actual (real-world) clinical settings...
  5. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
    ..Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease...
  6. doi request reprint Endpoints and clinical trial design for nonalcoholic steatohepatitis
    Arun J Sanyal
    Department of Gastroenterology, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 54:344-53. 2011
    ..These provide the rationale for developing consensus on key endpoints and clinical trial design for NASH...
  7. ncbi request reprint A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
    Clin Gastroenterol Hepatol 2:1107-15. 2004
    ....
  8. ncbi request reprint The management of hepatorenal syndrome
    D E Carl
    Department of Medicine, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298 0160, USA
    Minerva Gastroenterol Dietol 55:207-26. 2009
    ..This review will discuss new advances in the diagnosis and pathogenesis of HRS, with an emphasis on the management...
  9. doi request reprint Abnormalities of lipid metabolism in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Semin Liver Dis 28:351-9. 2008
    ..In this review, recent advances in the study of abnormal lipid metabolism and its impacts on histology and dysregulation of various cellular processes implicated in the genesis of NAFLD will be discussed...
  10. ncbi request reprint Recent advances in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
    Curr Opin Gastroenterol 25:230-7. 2009
    ..This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD)...
  11. ncbi request reprint Clinical aspects of fatty liver disease
    Jayanta Choudhury
    Division of Gastroenterology, Hepatology and Nutrition, Dept of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Semin Liver Dis 24:349-62. 2004
    ..Liver biopsy remains the gold standard for diagnosis as well as for grading and staging of the disease process but its precise role in the diagnostic conundrum continues to be debated...
  12. ncbi request reprint Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    Puneet Puri
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Gastroenterology 134:568-76. 2008
    ..The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology...
  13. ncbi request reprint Role of obesity, insulin resistance, and steatosis in hepatitis C virus infection
    Puneet Puri
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Health System, 1200 East Broad Street, Richmond, VA 23298, USA
    Clin Liver Dis 10:793-819. 2006
    ..Complex interplay between these conditions results in the ultimate phenotype of liver disease. This article focuses on the current understanding of host and viral interactions as well as on consequent clinical implications...
  14. ncbi request reprint A lipidomic analysis of nonalcoholic fatty liver disease
    Puneet Puri
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:1081-90. 2007
    ..The n-6:n-3 FFA ratio increased in NASH (P < 0.05). CONCLUSIONS: NAFLD is associated with numerous changes in the lipid composition of the liver. The potential implications are discussed...
  15. doi request reprint A decision analysis study of the value of a liver biopsy in nonalcoholic steatohepatitis
    Jill K J Gaidos
    Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 28:650-8. 2008
    ..Liver biopsy (LB) is the only way to determine the severity of disease. However, LB is invasive, has complications and financial costs. The aim of this study is to determine the benefits of early LB for diagnosis and early treatment...
  16. pmc Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Hepatology 47:1118-27. 2008
    ..Although we did identify genotype 3, increased BMI, and diabetes as risk factors, we found no independent association with antiretroviral therapy...
  17. ncbi request reprint Role of microRNAs in non-alcoholic steatohepatitis
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Dept of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Curr Pharm Des 16:1952-7. 2010
    ..It is hoped that further understanding of the role of microRNA in NAFLD will advance potential therapeutics and preventive measures to modify and alter this disease process...
  18. doi request reprint Recent advances in nonalcholic fatty liver disease
    Victoria Greenfield
    Divisoipn of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Curr Opin Gastroenterol 24:320-7. 2008
    ..The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease...
  19. ncbi request reprint Hepatitis C and nonalcoholic fatty liver disease
    Seela Ramesh
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Semin Liver Dis 24:399-413. 2004
    ..In this article, we will review the epidemiology of HCV and NAFLD, their impact on each other, and the course of the liver disease in individuals afflicted with both conditions...
  20. ncbi request reprint Evaluation and management of non-alcoholic steatohepatitis
    B Marie Reid
    Division of Gastroenterology, Hepatology and Nutrition, Dept of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    Eur J Gastroenterol Hepatol 16:1117-22. 2004
    ..The goals of treatment include (1) correction of the underlying risk factors, (2) avoidance of factors that promote progression of liver disease, and (3) specific treatment of non-alcoholic steatohepatitis...
  21. ncbi request reprint Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease
    Jayanta Choudhury
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Box 980711 Richmond, VA 23298 0711, USA
    Clin Liver Dis 8:575-94, ix. 2004
    ..It is now universally accepted that insulin resistance and subsequent hyperinsulinemia are key factors that lead to both NAFL and NASH.This article reviews the role of insulin resistance in the genesis of these conditions...
  22. ncbi request reprint The metabolic abnormalities associated with non-alcoholic fatty liver disease
    Mahmadul Haque
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, MCV Box 980711, Richmond, VA 23298 0711, USA
    Best Pract Res Clin Gastroenterol 16:709-31. 2002
    ..While much work remains to be done, the current understanding of the pathogenesis of NAFLD provides direction for both future investigation and development of therapeutic trials...
  23. ncbi request reprint AGA technical review on nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine Virginia Commonwealth University Medical College of Virginia Richmond, Virginia, USA
    Gastroenterology 123:1705-25. 2002
  24. ncbi request reprint The clinicopathologic spectrum and management of nonalcoholic fatty liver disease
    Melissa J Contos
    Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    Adv Anat Pathol 9:37-51. 2002
    ..The clinical and histologic features of NASH are described, and an approach to the diagnosis and treatment of NAFLD is provided...
  25. ncbi request reprint Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome
    Arun J Sanyal
    Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Am J Gastroenterol 98:2064-71. 2003
    ....
  26. ncbi request reprint The North American Study for the Treatment of Refractory Ascites
    Arun J Sanyal
    Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastroenterology 124:634-41. 2003
    ..The clinical utility of transjugular intrahepatic portosystemic shunts (TIPS) vis-à-vis total paracentesis in the management of refractory ascites is unclear...
  27. ncbi request reprint The clinical spectrum of hepatitis C virus in HIV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Richmond, Virginia, USA
    J Acquir Immune Defic Syndr 32:30-7. 2003
    ..The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity...
  28. ncbi request reprint Drug-induced steatohepatitis
    R Todd Stravitz
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, 1200 East Broad Street, Room 1496, Richmond, VA 23298, USA
    Clin Liver Dis 7:435-51. 2003
    ..Further research should determine the mechanisms by which drug-induced steatosis, a benign lesion, evolves to steatohepatitis and progressive fibrosis...
  29. pmc Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease
    Amy G Shah
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:1104-12. 2009
    ..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
  30. doi request reprint Endoplasmic reticulum stress and the unfolded protein response
    Ashwani Kapoor
    Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, 1200 East Broad Street, MCV Box 980341, Richmond, VA 23298 0341, USA
    Clin Liver Dis 13:581-90. 2009
    ..This article reviews the pathways by which the UPR unfolds and its potential role in the development and progression of NAFLD...
  31. ncbi request reprint Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ....
  32. doi request reprint Recent advances in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Curr Opin Gastroenterol 26:202-8. 2010
    ..This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD)...
  33. ncbi request reprint Treatment of non-alcoholic fatty liver disease
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Virginia, USA
    J Gastroenterol Hepatol 17:S385-8. 2002
  34. doi request reprint Hepatitis C infection and nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Clin Liver Dis 12:573-85, viii-ix. 2008
    ..This article focuses on the current understanding of the interplay between host and viral factors that are involved in the interaction between NAFLD and HCV...
  35. pmc A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
    Gastroenterology 134:1360-8. 2008
    ..The aim of this study was to evaluate the efficacy and safety of terlipressin, a systemic arterial vasoconstrictor, for cirrhosis type 1 HRS...
  36. ncbi request reprint Nonalcoholic fatty liver disease
    Pouneh S Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical College of Virginia, Richmond, USA
    MedGenMed 5:14. 2003
  37. ncbi request reprint Evaluation and management of non-alcoholic steatohepatitis
    Seela Ramesh
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    J Hepatol 42:S2-12. 2005
  38. ncbi request reprint Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Nat Clin Pract Gastroenterol Hepatol 2:46-53. 2005
    ..The pathogenesis of cytologic ballooning and Mallory body formation and their role in NAFLD remain to be defined. In addition, inflammation and fibrosis are likely to be secondary to hepatocyte injury and death...
  39. ncbi request reprint Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    Arun J Sanyal
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Hepatology 43:682-9. 2006
    ..It is also associated with a lower rate of development of ascites, hyperbilirubinemia, and hepatocellular carcinoma. However, cardiovascular mortality is greater in patients with NASH...
  40. ncbi request reprint Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cells
    Jayanta Choudhury
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Metabolism 55:1317-22. 2006
    ..At these concentrations, leptin does not affect MMP-1 or TIMP-1 expression or collagenolytic activity of HSC...
  41. ncbi request reprint The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis
    Arun J Sanyal
    Division of Gastroenterology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastrointest Endosc 64:855-64. 2006
    ..The factors predictive of the presence or the absence of esophageal varices in hepatitis C virus (HCV) and advanced fibrosis have not been defined...
  42. ncbi request reprint Sepsis-induced cholestasis
    Nisha Chand
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Hepatology 45:230-41. 2007
  43. ncbi request reprint Treatment of chronic hepatitis C virus in African Americans with genotypes 2 and 3
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Am J Gastroenterol 102:761-6. 2007
    ..These results suggest that African Americans have a global defect in their ability to eradicate HCV infection following treatment with interferon and ribavirin which transcends across all genotypes...
  44. ncbi request reprint A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantation
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Transpl 13:975-83. 2007
    ..However, complications associated with sepsis, not recurrent cirrhosis, was the most common cause of death in patients with recurrent HCV and this was similar in patients with or without advanced fibrosis...
  45. ncbi request reprint The histologic spectrum of nonalcoholic fatty liver disease
    Melissa J Contos
    Department of Pathology, Virginia Commonwealth University, Box 980662, Richmond, VA 23298, USA
    Clin Liver Dis 8:481-500, vii. 2004
    ..This article provides an understanding of the histologic features of NAFLD and the potential pitfalls in the histologic assessment of this condition...
  46. ncbi request reprint The spectrum of chronic hepatitis C virus infection in the Virginia Correctional System: development of a strategy for the evaluation and treatment of inmates with HCV
    Richard K Sterling
    Hepatology Section and Division of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia
    Am J Gastroenterol 100:313-21. 2005
    ..Our objective was to develop an economic strategy for evaluation and treatment of inmates with chronic HCV...
  47. ncbi request reprint A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African Americans
    Richard K Sterling
    Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
    Clin Gastroenterol Hepatol 2:469-73. 2004
    ..Differences in hepatitis C virus (HCV)-related liver disease between Caucasians and African Americans remain controversial...
  48. ncbi request reprint Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfection
    Richard K Sterling
    Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
    Clin Gastroenterol Hepatol 2:432-9. 2004
    ....
  49. doi request reprint The plasma lipidomic signature of nonalcoholic steatohepatitis
    Puneet Puri
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 50:1827-38. 2009
    ..Conclusions: Although increased lipogenesis, desaturases, and LOX activities characterize NAFL and NASH, impaired peroxisomal polyunsaturated fatty acid (PUFA) metabolism and nonenzymatic oxidation is associated with progression to NASH...