Research Topics
| A SanyalSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
| Collaborators
|
Detail Information
Publications
The impact of fat distribution on the severity of nonalcoholic fatty liver disease and metabolic syndromeOnpan Cheung
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Richmond, VA 23298, USA
Hepatology 46:1091-100. 2007..However, DCL is most strongly associated with severity of steatohepatitis. WC and BMI added modestly to the contribution of DCL to severity of nonalcoholic steatohepatitis...
Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expressionOnpan Cheung
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
Hepatology 48:1810-20. 2008..Conclusions: NASH is associated with altered hepatic microRNA expression. Underexpression of miR-122 potentially contributes to altered lipid metabolism implicated in the pathogenesis of NASH...
The etiology of hepatocellular carcinoma and consequences for treatmentArun J Sanyal
Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
Oncologist 15:14-22. 2010....- Population-based risk factors and resource utilization for HCC: US perspectiveA Sanyal
Virginia Commonwealth University Healthcare System, Richmond, VA 23298 0341, USA
Curr Med Res Opin 26:2183-91. 2010..HCC cases in the United States (US) were identified from a claims database to analyze the risk factors, the health care provider referral patterns, and treatment options in actual (real-world) clinical settings... - Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisArun J Sanyal
Virginia Commonwealth University, Richmond, USA
N Engl J Med 362:1675-85. 2010..Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease... - Endpoints and clinical trial design for nonalcoholic steatohepatitisArun J Sanyal
Department of Gastroenterology, Virginia Commonwealth University, Richmond, VA, USA
Hepatology 54:344-53. 2011.... - A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitisArun J Sanyal
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
Clin Gastroenterol Hepatol 2:1107-15. 2004.... - The management of hepatorenal syndromeD E Carl
Department of Medicine, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298 0160, USA
Minerva Gastroenterol Dietol 55:207-26. 2009..This review will discuss new advances in the diagnosis and pathogenesis of HRS, with an emphasis on the management... - Abnormalities of lipid metabolism in nonalcoholic fatty liver diseaseOnpan Cheung
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
Semin Liver Dis 28:351-9. 2008..In this review, recent advances in the study of abnormal lipid metabolism and its impacts on histology and dysregulation of various cellular processes implicated in the genesis of NAFLD will be discussed... - Recent advances in nonalcoholic fatty liver diseaseOnpan Cheung
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
Curr Opin Gastroenterol 25:230-7. 2009..This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD)... - Clinical aspects of fatty liver diseaseJayanta Choudhury
Division of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
Semin Liver Dis 24:349-62. 2004..Liver biopsy remains the gold standard for diagnosis as well as for grading and staging of the disease process but its precise role in the diagnostic conundrum continues to be debated... - Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseasePuneet Puri
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
Gastroenterology 134:568-76. 2008..The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology... - Role of obesity, insulin resistance, and steatosis in hepatitis C virus infectionPuneet Puri
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Health System, 1200 East Broad Street, Richmond, VA 23298, USA
Clin Liver Dis 10:793-819. 2006..Complex interplay between these conditions results in the ultimate phenotype of liver disease. This article focuses on the current understanding of host and viral interactions as well as on consequent clinical implications... - A lipidomic analysis of nonalcoholic fatty liver diseasePuneet Puri
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Hepatology 46:1081-90. 2007..The n-6:n-3 FFA ratio increased in NASH (P < 0.05). CONCLUSIONS: NAFLD is associated with numerous changes in the lipid composition of the liver. The potential implications are discussed... - A decision analysis study of the value of a liver biopsy in nonalcoholic steatohepatitisJill K J Gaidos
Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
Liver Int 28:650-8. 2008..Liver biopsy (LB) is the only way to determine the severity of disease. However, LB is invasive, has complications and financial costs. The aim of this study is to determine the benefits of early LB for diagnosis and early treatment... - Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfectionRichard K Sterling
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
Hepatology 47:1118-27. 2008..Although we did identify genotype 3, increased BMI, and diabetes as risk factors, we found no independent association with antiretroviral therapy... - Role of microRNAs in non-alcoholic steatohepatitisOnpan Cheung
Division of Gastroenterology, Hepatology and Nutrition, Dept of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Curr Pharm Des 16:1952-7. 2010..It is hoped that further understanding of the role of microRNA in NAFLD will advance potential therapeutics and preventive measures to modify and alter this disease process... - Recent advances in nonalcholic fatty liver diseaseVictoria Greenfield
Divisoipn of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Curr Opin Gastroenterol 24:320-7. 2008..The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease... - Hepatitis C and nonalcoholic fatty liver diseaseSeela Ramesh
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Semin Liver Dis 24:399-413. 2004..In this article, we will review the epidemiology of HCV and NAFLD, their impact on each other, and the course of the liver disease in individuals afflicted with both conditions... - Evaluation and management of non-alcoholic steatohepatitisB Marie Reid
Division of Gastroenterology, Hepatology and Nutrition, Dept of Internal Medicine, Virginia Commonwealth University, Richmond, USA
Eur J Gastroenterol Hepatol 16:1117-22. 2004..The goals of treatment include (1) correction of the underlying risk factors, (2) avoidance of factors that promote progression of liver disease, and (3) specific treatment of non-alcoholic steatohepatitis... - Insulin resistance and the pathogenesis of nonalcoholic fatty liver diseaseJayanta Choudhury
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Box 980711 Richmond, VA 23298-0711, USA
Clin Liver Dis 8:575-94, ix. 2004..It is now universally accepted that insulin resistance and subsequent hyperinsulinemia are key factors that lead to both NAFL and NASH.This article reviews the role of insulin resistance in the genesis of these conditions... - The metabolic abnormalities associated with non-alcoholic fatty liver diseaseMahmadul Haque
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, MCV Box 980711, Richmond, VA 23298-0711, USA
Best Pract Res Clin Gastroenterol 16:709-31. 2002..While much work remains to be done, the current understanding of the pathogenesis of NAFLD provides direction for both future investigation and development of therapeutic trials... - AGA technical review on nonalcoholic fatty liver diseaseArun J Sanyal
Department of Internal Medicine Virginia Commonwealth University Medical College of Virginia Richmond, Virginia, USA
Gastroenterology 123:1705-25. 2002 - The clinicopathologic spectrum and management of nonalcoholic fatty liver diseaseMelissa J Contos
Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
Adv Anat Pathol 9:37-51. 2002..The clinical and histologic features of NASH are described, and an approach to the diagnosis and treatment of NAFLD is provided... - Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndromeArun J Sanyal
Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
Am J Gastroenterol 98:2064-71. 2003..Advanced fibrosis in such patients is related to weight, presence of diabetes, and presence and degree of cytological ballooning... - The North American Study for the Treatment of Refractory AscitesArun J Sanyal
Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia, USA
Gastroenterology 124:634-41. 2003..The clinical utility of transjugular intrahepatic portosystemic shunts (TIPS) vis-à-vis total paracentesis in the management of refractory ascites is unclear... - The clinical spectrum of hepatitis C virus in HIV coinfectionRichard K Sterling
Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Richmond, Virginia, USA
J Acquir Immune Defic Syndr 32:30-7. 2003..The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity... - Drug-induced steatohepatitisR Todd Stravitz
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, 1200 East Broad Street, Room 1496, Richmond, VA 23298, USA
Clin Liver Dis 7:435-51. 2003..Further research should determine the mechanisms by which drug-induced steatosis, a benign lesion, evolves to steatohepatitis and progressive fibrosis... - Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver diseaseAmy G Shah
Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Clin Gastroenterol Hepatol 7:1104-12. 2009..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD... - Endoplasmic reticulum stress and the unfolded protein responseAshwani Kapoor
Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, 1200 East Broad Street, MCV Box 980341, Richmond, VA 23298 0341, USA
Clin Liver Dis 13:581-90. 2009..This article reviews the pathways by which the UPR unfolds and its potential role in the development and progression of NAFLD... - Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT valuesPouneh Mofrad
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
Hepatology 37:1286-92. 2003.... - Recent advances in nonalcoholic fatty liver diseaseOnpan Cheung
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
Curr Opin Gastroenterol 26:202-8. 2010..This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD)... - Treatment of non-alcoholic fatty liver diseaseArun J Sanyal
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Health System-Medical College of Virginia Hospitals, Virginia, USA
J Gastroenterol Hepatol 17:S385-8. 2002 - Hepatitis C infection and nonalcoholic fatty liver diseaseOnpan Cheung
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Clin Liver Dis 12:573-85, viii-ix. 2008..This article focuses on the current understanding of the interplay between host and viral factors that are involved in the interaction between NAFLD and HCV... - A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndromeArun J Sanyal
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
Gastroenterology 134:1360-8. 2008..The aim of this study was to evaluate the efficacy and safety of terlipressin, a systemic arterial vasoconstrictor, for cirrhosis type 1 HRS... - Nonalcoholic fatty liver diseasePouneh S Mofrad
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University-Medical College of Virginia, Richmond, USA
MedGenMed 5:14. 2003 - Evaluation and management of non-alcoholic steatohepatitisSeela Ramesh
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
J Hepatol 42:S2-12. 2005 - Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver diseaseArun J Sanyal
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
Nat Clin Pract Gastroenterol Hepatol 2:46-53. 2005..The pathogenesis of cytologic ballooning and Mallory body formation and their role in NAFLD remain to be defined. In addition, inflammation and fibrosis are likely to be secondary to hepatocyte injury and death... - Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis CArun J Sanyal
Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
Hepatology 43:682-9. 2006..It is also associated with a lower rate of development of ascites, hyperbilirubinemia, and hepatocellular carcinoma. However, cardiovascular mortality is greater in patients with NASH... - Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cellsJayanta Choudhury
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
Metabolism 55:1317-22. 2006..At these concentrations, leptin does not affect MMP-1 or TIMP-1 expression or collagenolytic activity of HSC... - The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosisArun J Sanyal
Division of Gastroenterology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
Gastrointest Endosc 64:855-64. 2006..758). CONCLUSIONS: The risk of having varices increases with decreasing platelet counts, increasing bilirubin, and INR. The probability of having medium or large varices at platelet counts >150,000/mm(3) is negligible in this population... - Sepsis-induced cholestasisNisha Chand
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0341, USA
Hepatology 45:230-41. 2007 - Treatment of chronic hepatitis C virus in African Americans with genotypes 2 and 3Mitchell L Shiffman
Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
Am J Gastroenterol 102:761-6. 2007..These results suggest that African Americans have a global defect in their ability to eradicate HCV infection following treatment with interferon and ribavirin which transcends across all genotypes... - A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantationNevin Yilmaz
Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
Liver Transpl 13:975-83. 2007..However, complications associated with sepsis, not recurrent cirrhosis, was the most common cause of death in patients with recurrent HCV and this was similar in patients with or without advanced fibrosis... - The histologic spectrum of nonalcoholic fatty liver diseaseMelissa J Contos
Department of Pathology, Virginia Commonwealth University, Box 980662, Richmond, VA 23298, USA
Clin Liver Dis 8:481-500, vii. 2004..This article provides an understanding of the histologic features of NAFLD and the potential pitfalls in the histologic assessment of this condition... - The spectrum of chronic hepatitis C virus infection in the Virginia Correctional System: development of a strategy for the evaluation and treatment of inmates with HCVRichard K Sterling
Hepatology Section and Division of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia
Am J Gastroenterol 100:313-21. 2005.... - A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African AmericansRichard K Sterling
Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
Clin Gastroenterol Hepatol 2:469-73. 2004..Differences in hepatitis C virus (HCV)-related liver disease between Caucasians and African Americans remain controversial... - Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfectionRichard K Sterling
Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
Clin Gastroenterol Hepatol 2:432-9. 2004.... - The plasma lipidomic signature of nonalcoholic steatohepatitisPuneet Puri
Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
Hepatology 50:1827-38. 2009..Conclusions: Although increased lipogenesis, desaturases, and LOX activities characterize NAFL and NASH, impaired peroxisomal polyunsaturated fatty acid (PUFA) metabolism and nonenzymatic oxidation is associated with progression to NASH...