A J Sanyal

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Hepatorenal syndrome
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0341, USA
    J Gastroenterol Hepatol 17:S248-52. 2002
  2. ncbi A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
    Clin Gastroenterol Hepatol 2:1107-15. 2004
  3. ncbi Review article: non-alcoholic fatty liver disease and hepatitis C--risk factors and clinical implications
    A J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Health System, Richmond, VA 23298 0711, USA
    Aliment Pharmacol Ther 22:48-51. 2005
  4. ncbi Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Nat Clin Pract Gastroenterol Hepatol 2:46-53. 2005
  5. ncbi Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    Arun J Sanyal
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Hepatology 43:682-9. 2006
  6. ncbi The North American Study for the Treatment of Refractory Ascites
    Arun J Sanyal
    Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastroenterology 124:634-41. 2003
  7. ncbi Treatment of non-alcoholic fatty liver disease
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Health System-Medical College of Virginia Hospitals, Virginia, USA
    J Gastroenterol Hepatol 17:S385-8. 2002
  8. ncbi Role of insulin resistance and hepatic steatosis in the progression of fibrosis and response to treatment in hepatitis C
    Arun J Sanyal
    Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Liver Int 31:23-8. 2011
  9. ncbi Portal hypertension and its complications
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Gastroenterology 134:1715-28. 2008
  10. ncbi The use and misuse of transjugular intrahepatic portasystemic shunts
    A J Sanyal
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical College of Virginia Campus of the Virginia Commonwealth University, MCV Box 980341, Richmond, VA 23298 0341, USA
    Curr Gastroenterol Rep 2:61-71. 2000

Research Grants

  1. CLINICAL STUDIES OF NONALCOHOLIC STEATOHEPATITIS
    Arun Sanyal; Fiscal Year: 2007
  2. Studies of Mechanisms and Treatment of Liver Diseases
    Arun Sanyal; Fiscal Year: 2007
  3. Biliary Microlithiasis in Alcohol Induced Pancreatitis
    Arun Sanyal; Fiscal Year: 2007
  4. Training Grant in Digestive Diseases and Liver Diseases
    Arun Sanyal; Fiscal Year: 2007

Detail Information

Publications104 found, 100 shown here

  1. ncbi Hepatorenal syndrome
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0341, USA
    J Gastroenterol Hepatol 17:S248-52. 2002
  2. ncbi A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Comonwealth University Medical Center, Richmond, VA 23298 0711, USA
    Clin Gastroenterol Hepatol 2:1107-15. 2004
    ....
  3. ncbi Review article: non-alcoholic fatty liver disease and hepatitis C--risk factors and clinical implications
    A J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Health System, Richmond, VA 23298 0711, USA
    Aliment Pharmacol Ther 22:48-51. 2005
    ..Subjects with hepatitis C and NAFLD are more likely to be virologic nonresponders following anti-HCV therapy. The value of treating insulin resistance and NAFLD prior to antiviral therapy remains to be experimentally verified...
  4. ncbi Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Nat Clin Pract Gastroenterol Hepatol 2:46-53. 2005
    ..The pathogenesis of cytologic ballooning and Mallory body formation and their role in NAFLD remain to be defined. In addition, inflammation and fibrosis are likely to be secondary to hepatocyte injury and death...
  5. ncbi Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    Arun J Sanyal
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Hepatology 43:682-9. 2006
    ..It is also associated with a lower rate of development of ascites, hyperbilirubinemia, and hepatocellular carcinoma. However, cardiovascular mortality is greater in patients with NASH...
  6. ncbi The North American Study for the Treatment of Refractory Ascites
    Arun J Sanyal
    Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastroenterology 124:634-41. 2003
    ..The clinical utility of transjugular intrahepatic portosystemic shunts (TIPS) vis-à-vis total paracentesis in the management of refractory ascites is unclear...
  7. ncbi Treatment of non-alcoholic fatty liver disease
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Health System-Medical College of Virginia Hospitals, Virginia, USA
    J Gastroenterol Hepatol 17:S385-8. 2002
  8. ncbi Role of insulin resistance and hepatic steatosis in the progression of fibrosis and response to treatment in hepatitis C
    Arun J Sanyal
    Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0341, USA
    Liver Int 31:23-8. 2011
    ..Newer efforts focused on the role of specific micro RNAs in mediating the metabolic effects of hepatitis C virus infection may provide to ameliorate the metabolic risks of HCV infection...
  9. ncbi Portal hypertension and its complications
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Gastroenterology 134:1715-28. 2008
  10. ncbi The use and misuse of transjugular intrahepatic portasystemic shunts
    A J Sanyal
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical College of Virginia Campus of the Virginia Commonwealth University, MCV Box 980341, Richmond, VA 23298 0341, USA
    Curr Gastroenterol Rep 2:61-71. 2000
    ..Also reviewed herein is the management of patients after TIPS placement...
  11. ncbi Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    A J Sanyal
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia 23298 0711, USA
    Gastroenterology 120:1183-92. 2001
    ....
  12. ncbi A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome
    Arun J Sanyal
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
    Gastroenterology 134:1360-8. 2008
    ..The aim of this study was to evaluate the efficacy and safety of terlipressin, a systemic arterial vasoconstrictor, for cirrhosis type 1 HRS...
  13. ncbi A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia
    M L Shiffman
    Hepatology Section, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA
    Gastroenterology 117:1164-72. 1999
    ..Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histological progression in this subset of nonresponders...
  14. ncbi Modified-orientation log to assess hepatic encephalopathy
    M Salam
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, USA
    Aliment Pharmacol Ther 35:913-20. 2012
    ..The new HE classification has emphasised assessment of orientation. The modified-orientation log (MO-log, eight questions, scores 0-24; 24 normal) is adapted from a validated brain injury measure...
  15. ncbi Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy
    M L Shiffman
    Hepatology Section, Medical College of Virginia Commonwealth University, Richmond, VA 23298, USA
    J Infect Dis 182:1595-601. 2000
    ..Persons with chronic HCV infection and persistently normal serum ALT levels have milder liver disease than, and respond to IFN therapy similarly to, persons with elevated ALT levels...
  16. ncbi A randomized, controlled trial to determine whether continued ribavirin monotherapy in hepatitis C virus-infected patients who responded to interferon-ribavirin combination therapy will enhance sustained virologic response
    M L Shiffman
    Hepatology Section, Medical College of Virginia Commonwealth University, Richmond, VA 23298, USA
    J Infect Dis 184:405-9. 2001
    ..56%) and in patients with a virus titer < 2 x 10(6) copies/mL (93% vs. 43%). The results indicate that continuing ribavirin monotherapy after achieving a virologic response does not improve sustained virologic response...
  17. ncbi Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis
    M J Contos
    Department of Pathology, Division of Gastroenterology/Hepatology/Nutrition, Virginia Commonwealth University-Medical College of Virginia, Richmond, VA, USA
    Liver Transpl 7:363-73. 2001
    ..Despite the frequent histological recurrence of disease, clinical outcomes are similar to those of other groups of patients undergoing OLT...
  18. ncbi Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
    ..Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease...
  19. ncbi A prospective evaluation of fibrosis progression in patients with recurrent hepatitis C virus following liver transplantation
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Transpl 13:975-83. 2007
    ..However, complications associated with sepsis, not recurrent cirrhosis, was the most common cause of death in patients with recurrent HCV and this was similar in patients with or without advanced fibrosis...
  20. ncbi Treatment of chronic hepatitis C virus in the virginia department of corrections: can compliance overcome racial differences to response?
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298 0341, USA
    Am J Gastroenterol 99:866-72. 2004
    ..The present study describes our experience of treating HCV in the inmate population of the Virginia Department of Corrections...
  21. ncbi Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis
    Heather M Patton
    Division of Gastroenterology, University of California, San Diego, San Diego, California 92103, USA
    Gastroenterology 135:1961-1971.e2. 2008
    ..Noninvasive means to discriminate between NAFLD and nonalcoholic steatohepatitis (NASH) might diminish the requirement for liver biopsy or predict those at increased risk for progression...
  22. ncbi Esophageal varices. II. TIPS (transjugular intrahepatic portosystemic shunt) and surgical therapy
    V A Luketic
    Department of Medicine, Medical College of Virginia Commonwealth University, Richmond, USA
    Gastroenterol Clin North Am 29:387-421, vi. 2000
    ..The effects of TIPS on portal and systemic hemodynamics and clinical usefulness in the management of variceal hemorrhage are discussed. A treatment algorithm for the integrated use of the various treatments is provided...
  23. ncbi Primary sclerosing cholangitis: evaluation with MR cholangiography-a case-control study
    A S Fulcher
    Department of Radiology, Medical College of Virginia of Virginia Commonwealth University, Main Hospital, Richmond, VA 23298, USA
    Radiology 215:71-80. 2000
    ..To determine the accuracy of magnetic resonance (MR) cholangiography for detection of primary sclerosing cholangitis (PSC) and localization of PSC in the biliary tract...
  24. ncbi The spectrum of chronic hepatitis C virus infection in the Virginia Correctional System: development of a strategy for the evaluation and treatment of inmates with HCV
    Richard K Sterling
    Hepatology Section and Division of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia
    Am J Gastroenterol 100:313-21. 2005
    ....
  25. ncbi The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis
    Arun J Sanyal
    Division of Gastroenterology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastrointest Endosc 64:855-64. 2006
    ..758). CONCLUSIONS: The risk of having varices increases with decreasing platelet counts, increasing bilirubin, and INR. The probability of having medium or large varices at platelet counts >150,000/mm(3) is negligible in this population...
  26. ncbi PROMIS computerised adaptive tests are dynamic instruments to measure health-related quality of life in patients with cirrhosis
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, 23249, USA
    Aliment Pharmacol Ther 34:1123-32. 2011
    ..CAT presents five to seven questions/domain depending on the patient's response, from large validated question banks. This provides brevity and precision equivalent to the entire question bank...
  27. ncbi Esophageal varices. I. Clinical presentation, medical therapy, and endoscopic therapy
    V A Luketic
    Department of Medicine, Medical College of Virginia Commonwealth University, Richmond, USA
    Gastroenterol Clin North Am 29:337-85. 2000
    ..The use of these agents in a given patient must be based on an understanding of the stage in the natural history of the disease and the relative efficacy and safety of the available treatment options...
  28. ncbi Percutaneous liver biopsy in adult haemophiliacs with hepatitis C virus: safety of outpatient procedure and impact of human immunodeficiency virus coinfection on the spectrum of liver disease
    R K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, VA 23298, USA
    Haemophilia 13:164-71. 2007
    ..These data support the hypothesis that HIV accelerates fibrosis progression in those coinfected with HCV and highlights the importance of liver histology in this population...
  29. ncbi A prospective, randomized-controlled pilot study of ursodeoxycholic acid combined with mycophenolate mofetil in the treatment of primary sclerosing cholangitis
    R K Sterling
    Division of Gastroenterology and Hepatology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Aliment Pharmacol Ther 20:943-9. 2004
    ..Mycophenolate mofetil is a potent immunosuppressant that is now widely used in organ transplantation...
  30. ncbi Clinical aspects of fatty liver disease
    Jayanta Choudhury
    Division of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Semin Liver Dis 24:349-62. 2004
    ..Liver biopsy remains the gold standard for diagnosis as well as for grading and staging of the disease process but its precise role in the diagnostic conundrum continues to be debated...
  31. ncbi Treatment of chronic hepatitis C virus in African Americans with genotypes 2 and 3
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    Am J Gastroenterol 102:761-6. 2007
    ..These results suggest that African Americans have a global defect in their ability to eradicate HCV infection following treatment with interferon and ribavirin which transcends across all genotypes...
  32. ncbi A lipidomic analysis of nonalcoholic fatty liver disease
    Puneet Puri
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:1081-90. 2007
    ..The n-6:n-3 FFA ratio increased in NASH (P < 0.05). CONCLUSIONS: NAFLD is associated with numerous changes in the lipid composition of the liver. The potential implications are discussed...
  33. ncbi Endothelial cells lining transjugular intrahepatic portasystemic shunts originate in hepatic sinusoids: implications for pseudointimal hyperplasia
    A J Sanyal
    Department of Internal Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298 0711, USA
    Hepatology 29:710-8. 1999
    ..These data indicate that TIPS pseudointima are lined by hepatic sinusoidal endothelial cells, which stimulate pseudointima formation by increasing SMC migration and proliferation...
  34. ncbi Minimizing ascites. Complication of cirrhosis signals clinical deterioration
    N Garcia
    Division of Gastroenterology, Virginia Commonwealth University School of Medicine, Sanger Hall, Room B3-040, PO Box 980711, Richmond, VA 23298-0711, USA
    Postgrad Med 109:91-6, 101-3. 2001
    ..Early recognition of these complications allows therapeutic interventions that minimize further clinical deterioration in already chronically ill patients...
  35. ncbi Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial
    Robert J Fontana
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 101:983-92. 2006
    ..The clinical relevance of these findings will be further explored during the randomized phase of the HALT-C study...
  36. ncbi Ascites: diagnosis and management
    Wei Hou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, MCV Box 980341, Richmond, VA 23298 0341, USA
    Med Clin North Am 93:801-17, vii. 2009
    ..These include repeated large volume paracentesis and transjugular intrahepatic portosystemic shunts. This review article summarizes diagnostic tools and provides an evidence-based approach to the management of ascites...
  37. ncbi The impact of fat distribution on the severity of nonalcoholic fatty liver disease and metabolic syndrome
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Richmond, VA 23298, USA
    Hepatology 46:1091-100. 2007
    ..However, DCL is most strongly associated with severity of steatohepatitis. WC and BMI added modestly to the contribution of DCL to severity of nonalcoholic steatohepatitis...
  38. ncbi Hepatitis C and nonalcoholic fatty liver disease
    Seela Ramesh
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Semin Liver Dis 24:399-413. 2004
    ..In this article, we will review the epidemiology of HCV and NAFLD, their impact on each other, and the course of the liver disease in individuals afflicted with both conditions...
  39. ncbi Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 48:1810-20. 2008
    ..Conclusions: NASH is associated with altered hepatic microRNA expression. Underexpression of miR-122 potentially contributes to altered lipid metabolism implicated in the pathogenesis of NASH...
  40. ncbi Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome
    Arun J Sanyal
    Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Am J Gastroenterol 98:2064-71. 2003
    ..Advanced fibrosis in such patients is related to weight, presence of diabetes, and presence and degree of cytological ballooning...
  41. ncbi The metabolic abnormalities associated with non-alcoholic fatty liver disease
    Mahmadul Haque
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, MCV Box 980711, Richmond, VA 23298-0711, USA
    Best Pract Res Clin Gastroenterol 16:709-31. 2002
    ..While much work remains to be done, the current understanding of the pathogenesis of NAFLD provides direction for both future investigation and development of therapeutic trials...
  42. ncbi Portal hypertension
    N Garcia
    Department of Medicine, Gastroenterology, and Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Liver Dis 5:509-40. 2001
    ..Specific treatment may be provided with EVL while these patients await transplantation. Patients who fail endoscopic treatment may be treated by TIPS or surgery...
  43. ncbi Are TIPS tops in the treatment of portal hypertension? A review on the use and misuse of transjugular intrahepatic portosystemic shunts
    R K Sterling
    Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0341, USA
    Can J Gastroenterol 14:122D-128D. 2000
    ..Until further clinical trials become available, TIPS should be considered as a therapeutic option for the treatment of refractory variceal hemorrhage and refractory ascites in selected patients...
  44. ncbi Comparison of three commercially available assays for HCV RNA using the international unit standard: implications for management of patients with chronic hepatitis C virus infection in clinical practice
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, Virginia 23298, USA
    Am J Gastroenterol 98:1159-66. 2003
    ..The present study was performed to evaluate the impact of the international unit standard for measuring HCV RNA in the management of patients with chronic hepatitis C virus (HCV) infection...
  45. ncbi Hepatitis C virus infection: molecular pathways to metabolic syndrome
    Muhammad Y Sheikh
    Division of Gastroenterology and Hepatology, University of California San Francisco Fresno Education Program, Community Regional Medical Center, Fresno, CA 93721, USA
    Hepatology 47:2127-33. 2008
    ..This chain of events may be initiated by HCV-associated IR and provides a direction for future research in the areas of therapeutic intervention...
  46. ncbi Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epoetin alpha
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:371-9. 2007
    ..In contrast, a higher starting dose of RVN was associated with a lower relapse rate and higher rate of SVR...
  47. ncbi Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    Am J Gastroenterol 104:1130-4. 2009
    ..The aim of this study was to determine whether PPI use in cirrhotics with ascites is associated with SBP...
  48. ncbi The clinical spectrum of hepatitis C virus in HIV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System Medical College of Virginia Hospitals, Richmond, Virginia, USA
    J Acquir Immune Defic Syndr 32:30-7. 2003
    ..The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity...
  49. ncbi Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C
    Robert J Fontana
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0362, USA
    Gastroenterology 138:2321-31, 2331.e1-2. 2010
    ..We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis...
  50. ncbi The clinicopathologic spectrum and management of nonalcoholic fatty liver disease
    Melissa J Contos
    Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    Adv Anat Pathol 9:37-51. 2002
    ..The clinical and histologic features of NASH are described, and an approach to the diagnosis and treatment of NAFLD is provided...
  51. ncbi Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome
    Richard Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Am J Med 121:119-26. 2008
    ..We hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation...
  52. ncbi Steatohepatitis: Risk factors and impact on disease severity in human immunodeficiency virus/hepatitis C virus coinfection
    Richard K Sterling
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Hepatology 47:1118-27. 2008
    ..Although we did identify genotype 3, increased BMI, and diabetes as risk factors, we found no independent association with antiretroviral therapy...
  53. ncbi Drug-induced steatohepatitis
    R Todd Stravitz
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, 1200 East Broad Street, Room 1496, Richmond, VA 23298, USA
    Clin Liver Dis 7:435-51. 2003
    ..Further research should determine the mechanisms by which drug-induced steatosis, a benign lesion, evolves to steatohepatitis and progressive fibrosis...
  54. ncbi Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  55. ncbi The histologic spectrum of nonalcoholic fatty liver disease
    Melissa J Contos
    Department of Pathology, Virginia Commonwealth University, Box 980662, Richmond, VA 23298, USA
    Clin Liver Dis 8:481-500, vii. 2004
    ..This article provides an understanding of the histologic features of NAFLD and the potential pitfalls in the histologic assessment of this condition...
  56. ncbi Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantation
    Mitchell L Shiffman
    Hepatology Section, Division of Surgical Pathology, Virginia Commonwealth University Medical Center, Richmond, VA, 23298, USA
    Liver Transpl 10:1248-55. 2004
    ..9, compared with 59% with fibrosis and a mean score of.9 after LDLT. In conclusion, these data strongly suggest that fibrosis progression from recurrent HCV is not more severe in patients after LDLT...
  57. ncbi Use of desirability functions to evaluate health status in patients with cirrhosis
    Chris Gennings
    Department of Biostatistics, Virginia Commonwealth University, Theatre Row, Rm 3026, 730 East Broad Street, Richmond, VA 23298 0032, USA
    J Hepatol 52:665-71. 2010
    ....
  58. ncbi Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
    R Todd Stravitz
    Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Transpl 10:850-8. 2004
    ..In conclusion, interferon treatment of recurrent hepatitis C does not consistently improve histologic disease after virologic response, and it may increase the risk of allograft rejection...
  59. ncbi A comparison of the spectrum of chronic hepatitis C virus between Caucasians and African Americans
    Richard K Sterling
    Division of Gastroenterology, Virginia Commonwealth University Medical Center, Richmond 23298 0341, USA
    Clin Gastroenterol Hepatol 2:469-73. 2004
    ..Differences in hepatitis C virus (HCV)-related liver disease between Caucasians and African Americans remain controversial...
  60. ncbi Impact of highly active antiretroviral therapy on the spectrum of liver disease in HCV-HIV coinfection
    Richard K Sterling
    Virginia Commonwealth University, Medical College of Virginia, Richmond, USA
    Clin Gastroenterol Hepatol 2:432-9. 2004
    ....
  61. ncbi Role of microRNAs in non-alcoholic steatohepatitis
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Dept of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Curr Pharm Des 16:1952-7. 2010
    ..It is hoped that further understanding of the role of microRNA in NAFLD will advance potential therapeutics and preventive measures to modify and alter this disease process...
  62. ncbi Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
    ....
  63. ncbi Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  64. ncbi Similar progression of fibrosis between HIV/HCV-infected and HCV-infected patients: Analysis of paired liver biopsy samples
    Richard K Sterling
    Virginia Commonwealth University Health System, Richmond, USA
    Clin Gastroenterol Hepatol 8:1070-6. 2010
    ..However, no studies have directly compared fibrosis progression by paired liver biopsy between patients infected with HIV and HCV versus those infected with only HCV...
  65. ncbi Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients
    J S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Aliment Pharmacol Ther 31:1012-7. 2010
    ..Lactulose is considered first-line therapy for hepatic encephalopathy. However, the effect of adherence with lactulose on recurrence of hepatic encephalopathy outside clinical trials remains unclear...
  66. ncbi Insulin resistance in NASH
    J Choudhury
    Division of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Front Biosci 10:1520-33. 2005
    ..In this review we will discuss the various processes that are involved in the pathogenesis of NAFLD...
  67. ncbi A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitis
    Jonathan T Hlivko
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0341, USA
    Clin Gastroenterol Hepatol 6:1036-40. 2008
    ..Although this regimen achieves remission in approximately 80%, some patients are intolerant or do not respond. Mycophenolate mofetil (MMF) is a potent immunosuppressant. However, its utility in AIH is not well-defined...
  68. ncbi Abnormalities of lipid metabolism in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Semin Liver Dis 28:351-9. 2008
    ..In this review, recent advances in the study of abnormal lipid metabolism and its impacts on histology and dysregulation of various cellular processes implicated in the genesis of NAFLD will be discussed...
  69. ncbi Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease
    K D Kistler
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    Aliment Pharmacol Ther 31:396-406. 2010
    ..Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD...
  70. ncbi Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
    ..Aims: To assess impact of pretransplant hyponatraemia on post-transplant outcomes...
  71. ncbi Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
    ..ICT, but not SPT performance is significantly associated with prior and future crashes and violations. There was an excellent agreement between self- and DOT-reports...
  72. ncbi Recent advances in nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0341, USA
    Curr Opin Gastroenterol 25:230-7. 2009
    ..This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD)...
  73. ncbi Recent advances in nonalcholic fatty liver disease
    Victoria Greenfield
    Divisoipn of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Curr Opin Gastroenterol 24:320-7. 2008
    ..The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease...
  74. ncbi Role of obesity, insulin resistance, and steatosis in hepatitis C virus infection
    Puneet Puri
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Health System, 1200 East Broad Street, Richmond, VA 23298, USA
    Clin Liver Dis 10:793-819. 2006
    ..Complex interplay between these conditions results in the ultimate phenotype of liver disease. This article focuses on the current understanding of host and viral interactions as well as on consequent clinical implications...
  75. ncbi Management of ascites in cirrhosis
    Bimaljit Singh Sandhu
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, MCV Box 980341, Richmond, VA 23298, USA
    Clin Liver Dis 9:715-32, viii. 2005
    ..Large volume paracentesis and transjugular intrahepatic porto-systemic shunts are useful in managing patients with refractory ascites. Liver transplant is the only way to improve survival in ascites caused by cirrhosis...
  76. ncbi AGA technical review on nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine Virginia Commonwealth University Medical College of Virginia Richmond, Virginia, USA
    Gastroenterology 123:1705-25. 2002
  77. ncbi Prophylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 years
    Nevin Yilmaz
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Liver Int 28:72-8. 2008
    ..Maintaining a serum anti-HB surface level above a minimum arbitrary titre of 200 pg/mL did not appear to be necessary for effective HBIG prophylaxis...
  78. ncbi Recurrent flares of pancreatitis predict development of exocrine insufficiency in chronic pancreatitis
    Bimaljit S Sandhu
    Pancreatitis Center, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 5:1085-91; quiz 1007. 2007
    ..The natural history of specific morphologic stages of chronic pancreatitis (CP) is not well defined. The aim of this study was to determine if worsening morphologic stages of CP are associated with poorer clinical outcomes...
  79. ncbi Laboratory assessment of hepatic hemodynamics
    N Garcia
    Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Medical College of Virginia, Virginia Commonwealth University, USA
    Clin Liver Dis 5:591-615. 2001
    ..All methods have their own attributes and limitations. No one method is superior to the others, but, depending on the aspect of hepatic hemodynamics to be investigated, a particular methodology may yield distinct advantages...
  80. ncbi Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
    ..These results identify a readily modifiable environmental risk factor that may ameliorate disease progression in patients with NAFLD...
  81. ncbi Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease
    Amy G Shah
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:1104-12. 2009
    ..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
  82. ncbi Acute variceal hemorrhage
    Adil Habib
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, MCV Box 980341, Richmond, VA 23298 0341, USA
    Gastrointest Endosc Clin N Am 17:223-52, v. 2007
    ..These strategies involve pharmacological, endoscopic, surgical, and interventional radiological modalities. This article reviews management of acute variceal bleeding...
  83. ncbi The plasma lipidomic signature of nonalcoholic steatohepatitis
    Puneet Puri
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 50:1827-38. 2009
    ..Conclusions: Although increased lipogenesis, desaturases, and LOX activities characterize NAFL and NASH, impaired peroxisomal polyunsaturated fatty acid (PUFA) metabolism and nonenzymatic oxidation is associated with progression to NASH...
  84. ncbi Hepatitis C infection and nonalcoholic fatty liver disease
    Onpan Cheung
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Clin Liver Dis 12:573-85, viii-ix. 2008
    ..This article focuses on the current understanding of the interplay between host and viral factors that are involved in the interaction between NAFLD and HCV...
  85. ncbi Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    Pouneh Mofrad
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 37:1286-92. 2003
    ....
  86. ncbi The effect of fatigue on driving skills in patients with hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 104:898-905. 2009
    ..Hepatic encephalopathy, both overt (OHE) and minimal (MHE), is associated with poor quality of life and fatigue. The aim of this study was to define the effect of fatigue on driving skills in MHE and OHE patients...
  87. ncbi Hypercoagulation and thrombophilia in liver disease
    P G Northup
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    J Thromb Haemost 6:2-9. 2008
    ..Critical areas lacking clinical information are highlighted and future areas of research interest are defined with an aim to foster clinical research in this field...
  88. ncbi Recurrent variceal bleeding despite endoscopic and medical therapy
    Anastasios A Mihas
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond 23298-0711, USA
    Gastroenterology 127:621-9. 2004
  89. ncbi Grading portal gastropathy: validation of a gastropathy scoring system
    Charmaine A Stewart
    Division of Gastroenterology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 98:1758-65. 2003
    ..CONCLUSIONS: The PHG scoring system is reproducible and accurately reflects the risks of PHG-related bleeding in patients with cirrhosis...
  90. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..
  91. ncbi Calcineurin inhibitor-induced chronic nephrotoxicity in liver transplant patients is reversible using rapamycin as the primary immunosuppressive agent
    Adrian H Cotterell
    Division of Transplantation Surgery, Department of Surgery, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Clin Transplant 16:49-51. 2002
    ..Rapamycin is an effective replacement agent as primary immunosuppressive therapy following withdrawal of CNIs in liver transplant patients with CNI-induced chronic nephrotoxicity...
  92. ncbi Insulin resistance and tissue repair: a "fato-logical" phenomenon
    Arun J Sanyal
    Gastroenterology 125:1886-9. 2003
  93. ncbi Quality of life in refractory ascites: transjugular intrahepatic portal-systemic shunting versus medical therapy
    Mical S Campbell
    Division of Gastroenterology, University of Pennsylvania Health Services, Philadelphia, PA 19104, USA
    Hepatology 42:635-40. 2005
    ..Competing effects of hepatic encephalopathy, requirement for repeated LVP, and need for hospitalizations explain similar changes in quality of life between the two groups...
  94. ncbi Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
    ..CONCLUSION: The V(2) receptor antagonist satavaptan improves the control of ascites and increases serum sodium in patients with cirrhosis, ascites, and hyponatremia under diuretic treatment...
  95. ncbi Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways
    Xudong Wu
    Jiangsu Center for Drug Screening, Jiangsu Center for Pharmacodynamic Research and Evaluation, China Pharmaceutical University, Nanjing, Jiangsu, People s Republic of China
    Hepatology 47:1905-15. 2008
    ..CONCLUSION: GA significantly reduced FFA/HFD-induced hepatic lipotoxicity by stabilizing the integrity of lysosomes and mitochondria and inhibiting cathepsin B expression and enzyme activity...
  96. ncbi A decision analysis study of the value of a liver biopsy in nonalcoholic steatohepatitis
    Jill K J Gaidos
    Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 28:650-8. 2008
    ..Liver biopsy (LB) is the only way to determine the severity of disease. However, LB is invasive, has complications and financial costs. The aim of this study is to determine the benefits of early LB for diagnosis and early treatment...
  97. ncbi Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008
    ..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
  98. ncbi Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    Puneet Puri
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    Gastroenterology 134:568-76. 2008
    ..The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology...
  99. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VACT Healthcare System, New Haven, CT, USA
    Hepatology 46:922-38. 2007
  100. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VA-CT Healthcare System, New Haven, Connecticut 06520, USA
    Am J Gastroenterol 102:2086-102. 2007
  101. ncbi Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
    Angela M Zivkovic
    Department of Food Science and Technology, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 86:285-300. 2007
    ..The premises, effects, barriers, and issues related to current dietary guidelines and specific diets are discussed, and the question, "Will it work for the pathogenesis of NAFLD and NASH? ", is addressed...

Research Grants4

  1. CLINICAL STUDIES OF NONALCOHOLIC STEATOHEPATITIS
    Arun Sanyal; Fiscal Year: 2007
    ..A prospective, randomized short-term ( 1 year duration) clinical trial to test this hypothesis is proposed. The primary endpoint is the necro-inflammatory grade. Both studies will require participation of the network. ..
  2. Studies of Mechanisms and Treatment of Liver Diseases
    Arun Sanyal; Fiscal Year: 2007
    ..Much progress has been made and supports the hypothesis. The institutional environment and facilities/resources are excellent for career development in academic medicine. ..
  3. Biliary Microlithiasis in Alcohol Induced Pancreatitis
    Arun Sanyal; Fiscal Year: 2007
    ..The long-term goal is to use data from this R21 proposal to develop a RO1 proposal about a large scale phase III clinical trial of UDCA for alcohol-induced pancreatitis. ..
  4. Training Grant in Digestive Diseases and Liver Diseases
    Arun Sanyal; Fiscal Year: 2007
    ..The need for research training, the strong record and continued research strengths of this program for the basis for this application for renewal of this T-32 Training Grant. ..