Research Topics
Genomes and Genes
| Brien P RileySummaryAffiliation: Virginia Commonwealth University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Linkage studies of schizophreniaBrien Riley
Departments of Psychiatry and Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
Neurotox Res 6:17-34. 2004..These converging lines of evidence suggest that the genetics of schizophrenia, long considered a most intractable problem, are at last beginning to be unraveled...- A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study... 
Candidate genes for schizophrenia: a survey of association studies and gene rankingJingchun Sun
Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet B Neuropsychiatr Genet 147:1173-81. 2008..The evaluation of this candidate gene set against sets selected by other methods suggested its utility in follow-up association studies and in further bioinformatics analysis. We also examined the functional biases of the selected genes...- Molecular genetic studies of schizophreniaBrien Riley
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
Eur J Hum Genet 14:669-80. 2006..Assessment of the combined evidence for the DTNBP1 gene gives some insight into the nature of the problems remaining to be solved... 
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sampleB Riley
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Mol Psychiatry 15:29-37. 2010..This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia...- Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sampleB P Riley
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Mol Psychiatry 11:1025-31. 2006.... - The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sampleBrien Riley
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
Schizophr Res 115:245-53. 2009..DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples... - The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sampleVladimir I Vladimirov
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Biotech 1 110, Richmond VA 23298, USA
Schizophr Res 107:249-54. 2009..0564 (1.0078-1.1074); p=0.02], while nominally significant, did not survive correction for multiple testing. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample... - Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)Laura M Hack
Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
Alcohol Clin Exp Res 35:376-85. 2011..Many linkage and association studies have examined these relationships with inconsistent results, possibly because of low power, poor marker coverage, and/or an inappropriate correction for multiple testing... - AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia familiesDawn L Thiselton
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
Biol Psychiatry 63:449-57. 2008..The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients... - No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sampleSarah E Bergen
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010..Several possibilities, such as differing risk haplotypes, may explain this finding... - Comprehensive gene-based association study of a chromosome 20 linked region implicates novel risk loci for depressive symptoms in psychotic illnessT Bernard Bigdeli
Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
PLoS ONE 6:e21440. 2011..Prior genomewide scans of schizophrenia support evidence of linkage to regions of chromosome 20. However, association analyses have yet to provide support for any etiologically relevant variants... - MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disordersAlbert H Kim
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Schizophr Res 124:183-91. 2010..Hsa-miR-132 and -212 were negatively correlated with TH (p = 0.0001 and 0.0017) and with PGD (p = 0.0054 and 0.017, respectively)... - A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom countsGursharan Kalsi
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
Hum Mol Genet 19:2497-506. 2010..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings... - Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophreniaBrion S Maher
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Hum Hered 69:71-9. 2010..We contend that current approaches may obscure interesting phenomena in genetic association data. However, an appropriate approach to examining heterogeneity across studies is lacking... - Meta-analyses of genome-wide linkage scans of anxiety-related phenotypesBradley T Webb
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
Eur J Hum Genet 20:1078-84. 2012..This may prove useful for prioritizing emerging genome-wide association data for anxiety disorders... - Unraveling the molecular mechanisms of alcohol dependenceGursharan Kalsi
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, PO Box 980424, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Trends Genet 25:49-55. 2009.... - The AVPR1A gene and substance use disorders: association, replication, and functional evidenceBrion S Maher
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Biol Psychiatry 70:519-27. 2011..The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms... - Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association studyZhongming Zhao
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
BMC Genomics 13:S16. 2012..Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation... - No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small... - Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorderDebra L Foley
Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virgoinia Commonwaelth University, Richmond, 23298 0003, USA
Arch Gen Psychiatry 61:738-44. 2004..Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder... - The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replicationKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
Arch Gen Psychiatry 62:529-35. 2005..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?.. - A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorderKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Alcohol Clin Exp Res 30:1972-7. 2006..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?.. - Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol DependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Alcohol Clin Exp Res 30:1807-16. 2006..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits... - Nature and nurture in neuropsychiatric genetics: where do we stand?Danielle M Dick
Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Richmond 23298, USA
Dialogues Clin Neurosci 12:7-23. 2010..We will review the fields of genetic epidemiology and molecular genetics, providing examples from the literature to illustrate the key concepts emerging from this work... - Commentary on 'The case for gene-environment interactions in psychiatry'Brien P Riley
Department of Psychiatry, Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
Curr Opin Psychiatry 21:324-5. 2008 - A genome-wide scan for modifier loci in schizophreniaAyman H Fanous
Washington VA Medical Center, Washington, DC 20422, USA
Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007..06. We conclude that genes located near 9q33.1 and 14q24.2 may modify the clinical course and severity of schizophrenia. A gene in 6q may affect several clinical features of illness... - Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophreniaAyman H Fanous
Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
Am J Psychiatry 162:1824-32. 2005.... - Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density familiesAyman H Fanous
Washington VA Medical Center, Washington, DC, USA
Biol Psychiatry 64:121-7. 2008..Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci... - Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence... - Level of functioning in autism spectrum disorders: phenotypic congruence among affected siblingsRobin P Goin-Kochel
Molecular and Human Genetics, Baylor College of Medicine, Texas Children s Hospital, 6621 Fannin Street, CC1560, Houston, TX 77030, USA
J Autism Dev Disord 38:1019-27. 2008..Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others...
Research Grants
- MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIABrien Riley; Fiscal Year: 2007....
- A genome-wide association study of schizophrenia in IrelandBrien Riley; Fiscal Year: 2009..The illness is a major public health burden because of the early onset, non-fatal course and need for long-term care for many patients. ..
- A genome-wide association study of schizophrenia in IrelandBrien P Riley; Fiscal Year: 2010..The illness is a major public health burden because of the early onset, non-fatal course and need for long-term care for many patients. ..