Brien P Riley

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Linkage studies of schizophrenia
    Brien Riley
    Departments of Psychiatry and Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Neurotox Res 6:17-34. 2004
  2. ncbi request reprint A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007
  3. doi request reprint Candidate genes for schizophrenia: a survey of association studies and gene ranking
    Jingchun Sun
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1173-81. 2008
  4. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
  5. pmc The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
    Brien Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 115:245-53. 2009
  6. ncbi request reprint Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample
    B P Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 11:1025-31. 2006
  7. ncbi request reprint Molecular genetic studies of schizophrenia
    Brien Riley
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Eur J Hum Genet 14:669-80. 2006
  8. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
  9. pmc The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample
    Vladimir I Vladimirov
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Biotech 1 110, Richmond VA 23298, USA
    Schizophr Res 107:249-54. 2009
  10. pmc Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)
    Laura M Hack
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:376-85. 2011

Detail Information

Publications31

  1. ncbi request reprint Linkage studies of schizophrenia
    Brien Riley
    Departments of Psychiatry and Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Neurotox Res 6:17-34. 2004
    ..These converging lines of evidence suggest that the genetics of schizophrenia, long considered a most intractable problem, are at last beginning to be unraveled...
  2. ncbi request reprint A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007
    ..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study...
  3. doi request reprint Candidate genes for schizophrenia: a survey of association studies and gene ranking
    Jingchun Sun
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1173-81. 2008
    ..The evaluation of this candidate gene set against sets selected by other methods suggested its utility in follow-up association studies and in further bioinformatics analysis. We also examined the functional biases of the selected genes...
  4. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
    ..Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation...
  5. pmc The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
    Brien Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 115:245-53. 2009
    ..DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples...
  6. ncbi request reprint Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample
    B P Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 11:1025-31. 2006
    ....
  7. ncbi request reprint Molecular genetic studies of schizophrenia
    Brien Riley
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Eur J Hum Genet 14:669-80. 2006
    ..Assessment of the combined evidence for the DTNBP1 gene gives some insight into the nature of the problems remaining to be solved...
  8. pmc Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
    B Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 15:29-37. 2010
    ..This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia...
  9. pmc The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample
    Vladimir I Vladimirov
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Biotech 1 110, Richmond VA 23298, USA
    Schizophr Res 107:249-54. 2009
    ..0564 (1.0078-1.1074); p=0.02], while nominally significant, did not survive correction for multiple testing. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample...
  10. pmc Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)
    Laura M Hack
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:376-85. 2011
    ..Many linkage and association studies have examined these relationships with inconsistent results, possibly because of low power, poor marker coverage, and/or an inappropriate correction for multiple testing...
  11. pmc AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families
    Dawn L Thiselton
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
    Biol Psychiatry 63:449-57. 2008
    ..The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients...
  12. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
    ..Several possibilities, such as differing risk haplotypes, may explain this finding...
  13. pmc Comprehensive gene-based association study of a chromosome 20 linked region implicates novel risk loci for depressive symptoms in psychotic illness
    T Bernard Bigdeli
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e21440. 2011
    ..Prior genomewide scans of schizophrenia support evidence of linkage to regions of chromosome 20. However, association analyses have yet to provide support for any etiologically relevant variants...
  14. doi request reprint MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders
    Albert H Kim
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Schizophr Res 124:183-91. 2010
    ..Hsa-miR-132 and -212 were negatively correlated with TH (p = 0.0001 and 0.0017) and with PGD (p = 0.0054 and 0.017, respectively)...
  15. pmc A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts
    Gursharan Kalsi
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Hum Mol Genet 19:2497-506. 2010
    ..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings...
  16. pmc Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes
    Bradley T Webb
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Hum Genet 20:1078-84. 2012
    ..This may prove useful for prioritizing emerging genome-wide association data for anxiety disorders...
  17. doi request reprint Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Hum Hered 69:71-9. 2010
    ..We contend that current approaches may obscure interesting phenomena in genetic association data. However, an appropriate approach to examining heterogeneity across studies is lacking...
  18. doi request reprint Unraveling the molecular mechanisms of alcohol dependence
    Gursharan Kalsi
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, PO Box 980424, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Trends Genet 25:49-55. 2009
    ....
  19. doi request reprint The AVPR1A gene and substance use disorders: association, replication, and functional evidence
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Biol Psychiatry 70:519-27. 2011
    ..The liability to addiction has been shown to be highly genetically correlated across drug classes, suggesting nondrug-specific mechanisms...
  20. ncbi request reprint Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder
    Debra L Foley
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virgoinia Commonwaelth University, Richmond, 23298 0003, USA
    Arch Gen Psychiatry 61:738-44. 2004
    ..Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder...
  21. ncbi request reprint The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 62:529-35. 2005
    ..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?..
  22. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  23. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  24. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  25. pmc Nature and nurture in neuropsychiatric genetics: where do we stand?
    Danielle M Dick
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Dialogues Clin Neurosci 12:7-23. 2010
    ..We will review the fields of genetic epidemiology and molecular genetics, providing examples from the literature to illustrate the key concepts emerging from this work...
  26. doi request reprint Commentary on 'The case for gene-environment interactions in psychiatry'
    Brien P Riley
    Department of Psychiatry, Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Curr Opin Psychiatry 21:324-5. 2008
  27. ncbi request reprint Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Am J Psychiatry 162:1824-32. 2005
    ....
  28. ncbi request reprint A genome-wide scan for modifier loci in schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007
    ..06. We conclude that genes located near 9q33.1 and 14q24.2 may modify the clinical course and severity of schizophrenia. A gene in 6q may affect several clinical features of illness...
  29. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  30. doi request reprint Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC, USA
    Biol Psychiatry 64:121-7. 2008
    ..Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci...
  31. ncbi request reprint Level of functioning in autism spectrum disorders: phenotypic congruence among affected siblings
    Robin P Goin-Kochel
    Molecular and Human Genetics, Baylor College of Medicine, Texas Children s Hospital, 6621 Fannin Street, CC1560, Houston, TX 77030, USA
    J Autism Dev Disord 38:1019-27. 2008
    ..Preliminary twin correlations indicated strong genetic effects for some skill domains and the influence of shared environmental factors for others...

Research Grants7

  1. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Brien Riley; Fiscal Year: 2007
    ....
  2. A genome-wide association study of schizophrenia in Ireland
    Brien Riley; Fiscal Year: 2009
    ..The illness is a major public health burden because of the early onset, non-fatal course and need for long-term care for many patients. ..
  3. A genome-wide association study of schizophrenia in Ireland
    Brien P Riley; Fiscal Year: 2010
    ..The illness is a major public health burden because of the early onset, non-fatal course and need for long-term care for many patients. ..