Dharmendar Rathore

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. ncbi request reprint Binding and invasion of liver cells by Plasmodium falciparum sporozoites. Essential involvement of the amino terminus of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892 0425, USA
    J Biol Chem 277:7092-8. 2002
  2. ncbi request reprint An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Biol Chem 280:20524-9. 2005
  3. ncbi request reprint Targeting parasite-mediated host hemoglobin degradation in malaria
    Dharmendar Rathore
    Malaria Research Laboratory, Virginia Bioinformatics Institute, 1 Washington Street, Blacksburg, VA 24061, USA
    IDrugs 10:877-80. 2007
  4. ncbi request reprint American Society of Tropical Medicine and Hygiene--55th Annual Meeting. 12-16 November 2006, Atlanta, GA, USA
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, 1 Washington Street, MC 0477, Blacksburg, VA 24061, USA
    IDrugs 10:93-5. 2007
  5. pmc HDP-a novel heme detoxification protein from the malaria parasite
    Dewal Jani
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS Pathog 4:e1000053. 2008
  6. ncbi request reprint Antimalarial drugs: current status and new developments
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, Blacksburg, VA 24061, USA
    Expert Opin Investig Drugs 14:871-83. 2005
  7. doi request reprint Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent
    Jeannine S Strobl
    Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, Virginia 24060, USA
    J Parasitol 95:215-23. 2009
  8. ncbi request reprint Ambient glucose concentration and gene expression in Plasmodium falciparum
    Jun Fang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 133:125-9. 2004
  9. ncbi request reprint Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:40905-10. 2003
  10. pmc Identification, cloning, expression, and characterization of the gene for Plasmodium knowlesi surface protein containing an altered thrombospondin repeat domain
    Babita Mahajan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    Infect Immun 73:5402-9. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Binding and invasion of liver cells by Plasmodium falciparum sporozoites. Essential involvement of the amino terminus of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892 0425, USA
    J Biol Chem 277:7092-8. 2002
    ..This indicates that both assays are measuring interrelated phenomenon and points to the essential involvement for the amino-terminal portion of the CS protein in these processes...
  2. ncbi request reprint An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Biol Chem 280:20524-9. 2005
    ....
  3. ncbi request reprint Targeting parasite-mediated host hemoglobin degradation in malaria
    Dharmendar Rathore
    Malaria Research Laboratory, Virginia Bioinformatics Institute, 1 Washington Street, Blacksburg, VA 24061, USA
    IDrugs 10:877-80. 2007
    ..Given that this parasite-mediated catabolization is critical for the growth of Plasmodium within the host cell, the degradation of hemoglobin has become one of the most well-established targets for antimalarial drug discovery...
  4. ncbi request reprint American Society of Tropical Medicine and Hygiene--55th Annual Meeting. 12-16 November 2006, Atlanta, GA, USA
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, 1 Washington Street, MC 0477, Blacksburg, VA 24061, USA
    IDrugs 10:93-5. 2007
  5. pmc HDP-a novel heme detoxification protein from the malaria parasite
    Dewal Jani
    Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS Pathog 4:e1000053. 2008
    ..As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target...
  6. ncbi request reprint Antimalarial drugs: current status and new developments
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, Blacksburg, VA 24061, USA
    Expert Opin Investig Drugs 14:871-83. 2005
    ....
  7. doi request reprint Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent
    Jeannine S Strobl
    Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, Virginia 24060, USA
    J Parasitol 95:215-23. 2009
    ..gondii tachyzoites in vitro and that NSC3852 is a potent T. gondii inhibitor that acts by indirect generation of oxidative stress in T. gondii...
  8. ncbi request reprint Ambient glucose concentration and gene expression in Plasmodium falciparum
    Jun Fang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 133:125-9. 2004
  9. ncbi request reprint Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:40905-10. 2003
    ..falciparum CSP (PfCSP). We suggest that a difference in the binding affinity for the liver cell receptor is a mechanism involved in maintaining the host specificity by the malaria parasite...
  10. pmc Identification, cloning, expression, and characterization of the gene for Plasmodium knowlesi surface protein containing an altered thrombospondin repeat domain
    Babita Mahajan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    Infect Immun 73:5402-9. 2005
    ..Further efficacy evaluation studies in the P. knowlesi-rhesus monkey sporozoite challenge model will help to decide whether the SPATR molecule should be developed as a vaccine against human malarias...
  11. ncbi request reprint PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodies
    Rana Chattopadhyay
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    J Biol Chem 278:25977-81. 2003
    ..falciparum sporozoites specifically recognized the expression of this protein on transfected COS-7 cells. These data support the evaluation of this protein as a vaccine candidate...
  12. pmc Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen
    William O Rogers
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Infect Immun 70:4329-35. 2002
    ..These findings demonstrate that a multistage, multiantigen, DNA priming and poxvirus boosting vaccine regimen can protect nonhuman primates from an otherwise lethal malaria sporozoite challenge...
  13. pmc Compensatory evolution in the human malaria parasite Plasmodium ovale
    Thomas F McCutchan
    Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Genetics 166:637-40. 2004
    ..The appearance of compensatory mutations and intermediate states in P. ovale raises interesting questions about population structure that could have considerable impact on the control of the associated disease...
  14. ncbi request reprint Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein
    Rita Tewari
    Department of Biological Sciences, SAF Building, Imperial College, Imperial College Road, London SW7 2AZ, UK
    Cell Microbiol 7:699-707. 2005
    ..This was not observed in control infections or in A. gambiae infections. These findings shed new light on the role of the CS protein in the interaction of the parasite with both the mosquito vector and the rodent host...
  15. ncbi request reprint Construction of Plasmodium falciparum lambda cDNA libraries
    David A Fidock
    Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, The Bronx, NY, USA
    Methods Mol Med 72:265-75. 2002