Affiliation: Virginia Polytechnic Institute and State University
- Binding and invasion of liver cells by Plasmodium falciparum sporozoites. Essential involvement of the amino terminus of circumsporozoite proteinDharmendar Rathore
Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID/National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892-0425, USA
J Biol Chem 277:7092-8. 2002..This indicates that both assays are measuring interrelated phenomenon and points to the essential involvement for the amino-terminal portion of the CS protein in these processes...
- An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasionDharmendar Rathore
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
J Biol Chem 280:20524-9. 2005....
- Targeting parasite-mediated host hemoglobin degradation in malariaDharmendar Rathore
Malaria Research Laboratory, Virginia Bioinformatics Institute, 1 Washington Street, Blacksburg, VA 24061, USA
IDrugs 10:877-80. 2007..Given that this parasite-mediated catabolization is critical for the growth of Plasmodium within the host cell, the degradation of hemoglobin has become one of the most well-established targets for antimalarial drug discovery...
- American Society of Tropical Medicine and Hygiene--55th Annual Meeting. 12-16 November 2006, Atlanta, GA, USADharmendar Rathore
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, 1 Washington Street, MC 0477, Blacksburg, VA 24061, USA
IDrugs 10:93-5. 2007
- HDP-a novel heme detoxification protein from the malaria parasiteDewal Jani
Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
PLoS Pathog 4:e1000053. 2008..As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target...
- Antimalarial drugs: current status and new developmentsDharmendar Rathore
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, Blacksburg, VA 24061, USA
Expert Opin Investig Drugs 14:871-83. 2005....
- Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agentJeannine S Strobl
Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, Virginia 24060, USA
J Parasitol 95:215-23. 2009..gondii tachyzoites in vitro and that NSC3852 is a potent T. gondii inhibitor that acts by indirect generation of oxidative stress in T. gondii...
- Ambient glucose concentration and gene expression in Plasmodium falciparumJun Fang
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biochem Parasitol 133:125-9. 2004
- Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite proteinDharmendar Rathore
Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:40905-10. 2003..falciparum CSP (PfCSP). We suggest that a difference in the binding affinity for the liver cell receptor is a mechanism involved in maintaining the host specificity by the malaria parasite...
- Identification, cloning, expression, and characterization of the gene for Plasmodium knowlesi surface protein containing an altered thrombospondin repeat domainBabita Mahajan
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
Infect Immun 73:5402-9. 2005..Further efficacy evaluation studies in the P. knowlesi-rhesus monkey sporozoite challenge model will help to decide whether the SPATR molecule should be developed as a vaccine against human malarias...
- PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodiesRana Chattopadhyay
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
J Biol Chem 278:25977-81. 2003..falciparum sporozoites specifically recognized the expression of this protein on transfected COS-7 cells. These data support the evaluation of this protein as a vaccine candidate...
- Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimenWilliam O Rogers
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
Infect Immun 70:4329-35. 2002..These findings demonstrate that a multistage, multiantigen, DNA priming and poxvirus boosting vaccine regimen can protect nonhuman primates from an otherwise lethal malaria sporozoite challenge...
- Compensatory evolution in the human malaria parasite Plasmodium ovaleThomas F McCutchan
Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
Genetics 166:637-40. 2004..The appearance of compensatory mutations and intermediate states in P. ovale raises interesting questions about population structure that could have considerable impact on the control of the associated disease...
- Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite proteinRita Tewari
Department of Biological Sciences, SAF Building, Imperial College, Imperial College Road, London SW7 2AZ, UK
Cell Microbiol 7:699-707. 2005..This was not observed in control infections or in A. gambiae infections. These findings shed new light on the role of the CS protein in the interaction of the parasite with both the mosquito vector and the rodent host...
- Construction of Plasmodium falciparum lambda cDNA librariesDavid A Fidock
Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, The Bronx, NY, USA
Methods Mol Med 72:265-75. 2002