Yun Qu

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Structural consequences of a 3'-->3' DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Biol Inorg Chem 14:969-77. 2009
  2. ncbi request reprint A surprisingly stable macrochelate formed from the reaction of cis dinuclear platinum antitumor compounds with reduced glutathione
    Michael E Oehlsen
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Inorg Chem 44:3004-6. 2005
  3. ncbi request reprint Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine
    Michael E Oehlsen
    Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284 2006, USA
    J Biol Inorg Chem 10:433-42. 2005
  4. ncbi request reprint Comparison of structural effects in 1,4 DNA-DNA interstrand cross-links formed by dinuclear and trinuclear platinum complexes
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, P O Box 842006, Richmond, VA 23284, USA
    J Inorg Biochem 98:1585-90. 2004
  5. ncbi request reprint Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, PO Box 842006, Richmond, VA 23284, USA
    J Biol Inorg Chem 8:19-28. 2003
  6. ncbi request reprint Unique cooperative binding interaction observed between a minor groove binding Pt antitumor agent and Hoechst dye 33258
    Amanda Harris
    Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, Virginia 23284 2006, USA
    Inorg Chem 44:1196-8. 2005
  7. ncbi request reprint Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, VA 23284 2006, USA
    J Inorg Biochem 98:1591-8. 2004
  8. ncbi request reprint Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand
    John W Williams
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Inorg Chem 46:5820-2. 2007
  9. ncbi request reprint Reaction of polynuclear platinum antitumor compounds with reduced glutathione studied by multinuclear (1H, 1H-15N gradient heteronuclear single-quantum coherence, and 195Pt) NMR spectroscopy
    Michael E Oehlsen
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Inorg Chem 42:5498-506. 2003
  10. ncbi request reprint Mechanism of the membrane interaction of polynuclear platinum anticancer agents. Implications for cellular uptake
    Qin Liu
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Biochemistry 45:4248-56. 2006

Collaborators

  • N Farrell
  • Rik van Antwerpen
  • Michael E Oehlsen
  • John W Williams
  • Qin Liu
  • Amanda Harris
  • Alexander Hegmans
  • Tracey D McGregor
  • Eugenio Alvorado
  • Genevieve H Bulluss
  • Wendi Bousfield

Detail Information

Publications11

  1. pmc Structural consequences of a 3'-->3' DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Biol Inorg Chem 14:969-77. 2009
    ..Thus, differences in protein recognition and repair efficiency among the various interstrand cross-links are likely and a subject worthy of detailed exploration...
  2. ncbi request reprint A surprisingly stable macrochelate formed from the reaction of cis dinuclear platinum antitumor compounds with reduced glutathione
    Michael E Oehlsen
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Inorg Chem 44:3004-6. 2005
    ..The remarkable stability of I is discussed in terms of possible biological implications...
  3. ncbi request reprint Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine
    Michael E Oehlsen
    Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284 2006, USA
    J Biol Inorg Chem 10:433-42. 2005
    ..Further, the 1,1/c,c geometry resulted in slower reaction than the trans isomer, because of steric hindrance of the bridge, as observed previously in reactions with DNA and model nucleotides...
  4. ncbi request reprint Comparison of structural effects in 1,4 DNA-DNA interstrand cross-links formed by dinuclear and trinuclear platinum complexes
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, P O Box 842006, Richmond, VA 23284, USA
    J Inorg Biochem 98:1585-90. 2004
    ..The similarity in the structures suggests opportunities to "deliver" the cross-link in a more efficient manner than the current clinically tested drug...
  5. ncbi request reprint Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, PO Box 842006, Richmond, VA 23284, USA
    J Biol Inorg Chem 8:19-28. 2003
    ....
  6. ncbi request reprint Unique cooperative binding interaction observed between a minor groove binding Pt antitumor agent and Hoechst dye 33258
    Amanda Harris
    Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, Virginia 23284 2006, USA
    Inorg Chem 44:1196-8. 2005
    ....
  7. ncbi request reprint Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes
    Yun Qu
    Department of Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, VA 23284 2006, USA
    J Inorg Biochem 98:1591-8. 2004
    ..The melting point study showed that the non-covalent polynuclear platinum complexes stabilized the duplex DNA and the higher the electrical charge of the complexes the greater the stabilization observed...
  8. ncbi request reprint Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand
    John W Williams
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Inorg Chem 46:5820-2. 2007
    ..The stability of cis-geometry complexes may make them viable second-generation polynuclear platinum clinical candidates...
  9. ncbi request reprint Reaction of polynuclear platinum antitumor compounds with reduced glutathione studied by multinuclear (1H, 1H-15N gradient heteronuclear single-quantum coherence, and 195Pt) NMR spectroscopy
    Michael E Oehlsen
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Inorg Chem 42:5498-506. 2003
    ....
  10. ncbi request reprint Mechanism of the membrane interaction of polynuclear platinum anticancer agents. Implications for cellular uptake
    Qin Liu
    Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284 2006, USA
    Biochemistry 45:4248-56. 2006
    ..The implications of these results for the mechanism of cellular uptake of polynuclear platinum complexes are discussed...
  11. ncbi request reprint Circular dichroism study of the irreversibility of conformational changes induced by polyamine-linked dinuclear platinum compounds
    Tracey D McGregor
    Department of Chemistry, Virginia Commonwealth University, 101 West Main Street, Richmond, VA 23284 2006, USA
    J Inorg Biochem 91:212-9. 2002
    ..The relevance of these changes to the novel biological action of polynuclear platinum compounds is discussed...