C A Prescott

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Associations between marital status and alcohol consumption in a longitudinal study of female twins
    C A Prescott
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    J Stud Alcohol 62:589-604. 2001
  2. ncbi Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0126, USA
    Alcohol Clin Exp Res 23:1136-44. 1999
  3. ncbi Chorion type as a possible influence on the results and interpretation of twin study data
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond 23298, USA
    Twin Res 2:244-9. 1999
  4. ncbi Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins
    C A Prescott
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Arch Gen Psychiatry 57:803-11. 2000
  5. ncbi Influence of ascertainment strategy on finding sex differences in genetic estimates from twin studies of alcoholism
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet 96:754-61. 2000
  6. ncbi A population-based twin study of generalized anxiety disorder in men and women
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    J Nerv Ment Dis 189:413-20. 2001
  7. ncbi The genetic epidemiology of irrational fears and phobias in men
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, 800 E Leigh St, PO Box 980126, Richmond, VA 23298-0126, USA
    Arch Gen Psychiatry 58:257-65. 2001
  8. ncbi The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298-0126, USA
    Psychol Med 33:1423-32. 2003
  9. ncbi Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Am J Psychiatry 158:587-93. 2001
  10. ncbi Personality and the experience of environmental adversity
    K S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298-0126, USA
    Psychol Med 33:1193-202. 2003

Detail Information

Publications83

  1. ncbi Associations between marital status and alcohol consumption in a longitudinal study of female twins
    C A Prescott
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    J Stud Alcohol 62:589-604. 2001
    ..Data from a longitudinal study of female twins were used to address whether longitudinal drinking trajectories are more closely related to current marital status or to patterns of marital status over time...
  2. ncbi Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0126, USA
    Alcohol Clin Exp Res 23:1136-44. 1999
    ..S. adults. The goal of this study was to test whether the magnitude and sources of genetic and environmental influences on liability for alcohol abuse and dependence differ for men and women...
  3. ncbi Chorion type as a possible influence on the results and interpretation of twin study data
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond 23298, USA
    Twin Res 2:244-9. 1999
    ..We develop models for quantifying this bias and estimating the influence of chorion type on estimates of heritability...
  4. ncbi Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins
    C A Prescott
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Arch Gen Psychiatry 57:803-11. 2000
    ..We studied the importance of genetic influences on risk for lifetime comorbidity of major depression and alcoholism by means of a population-based twin sample...
  5. ncbi Influence of ascertainment strategy on finding sex differences in genetic estimates from twin studies of alcoholism
    C A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet 96:754-61. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:754-761, 2000...
  6. ncbi A population-based twin study of generalized anxiety disorder in men and women
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    J Nerv Ment Dis 189:413-20. 2001
    ..The familial aggregation of GAD in this sample was only modest. In the best-fitting models, the heritability of GAD was the same in men and women, estimated at about 15% to 20%, with no effects of gender-specific genes detected...
  7. ncbi The genetic epidemiology of irrational fears and phobias in men
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, 800 E Leigh St, PO Box 980126, Richmond, VA 23298-0126, USA
    Arch Gen Psychiatry 58:257-65. 2001
    ..Family environment probably has an impact on risk for agoraphobia and social phobia. The genetic liability to blood/injury phobias is not distinct from those of the more typical phobias...
  8. ncbi The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298-0126, USA
    Psychol Med 33:1423-32. 2003
    ..CONCLUSIONS: Prior psychiatric disorders are significant risk factors for the development of MDD, independent of the length of the intervening period between the onset of the first disorder and that of MDD...
  9. ncbi Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Am J Psychiatry 158:587-93. 2001
    ..The results suggest that the greater prevalence of major depression in women versus men is due neither to differences in the rates of reported stressful life events nor to differential sensitivity to their pathogenic effect...
  10. ncbi Personality and the experience of environmental adversity
    K S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298-0126, USA
    Psychol Med 33:1193-202. 2003
    ..Developmental models of psychiatric illness should adopt an interactionist view of individuals and their environment (person and environment)...
  11. ncbi Neuroticism, major depression and gender: a population-based twin study
    A Fanous
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:719-28. 2002
    ....
  12. ncbi Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach
    A Agrawal
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1 154, Richmond, VA 23298 0003, USA
    Addict Behav 30:1043-8. 2005
    ..Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences...
  13. ncbi Caffeine intake, tolerance, and withdrawal in women: a population-based twin study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, and the Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Am J Psychiatry 156:223-8. 1999
    ..However, the impact of genetic factors on caffeine consumption, heavy use, intoxication, tolerance, and withdrawal is largely unknown...
  14. ncbi Panic syndromes in a population-based sample of male and female twins
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    Psychol Med 31:989-1000. 2001
    ..to a similar degree, on the liability to PD in males and females...
  15. ncbi Interpersonal dependence and major depression: aetiological inter-relationship and gender differences
    V A Sanathara
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 33:927-31. 2003
    ..IPD scores in males were more predictive of lifetime MD than for females. The higher levels of IPD in women than in men may contribute meaningfully to the sex differences in risk for MD...
  16. ncbi Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample
    B P Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
    Mol Psychiatry 11:1025-31. 2006
    ....
  17. ncbi Childhood parental loss and risk for first-onset of major depression and alcohol dependence: the time-decay of risk and sex differences
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:1187-94. 2002
    ....
  18. ncbi The joint analysis of personal interview and family history diagnoses: evidence for validity of diagnosis and increased heritability estimates
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0126, USA
    Psychol Med 32:829-42. 2002
    ..However, account must be taken of the fact that family history reports are systematically biased. While promising, these results are preliminary and require replication...
  19. ncbi Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:605-16. 2001
    ..Is the heritability of MD different in men and women? Do the same genetic risk factors predispose to MD in the two sexes?..
  20. ncbi Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs
    L M Karkowski
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Richmond, Virginia, USA
    Am J Med Genet 96:665-70. 2000
    ..Degree of influence of the factors differs for the substances examined. However, no specific genetic or familial environmental factors were found to contribute significantly to use of any of the illicit substances...
  21. ncbi Sex differences in genetic and environmental risk factors for irrational fears and phobias
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:209-17. 2002
    ..How does sex impact on the familial transmission of liability to fears and phobias?..
  22. ncbi A twin study of sex differences in social support
    A Agrawal
    Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond 23298, USA
    Psychol Med 32:1155-64. 2002
    ..Shared environmental factors influence relative support and relative problems in both sexes. Sex differences were detected for confidants and relative support...
  23. ncbi Fatigue in a community sample of twins
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298-0126, USA
    Psychol Med 33:263-81. 2003
    ..CONCLUSIONS: IF is a complex and common human symptom that is highly heterogeneous. More precise understanding of the determinants of IF may lead to a fuller understanding of more extreme conditions like chronic fatigue syndrome...
  24. ncbi Features of childhood sexual abuse and the development of psychiatric and substance use disorders
    C M Bulik
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Br J Psychiatry 179:444-9. 2001
    ..Childhood sexual abuse (CSA) is associated with an increased risk of subsequent psychiatric disorders...
  25. ncbi Are there sex differences in the reliability of a lifetime history of major depression and its predictors?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:617-25. 2001
    ..Given the large impact of sex on risk for LTMD, it is of interest to know if there are sex differences in the reliability of LTMD and its predictors...
  26. ncbi Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence
    K S Kendler
    Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Mol Psychiatry 17:1306-15. 2012
    ..While tentative and in need of replication, these results, consistent with the rodent literature, were validated by examining predictions of the genetic factor scores and have implications for gene-finding efforts in AD...
  27. ncbi Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4
    C A Prescott
    Department of Psychology, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA
    Mol Psychiatry 11:603-11. 2006
    ..The results of this study suggest the importance of genetic variation in chromosome 4 in the etiology and severity of alcoholism in Caucasian populations...
  28. ncbi The prediction of thoughts of death or self-harm in a population-based sample of female twins
    A H Fanous
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 34:301-12. 2004
    ..We cannot rule out that differences between these analyses and previous reports were due to our use of TD/SH as the dependent variable instead of thoughts of committing suicide per se...
  29. ncbi A twin study of personality and illicit drug use and abuse/dependence
    Arpana Agrawal
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Depts Of Human Genetics and Psychiatry, Richmond, USA
    Twin Res 7:72-81. 2004
    ..NS was most closely related to cannabis use while N showed significant genetic overlap with sedative use. NS in males appears to be a good indicator of risk for cannabis use. This result may be useful for candidate gene studies...
  30. ncbi Mixed-effects variance components models for biometric family analyses
    John J McArdle
    Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
    Behav Genet 35:631-52. 2005
    ....
  31. ncbi The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history
    Carol A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 29:417-29. 2005
    ....
  32. ncbi Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issue
    Carol A Prescott
    Department of Psychology, University of Southern California, SGM 501, Los Angeles, CA, 90036, USA
    Behav Genet 36:473-82. 2006
    ....
  33. ncbi The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 62:529-35. 2005
    ..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?..
  34. ncbi A population-based twin study of the relationship between neuroticism and internalizing disorders
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:857-64. 2006
    ..The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity...
  35. ncbi The differential impact of risk factors on illicit drug involvement in females
    Arpana Agrawal
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Dept of Human Genetics, Richmond, VA, USA
    Soc Psychiatry Psychiatr Epidemiol 40:454-66. 2005
    ..Are there risk factors that associate with illicit drug use or illicit drug abuse/dependence? Is the magnitude of the association the same for use and abuse/dependence? Does this pattern of association differ across categories of drugs?..
  36. ncbi Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA
    Behav Genet 36:536-52. 2006
    ..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences...
  37. ncbi Toward a comprehensive developmental model for major depression in men
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:115-24. 2006
    ..In 2002, the authors presented a developmental model for major depression in women. Based on similar methods, they here present an analogous model for men...
  38. ncbi Genetic and environmental influences on illicit drug use and tobacco use across birth cohorts
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:1349-56. 2005
    ..One theory, which postulates that heritability of deviant traits increases in permissive environments, predicts a positive relationship across cohorts between prevalence and heritability of substance use...
  39. ncbi The temporal relationship of the onsets of alcohol dependence and major depression: using a genetically informative study design
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:1153-62. 2006
    ..In this longitudinal study, we used a genetically informative population-based twin sample to examine the age-at-onset distributions and the temporal relationship of AD and MD...
  40. ncbi Lifestyle risk and delaying factors
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Alzheimer Dis Assoc Disord 20:S84-8. 2006
    ..Such findings point to the importance of taking a life-course perspective to designing interventions to delay or to prevent dementia...
  41. ncbi Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood
    Kenneth S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical School of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:674-82. 2008
    ..While both environmental and genetic factors are important in the etiology of psychoactive substance use (PSU), we know little of how these influences differ through development...
  42. ncbi Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  43. ncbi Genomewide linkage survey of nicotine dependence phenotypes
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Drug Alcohol Depend 93:210-6. 2008
    ..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses...
  44. ncbi Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 64:1313-20. 2007
    ..Although genetic risk factors have been found to contribute to dependence on both licit and illicit psychoactive substances, we know little of how these risk factors interrelate...
  45. ncbi Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Meyer 115, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 164:1714-21. 2007
    ....
  46. ncbi Creating a social world: a developmental twin study of peer-group deviance
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, VA 23298 0126, USA
    Arch Gen Psychiatry 64:958-65. 2007
    ..Peer-group deviance is strongly associated with externalizing behaviors. We have limited knowledge of the sources of individual differences in peer-group deviance...
  47. ncbi Factor and item-response analysis DSM-IV criteria for abuse of and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opioids
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA 23219 1534, USA
    Addiction 102:920-30. 2007
    ....
  48. ncbi Twin pair resemblance for psychiatric hospitalization in the Swedish Twin Registry: a 32-year follow-up study of 29,602 twin pairs
    Carol A Prescott
    Department of Psychology, University of Southern California, 3620 S McClintock Ave, SGM 501, Los Angeles, CA 90089 1061, USA
    Behav Genet 37:547-58. 2007
    ..The present report updates the prior results by using 17 additional years of follow-up, including members of opposite-sex twin pairs, and addressing biases arising from cohort effects and from excluding pairs with unknown zygosity...
  49. ncbi Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Psychol Med 37:947-59. 2007
    ..Although an obvious environmental factor influencing drug use, the sources of individual differences in drug availability (DA) are unknown...
  50. ncbi A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007
    ..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study...
  51. ncbi A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  52. ncbi Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  53. ncbi The impact of generalized anxiety disorder and stressful life events on risk for major depressive episodes
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:789-95. 2006
    ..In this study, we sought to analyze the joint effects of prior history of GAD and recent SLEs on risk for major depressive episodes, comparing these in men and women...
  54. ncbi Personality and comorbidity of common psychiatric disorders
    Amir A Khan
    Mental Health and Behavioral Sciences Service, Providence VA Medical Center, 830 Chalkstone Ave, Providence, RI 02908, USA
    Br J Psychiatry 186:190-6. 2005
    ..We know little about the degree to which comorbidity, socommonly seen among psychiatric disorders, arises from variation in normal personality...
  55. ncbi Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and females
    Arpana Agrawal
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 34:217-28. 2004
    ..Overall, our results suggest that the use and abuse/dependence of cannabis and other illicit drugs are strongly linked via common risk factors that jointly influence their individual liabilities...
  56. ncbi Is risk for alcoholism mediated by individual differences in drinking motivations?
    Carol A Prescott
    Virginia Institute of Psychiatric and Behavioral Genetics, Departments of Psychiatry and Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
    Alcohol Clin Exp Res 28:29-39. 2004
    ....
  57. ncbi Using the Mplus computer program to estimate models for continuous and categorical data from twins
    Carol A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126
    Behav Genet 34:17-40. 2004
    ....
  58. ncbi Major depression and associated impairment: same or different genetic and environmental risk factors?
    Debra L Foley
    Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
    Am J Psychiatry 160:2128-33. 2003
    ..Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses?..
  59. ncbi The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0126, USA
    Arch Gen Psychiatry 60:929-37. 2003
    ..The pattern of lifetime comorbidity of common psychiatric and substance use disorders results largely from the effects of genetic risk factors...
  60. ncbi Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 60:789-96. 2003
    ..The event dimensions that preceded mixed MD-GAS episodes were largely the sum of those that preceded pure MD and pure GAS episodes...
  61. ncbi Sex differences in the genetic risk for alcoholism
    Carol A Prescott
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    Alcohol Res Health 26:264-73. 2002
    ..However, the genetic epidemiology research conducted to date on this issue has several limitations, some of which may be resolved by future molecular genetic studies...
  62. ncbi Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    Am J Psychiatry 160:687-95. 2003
    ..Data on use and misuse of six classes of illicit substances by male twin pairs were used to examine whether genetic and shared environmental risk factors for substance use disorders are substance-specific or -nonspecific in their effect...
  63. ncbi Dimensions of religiosity and their relationship to lifetime psychiatric and substance use disorders
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 160:496-503. 2003
    ..This study used data from a general population sample to clarify the dimensions of religiosity and the relationships of these dimensions to risk for lifetime psychiatric and substance use disorders...
  64. ncbi Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs
    Amir A Khan
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 159:1427-9. 2002
    ..Gender differences in the symptoms of major depression have received limited research attention. The aim of this study was to explore these differences in male-female twin pairs...
  65. ncbi Toward a comprehensive developmental model for major depression in women
    Kenneth S Kendler
    Department of Psychiatry, PO Box 980126, Medical College of Virginia, Richmond, VA 23298 0126, USA
    Am J Psychiatry 159:1133-45. 2002
    ..The authors used structural equation modeling to generate a developmental model for the etiology of major depression in women...
  66. ncbi The subtypes of major depression in a twin registry
    Patrick F Sullivan
    Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
    J Affect Disord 68:273-84. 2002
    ..The subtypes of major depression (MD) remain incompletely understood. While there is consensus about the existence of MD with 'typical' vegetative features, further data are required to evaluate the existence of MD with atypical features...
  67. ncbi Sex differences in the genetic and environmental influences on the development of antisocial behavior
    Kristen C Jacobson
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    Dev Psychopathol 14:395-416. 2002
    ..We speculate that sex differences in timing of puberty may account for the earlier presence of genetic effects among females...
  68. ncbi Sex influences on shared risk factors for bulimia nervosa and other psychiatric disorders
    Tracey D Wade
    School of Psychology, Flinders University, Adelaide, Australia
    Arch Gen Psychiatry 61:251-6. 2004
    ..The examination of opposite-sex and same-sex dizygotic twins allows us to explore the sex-specific comorbidity of psychiatric disorders. To date, this question has not been explored in eating disorders...
  69. ncbi Sources of individual differences in stressful life event exposure in male and female twins
    P Kevin Bolinskey
    Medical College of Virginia Commonwealth University, Richmond, USA
    Twin Res 7:33-8. 2004
    ..Genetic correlations between males and females suggest that many of the same genetic factors are acting within both genders...
  70. ncbi Childhood sexual abuse, stressful life events and risk for major depression in women
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia, Richmond, VA 23298-0126, USA
    Psychol Med 34:1475-82. 2004
    ..Both genetic and early environmental risk factors can produce long-term increase in the sensitivity of individuals to depressogenic life experiences...
  71. ncbi The Washington University Twin Study of alcoholism
    Carol A Prescott
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 134:48-55. 2005
    ..Power to test other sources of heterogeneity was limited, but the results suggest no evidence for higher heritability for male early onset alcoholism or for alcoholism with comorbid antisocial personality...
  72. ncbi The structure of genetic and environmental risk factors for anxiety disorders in men and women
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 62:182-9. 2005
    ..The anxiety disorders exhibit high levels of lifetime comorbidity with one another. Understanding the underlying causes of this comorbidity can provide insight into the etiology of the disorders and inform classification and treatment...
  73. ncbi Level of family dysfunction and genetic influences on smoking in women
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 34:1263-9. 2004
    ..An adoption study of alcoholism suggests that in women, the impact of genetic risk factors become greater in the presence of conflict in the family of origin. Is the same true for cigarette smoking (CS)?..
  74. ncbi A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004
    ..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary...
  75. ncbi A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugs
    Arpana Agrawal
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond, VA 23298 0003, USA
    Psychol Med 34:1227-37. 2004
    ..Gateway and common liabilities models have been employed to explain this relationship. We sought to examine this association using a combination of the discordant twin design and modeling methods...
  76. ncbi Sex differences in the relationship between social support and risk for major depression: a longitudinal study of opposite-sex twin pairs
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0126, USA
    Am J Psychiatry 162:250-6. 2005
    ..Clarification of the nature of the causal links between low social support and depression in women is needed...
  77. ncbi Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 161:1581-7. 2004
    ..Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored...
  78. ncbi Forms of cannabis and cocaine: a twin study
    Arpana Agrawal
    Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Am J Med Genet B Neuropsychiatr Genet 129:125-8. 2004
    ..These findings also reinforce the validity of composite variables in epidemiological and genetic research...
  79. ncbi A population based twin study of sex differences in depressive symptoms
    Arpana Agrawal
    Department of Human Genetics, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond 23298, USA
    Twin Res 7:176-81. 2004
    ..Our analyses suggest that while there may be mean differences in the levels of depressive symptoms across sexes, the genetic and environmental factors that predispose males and females to depressive symptoms are not different...
  80. ncbi The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 161:631-6. 2004
    ..Little is known about how they interrelate in the etiology of depressive illness...
  81. ncbi The etiology of phobias: an evaluation of the stress-diathesis model
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh St, Box 980126, Richmond, VA 23298-0126, USA
    Arch Gen Psychiatry 59:242-8. 2002
    ..The stress-diathesis model may not be an appropriate paradigm for phobic disorders...
  82. ncbi The types of regular cigarette smokers: a latent class analysis
    Helena Furberg
    Department of Genetics, University of North Carolina at Chapel Hill, School of Medicine 27599 7264, USA
    Nicotine Tob Res 7:351-60. 2005
    ....
  83. ncbi The differential heritability of regular tobacco use based on method of administration
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0126, USA
    Twin Res Hum Genet 8:60-2. 2005
    ..Thus, the genetic influences on the liability for regular tobacco use appear to vary based on tobacco type. The causes for the use of different forms of tobacco are complex and worthy of further study...