Research Topics
| John T PovlishockSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Publications
Posthypothermic rewarming considerations following traumatic brain injuryJohn T Povlishock
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0709, USA
J Neurotrauma 26:333-40. 2009..Collectively, this review highlights not only the benefits of hypothermic intervention, but also the rate of posthypothermic rewarming as an important variable in assuring maximal efficacy following the use of hypothermic intervention...
Update of neuropathology and neurological recovery after traumatic brain injuryJohn T Povlishock
Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, 1101 East Marshall St, PO Box 980709, Richmond, VA 23298, USA
J Head Trauma Rehabil 20:76-94. 2005....- The long-term microvascular and behavioral consequences of experimental traumatic brain injury after hypothermic interventionEnoch P Wei
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0709, USA
J Neurotrauma 26:527-37. 2009..These findings further illustrate the complexity of TBI and highlight the fact that the chosen hypothermic intervention may not necessarily exert a global protective response... - Combinational therapy using hypothermia and the immunophilin ligand FK506 to target altered pial arteriolar reactivity, axonal damage, and blood-brain barrier dysfunction after traumatic brain injury in ratYasutaka Oda
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
J Cereb Blood Flow Metab 31:1143-54. 2011..This suggests that hypothermia not only protects but also extends the therapeutic window for improved FK506 efficacy... - Effects of delayed, prolonged hypothermia on the pial vascular response after traumatic brain injury in ratsYuji Ueda
Department of Anatomy, Medical College of Virginia, Campus of Virginia Commonwealth University, Richmond, Virginia 23298-0709, USA
J Neurosurg 99:899-906. 2003..CONCLUSIONS: The results of this study show that early as well as delayed but prolonged hypothermia attenuate the impaired vascular responsiveness seen after TBI, indicating the potential clinical usefulness of this treatment... - Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsivenessYuji Ueda
Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298-0709, USA
Stroke 35:601-6. 2004..Our data with acetylcholine and SNP suggest that rapid rewarming most likely causes abnormality at both the vascular smooth muscle and endothelial levels... - Mechanoporation induced by diffuse traumatic brain injury: an irreversible or reversible response to injury?Orsolya Farkas
Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 26:3130-40. 2006..0 and 35.4%, respectively, showing CMSP. These studies illustrate that DTBI evokes evolving plasmalemmal changes that highlight mechanical and potential secondary events in membrane poration... - Preferential neuroprotective effect of tacrolimus (FK506) on unmyelinated axons following traumatic brain injuryThomas M Reeves
Department of Anatomy and Neurobiology, 1217 E Marshall Street, Room 740, Medical Campus Box 980709, Virginia Commonwealth University, Richmond, VA 23298, USA
Brain Res 1154:225-36. 2007..Collectively, these studies further substantiate a distinctive role of unmyelinated axons in TAI, and suggest a highly efficacious neuroprotective strategy to target this axonal population... - The adverse pial arteriolar and axonal consequences of traumatic brain injury complicated by hypoxia and their therapeutic modulation with hypothermia in ratGuoyi Gao
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
J Cereb Blood Flow Metab 30:628-37. 2010..Although this damage is attenuated by hypothermia, this follows only when hypoxia occurs during hypothermia, with no benefit found if the hypoxic insult proceeds or follows hypothermia... - The combination of either tempol or FK506 with delayed hypothermia: implications for traumatically induced microvascular and axonal protectionMotoki Fujita
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
J Neurotrauma 28:1209-18. 2011..These divergent results may be a reflection of the different animal models used and/or their associated injury severity... - Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degenerationBrian J Kelley
Department of Anatomy and Neurobiology, Medical College of Virginia Campus at Virginia Commonwealth University, Richmond, VA 23298-0709, USA
Exp Neurol 198:350-60. 2006..Collectively, this DBI-mediated ultrarapid perisomatic axotomy and its sequelae further illustrate the varied axonal responses to trauma... - Administration of the immunophilin ligand FK506 differentially attenuates neurofilament compaction and impaired axonal transport in injured axons following diffuse traumatic brain injuryChristina R Marmarou
Department of Anatomy and Neurobiology, Virginia Commonwealth University, PO Box 980709, Richmond, 23298, USA
Exp Neurol 197:353-62. 2006..Because FK506 targets IAT, calcineurin appears to be a major target for neuroprotection in damaged axons demonstrating IAT... 
Cerebral vascular responsiveness after experimental traumatic brain injury: the beneficial effects of delayed hypothermia combined with superoxide dismutase administrationAnna I Baranova
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
J Neurosurg 109:502-9. 2008....- Intensity- and interval-specific repetitive traumatic brain injury can evoke both axonal and microvascular damageMotoki Fujita
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
J Neurotrauma 29:2172-80. 2012..Additionally, they also demonstrate that these axonal changes parallel changes in the cerebral microcirculation, which also may have adverse consequences for the injured brain... - Traumatic axonal injury in the optic nerve: evidence for axonal swelling, disconnection, dieback, and reorganizationJiaqiong Wang
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
J Neurotrauma 28:1185-98. 2011..Collectively, the results of this study within the injured optic nerve provide unprecedented insight into the evolving pathobiology associated with TAI... - Quantitative analysis of the relationship between intra- axonal neurofilament compaction and impaired axonal transport following diffuse traumatic brain injuryChristina R Marmarou
Department of Anatomy and Neurobiology, Virginia Commonwealth University Health Center, Virginia Commonwealth University, Richmond, VA 23298, USA
J Neurotrauma 22:1066-80. 2005..Our findings argue for the use of multiple markers when evaluating the extent of TAI or the efficacy of therapies targeting the treatment of TAI... - Identification and characterization of heterogeneous neuronal injury and death in regions of diffuse brain injury: evidence for multiple independent injury phenotypesRichard H Singleton
Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 24:3543-53. 2004.... - Diffuse traumatic axonal injury in the mouse induces atrophy, c-Jun activation, and axonal outgrowth in the axotomized neuronal populationJohn E Greer
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
J Neurosci 31:5089-105. 2011..Collectively, these TAI-linked events are consistent with sustained neuronal recovery, an activation of a regenerative genetic program, and subsequent axonal reorganization suggestive of some form of regenerative response... - Increased intracranial pressure after diffuse traumatic brain injury exacerbates neuronal somatic membrane poration but not axonal injury: evidence for primary intracranial pressure-induced neuronal perturbationAudrey D Lafrenaye
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
J Cereb Blood Flow Metab 32:1919-32. 2012..These findings indicate that persistently increased ICP, without deleterious alteration of CPP, exacerbates neuronal plasmalemmal perturbation that could precipitate persistent neuronal impairment and ultimate neuronal death... - Electrophysiological abnormalities in both axotomized and nonaxotomized pyramidal neurons following mild traumatic brain injuryJohn E Greer
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298, USA
J Neurosci 32:6682-7. 2012..Together, these results demonstrate that intact and axotomized neurons are both affected by mTBI, resulting in different changes in neuronal excitability that may contribute to network dysfunction following TBI... - Posttraumatic hypothermia followed by slow rewarming protects the cerebral microcirculationEiichi Suehiro
Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298-0709, USA
J Neurotrauma 20:381-90. 2003.... - Cellular and subcellular change evoked by diffuse traumatic brain injury: a complex web of change extending far beyond focal damageOrsolya Farkas
Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, P O Box 980709, Richmond, VA 23298, USA
Prog Brain Res 161:43-59. 2007..This review further illustrates that our once simplistic views framed by evidence based upon contusional and/or ischemic change do not fully explain the complex repertoire of change evoked by diffuse traumatic brain injury... - Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusionMelissa J McGinn
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA
J Neuropathol Exp Neurol 68:241-9. 2009..These results confirm the widespread occurrence of calpain-mediated spectrin proteolysis after diffuse TBI without contusion and support the potential utility of SBDPs as biomarkers of a diffusely injured brain... - Perivascular nerve damage in the cerebral circulation following traumatic brain injuryYuji Ueda
Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, Box 980709, Richmond, VA 23298-0709, USA
Acta Neuropathol (Berl) 112:85-94. 2006..5 immunoreactivity occurred, however, it did not reach a control-like distribution. These studies suggest that neurogenic damage occurs following TBI and may be a contributor to some of the associated vascular abnormalities... - A persistent change in subcellular distribution of calcineurin following fluid percussion injury in the ratJonathan E Kurz
Department of Neurology, Virginia Commonwealth University, Box 980599, Richmond, VA 23298, USA
Brain Res 1048:153-60. 2005..These changes have broad physiological implications, possibly resulting in altered cellular excitability or a greater likelihood of neuronal cell death... - Matrix metalloproteinase inhibition alters functional and structural correlates of deafferentation-induced sprouting in the dentate gyrusThomas M Reeves
Department of Anatomy and Neurobiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 23:10182-9. 2003..These results establish a role for MMP-dependent processes in the deafferentation/sprouting cycle... - Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteinsZhibing Zhang
Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Cell Motil Cytoskeleton 64:360-76. 2007..The findings also demonstrate that SPAG6 and SPAG16L have related roles in controlling the function of cilia in the brain and lung... - Traumatically induced axotomy adjacent to the soma does not result in acute neuronal deathRichard H Singleton
Departments of Anatomy and Anesthesiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 22:791-802. 2002..Rather, some somata showed evidence of potential reorganization and repair. This study demonstrates a novel somatic response to TAI in the perisomatic domain and also provides insight into the multifaceted pathology associated with TBI... - Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injuryThomas M Reeves
Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, 1217 E Marshall Street, Room 740, MCV Campus Box 980709, Richmond, VA 23298, USA
Exp Neurol 196:126-37. 2005..Collectively, these findings demonstrate differential vulnerabilities of axons to brain injury and suggest that damage to unmyelinated fibers may play a significant role in morbidity associated with brain injury... - Effects of hypothermia on cerebral autoregulatory vascular responses in two rodent models of traumatic brain injuryMotoki Fujita
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
J Neurotrauma 29:1491-8. 2012..Collectively, these studies also demonstrate that different animal models of TBI can evoke different biological responses to injury... - The effects of combined fluid percussion traumatic brain injury and unilateral entorhinal deafferentation on the juvenile rat brainMayumi L Prins
Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
Brain Res Dev Brain Res 140:93-104. 2003..Moreover, when deafferented tissue is assessed morphologically, evidence exists for aberrant plasticity and abnormal synaptic reorganization in the juvenile brain... - Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid Beta peptide in traumatic axonal injuryJames R Stone
Department of Neurosurgery, University of Virginia, Charlottesville, Virginia 22908 0212, USA
J Neurotrauma 19:601-14. 2002..These findings are of interest given recent epidemiological studies supporting an association between TBI and later risk for AD development... - Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injuryJames R Stone
Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908, USA
Exp Neurol 190:59-69. 2004..This finding underscores the need of multiple approaches to fully assess the axonal response to TBI... - Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injuryOrsolya Farkas
Department of Neurosurgery, , Medical Faculty, Hungary
Regul Pept 123:69-75. 2004.... - Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in ratsAndrea Tamas
Department of Anatomy Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, University of Pecs, Medical Faculty, Pecs, Hungary
J Neurotrauma 23:686-95. 2006..While the results of this study highlighted the complexity of the pathogenesis and manifestation of diffuse axonal injury, they also indicate that PACAP should be considered a potential therapeutic agent in TBI... - Guidelines for the management of severe traumatic brain injury. Editor's CommentaryM Ross Bullock
J Neurotrauma 24:2 p preceding S1. 2007 - The classification of traumatic brain injury (TBI) for targeted therapiesJohn T Povlishock
J Neurotrauma 25:717-8. 2008
Research Grants
- THE BRAIN PARENCHYMAL AND VASCULAR RESPONSE TO TRAUMAJOHN POVLISHOCK; Fiscal Year: 2005..abstract_text> ..
- THE AXONAL RESPONSE TO TRAUMATIC BRAIN INJURYJOHN POVLISHOCK; Fiscal Year: 2007..Collectively, these studies should provide information of both therapeutic and mechanistic importance, which should have relevance to several ongoing clinical trials. ..
- VCU Neuroscience Center Core GrantJOHN POVLISHOCK; Fiscal Year: 2007..Together with the P.I., there is every expectation that they will function in a highly productive fashion, assuring the overall success of this application. ..