Research Topics
| J H PorterSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Publications
Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studiesJoseph H Porter
Department of Psychology, Virginia Commonwealth University, 806 West Franklin Street, P O Box 842018, Richmond, VA, USA
Psychopharmacology (Berl) 203:279-94. 2009....- The discriminative stimulus properties of the atypical antipsychotic olanzapine in ratsJ H Porter
Department of Psychology, Virginia Commonwealth University, Richmond 23284 2018, USA
Psychopharmacology (Berl) 148:224-33. 2000..Analysis of the preclinical behavioral effects of atypical antipsychotic agents will provide a better understanding of how they differ from typical antipsychotics and aid in the development of future atypical antipsychotic drugs... - Clozapine discrimination with a low training dose distinguishes atypical from typical antipsychotic drugs in ratsJ H Porter
Department of Psychology, Virginia Commonwealth University, Richmond 23284 2018, USA
Psychopharmacology (Berl) 149:189-93. 2000..Previous drug discrimination studies with clozapine have not reliably distinguished between atypical and typical antipsychotics... - Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in ratsJoseph H Porter
Department of Psychology, Virginia Commonwealth University, PO Box 842018, 808 West Franklin Street, Richmond, VA 23284 2018, USA
Psychopharmacology (Berl) 178:67-77. 2005..The atypical antipsychotic drug (APD) clozapine elicits a robust discriminative cue that is generally selective for other atypical APDS in two-choice drug discrimination (DD) procedures... - A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred miceJoseph H Porter
Department of Psychology, Virginia Commonwealth University, Richmond, Virginia 23284 2018, USA
Behav Pharmacol 19:530-42. 2008..Differences in dopamine-mediated functions between the two strains of mice may explain some of the findings in this study... - Effects of antipsychotic drugs on operant responding after acute and repeated administrationS A Varvel
Department of Pharmacology and Toxicology, VCU, P O Box 980613, Richmond, VA 23298, USA
Psychopharmacology (Berl) 160:182-91. 2002..However, a theoretical framework and adequate preclinical models have not yet been developed to predict or explain differences among the atypical antipsychotics, a necessary component of future development... - Effects of phencyclidine-like drugs on punished behavior in ratsJ H Porter
Department of Psychology, Virginia Commonwealth University, Richmond
J Pharmacol Exp Ther 248:997-1002. 1989..The concordance between the discriminative stimulus properties and antipunishment effects of PCP-like drugs and actions at the PCP receptor suggests that the PCP receptor may play a role in both behavioral actions of this group of drugs... - Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination taskA J Prus
Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284-2018, USA
Behav Pharmacol 16:511-20. 2005..0 mg/kg CLZ training dose. Full substitution by olanzapine for only the 5.0 mg/kg CLZ dose suggests that this higher training dose is also important for screening atypical APDs... - Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicleRobert E Vann
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
Drug Alcohol Depend 103:124-30. 2009..Taken together, these results suggest that methadone's shared subjective effects with abused opioids, as well as its unique metabolic properties contribute to its efficacy in opioid maintenance therapy... - Effects of modulation of NMDA neurotransmission on response rate and duration in a conflict procedure in ratsJ L Wiley
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
Neuropharmacology 37:1527-34. 1998..Further research is needed to clarify the experimental conditions under which the anxiolytic potential of NMDA antagonists is most evident... - The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in ratsAdam J Prus
Department of Psychology, Northern Michigan University, Marquette, MI, USA
Psychopharmacology (Berl) 203:295-301. 2009..Recent studies have indicated that the active CLZ metabolite N-desmethylclozapine (NDMC) may play a role in mediating the cognitive efficacy of CLZ and may also have atypical antipsychotic properties... - Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 miceScott D Philibin
Department of Psychology, Virginia Commonwealth University, 808 West Franklin Street, PO Box 842018, Richmond, VA 23284-2018, USA
Psychopharmacology (Berl) 180:49-56. 2005..These results suggest that CLZ drug discrimination in C57BL/6 mice may be an effective preclinical behavioral assay for screening atypical from typical antipsychotic drugs... - Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25 mg/kg clozapine vs. 5.0 mg/kg clozapine vs. vehicleAdam J Prus
Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Behav Pharmacol 17:185-94. 2006....