Takeshi Otowa

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Parenting and risk for mood, anxiety and substance use disorders: a study in population-based male twins
    Takeshi Otowa
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Soc Psychiatry Psychiatr Epidemiol 48:1841-9. 2013
  2. doi request reprint Association study of PDE4B with panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:545-9. 2011
  3. doi request reprint Association of RGS2 variants with panic disorder in a Japanese population
    Takeshi Otowa
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 156:430-4. 2011
  4. ncbi request reprint Association study between the TNXB locus and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 144:305-9. 2007
  5. ncbi request reprint No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 88:260-4. 2006
  6. doi request reprint Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:62-5. 2009
  7. doi request reprint An association analysis of Per2 with panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hum Genet 56:748-50. 2011
  8. doi request reprint No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 54:437-9. 2009
  9. doi request reprint Replication of a genome-wide association study of panic disorder in a Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, The University of Tokyo, Japan
    J Hum Genet 55:91-6. 2010
  10. ncbi request reprint Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 60:524-6. 2006

Collaborators

Detail Information

Publications33

  1. pmc Parenting and risk for mood, anxiety and substance use disorders: a study in population-based male twins
    Takeshi Otowa
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Soc Psychiatry Psychiatr Epidemiol 48:1841-9. 2013
    ..Previous studies consistently identified a relationship between parenting behavior and psychopathology. In this study, we extended prior analyses performed in female twins to a large sample of twins from male-male pairs...
  2. doi request reprint Association study of PDE4B with panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:545-9. 2011
    ..Several studies indicated that PDE4B may be involved in the regulation of anxiety and depression. Therefore, we investigate the association of PDE4B with PD in the Japanese population...
  3. doi request reprint Association of RGS2 variants with panic disorder in a Japanese population
    Takeshi Otowa
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 156:430-4. 2011
    ..038, OR = 0.80, 95%CI = 0.68-0.95; T-C-T, permutation P = 0.004, OR = 0.38, 95%CI = 0.21-0.70). These results provide support for an association of RGS2 with PD in a Japanese population...
  4. ncbi request reprint Association study between the TNXB locus and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 144:305-9. 2007
    ..Although these associations became insignificant after Bonferroni correction, the findings might provide support for the association of the TNXB locus or its adjacent region of the NOTCH4 locus with schizophrenia...
  5. ncbi request reprint No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 88:260-4. 2006
    ..Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population...
  6. doi request reprint Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:62-5. 2009
    ..The results of this study suggest that these polymorphisms in RA susceptibility genes do not contribute to genetic susceptibility to schizophrenia...
  7. doi request reprint An association analysis of Per2 with panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hum Genet 56:748-50. 2011
    ..046, uncorrected), whereas we could not replicate the association in the second sample of 460 patients and 460 controls. Our results suggest that Per2 may not have a major role in the pathogenesis of PD in the Japanese population...
  8. doi request reprint No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 54:437-9. 2009
    ..No association of the Val66Met was consistent with two small studies in Japanese and Chinese populations. We therefore conclude that the BDNF polymorphism may not play a major role in PD in the East Asian populations...
  9. doi request reprint Replication of a genome-wide association study of panic disorder in a Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, The University of Tokyo, Japan
    J Hum Genet 55:91-6. 2010
    ..Our results failed to show any significant association with PD in these genes. Further studies on these variants with a larger sample size may be worth testing to confirm the results...
  10. ncbi request reprint Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Clin Neurosci 60:524-6. 2006
    ..004, uncorrected, anova), while no relationship was observed concerning Neuroticism. The present result suggests an association between CRHR2 and the personality trait of Openness...
  11. ncbi request reprint Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pharmacogenet Genomics 17:867-72. 2007
    ..The association between the MAOB polymorphism and personality traits was also explored...
  12. ncbi request reprint No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1122-4. 2006
    ..As a result, no significant association was observed between the genotypes and the scores of the NEO PI-R or the STAI. The present results suggest that CC16 may not have a major role in the development of personality traits...
  13. ncbi request reprint Genome-wide association study of panic disorder in the Japanese population
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 54:122-6. 2009
    ..Studies with other samples are required to confirm the results...
  14. ncbi request reprint Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Lett 398:333-6. 2006
    ..Thus, the present study suggested the association between the short allele of the DRD4 exon III polymorphism and personality trait of Neuroticism in Japanese subjects...
  15. ncbi request reprint Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 56:154-8. 2006
    ..The results might be similar to a previous Asian study, but specific haplotypes suggested for the association differed between the studies. Studies with more markers and subjects may be required before firm conclusions can be reached...
  16. ncbi request reprint Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Med Genet B Neuropsychiatr Genet 128:37-40. 2004
    ..In conclusion, the present study provided no clear evidence for an association between the NOTCH4 gene and schizophrenia in the Japanese population...
  17. ncbi request reprint Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Psychiatr Genet 15:67-9. 2005
    ..Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits...
  18. doi request reprint The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A
    Yoshiya Kawamura
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
    J Affect Disord 127:31-7. 2010
    ..The objective of this study is to assess the association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments...
  19. ncbi request reprint No association between the CNTF null mutation and schizophrenia or personality
    Jun Nishiyama
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatr Genet 16:217-9. 2006
    ..The present study did not provide evidence for the association between the CNTF gene and schizophrenia or personality traits in the Japanese population...
  20. ncbi request reprint Mitochondrial DNA polymorphisms and extraversion
    Chieko Kato
    Department of Psychiatry, Health Service Center, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113, Japan
    Am J Med Genet B Neuropsychiatr Genet 128:76-9. 2004
    ..042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait...
  21. doi request reprint Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population
    Xiaoxi Liu
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hum Genet 55:137-41. 2010
    ..In conclusion, our study might support that OXTR has a significant role in conferring the risk of ASD in the Japanese population...
  22. ncbi request reprint Six-year stability of affective temperaments as measured by TEMPS-A
    Yoshiya Kawamura
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, Japan
    Psychopathology 43:240-7. 2010
    ....
  23. ncbi request reprint Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    Neurosci Res 54:180-5. 2006
    ..04, after Bonferroni correction). These results may provide evidence for the association between metabolic change of catecholamines and personality traits, which may be due to the additive effect of the three genes...
  24. ncbi request reprint No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Lett 403:100-2. 2006
    ..The genes might not have major role in the development of personality traits, although further investigation with larger sample size may be recommended for conclusion...
  25. ncbi request reprint Gender-Specific Association between the COMT Val158Met Polymorphism and Openness to Experience in Panic Disorder Patients
    Yoshiaki Konishi
    Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Tsu, Japan
    Neuropsychobiology 69:165-74. 2014
    ..Conclusion: The gender-specific effect of the COMT genotype suggests that the COMT Val/Met genotype may influence a personality trait, openness to experience, in males with panic disorder. © 2014 S. Karger AG, Basel. ..
  26. ncbi request reprint Season of birth effect on personality in a general population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Neurosci Lett 365:120-3. 2004
    ..Evaluation of cognitive functions and behaviors using other measures including event-related potentials and functional MRI may also help the interpretation of the present result...
  27. doi request reprint Appropriate data cleaning methods for genome-wide association study
    Taku Miyagawa
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, 113 0033, Japan
    J Hum Genet 53:886-93. 2008
    ..We found that appropriate data cleaning could be achieved using these four parameters. Our findings offer an avenue for obtaining appropriate data from GWAS...
  28. ncbi request reprint Insertional polymorphism of endogenous retrovirus HERV-K115 in schizophrenia
    Takeshi Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Neurosci Lett 408:226-9. 2006
    ..These results preliminarily suggest that HERV-K115 may not be associated with schizophrenia in general, but that it could play a partial role in early precipitation of the disease...
  29. ncbi request reprint No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo113 8655, Japan
    Schizophr Res 87:45-7. 2006
    ..Thus, the present study did not provide evidence for an association between the BDNF gene and schizophrenia or personality traits in the Japanese population...
  30. ncbi request reprint A two-stage case-control association study of PADI2 with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:430-2. 2009
    ..However, we could not replicate this association in a confirmatory population of 2126 patients and 2228 control individuals. The results of this study suggest that PADI2 does not contribute to genetic susceptibility to schizophrenia...
  31. doi request reprint Gene×gene×gender interaction of BDNF and COMT genotypes associated with panic disorder
    Yoshiaki Konishi
    Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center BSAM, Mie University, Mie, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 51:119-25. 2014
    ..A significant BDNF × COMT × gender interaction was observed in the PD patients but not in the controls. Our findings partly demonstrated the involvement of a gene × gene × gender interaction in the pathogenesis of PD...
  32. pmc Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 70:888-96. 2011
    ....
  33. ncbi request reprint Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia
    Mamoru Tochigi
    Department of Psychiatry, Haryugaoka Hospital, 11 Tensyodan, Otsuki machi, Koriyama City, Fukushima 963 0201, Japan
    Neurosci Lett 329:201-4. 2002
    ..No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population...