JOHN NESTLER

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, P O Box 980663, Richmond, VA 23298 0663, USA
    Trans Am Clin Climatol Assoc 123:209-19; discussion 219-20. 2012
  2. doi request reprint Metformin for the treatment of the polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    N Engl J Med 358:47-54. 2008
  3. ncbi request reprint Effect of macronutrient composition on postprandial peptide YY levels
    Paulina A Essah
    Departments of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0111, USA
    J Clin Endocrinol Metab 92:4052-5. 2007
  4. ncbi request reprint Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers
    Susmeeta T Sharma
    Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, P O Box 980111, Richmond, VA 23298 0111, USA
    Best Pract Res Clin Endocrinol Metab 20:245-60. 2006
  5. ncbi request reprint Changes in glucose tolerance with metformin treatment in polycystic ovary syndrome: a retrospective analysis
    Susmeeta T Sharma
    The Division of Endocrinology and Metabolism, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0111, USA
    Endocr Pract 13:373-9. 2007
  6. ncbi request reprint Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Fertil Steril 77:209-15. 2002
  7. ncbi request reprint Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?
    Kai I Cheang
    Department of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Reprod Biomed Online 8:440-7. 2004
  8. ncbi request reprint Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome
    Maria J Iuorno
    Department of Medicine, Medical College of Virginia, Virginia, Commonwealth University, Richmond, Virginia, USA
    Endocr Pract 8:417-23. 2002
  9. pmc Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome
    Kai I Cheang
    Department of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Diab Vasc Dis Res 6:110-9. 2009
  10. ncbi request reprint Should patients with polycystic ovarian syndrome be treated with metformin?: an enthusiastic endorsement
    John E Nestler
    Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hum Reprod 17:1950-3. 2002

Research Grants

  1. Polycystic Ovary Syndrome: Role of Insulin Resistance
    JOHN NESTLER; Fiscal Year: 2007
  2. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2007
  3. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2004
  4. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2000
  5. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    John E Nestler; Fiscal Year: 2010

Collaborators

Detail Information

Publications43

  1. pmc A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, P O Box 980663, Richmond, VA 23298 0663, USA
    Trans Am Clin Climatol Assoc 123:209-19; discussion 219-20. 2012
    ..We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)...
  2. doi request reprint Metformin for the treatment of the polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    N Engl J Med 358:47-54. 2008
  3. ncbi request reprint Effect of macronutrient composition on postprandial peptide YY levels
    Paulina A Essah
    Departments of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0111, USA
    J Clin Endocrinol Metab 92:4052-5. 2007
    ..The amount of PYY released is proportional to calories ingested. Fat ingestion has also been reported to stimulate PYY release...
  4. ncbi request reprint Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers
    Susmeeta T Sharma
    Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, P O Box 980111, Richmond, VA 23298 0111, USA
    Best Pract Res Clin Endocrinol Metab 20:245-60. 2006
    ..For these reasons, insulin-sensitizing drugs are proving to be a promising and unique therapeutic option for chronic treatment of PCOS...
  5. ncbi request reprint Changes in glucose tolerance with metformin treatment in polycystic ovary syndrome: a retrospective analysis
    Susmeeta T Sharma
    The Division of Endocrinology and Metabolism, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0111, USA
    Endocr Pract 13:373-9. 2007
    ..To determine whether treatment with metformin would prevent progression to glucose intolerance and type 2 diabetes in women with polycystic ovary syndrome (PCOS)...
  6. ncbi request reprint Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Fertil Steril 77:209-15. 2002
    ....
  7. ncbi request reprint Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?
    Kai I Cheang
    Department of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Reprod Biomed Online 8:440-7. 2004
    ..Based on these data, metformin should be a first-line therapy for women with PCOS...
  8. ncbi request reprint Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome
    Maria J Iuorno
    Department of Medicine, Medical College of Virginia, Virginia, Commonwealth University, Richmond, Virginia, USA
    Endocr Pract 8:417-23. 2002
    ....
  9. pmc Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome
    Kai I Cheang
    Department of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Diab Vasc Dis Res 6:110-9. 2009
    ..0369 for interaction). In conclusion, metformin improved the metabolic profile of women with PCOS over 36.1 months, particularly in HDL cholesterol, diastolic blood pressure and BMI...
  10. ncbi request reprint Should patients with polycystic ovarian syndrome be treated with metformin?: an enthusiastic endorsement
    John E Nestler
    Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hum Reprod 17:1950-3. 2002
    ..Hence, PCOS should be regarded as a general health issue and the use of insulin-sensitizing drugs such as metformin should be considered for the prevention of type 2 diabetes...
  11. ncbi request reprint Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome
    Paulina A Essah
    Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0111, USA
    Fertil Steril 86:230-2. 2006
    ..3-6 months, 77% vs. 55%)...
  12. ncbi request reprint Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?
    Kai I Cheang
    Department of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298 0111, USA
    Gynecol Endocrinol 22:595-604. 2006
    ..In conclusion, there is strong evidence supporting the use of metformin as a primary ovulatory agent in women with PCOS...
  13. pmc Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome
    Kai I Cheang
    Department of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
    Metabolism 57:1390-7. 2008
    ..The significant relationship between DCI-IPG release and insulin sensitivity suggests that the DCI-IPG mediator may be a target for therapeutic interventions in PCOS...
  14. ncbi request reprint Leptin secretory burst mass correlates with body mass index and insulin in normal women but not in women with polycystic ovary syndrome
    Maria J Iuorno
    Division of Endocrinology, Department of Internal Medicine, Virginia Commonwealth University Health System, Virginia Commonwealth University, Richmond, VA 22908, USA
    Metabolism 56:1561-5. 2007
    ....
  15. ncbi request reprint Is metformin or clomiphene citrate more effective for ovulation induction in polycystic ovary syndrome?
    John E Nestler
    Virginia Commonwealth University, Medical College of Virginia, Richmond, VA 23298 0111, USA
    Nat Clin Pract Endocrinol Metab 2:128-9. 2006
  16. ncbi request reprint Metabolic syndrome in women with polycystic ovary syndrome
    Paulina A Essah
    Department of Internal Medicine, Virginia Commonwealth University Medical Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0111, USA
    Fertil Steril 86:S18-9. 2006
    ..The prevalence of the metabolic syndrome in polycystic ovary syndrome (PCOS) is high across all age groups. Dyslipidemia, particularly a decreased high-density lipoprotein cholesterol level, also is common in women with PCOS...
  17. ncbi request reprint The metabolic syndrome in polycystic ovary syndrome
    Paulina A Essah
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Obstet Gynecol 50:205-25. 2007
    ..Insulin-sensitizing drugs may also ameliorate features of the metabolic syndrome in PCOS but long-term prospective studies are needed to determine the role of these drugs in the prevention of the metabolic syndrome...
  18. pmc Risk of cardiovascular events in mothers of women with polycystic ovary syndrome
    Kai I Cheang
    Department of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298 0111, USA
    Endocr Pract 14:1084-94. 2008
    ..To assess the prevalence of cardiovascular events in an older population of women with polycystic ovary syndrome (PCOS)...
  19. ncbi request reprint Glucose intolerance in polycystic ovary syndrome--a position statement of the Androgen Excess Society
    Kelsey E S Salley
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, PO Box 980111, Richmond, Virginia 23298 0111, USA
    J Clin Endocrinol Metab 92:4546-56. 2007
    ..The purpose of this statement is to determine the optimal screening method, timing of screening, and treatment modalities for impaired glucose tolerance (IGT) among women with PCOS...
  20. ncbi request reprint Dermatology of androgen-related disorders
    Paulina A Essah
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Dermatol 24:289-98. 2006
    ..Treatments for the dermatologic conditions of hyperandrogenism include lifestyle modification, oral contraceptives, antiandrogens, and insulin-sensitizing medications...
  21. ncbi request reprint Genetics of serum dehydroepiandrosterone sulfate and its relationship to insulin in a population-based cohort of twin subjects
    John E Nestler
    Division of Endocrinology, Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23398, USA
    J Clin Endocrinol Metab 87:682-6. 2002
    ..Variations in DHEA-S are due to age, sex, obesity, and substantial polygenic genetic influences...
  22. ncbi request reprint Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome
    Teimuraz Apridonidze
    Department of Internal Medicine, Medical College of Virginia, P O Box 980111, Richmond, Virginia 23298 0111, USA
    J Clin Endocrinol Metab 90:1929-35. 2005
    ....
  23. ncbi request reprint Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome
    Jean Patrice Baillargeon
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Diabetes Care 29:300-5. 2006
    ..We hypothesize that a deficiency in D-chiro-inositol (DCI) and/or a DCI-containing IPG (DCI-IPG) may contribute to insulin resistance in humans...
  24. ncbi request reprint Insulin resistance syndrome and polycystic ovary syndrome
    John E Nestler
    Endocr Pract 9:86-9. 2003
  25. pmc Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial
    Peter G McGovern
    Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 90:1283-6. 2008
    ....
  26. ncbi request reprint Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome
    Jean Patrice Baillargeon
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, J1H SN4 Canada
    J Clin Endocrinol Metab 89:242-9. 2004
    ..We conclude that in obese women with PCOS, metformin may improve the action of insulin in part by improving insulin-mediated release of DCI-IPG mediators, as evidenced by increased bioactive DCI-IPG released per unit of insulin...
  27. ncbi request reprint Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy
    Daniela J Jakubowicz
    Hospital de Clinicas Caracas, and Central University of Venezuela, Caracas 1040, Venezuela
    J Clin Endocrinol Metab 89:833-9. 2004
    ..These decreases are likely to be secondary to hyperinsulinemia and reduced insulin sensitivity...
  28. ncbi request reprint Insulin sensitizers for polycystic ovary syndrome
    Jean Patrice Baillargeon
    Department of Internal Medicine, Universite de Sherbrooke, Sherbrooke, Canada
    Clin Obstet Gynecol 46:325-40. 2003
  29. ncbi request reprint Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity
    Jean Patrice Baillargeon
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Fertil Steril 82:893-902. 2004
    ....
  30. ncbi request reprint A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills
    Evanthia Diamanti-Kandarakis
    First Department of Medicine, University of Athens, GR 17548 Athens, Greece
    J Clin Endocrinol Metab 88:1927-32. 2003
  31. ncbi request reprint Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
    N Engl J Med 356:551-66. 2007
    ..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior...
  32. ncbi request reprint Effects of metformin on early pregnancy loss in the polycystic ovary syndrome
    Daniela J Jakubowicz
    Hospital de Clinicas Caracas and Central University of Venezuela, Caracas 1040, Venezuela
    J Clin Endocrinol Metab 87:524-9. 2002
    ..3% (7 of 12 pregnancies) in the control group (P = 0.002). Metformin administration during pregnancy reduces first-trimester pregnancy loss in women with the polycystic ovary syndrome...
  33. ncbi request reprint The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Fertil Steril 86:914-33. 2006
    ..To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS)...
  34. ncbi request reprint Commentary: polycystic ovary syndrome: a syndrome of ovarian hypersensitivity to insulin?
    Jean Patrice Baillargeon
    Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 91:22-4. 2006
  35. ncbi request reprint The Androgen Excess Society guidelines on glucose intolerance in the polycystic ovary syndrome: what do they mean and what should we do?
    John E Nestler
    Pol Arch Med Wewn 118:264-6. 2008
  36. ncbi request reprint Fertility in polycystic ovary syndrome
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Endocrinol Metab Clin North Am 35:137-55, vii. 2006
  37. pmc Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome
    Nicholas A Cataldo
    Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Endocrinol Metab 93:3124-7. 2008
    ..It has been suggested that metformin in combination with clomiphene can restore ovulation to some clomiphene-resistant anovulators with polycystic ovary syndrome (PCOS)...
  38. pmc Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism
    Jean Patrice Baillargeon
    Department of Medicine, Universite Sherbrooke, Sherbrooke, Canada J1H 5N4
    Hum Reprod 23:1439-46. 2008
    ....
  39. pmc Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 93:792-800. 2008
    ..Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood...
  40. ncbi request reprint Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome
    William S Evans
    Department of Medicine, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, 22908, USA
    Fertil Steril 88:118-24. 2007
    ..To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS)...
  41. ncbi request reprint Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial
    Evan R Myers
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, United States
    Contemp Clin Trials 26:271-80. 2005
    ..The PPCOS trial should definitively answer the question of the relative efficacy of metformin, clomiphene, and combination therapy in the treatment of infertile women with PCOS...
  42. pmc Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome
    Peter G McGovern
    Department of Obstetrics, Gynecology and Women s Health, UMDNJ New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 87:442-4. 2007
    ..Other than failure to demonstrate laboratory evidence of hyperandrogenemia, the most common reasons for subject exclusion were persistent oligospermia and tubal factor infertility...
  43. pmc Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective
    John E Nestler
    Fertil Steril 90:14-6. 2008
    ..Evidence is provided for the use of metformin in selected patients...

Research Grants15

  1. Polycystic Ovary Syndrome: Role of Insulin Resistance
    JOHN NESTLER; Fiscal Year: 2007
    ..As a result of the K24 renewal, Dr. Nestler will be able to devote 75-85% effort to research, personal development in clinical research, and, most importantly, the training and mentorship of young investigators. ..
  2. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2007
    ..Such a mechanism could account for the observation that insulin resistance in women with PCOS is substantially greater than that of age- and BMI-matched healthy women. ..
  3. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2004
    ..abstract_text> ..
  4. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    JOHN NESTLER; Fiscal Year: 2000
    ....
  5. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    John E Nestler; Fiscal Year: 2010
    ..Such a mechanism could account for the observation that insulin resistance in women with PCOS is substantially greater than that of age- and BMI-matched healthy women. ..