Michael C Neale

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Multivariate genetic analysis of sex limitation and G x E interaction
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, United States of America
    Twin Res Hum Genet 9:481-9. 2006
  2. pmc Nonpaternity in linkage studies of extremely discordant sib pairs
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Hum Genet 70:526-9. 2002
  3. ncbi request reprint Extensions to the modeling of initiation and progression: applications to substance use and abuse
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 980126, Richmond, VA, 23298 0126, USA
    Behav Genet 36:507-24. 2006
  4. ncbi request reprint Methodological issues in the assessment of substance use phenotypes
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980126, Richmond, VA 23298 0126, USA
    Addict Behav 31:1010-34. 2006
  5. ncbi request reprint A finite mixture distribution model for data collected from twins
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298, USA
    Twin Res 6:235-9. 2003
  6. pmc Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Psychol Med 37:947-59. 2007
  7. pmc A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes
    Hermine H Maes
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980003, Richmond, VA 23298 0003, USA
    Behav Genet 41:680-90. 2011
  8. ncbi request reprint A population-based twin study of the relationship between neuroticism and internalizing disorders
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:857-64. 2006
  9. pmc Flexible Mx specification of various extended twin kinship designs
    Hermine H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
    Twin Res Hum Genet 12:26-34. 2009
  10. ncbi request reprint The structure of genetic and environmental risk factors for anxiety disorders in men and women
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 62:182-9. 2005

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Multivariate genetic analysis of sex limitation and G x E interaction
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, United States of America
    Twin Res Hum Genet 9:481-9. 2006
    ..It is shown that similar problems exist with a variety of multivariate and longitudinal models, and in a variety of models of genotype x environment interaction. Several solutions to these problems are described...
  2. pmc Nonpaternity in linkage studies of extremely discordant sib pairs
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Hum Genet 70:526-9. 2002
    ..The proportion in discordant pairs may be much higher. The present article explores this potential inflation as a function of the resemblance of sib pairs and the criteria for discordance used for selection...
  3. ncbi request reprint Extensions to the modeling of initiation and progression: applications to substance use and abuse
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 980126, Richmond, VA, 23298 0126, USA
    Behav Genet 36:507-24. 2006
    ..Other suitable applications include the relationship between symptoms and diagnosis, such as fears and the progression to phobia...
  4. ncbi request reprint Methodological issues in the assessment of substance use phenotypes
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980126, Richmond, VA 23298 0126, USA
    Addict Behav 31:1010-34. 2006
    ..g., substance dependence symptoms, are systematically missing in those who have not initiated use of the substance in question...
  5. ncbi request reprint A finite mixture distribution model for data collected from twins
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298, USA
    Twin Res 6:235-9. 2003
    ..The method is shown to perform quite well even when no information on zygosity is available, and may be applied when pair-specific estimates of zygosity probabilities are available...
  6. pmc Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Psychol Med 37:947-59. 2007
    ..Although an obvious environmental factor influencing drug use, the sources of individual differences in drug availability (DA) are unknown...
  7. pmc A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes
    Hermine H Maes
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980003, Richmond, VA 23298 0003, USA
    Behav Genet 41:680-90. 2011
    ..Including phenotypic data on ungenotyped relatives can improve the statistical power to detect the effects of genetic variants when they contribute to individual differences in the phenotype...
  8. ncbi request reprint A population-based twin study of the relationship between neuroticism and internalizing disorders
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:857-64. 2006
    ..The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity...
  9. pmc Flexible Mx specification of various extended twin kinship designs
    Hermine H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
    Twin Res Hum Genet 12:26-34. 2009
    ..Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest...
  10. ncbi request reprint The structure of genetic and environmental risk factors for anxiety disorders in men and women
    John M Hettema
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
    Arch Gen Psychiatry 62:182-9. 2005
    ..The anxiety disorders exhibit high levels of lifetime comorbidity with one another. Understanding the underlying causes of this comorbidity can provide insight into the etiology of the disorders and inform classification and treatment...
  11. pmc Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 150:926-33. 2009
    ..However, the opposite effects with nicotine dependence and alcohol abuse/dependence were puzzling and future studies are necessary to resolve this issue...
  12. pmc The genetic covariation between fear conditioning and self-report fears
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 63:587-93. 2008
    ..Although prior studies have demonstrated that fear conditioning and self-report fears are heritable, no studies have determined whether they share a common genetic basis...
  13. ncbi request reprint A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
    Hermine H Maes
    Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
    Psychol Med 34:1251-61. 2004
    ..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary...
  14. pmc Association study between GABA receptor genes and anxiety spectrum disorders
    Xuan Pham
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Depress Anxiety 26:998-1003. 2009
    ..In this investigation, we explored four GABA receptor genes for their possible associations with genetic risk for anxiety disorders and depression...
  15. ncbi request reprint The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Arch Gen Psychiatry 60:929-37. 2003
    ..We do not know how genetic and environmental risk factors contribute to this pattern of comorbidity or whether the etiologic structure of these groups differ in men and women...
  16. pmc The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:1438-46. 2008
    ....
  17. ncbi request reprint A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007
    ..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study...
  18. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  19. pmc Two-part random effects growth modeling to identify risks associated with alcohol and cannabis initiation, initial average use and changes in drug consumption in a sample of adult, male twins
    Nathan A Gillespie
    Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Drug Alcohol Depend 123:220-8. 2012
    ..Our aim was to profile alcohol and cannabis initiation and to characterize the effects of developmental and environmental risk factors on changes in average drug use over time...
  20. pmc Characteristics of monozygotic male and female twins discordant for overweight: a descriptive study
    Karen S Mitchell
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Eat Behav 9:366-9. 2008
    ..BMI is highly heritable. Yet, trends in obesity highlight environmental influences on body weight. Monozygotic (MZ) twins discordant for overweight offer a unique opportunity to examine these factors...
  21. pmc Association study of CREB1 with Major Depressive Disorder and related phenotypes
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 150:1128-32. 2009
    ..However, none of these markers were significant in stage 2 in either sex individually or combined. Our data suggests that common variations in the CREB1 gene do not appear to increase susceptibility for MDD or related phenotypes...
  22. ncbi request reprint Dimensional representations of DSM-IV cluster A personality disorders in a population-based sample of Norwegian twins: a multivariate study
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:1583-91. 2006
    ..We have examined the relationship between the genetic and environmental risk factors for dimensional representations of these three personality disorders...
  23. ncbi request reprint Association of different adverse life events with distinct patterns of depressive symptoms
    Matthew C Keller
    Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA 23219, USA
    Am J Psychiatry 164:1521-9; quiz 1622. 2007
    ..The authors sought to determine whether, in a general population sample, different categories of adverse life events were associated with different patterns of depressive symptoms...
  24. pmc An investigation of a measure of twins' equal environments
    Karen S Mitchell
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Twin Res Hum Genet 10:840-7. 2007
    ..Measurement invariance issues, as well as distributions of equal environments traits, should be considered when evaluating the equal environments assumption, in order to produce accurate parameter estimates in twin models...
  25. ncbi request reprint A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugs
    Arpana Agrawal
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond, VA 23298 0003, USA
    Psychol Med 34:1227-37. 2004
    ..Gateway and common liabilities models have been employed to explain this relationship. We sought to examine this association using a combination of the discordant twin design and modeling methods...
  26. pmc A twin study of intracerebral volumetric relationships
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Suite 100, PO Box 980003, Richmond, VA, 23298 0003, USA
    Behav Genet 40:114-24. 2010
    ..Reanalysis including total brain volume as a covariate dramatically reduced the total residual variance and disproportionately influenced the additive genetic variance in all regions of interest...
  27. pmc Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Biol Psychiatry 64:302-10. 2008
    ..Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits...
  28. pmc A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Box 980126, 800 E Leigh St, Room 1 123, Richmond, VA 23298 0126, USA
    Arch Gen Psychiatry 65:421-9. 2008
    ..While the nature of common fears changes over development, we do not know whether genetic effects on fear-proneness are developmentally stable or developmentally dynamic...
  29. ncbi request reprint Level of family dysfunction and genetic influences on smoking in women
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 34:1263-9. 2004
    ..An adoption study of alcoholism suggests that in women, the impact of genetic risk factors become greater in the presence of conflict in the family of origin. Is the same true for cigarette smoking (CS)?..
  30. pmc Pathways to cannabis abuse: a multi-stage model from cannabis availability, cannabis initiation and progression to abuse
    Nathan A Gillespie
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Addiction 104:430-8. 2009
    ..Our aim is to determine whether the genetic and environmental risk factors for cannabis availability also generate variation in cannabis initiation and/or progression to DSM-IV symptoms of abuse...
  31. pmc Genetic association between RGS1 and internalizing disorders
    John M Hettema
    Departments of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23298 0126, USA
    Psychiatr Genet 23:56-60. 2013
    ..In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with a quantitative trait locus for rodent emotionality...
  32. pmc Cannabinoid receptor 1 gene association with nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, 800 Leigh St, Ste 1 110, Richmond, VA 23298, USA
    Arch Gen Psychiatry 65:816-24. 2008
    ..The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence...
  33. pmc Genetic and environmental transmission of body mass index fluctuation
    Jocilyn E Bergin
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, MCV, P O Box 980126, Richmond, VA 23298, USA
    Behav Genet 42:867-74. 2012
    ....
  34. pmc Modeling the genetic and environmental association between peer group deviance and cannabis use in male twins
    Nathan A Gillespie
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Addiction 104:420-9. 2009
    ..Peer group deviance (PGD) is linked strongly to liability to drug use, including cannabis. Our aim was to model the genetic and environmental association, including direction of causation, between PGD and cannabis use (CU)...
  35. doi request reprint Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Psychiatr Genet 18:73-9. 2008
    ..In this study, we examined, for the first time, the human analog of ASIC1, the amiloride-sensitive cation channel 2 (ACCN2) gene, for its association with genetic risk across a range of anxiety spectrum phenotypes...
  36. ncbi request reprint Endorsement frequencies and factor structure of DSM-III-R and DSM-IV Generalized Anxiety Disorder symptoms in women: implications for future research, classification, clinical practice and comorbidity
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 1026, USA
    Int J Methods Psychiatr Res 14:69-81. 2005
    ..For DSM-IV, all items loaded on one factor, and muscle tension also loaded on a second. Major depression, panic, phobias and alcohol dependence diagnoses also loaded on the first factor...
  37. pmc Assessment of generalized anxiety disorder diagnostic criteria in the National Comorbidity Survey and Virginia Adult Twin Study of Psychiatric and Substance Use Disorders
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 1026, USA
    Psychol Assess 20:206-16. 2008
    ....
  38. pmc Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Twin Res Hum Genet 17:89-98. 2014
    ....
  39. pmc Fetal and maternal genes' influence on gestational age in a quantitative genetic analysis of 244,000 Swedish births
    Timothy P York
    Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Epidemiol 178:543-50. 2013
    ..Since environmental factors explained most differences in the timing of birth, genetic studies may benefit from understanding the specific effect of fetal and maternal genes in the context of these yet-unidentified factors. ..
  40. pmc Eating disorder symptomatology and substance use disorders: prevalence and shared risk in a population based twin sample
    Jessica H Baker
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23284, USA
    Int J Eat Disord 43:648-58. 2010
    ..The objective of this study is to examine the prevalence, chronology, and possibility of shared familial risk between SUD and ED symptomatology...
  41. pmc The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, The Department of Psychiatry, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 168:29-39. 2011
    ..The authors sought to clarify the structure of the genetic and environmental risk factors for 22 DSM-IV disorders: 12 common axis I disorders and all 10 axis II disorders...
  42. pmc Variance decomposition of MRI-based covariance maps using genetically informative samples and structural equation modeling
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Neuroimage 47:56-64. 2009
    ..These findings are consistent with the limited existing knowledge on the genetics of cortical variability as well as our prior multivariate studies on cortical gyri...
  43. ncbi request reprint Genetic and cultural transmission of antisocial behavior: an extended twin parent model
    Hermine H Maes
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Twin Res Hum Genet 10:136-50. 2007
    ..This study showed significant heritability, which is slightly increased by assortative mating, and significant effects of primarily nonparental shared environment on CD...
  44. ncbi request reprint Factor and item-response analysis DSM-IV criteria for abuse of and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opioids
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA 23219 1534, USA
    Addiction 102:920-30. 2007
    ....
  45. ncbi request reprint The heritability of cluster A personality disorders assessed by both personal interview and questionnaire
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 37:655-65. 2007
    ..We wish to know whether the same set of PD vulnerability factors are assessed by these two methods...
  46. pmc Racial differences in genetic and environmental risk to preterm birth
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 5:e12391. 2010
    ..This study provides a comprehensive description of the relative genetic and environmental contributions to racial differences in gestational age...
  47. pmc Measurement non-invariance of DSM-IV narcissistic personality disorder criteria across age and sex in a population-based sample of Norwegian twins
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Int J Methods Psychiatr Res 19:156-66. 2010
    ..The results indicate that DSM-IV NPD criteria perform differently in males and females and across age. Differences in diagnostic rates across groups may not be valid without correcting for measurement non-invariance...
  48. ncbi request reprint DSM criteria for major depression: evaluating symptom patterns using latent-trait item response models
    Steven H Aggen
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia and Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:475-87. 2005
    ..The DSM-III-R criteria for major depression (MD) are examined to determine the degree to which latent trait item response models can extract additional useful information...
  49. ncbi request reprint Genetic and cultural transmission of smoking initiation: an extended twin kinship model
    Hermine H Maes
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 980003, 23298 0003, Richmond, VA 23298 0003, USA
    Behav Genet 36:795-808. 2006
    ....
  50. ncbi request reprint A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sample
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics and Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Neuroimage 35:70-82. 2007
    ..These findings are concordant with prior volumetric twin studies and support radial models of brain evolution...
  51. pmc Recent advances in the genetic epidemiology and molecular genetics of substance use disorders
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia and Virginia Commonwealth University, Richmond, Virginia, USA
    Nat Neurosci 15:181-9. 2012
    ..Identifying these risk genes and understanding their action will require large clinical samples, and interaction between these studies and work in model organisms...
  52. pmc Evidence for multiple genetic factors underlying DSM-IV criteria for major depression
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond 23298, USA
    JAMA Psychiatry 70:599-607. 2013
    ..We do not know whether the clinical criteria for major depression (MD) reflect a single or multiple dimensions of genetic risk...
  53. pmc Differential age and sex effects in the assessment of major depression: a population-based twin item analysis of the DSM criteria
    Steven H Aggen
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Twin Res Hum Genet 14:524-38. 2011
    ..The dimensional modeling results are discussed in the broader context of epidemiological research and clinical assessment of major depression...
  54. ncbi request reprint Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and females
    Arpana Agrawal
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 34:217-28. 2004
    ..Overall, our results suggest that the use and abuse/dependence of cannabis and other illicit drugs are strongly linked via common risk factors that jointly influence their individual liabilities...
  55. pmc An investigation of weight suppression in a population-based sample of female twins
    Karen S Mitchell
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Int J Eat Disord 44:44-9. 2011
    ..Weight suppression (WS), maintaining a body weight below one's maximum adult weight, is associated with bingeing, purging, and weight gain in clinical samples...
  56. pmc A finite mixture model for genotype and environment interactions: detecting latent population heterogeneity
    Nathan A Gillespie
    Virginia Institute of Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, 23219, USA
    Twin Res Hum Genet 9:412-23. 2006
    ..These results suggest that factor mixture modeling is sufficiently robust for detecting heterogeneous populations even when group mean differences are modest...
  57. ncbi request reprint Genetic and environmental influences on illicit drug use and tobacco use across birth cohorts
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:1349-56. 2005
    ..One theory, which postulates that heritability of deviant traits increases in permissive environments, predicts a positive relationship across cohorts between prevalence and heritability of substance use...
  58. pmc Efficient calculation of empirical P-values for genome-wide linkage analysis through weighted permutation
    Sarah E Medland
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Behav Genet 39:91-100. 2009
    ..We demonstrate the validity of this approach through simulation...
  59. ncbi request reprint Major depression and associated impairment: same or different genetic and environmental risk factors?
    Debra L Foley
    Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
    Am J Psychiatry 160:2128-33. 2003
    ..Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses?..
  60. pmc Psychometric modeling of cannabis initiation and use and the symptoms of cannabis abuse, dependence and withdrawal in a sample of male and female twins
    Nathan A Gillespie
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Drug Alcohol Depend 118:166-72. 2011
    ..Despite an emerging consensus that the DSM-IV diagnostic criteria for cannabis abuse and dependence are best represented by a single underlying liability, it remains unknown if latent class or hybrid models can better explain the data...
  61. ncbi request reprint The differential heritability of regular tobacco use based on method of administration
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0126, USA
    Twin Res Hum Genet 8:60-2. 2005
    ..Thus, the genetic influences on the liability for regular tobacco use appear to vary based on tobacco type. The causes for the use of different forms of tobacco are complex and worthy of further study...
  62. ncbi request reprint Problems with using sum scores for estimating variance components: contamination and measurement noninvariance
    Michael C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA 23219 1534, USA
    Twin Res Hum Genet 8:553-68. 2005
    ..Solutions to these problems include formal tests for measurement invariance across zygosity prior to analysis of the sum or scale scores, and multivariate genetic analysis at the individual item or symptom level...
  63. ncbi request reprint A twin study of the genetics of fear conditioning
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, 23298, USA
    Arch Gen Psychiatry 60:702-8. 2003
    ..The objective of this study was to determine the genetic and environmental sources of individual differences in fear conditioning by means of a twin sample...
  64. ncbi request reprint Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    Am J Psychiatry 160:687-95. 2003
    ..Data on use and misuse of six classes of illicit substances by male twin pairs were used to examine whether genetic and shared environmental risk factors for substance use disorders are substance-specific or -nonspecific in their effect...
  65. pmc Generalized anxiety disorder and anorexia nervosa: evidence of shared genetic variation
    Jocilyn E Dellava
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Depress Anxiety 28:728-33. 2011
    ..However, the shared genetic and environmental components of these disorders have not been explored. This study seeks to elucidate the shared genetic and environmental components between GAD and AN...
  66. ncbi request reprint The sensitivity of variance component estimates to underreporting: method and application to substance abuse data
    Paul W Andrews
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Twin Res Hum Genet 10:721-8. 2007
    ..We show how underreporting influences estimates of additive genetic, common environment, and specific environment variance components (A, C, and E) obtained for DAD in a classical twin design...
  67. ncbi request reprint Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics
    Patrick F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA, USA
    Am J Med Genet B Neuropsychiatr Genet 126:23-36. 2004
    ..Although the hypotheses resulting from these linkage and bioinformatic analyses are plausible and intriguing, their ultimate worth depends on replication in additional linkage samples and in future experimental studies...
  68. ncbi request reprint Associations among postpartum depression, eating disorders, and perfectionism in a population-based sample of adult women
    Suzanne E Mazzeo
    Department of Psychology, Virginia Commonwealth University, Richmond, Virginia 23284 2018, USA
    Int J Eat Disord 39:202-11. 2006
    ..The current study investigated associations among eating disorders, depressive symptoms during pregnancy and postpartum, and perfectionism in a population-based sample of women...
  69. pmc Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 10:683-94. 2007
    ....
  70. ncbi request reprint Implications of absence of measurement invariance for detecting sex limitation and genotype by environment interaction
    Gitta H Lubke
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23219 1534, USA
    Twin Res 7:292-8. 2004
    ..In both cases the interpretation would be in terms of a group-specific effect size of the genetic factor. This interpretation may be incorrect if individual items are non-invariant...
  71. ncbi request reprint Sources of individual differences in stressful life event exposure in male and female twins
    P Kevin Bolinskey
    Medical College of Virginia Commonwealth University, Richmond, USA
    Twin Res 7:33-8. 2004
    ..Genetic correlations between males and females suggest that many of the same genetic factors are acting within both genders...
  72. pmc Estimating fetal and maternal genetic contributions to premature birth from multiparous pregnancy histories of twins using MCMC and maximum-likelihood approaches
    Timothy P York
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 32398 0003, United States of America
    Twin Res Hum Genet 12:333-42. 2009
    ..We anticipate the flexibility of MCMC methods to handle increasingly complex models to be of particular relevance for the study of birth outcomes...
  73. ncbi request reprint Sexual dimorphism in innate immunity
    George Moxley
    McGuire VAMC, Richmond, VA 23249, USA
    Arthritis Rheum 46:250-8. 2002
    ..To establish whether variation in innate immunity, as measured by the level of tumor necrosis factor (TNF) in lipopolysaccharide (LPS)-stimulated whole-blood culture, is related to sex or HLA...
  74. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  75. ncbi request reprint Maternal smoking during pregnancy and risk to boys' conduct disturbance: an examination of the causal hypothesis
    Judy L Silberg
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
    Biol Psychiatry 53:130-5. 2003
    ..We undertook this study to determine whether the widely replicated link between maternal smoking and conduct disturbance (Cd) is better explained by a model of direct causation or of mother-offspring transmission of a latent Cd variable...
  76. ncbi request reprint Effect of sex and haplotype on plasma tryptase levels in healthy adults
    Hae Ki Min
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Allergy Clin Immunol 114:48-51. 2004
    ..The total level of alpha-tryptase and ss-tryptase in serum or plasma is used as a clinical indicator of the mast cell burden...
  77. ncbi request reprint The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences
    Johanna M Seddon
    Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Opthalmology, Harvaed Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 123:321-7. 2005
    ..The relative importance of genes and environment in the etiology of this major public health problem is not well understood...
  78. ncbi request reprint Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia
    O Joseph Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Meyer 115, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 164:1714-21. 2007
    ....
  79. ncbi request reprint Genetic and environmental influences on dimensional representations of DSM-IV cluster C personality disorders: a population-based multivariate twin study
    Ted Reichborn-Kjennerud
    Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
    Psychol Med 37:645-53. 2007
    ....
  80. ncbi request reprint The inclusion of measured covariates in the Neale and Kendler model fitting approach
    Soo Hyun Rhee
    Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309, USA
    Behav Genet 37:423-32. 2007
    ..An example of 13 models examining the comorbidity between alcohol dependence and illicit drug dependence is presented...
  81. pmc Exploring the relationship between genetic and environmental influences on initiation and progression of substance use
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Addiction 102:413-22. 2007
    ....
  82. ncbi request reprint Structural brain magnetic resonance imaging of pediatric twins
    Jay N Giedd
    Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Hum Brain Mapp 28:474-81. 2007
    ..Understanding of influences on trajectories of brain development may shed light on the emergence of psychopathology during childhood and adolescence and ultimately may guide therapeutic interventions...
  83. ncbi request reprint A genome-wide scan for modifier loci in schizophrenia
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 144:589-95. 2007
    ..06. We conclude that genes located near 9q33.1 and 14q24.2 may modify the clinical course and severity of schizophrenia. A gene in 6q may affect several clinical features of illness...
  84. pmc Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism
    Jan Fullerton
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 72:879-90. 2003
    ..One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous...
  85. ncbi request reprint The relationship between avoidant personality disorder and social phobia: a population-based twin study
    Ted Reichborn-Kjennerud
    Norwegian Institute of Public Health, Box 4404, Nydalen N 0403, Oslo, Norway
    Am J Psychiatry 164:1722-8. 2007
    ....
  86. ncbi request reprint Happiness and health: environmental and genetic contributions to the relationship between subjective well-being, perceived health, and somatic illness
    Espen Røysamb
    Norwegian Institute of Public Health, Oslo, Norway
    J Pers Soc Psychol 85:1136-46. 2003
    ..Results support a differentiated view of SWB-health relations, and imply that both genes and environment play important roles in the associations between well-being and health...
  87. ncbi request reprint Squeezing interval change from ordinal panel data: latent growth curves with ordinal outcomes
    Paras D Mehta
    Health Research and Policy Centers, University of Illinois at Chicago, USA
    Psychol Methods 9:301-33. 2004
    ..C. Neale, S. M. Boker, G. Xie, & H. H. Maes, 1999). The necessary conditions for the identification of growth models with ordinal data and the methodological implications of the model of threshold invariance are discussed...
  88. ncbi request reprint The structure of perfectionism: a twin study
    Federica Tozzi
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7160, USA
    Behav Genet 34:483-94. 2004
    ..Evidence of familial transmission suggests features of perfectionism may be genetically determined. This study examines the structure of perfectionism using classical twin design models...
  89. ncbi request reprint Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia
    Ayman H Fanous
    Washington VA Medical Center Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St NW, Washington, DC 20422, USA
    Am J Psychiatry 162:1824-32. 2005
    ....
  90. ncbi request reprint Genome-wide linkage scan to identify Loci for age at first cigarette in Dutch sibling pairs
    Jacqueline M Vink
    Department of Biological Psychology, Vrije Universiteit, BT Amsterdam, The Netherlands
    Behav Genet 36:100-11. 2006
    ..This peak encloses the D1A dopamine receptor gene which is a functional candidate gene for smoking behavior...
  91. ncbi request reprint Comorbidity between alcohol dependence and illicit drug dependence in adolescents with antisocial behavior and matched controls
    Soo Hyun Rhee
    Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
    Drug Alcohol Depend 84:85-92. 2006
    ..Discrepancies in results may reflect different analytical approaches or differences in the samples. Here, we examine the causes of comorbidity between alcohol dependence and illicit drug dependence in adolescents...
  92. ncbi request reprint Detecting genotype-environment interaction in monozygotic twin data: comparing the Jinks and Fulker test and a new test based on Marginal Maximum Likelihood estimation
    Sophie van der Sluis
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:377-92. 2006
    ..However, after a normalizing transformation, the Jinks and Fulker test performed slightly better. Some possible future extensions of the MML-based test are briefly discussed...
  93. ncbi request reprint The validity of the Neale and Kendler model-fitting approach in examining the etiology of comorbidity
    Soo Hyun Rhee
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Behav Genet 34:251-65. 2004
    ..As suggested by Neale and Kendler, the model-fitting approach can be applied to both unselected and selected data and to both twin and family data...
  94. ncbi request reprint Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC, USA
    Biol Psychiatry 64:121-7. 2008
    ..Genetic heterogeneity may decrease the signal-to-noise ratio in linkage and association studies. Therefore, linkage studies of clinically homogeneous classes of psychotic illness may result in greater power to detect at least some loci...
  95. pmc Genomewide linkage survey of nicotine dependence phenotypes
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Drug Alcohol Depend 93:210-6. 2008
    ..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses...
  96. ncbi request reprint A longitudinal study of personality and major depression in a population-based sample of male twins
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Psychol Med 37:1163-72. 2007
    ..The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other...