M C Neale

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint The use of likelihood-based confidence intervals in genetic models
    M C Neale
    Department of Psychiatry, Medical College of Virginia, Richmond 23298, USA
    Behav Genet 27:113-20. 1997
  2. ncbi request reprint Structured latent growth curves for twin data
    M C Neale
    Department of Psychiatry, Medical College of Virginia, Richmond 23298, USA
    Twin Res 3:165-77. 2000
  3. ncbi request reprint ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels
    M C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth, Richmond, VA 23298 0126, USA
    Genet Epidemiol 18:331-40. 2000
  4. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
  5. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
  6. pmc Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 147:661-6. 2008
  7. ncbi request reprint Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1234-40. 1998
  8. ncbi request reprint Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:479-84. 2001
  9. ncbi request reprint Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Richmond 23298 0710, USA
    Am J Psychiatry 152:749-54. 1995
  10. pmc A psychometric evaluation of the DSM-IV borderline personality disorder criteria: age and sex moderation of criterion functioning
    S H Aggen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 39:1967-78. 2009

Detail Information

Publications46

  1. ncbi request reprint The use of likelihood-based confidence intervals in genetic models
    M C Neale
    Department of Psychiatry, Medical College of Virginia, Richmond 23298, USA
    Behav Genet 27:113-20. 1997
    ..Despite the improvement in fit of the different prevalence model, the confidence intervals on all parameters broaden, owing to their covariance...
  2. ncbi request reprint Structured latent growth curves for twin data
    M C Neale
    Department of Psychiatry, Medical College of Virginia, Richmond 23298, USA
    Twin Res 3:165-77. 2000
    ..Though the growth curve model fit less well than some others, they make restrictive, falsifiable predictions about the mean, variance and twin covariance of other (not yet measured) occasions of measurement...
  3. ncbi request reprint ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels
    M C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth, Richmond, VA 23298 0126, USA
    Genet Epidemiol 18:331-40. 2000
    ..However, the ApoE locus accounts for only one-fourth of the genetic variation in ApoE levels...
  4. ncbi request reprint An association study of DRD5 with smoking initiation and progression to nicotine dependence
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:259-65. 2001
    ..These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors...
  5. ncbi request reprint Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study
    R E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
    Mol Psychiatry 4:129-44. 1999
    ....
  6. pmc Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 147:661-6. 2008
    ..Our data suggests that the HTR1A gene may not play a major role in the genetic susceptibility underlying depressive and anxiety-related phenotypes...
  7. ncbi request reprint Longitudinal population-based twin study of retrospectively reported premenstrual symptoms and lifetime major depression
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 155:1234-40. 1998
    ..In addition, we know little about the relationship of the familial risk factors for premenstrual symptoms and major depression...
  8. ncbi request reprint Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet 105:479-84. 2001
    ..If these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of TPH in the biosynthesis of serotonin...
  9. ncbi request reprint Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Richmond 23298 0710, USA
    Am J Psychiatry 152:749-54. 1995
    ..The authors sought to evaluate whether the pattern of schizophrenia and related disorders in probands and their relatives can be explained by a single underlying continuum of liability to the "schizophrenia spectrum."..
  10. pmc A psychometric evaluation of the DSM-IV borderline personality disorder criteria: age and sex moderation of criterion functioning
    S H Aggen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 39:1967-78. 2009
    ....
  11. pmc A multivariate twin study of hippocampal volume, self-esteem and well-being in middle-aged men
    T S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, 23219 0126, USA
    Genes Brain Behav 11:539-44. 2012
    ..09 (P > 0.05). Our results indicate that largely different genetic and environmental factors underlie self-esteem and well-being on one hand and hippocampal volume on the other...
  12. ncbi request reprint Religious attendance and frequency of alcohol use: same genes or same environments: a bivariate extended twin kinship model
    H H Maes
    Virginia Institute for Psychiatric Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Twin Res 2:169-79. 1999
    ....
  13. pmc A twin study of specific bulimia nervosa symptoms
    S E Mazzeo
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Psychol Med 40:1203-13. 2010
    ..The validity of the equal environment assumption (EEA) for BN was also tested...
  14. ncbi request reprint The genetic epidemiology of irrational fears and phobias in men
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, 800 E Leigh St, PO Box 980126, Richmond, VA 23298-0126, USA
    Arch Gen Psychiatry 58:257-65. 2001
    ..Family environment probably has an impact on risk for agoraphobia and social phobia. The genetic liability to blood/injury phobias is not distinct from those of the more typical phobias...
  15. pmc Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence
    K S Kendler
    Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Mol Psychiatry 17:1306-15. 2012
    ..While tentative and in need of replication, these results, consistent with the rodent literature, were validated by examining predictions of the genetic factor scores and have implications for gene-finding efforts in AD...
  16. pmc Assessing the heritability of anorexia nervosa symptoms using a marginal maximal likelihood approach
    S E Mazzeo
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Psychol Med 39:463-73. 2009
    ..We examined genetic and environmental contributions to liability to anorexia nervosa (AN) symptoms in a population-based twin sample using a genetic common pathway model...
  17. pmc Binge eating disorder: a symptom-level investigation of genetic and environmental influences on liability
    K S Mitchell
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    Psychol Med 40:1899-906. 2010
    ....
  18. ncbi request reprint Multivariate multipoint linkage analysis of quantitative trait loci
    L J Eaves
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 232928, USA
    Behav Genet 26:519-25. 1996
    ....
  19. ncbi request reprint Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
    J M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 11:752-62. 2006
    ..Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression...
  20. ncbi request reprint Genetic and environmental factors in relative body weight and human adiposity
    H H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 27:325-51. 1997
    ..These results are consistent with other studies in suggesting that genetic factors play a significant role in the causes of individual differences in relative body weight and human adiposity...
  21. doi request reprint Interleukin-1 region meta-analysis with osteoarthritis phenotypes
    G Moxley
    Virginia Commonwealth University, Richmond, VA 23298 0263, USA
    Osteoarthritis Cartilage 18:200-7. 2010
    ..Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes. The results have been suggestive for hand OA, negative for knee OA, and conflicting for hip OA...
  22. ncbi request reprint Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins
    D L Foley
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0003, USA
    Am J Med Genet 105:426-31. 2001
    ..Pregnancy and perinatal complications may be associated with an increased risk for eating disorders in women...
  23. ncbi request reprint Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study
    Ayman H Fanous
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004
    ..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
  24. ncbi request reprint Does the level of family dysfunction moderate the impact of genetic factors on the personality trait of neuroticism?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA
    Psychol Med 33:817-25. 2003
    ..Can a similar pattern be seen for the personality trait of Neuroticism (N)-which is a risk factor for many psychiatric conditions?..
  25. ncbi request reprint A review and meta-analysis of the genetic epidemiology of anxiety disorders
    J M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Pychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298-0126, USA
    Am J Psychiatry 158:1568-78. 2001
    ..The role of nonshared environmental experience is significant, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety...
  26. ncbi request reprint Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?
    K S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 31:605-16. 2001
    ..Is the heritability of MD different in men and women? Do the same genetic risk factors predispose to MD in the two sexes?..
  27. ncbi request reprint Genetic and environmental risk factors for depression assessed by subject-rated symptom check list versus structured clinical interview
    D L Foley
    Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond 23298-0003, USA
    Psychol Med 31:1413-23. 2001
    ..SCL depression scores may therefore be a useful screening measure for many of the genetic risk factors which influence liability to major depression...
  28. ncbi request reprint Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4
    C A Prescott
    Department of Psychology, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA
    Mol Psychiatry 11:603-11. 2006
    ..The results of this study suggest the importance of genetic variation in chromosome 4 in the etiology and severity of alcoholism in Caucasian populations...
  29. ncbi request reprint Genetic case-control association studies in neuropsychiatry
    P F Sullivan
    Virginia Institute for Psychiatric and Behavioral Genetics, PO Box 980126, Richmond, VA 23298 0126
    Arch Gen Psychiatry 58:1015-24. 2001
    ..If conducted with care and mindfulness of the potential pitfalls, case-control association studies can be an important tool for psychiatric genetic research...
  30. ncbi request reprint Genetic epidemiology of major depression: review and meta-analysis
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 157:1552-62. 2000
    ..The authors conducted a meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression...
  31. pmc Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men
    M S Panizzon
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 9293 0738, USA
    Neurology 75:874-80. 2010
    ..The aim of the present study was to examine the potential interaction of testosterone and APOE genotype with respect to hippocampal volume in middle age...
  32. ncbi request reprint Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach
    A Agrawal
    Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1 154, Richmond, VA 23298 0003, USA
    Addict Behav 30:1043-8. 2005
    ..Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences...
  33. ncbi request reprint A genetic analysis of the eating and attitudes associated with bulimia nervosa: dealing with the problem of ascertainment in twin studies
    T Wade
    Department of Psychology, Flinders University of South Australia, Australia
    Behav Genet 29:1-10. 1999
    ....
  34. ncbi request reprint Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy
    A H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
    Mol Psychiatry 12:958-65. 2007
    ..Power may therefore be increased in molecular genetic studies of schizophrenia if they incorporate measures of schizotypy in non-psychotic relatives...
  35. ncbi request reprint Cannabis use in the last year in a US national sample of twin and sibling pairs
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, USA
    Psychol Med 32:551-4. 2002
    ..We seek to replicate these results in a US national probability sample of twin and sibling pairs examining only last year cannabis use...
  36. pmc Endophenotype: a conceptual analysis
    K S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 15:789-97. 2010
    ....
  37. ncbi request reprint Possible confounds and their resolution in multivariate genetic analyses: comment on Bussell et al. (1999)
    M C Neale
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298 0126, USA
    Dev Psychol 35:1260-4. 1999
    ..Univariate analyses confirm that the common-environment effect is present for both sibling and parent-child relationships. Most other potential sources of common environment, such as sibling interaction, do not account for the data...
  38. ncbi request reprint Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence
    M A Silverman
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219 1534, USA
    Am J Med Genet 96:646-53. 2000
    ..None of the four polymorphisms we tested, nor their estimated haplotypes, were associated with smoking initiation or progression to nicotine dependence...
  39. doi request reprint Anti-thymocyte globulin for conditioning in matched unrelated donor hematopoietic cell transplantation provides comparable outcomes to matched related donor recipients
    D A Portier
    Bone Marrow Transplant Program, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Bone Marrow Transplant 47:1513-9. 2012
    ..We conclude that the administration of ATG to patients undergoing URD HCT preserves the anti-leukemia benefit of the transplant, while reducing the risk of developing GVHD, resulting in OS rates that are comparable to MRD HCT recipients...
  40. ncbi request reprint A whole genome association study of neuroticism using DNA pooling
    S Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Mol Psychiatry 13:302-12. 2008
    ..Our findings argue the need for much larger samples than anticipated in genetic association studies and that the biological basis of emotional disorders is extremely complex...
  41. ncbi request reprint Joint tests of linkage and association for quantitative traits
    D B Allison
    Department of Biostatistics Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Theor Popul Biol 60:239-51. 2001
    ..Finally, new classes of joint tests of linkage and association that do not require samples of related individuals are described...
  42. ncbi request reprint Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci
    A J Birley
    Queensland Institute of Medical Research and Joint Genetics Program, University of Queensland, 300 Herston Road, Herston, Brisbane, QLD, 4029, Australia
    Behav Genet 35:509-24. 2005
    ..Earlier analyses of these data suggested that alcohol metabolism is related to drinking behavior and imply that this QTL may be protective against alcohol dependence...
  43. ncbi request reprint The joint analysis of personal interview and family history diagnoses: evidence for validity of diagnosis and increased heritability estimates
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298 0126, USA
    Psychol Med 32:829-42. 2002
    ..Reports by family members provide additional information but may be biased. It is unclear how best to combine these two sources of diagnostic data...
  44. ncbi request reprint Linkage analysis of smoking initiation and quantity in Dutch sibling pairs
    J M Vink
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Pharmacogenomics J 4:274-82. 2004
    ..66) for SI and on chromosome 3 (LOD=1.98) for NC. Strikingly, on chromosome 10 a peak was found in the same region for both SI (LOD=1.92) and for NC (LOD=2.29) which may partly explain the overlapping etiological factors for SI and NC...
  45. ncbi request reprint Combined linkage and association tests in mx
    D Posthuma
    Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT The Netherlands
    Behav Genet 34:179-96. 2004
    ..These extensions can be implemented when parental genotypes are available or unavailable...
  46. pmc Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders The UCLA family study
    D L Fogelson
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA
    Schizophr Res 91:192-9. 2007
    ..This indicates that APD is a separate Sz-spectrum disorder, and not merely a sub-clinical form of SPD or PPD...