Walter Nance

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Audiological features of GJB2 (connexin 26) deafness
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Miami, Florida 33136, USA
    Ear Hear 26:361-9. 2005
  2. ncbi request reprint Models for the longitudinal genetic analysis of same-age twins: application to HDL cholesterol
    W E Nance
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298, USA
    Twin Res 1:3-8. 1998
  3. pmc Relevance of connexin deafness (DFNB1) to human evolution
    Walter E Nance
    Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Am J Hum Genet 74:1081-7. 2004
  4. ncbi request reprint The genetics of deafness
    Walter E Nance
    Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Ment Retard Dev Disabil Res Rev 9:109-19. 2003
  5. ncbi request reprint Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss
    Walter E Nance
    Department of Human Genetics and Otolaryngology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Clin Virol 35:221-5. 2006
  6. ncbi request reprint Relation between choice of partner and high frequency of connexin-26 deafness
    W E Nance
    Department of Human Genetics, Virginia Commonwealth University, Richmond 23298 0033, USA
    Lancet 356:500-1. 2000
  7. ncbi request reprint Frequency and distribution of GJB2 (connexin 26) and GJB6 (connexin 30) mutations in a large North American repository of deaf probands
    Arti Pandya
    Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Genet Med 5:295-303. 2003
  8. ncbi request reprint Familial unilateral deafness and delayed endolymphatic hydrops
    Kelley M Dodson
    Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet A 143:1661-5. 2007
  9. ncbi request reprint Superficial siderosis: a potentially important cause of genetic as well as non-genetic deafness
    Kelley M Dodson
    Department of Otolaryngology Head and Neck Surgery, Virginia Commonwealth University School of Medicine and Health Sciences, Medical College of Virginia Campus, Richmond, Virginia 23298 0146, USA
    Am J Med Genet A 130:22-5. 2004
  10. ncbi request reprint Mutations in the alternatively spliced exons of USH1C cause non-syndromic recessive deafness
    Xiao Mei Ouyang
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, FL 33136, USA
    Hum Genet 111:26-30. 2002

Research Grants

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Audiological features of GJB2 (connexin 26) deafness
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Miami, Florida 33136, USA
    Ear Hear 26:361-9. 2005
    ..The aim of the present study was to characterize audiological profiles in patients with GJB2 deafness..
  2. ncbi request reprint Models for the longitudinal genetic analysis of same-age twins: application to HDL cholesterol
    W E Nance
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298, USA
    Twin Res 1:3-8. 1998
    ..Because they include the effects of age-specific genes, the resulting heritabilities (0.80-0.83) were substantially higher than many previous estimates...
  3. pmc Relevance of connexin deafness (DFNB1) to human evolution
    Walter E Nance
    Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Am J Hum Genet 74:1081-7. 2004
    ....
  4. ncbi request reprint The genetics of deafness
    Walter E Nance
    Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Ment Retard Dev Disabil Res Rev 9:109-19. 2003
    ....
  5. ncbi request reprint Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss
    Walter E Nance
    Department of Human Genetics and Otolaryngology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Clin Virol 35:221-5. 2006
    ..No large population based studies of newborn hearing screening have reported the population frequency of more than one specific form of deafness...
  6. ncbi request reprint Relation between choice of partner and high frequency of connexin-26 deafness
    W E Nance
    Department of Human Genetics, Virginia Commonwealth University, Richmond 23298 0033, USA
    Lancet 356:500-1. 2000
    ....
  7. ncbi request reprint Frequency and distribution of GJB2 (connexin 26) and GJB6 (connexin 30) mutations in a large North American repository of deaf probands
    Arti Pandya
    Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Genet Med 5:295-303. 2003
    ....
  8. ncbi request reprint Familial unilateral deafness and delayed endolymphatic hydrops
    Kelley M Dodson
    Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet A 143:1661-5. 2007
    ..In this report, we describe two possible familial instances of delayed DEH. These patients raise the possibility that genetic factors may sometimes be the cause of this unusual syndrome...
  9. ncbi request reprint Superficial siderosis: a potentially important cause of genetic as well as non-genetic deafness
    Kelley M Dodson
    Department of Otolaryngology Head and Neck Surgery, Virginia Commonwealth University School of Medicine and Health Sciences, Medical College of Virginia Campus, Richmond, Virginia 23298 0146, USA
    Am J Med Genet A 130:22-5. 2004
    ....
  10. ncbi request reprint Mutations in the alternatively spliced exons of USH1C cause non-syndromic recessive deafness
    Xiao Mei Ouyang
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, FL 33136, USA
    Hum Genet 111:26-30. 2002
    ..None carried any mutations in these exons of USH1C. Our findings show that USH1C mutations can also cause non-syndromic deafness and that some harmonin isoforms are specifically required for inner ear function...
  11. ncbi request reprint Does universal newborn hearing screening identify all children with GJB2 (Connexin 26) deafness? Penetrance of GJB2 deafness
    Virginia W Norris
    Department of Biology, Gallaudet University, Washington, DC 20002, USA
    Ear Hear 27:732-41. 2006
    ..The objective of this study is to document nine additional children with two pathogenic GJB2 mutations who had non penetrance of hearing loss at birth...
  12. ncbi request reprint Newborn hearing screening--a silent revolution
    Cynthia C Morton
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:2151-64. 2006
  13. ncbi request reprint Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population
    Xiao Mei Ouyang
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
    Hum Genet 116:292-9. 2005
    ..The present study suggests that mutations in MYO7A and CDH23 are the two major components of causes for USH1, while PCDH15, USH1C, and SANS are less frequent causes...
  14. pmc Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study
    Ignacio del Castillo
    Unidad de Genetica Molecular, Hospital Ramon y Cajal, Madrid, Spain
    Am J Hum Genet 73:1452-8. 2003
    ..These results have important implications for the diagnosis and counseling of families with DFNB1 deafness...
  15. ncbi request reprint Evidence of a founder effect for the 235delC mutation of GJB2 (connexin 26) in east Asians
    Denise Yan
    Department of Otolaryngology, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
    Hum Genet 114:44-50. 2003
    ..Similarly, the finding that this mutation appears on a single haplotype provides no support for the possibility that recurrent mutation is the explanation for the high frequency of the allele...
  16. ncbi request reprint Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    Hum Mol Genet 12:1155-62. 2003
    ..Finally, the observation of this mutation only in the Caucasian probands indicated an association with a specific ethnic background. This study thereby reveals an essential function of prestin in human auditory processing...
  17. ncbi request reprint Chudley-McCullough syndrome: expanded phenotype and review of the literature
    Katherine Oelrich Welch
    Department of Biology, Gallaudet University, Washington DC, USA
    Am J Med Genet A 119:71-6. 2003
    ..We, therefore, recommend an audiological assessment for all children with hydrocephalus, especially those with obstruction of the foramen of Monro...
  18. ncbi request reprint The prevalence of connexin 26 ( GJB2) mutations in the Chinese population
    Xue Zhong Liu
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, Florida 33136, USA
    Hum Genet 111:394-7. 2002
    ..The 235delC mutation, rather than 35delG, is the most common mutation found in the Chinese deaf population. Our data support the view that specific combinations of GJB2 mutation exist in different populations...
  19. pmc Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22
    Ingrid Zwaenepoel
    Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique, Paris Cedex 15, France
    Proc Natl Acad Sci U S A 99:6240-5. 2002
    ..We propose that otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells...
  20. pmc A comparative analysis of the genetic epidemiology of deafness in the United States in two sets of pedigrees collected more than a century apart
    Kathleen S Arnos
    Department of Biology, Gallaudet University, Washington, DC 20002, USA
    Am J Hum Genet 83:200-7. 2008
    ....

Research Grants12

  1. GENETIC STUDIES OF NONSYNDROMIC DEAFNESS
    Walter Nance; Fiscal Year: 2001
    ..In addition, blood spots from all available students at the School for the Deaf in Ulaanbaatar will be screened for the mitochondrial mutation that is associated with sensitivity to streptomycin. ..
  2. CREATION OF A DNA REPOSITORY TO IDENTIFY DEAFNESS GENES
    Walter Nance; Fiscal Year: 2004
    ..abstract_text> ..