K S Murthy

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Sequential activation of heterotrimeric and monomeric G proteins mediates PLD activity in smooth muscle
    K S Murthy
    Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Physiol Gastrointest Liver Physiol 280:G381-8. 2001
  2. ncbi request reprint Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A
    Karnam S Murthy
    Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Gastrointest Liver Physiol 294:G327-35. 2008
  3. pmc Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA
    Wimolpak Sriwai
    Department of Physiology, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e66743. 2013
  4. pmc Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion
    Sunila Mahavadi
    Box 980551, Dept of Physiology, School of Medicine, Virginia Commonwealth Univ, Richmond, VA 23298 0551
    Am J Physiol Gastrointest Liver Physiol 305:G964-74. 2013
  5. doi request reprint Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle
    Othman Al-Shboul
    Dept of Physiology and Biophysics, Virginia Commonwealth Univ, Richmond, VA 23298 0711
    Am J Physiol Gastrointest Liver Physiol 305:G314-24. 2013
  6. pmc Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway
    Senthilkumar Rajagopal
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0551, USA
    Am J Physiol Gastrointest Liver Physiol 304:G527-35. 2013
  7. pmc Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat
    Chun Mei Xia
    Department of Physiology, Virginia Commonwealth University School of Medicine, 1220 East Broad Street, PO Box 0551, MMRB 5038, VA 23219 Richmond, Virginia, USA
    J Neuroinflammation 9:30. 2012
  8. pmc Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1
    K S Murthy
    Department of Physiology and Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Br J Pharmacol 153:1214-24. 2008
  9. ncbi request reprint Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC2 receptors in smooth muscle
    Karnam S Murthy
    Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Cell Physiol 294:C477-87. 2008
  10. pmc Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle
    K S Murthy
    Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0711, USA
    Biochem J 360:199-208. 2001

Collaborators

  • J R Grider
  • John F Kuemmerle
  • H I Akbarali
  • R O Heuckeroth
  • Hm Zhou
  • S KARNAM
  • S MURTHY KARNAM
  • Sunila Mahavadi
  • Othman Al-Shboul
  • Wimolpak Sriwai
  • M Al-Qudah
  • Divya P Kumar
  • Sayak Bhattacharya
  • Senthilkumar Rajagopal
  • Chun Mei Xia
  • C D Anderson
  • S Mahavadi
  • Z L Bradley
  • Chereena Clay
  • Carlos U Corvera
  • Ruizhe Zhou
  • Nigel W Bunnett
  • Gracious Ross
  • Sharon J Yu
  • B Q Teng
  • Melisa A Gulick
  • Li Ya Qiao

Detail Information

Publications17

  1. ncbi request reprint Sequential activation of heterotrimeric and monomeric G proteins mediates PLD activity in smooth muscle
    K S Murthy
    Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Physiol Gastrointest Liver Physiol 280:G381-8. 2001
    ..Thus agonist-stimulated PLD activity is mediated additively by G(13)-dependent RhoA and by ARF and PKC-alpha and is modulated by an inhibitory G(12)-dependent pathway...
  2. ncbi request reprint Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A
    Karnam S Murthy
    Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Gastrointest Liver Physiol 294:G327-35. 2008
    ....
  3. pmc Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA
    Wimolpak Sriwai
    Department of Physiology, VCU Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 8:e66743. 2013
    ..The pathway involves activation of the NF-kB to release catalytic subunit of PKA from its binding to IkBa and phosphorylation of RhoA at Ser(188)...
  4. pmc Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion
    Sunila Mahavadi
    Box 980551, Dept of Physiology, School of Medicine, Virginia Commonwealth Univ, Richmond, VA 23298 0551
    Am J Physiol Gastrointest Liver Physiol 305:G964-74. 2013
    ..We conclude that the integrity of caveolae is essential for contractile and relaxant activity in colonic smooth muscle and the maintenance of neuromuscular function at organ level...
  5. doi request reprint Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle
    Othman Al-Shboul
    Dept of Physiology and Biophysics, Virginia Commonwealth Univ, Richmond, VA 23298 0711
    Am J Physiol Gastrointest Liver Physiol 305:G314-24. 2013
    ..Thus higher expression of PDE5 and MRP5 in muscle cells from fundus correlates with tonic phenotype of muscle. ..
  6. pmc Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway
    Senthilkumar Rajagopal
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0551, USA
    Am J Physiol Gastrointest Liver Physiol 304:G527-35. 2013
    ..TGR5 receptor activation on smooth muscle reveals a novel mechanism for the regulation of gut motility by bile acids...
  7. pmc Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat
    Chun Mei Xia
    Department of Physiology, Virginia Commonwealth University School of Medicine, 1220 East Broad Street, PO Box 0551, MMRB 5038, VA 23219 Richmond, Virginia, USA
    J Neuroinflammation 9:30. 2012
    ..Studies with animal models have demonstrated that activation of primary afferent pathways may have a role in mediating viscero-visceral cross-organ sensitization...
  8. pmc Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1
    K S Murthy
    Department of Physiology and Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Br J Pharmacol 153:1214-24. 2008
    ..The aim of the present study was to determine whether contractile agonists modulate cGMP levels by cross-regulating PDE5 activity and to identify the mechanism of action...
  9. ncbi request reprint Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC2 receptors in smooth muscle
    Karnam S Murthy
    Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Cell Physiol 294:C477-87. 2008
    ..Phosphorylation of GRK2 by PKA enhances GRK2 activity and its ability to induce VPAC(2) receptor phosphorylation, internalization, desensitization, and degradation...
  10. pmc Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle
    K S Murthy
    Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0711, USA
    Biochem J 360:199-208. 2001
    ..Phosphorylation by PKG was direct and could be induced in vitro. Activation of PKA had no effect on soluble GC. Thus cGMP levels are regulated by PKG- and PKA-dependent activation of PDE5 and PKG-specific inhibition of soluble GC...
  11. ncbi request reprint Identification of a VIP-specific receptor in guinea pig tenia coli
    B Q Teng
    Departments of Physiology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0711, USA
    Am J Physiol Gastrointest Liver Physiol 281:G718-25. 2001
    ..We conclude that GP tenia coli express a VIP-specific receptor and that selectivity is determined by a pair of extracellular phenylalanine residues...
  12. ncbi request reprint Heterologous desensitization mediated by G protein-specific binding to caveolin
    K S Murthy
    Departments of Physiology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0711, USA
    J Biol Chem 275:30211-9. 2000
    ..Thus, transient binding of receptor-activated G protein subunits to caveolin impedes reassociation of the heterotrimeric species and leads to desensitization of response mediated by other receptors coupled to the same G protein...
  13. ncbi request reprint Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C
    M Al-Qudah
    Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia
    Am J Physiol Gastrointest Liver Physiol 306:G328-37. 2014
    ..We conclude that exogenous BDNF augments the CCh-induced contraction of longitudinal muscle from rabbit intestine by activating TrkB receptors and subsequent PLC activation. ..
  14. pmc Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor
    J R Grider
    Departments of Physiology and Biophysics, and Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Neurogastroenterol Motil 22:779-86. 2010
    ..The aim of the present study was to examine the role of GDNF as neuromodulator of the ascending phase of the peristaltic reflex...
  15. ncbi request reprint G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor
    K S Murthy
    Departments of Physiology and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0711, USA
    Am J Physiol 275:C1409-16. 1998
    ....
  16. ncbi request reprint cAMP inhibits IP(3)-dependent Ca(2+) release by preferential activation of cGMP-primed PKG
    K S Murthy
    Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0711, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1238-45. 2001
    ..The effect of PKA on agonist-induced Ca(2+) release probably reflects inhibition of IP(3) formation...
  17. ncbi request reprint Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth
    J F Kuemmerle
    Departments of Medicine and Physiology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 276:7187-94. 2001
    ....

Research Grants18

  1. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2000
    ..The combined approach embodied by these aims, all of which are supported by preliminary studies, should advance our knowledge of the cellular mechanisms mediating visceral smooth muscle relaxation. ..
  2. Hormonal Integration of Exocrine and Edocrine Organs
    S MURTHY KARNAM; Fiscal Year: 2010
    ..The studies will extend understanding of the function of Gj-coupled receptors in smooth muscle of the gut and in other tissues. ..
  3. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    S KARNAM; Fiscal Year: 2009
    ....
  4. Hormonal Integration of Exocrine and Edocrine Organs
    S KARNAM; Fiscal Year: 2009
    ..The studies will extend understanding of the function of Gj-coupled receptors in smooth muscle of the gut and in other tissues. ..
  5. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2007
    ..Each specific aim is supported by substantial preliminary studies. Their completion should advance our understanding of the molecular mechanisms mediating smooth muscle relaxation. ..
  6. HORMONAL INTEGRATION OF EXOCRINE AND ENDOCRINE ORGANS
    S KARNAM; Fiscal Year: 2007
    ..The studies will extend understanding of the function of Gi-coupled receptors in smooth muscle of the gut and in other tissues. ..
  7. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2006
    ..Each specific aim is supported by substantial preliminary studies. Their completion should advance our understanding of the molecular mechanisms mediating smooth muscle relaxation. ..
  8. HORMONAL INTEGRATION OF EXOCRINE AND ENDOCRINE ORGANS
    KARNAM MURTHY; Fiscal Year: 2006
    ..The studies will extend understanding of the function of Gi-coupled receptors in smooth muscle of the gut and in other tissues. ..
  9. HORMONAL INTEGRATION OF EXOCRINE AND ENDOCRINE ORGANS
    S KARNAM; Fiscal Year: 2005
    ..These pathways operate in concert to maintain MLC phosphorylation and sustained contraction at low Ca2+ levels. ..
  10. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2005
    ..Each specific aim is supported by substantial preliminary studies. Their completion should advance our understanding of the molecular mechanisms mediating smooth muscle relaxation. ..
  11. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2004
    ..Each specific aim is supported by substantial preliminary studies. Their completion should advance our understanding of the molecular mechanisms mediating smooth muscle relaxation. ..
  12. HORMONAL INTEGRATION OF EXOCRINE AND ENDOCRINE ORGANS
    KARNAM MURTHY; Fiscal Year: 2004
    ..These pathways operate in concert to maintain MLC phosphorylation and sustained contraction at low Ca2+ levels. ..
  13. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    S KARNAM; Fiscal Year: 2003
    ..The combined approach embodied by these aims, all of which are supported by preliminary studies, should advance our knowledge of the cellular mechanisms mediating visceral smooth muscle relaxation. ..
  14. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2002
    ..The combined approach embodied by these aims, all of which are supported by preliminary studies, should advance our knowledge of the cellular mechanisms mediating visceral smooth muscle relaxation. ..
  15. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    KARNAM MURTHY; Fiscal Year: 2001
    ..The combined approach embodied by these aims, all of which are supported by preliminary studies, should advance our knowledge of the cellular mechanisms mediating visceral smooth muscle relaxation. ..
  16. FUNCTION OF GUT PEPTIDES IN ISOLATED GUT MUSCLE CELLS
    S MURTHY KARNAM; Fiscal Year: 2010
    ....