Robert J McKallip

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    Robert J McKallip
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 174:3281-9. 2005
  2. ncbi Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock: CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage
    Robert J McKallip
    Department of Microbiology and Immunology, Massey Cancer Center, Virginia Commonwealth University Medical Center, Box 980678, Richmond, VA 23298 0678
    Infect Immun 73:50-61. 2005
  3. ncbi Combined deficiency in CD44 and Fas leads to exacerbation of lymphoproliferative and autoimmune disease
    Yoonkyung Do
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Int Immunol 15:1327-40. 2003
  4. ncbi Targeted deletion of CD44v7 exon leads to decreased endothelial cell injury but not tumor cell killing mediated by interleukin-2-activated cytolytic lymphocytes
    Robert J McKallip
    Departments of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 278:43818-30. 2003
  5. ncbi Fas Ligand-dependent and -independent mechanisms of toxicity induced by T cell lymphomas in lymphoid organs and in the liver
    Catherine Lombard
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Immunol 109:144-53. 2003
  6. ncbi Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo
    Robert J McKallip
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    J Pharmacol Exp Ther 302:451-65. 2002
  7. ncbi Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation
    Yoonkyung Do
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 173:2373-82. 2004
  8. ncbi Mouse B cell activation is inhibited by CD44 cross-linking
    Tiana L Wyant
    Virginia Commonwealth University MCV, Richmond, VA 23298, USA
    Immunol Invest 34:399-416. 2005
  9. ncbi Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced gene expression profile in vivo using pathway-specific cDNA arrays
    Ahmet Zeytun
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23113, USA
    Toxicology 178:241-60. 2002
  10. ncbi Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens
    Robert J McKallip
    Departments of Microbiology and Immunology and Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23298, USA
    Int Immunol 14:1015-26. 2002

Collaborators

Detail Information

Publications14

  1. ncbi Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    Robert J McKallip
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 174:3281-9. 2005
    ....
  2. ncbi Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock: CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage
    Robert J McKallip
    Department of Microbiology and Immunology, Massey Cancer Center, Virginia Commonwealth University Medical Center, Box 980678, Richmond, VA 23298 0678
    Infect Immun 73:50-61. 2005
    ....
  3. ncbi Combined deficiency in CD44 and Fas leads to exacerbation of lymphoproliferative and autoimmune disease
    Yoonkyung Do
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Int Immunol 15:1327-40. 2003
    ....
  4. ncbi Targeted deletion of CD44v7 exon leads to decreased endothelial cell injury but not tumor cell killing mediated by interleukin-2-activated cytolytic lymphocytes
    Robert J McKallip
    Departments of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 278:43818-30. 2003
    ..Together, this study suggests that the expression of CD44v7 on LAK cells plays a specific role in EC injury and that it may be possible to reduce EC injury but not tumor cell killing by specifically targeting CD44v7...
  5. ncbi Fas Ligand-dependent and -independent mechanisms of toxicity induced by T cell lymphomas in lymphoid organs and in the liver
    Catherine Lombard
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Immunol 109:144-53. 2003
    ..Together, these data suggested that, in mice bearing FasL(+) LSA tumor, the immunotoxicity is FasL-based, whereas the hepatotoxicity, at least in part, may be FasL-independent...
  6. ncbi Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo
    Robert J McKallip
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    J Pharmacol Exp Ther 302:451-65. 2002
    ..Together, these results suggest that in vivo exposure to THC can lead to significant suppression of the immune response by induction of apoptosis...
  7. ncbi Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation
    Yoonkyung Do
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 173:2373-82. 2004
    ..Together, our study demonstrates for the first time that endogenous and exogenous cannabinoids may suppress the immune response through their ability to induce apoptosis in DCs...
  8. ncbi Mouse B cell activation is inhibited by CD44 cross-linking
    Tiana L Wyant
    Virginia Commonwealth University MCV, Richmond, VA 23298, USA
    Immunol Invest 34:399-416. 2005
    ..These results suggest that CD44 cross-linking could control polyclonal B cell activation by CD40L, but allow sIgM/CD40L activation to continue...
  9. ncbi Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced gene expression profile in vivo using pathway-specific cDNA arrays
    Ahmet Zeytun
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23113, USA
    Toxicology 178:241-60. 2002
    ..Thus, pathway-specific cDNA arrays may help in the identification of specific gene expression profiles induced by xenobiotics and to delineate the molecular mechanisms of toxicity...
  10. ncbi Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens
    Robert J McKallip
    Departments of Microbiology and Immunology and Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23298, USA
    Int Immunol 14:1015-26. 2002
    ..Furthermore, targeting CD44 in vivo may constitute a novel approach to induce apoptosis in activated T cells, and therefore to treat autoimmune diseases, allograft rejection and graft versus host disease...
  11. ncbi Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
    Robert J McKallip
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Blood 100:627-34. 2002
    ..Also, because CB2 agonists lack psychotropic effects, they may serve as novel anticancer agents to selectively target and kill tumors of immune origin...
  12. ncbi Reference moist smokeless tobacco-induced apoptosis in human monocytes/macrophages cell line MM6
    Catherine Lombard
    RemX Specialty Staffing, c o Altria Client Services, Research, Development and Engineering, 601 East Jackson Street, Richmond, VA 23219, USA
    Int Immunopharmacol 10:1029-40. 2010
    ..Together, these data show for the first time that STE exposure leads to the induction of apoptosis in human monocyte/macrophage cells, which appears to be induced in part, by reference STE-mediated osmotic stress...
  13. ncbi Regulation of interleukin-2-induced vascular leak syndrome by targeting CD44 using hyaluronic acid and anti-CD44 antibodies
    Amjad Mustafa
    Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Immunother (1997) 25:476-88. 2002
    ..These studies demonstrate that molecular targeting of CD44 may serve as a useful tool to selectively alter the LAK activity and to prevent endothelial cell injury induced by IL-2...
  14. ncbi Role of CD4(+)CD25(+) T regulatory cells in IL-2-induced vascular leak
    Louise Melencio
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 6439 Garner s Ferry Road, Columbia, SC 29209, USA
    Int Immunol 18:1461-71. 2006
    ..Together, the results from this study suggest that CD4(+)CD25(+) T regulatory cells play an important role in the regulation of IL-2-induced EC injury...