Research Topics
| Sarah M McDonaldSummaryAffiliation: Virginia Polytechnic Institute and State University Country: USA Publications
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Detail Information
Publications
Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomicsSarah M McDonald
Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA
J Virol 86:9148-62. 2012..Thus, this large-scale, comparative genomic study of modern human RVs provides significant insight into how this pathogen evolves during its spread in the community...- Intra-genotypic diversity of archival G4P[8] human rotaviruses from Washington, DCSarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Infect Genet Evol 11:1586-94. 2011..Thus, archival human RVs sequenced in this study might represent evolutionary precursors to modern-day strains... - Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellationsSarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Pathog 5:e1000634. 2009..Elucidation of the selective pressures that favor maintenance of RVs with certain sets of genes may be necessary to anticipate future vaccine needs... - Rotavirus VP2 core shell regions critical for viral polymerase activationSarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6311, Bethesda, MD 20892 8026, USA
J Virol 85:3095-105. 2011..Based on these findings, we predict that several regions of VP2 engage the polymerase during the concerted processes of rotavirus core assembly and genome replication... - Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116EChristine M Rippinger
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Virology 405:201-13. 2010..The results of this study enhance our understanding of the molecular determinants of RV3 and 116E attenuation and are expected to aid in the ongoing development of these vaccine candidates... 
Structural insights into the coupling of virion assembly and rotavirus replicationShane D Trask
Rotavirus Molecular Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Microbiol 10:165-77. 2012..In this Review, we explore the current understanding of rotavirus replication and how it compares to replication of other Reoviridae family members...- The ins and outs of four-tunneled Reoviridae RNA-dependent RNA polymerasesSarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
Curr Opin Struct Biol 19:775-82. 2009..This intra-particle mechanism of RNA synthesis coordinates genome packaging with replication during the infectious cycle... - Shared and group-specific features of the rotavirus RNA polymerase reveal potential determinants of gene reassortment restrictionSarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20826 8026, USA
J Virol 83:6135-48. 2009..Together, the results of this study provide unprecedented insight into the structure and function of RV RdRps and support the notion that VP1 interactions may influence the emergence of reassortant viral strains... - Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactionsErica M Heiman
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8026, Room 6314, Bethesda, MD 20892 8026, USA
J Virol 82:11106-16. 2008..The results of this study provide evidence that group A HRV gene constellations exist and may be influenced by interactions among viral proteins during replication... - Assortment and packaging of the segmented rotavirus genomeSarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Trends Microbiol 19:136-44. 2011..However, as reviewed here, recent insights gained from the study of RV and two other segmented RNA viruses, influenza A virus and bacteriophage Φ6, reveal potential mechanisms of RV assortment and packaging... - Mechanism of intraparticle synthesis of the rotavirus double-stranded RNA genomeKristen M Guglielmi
Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:18123-8. 2010..This intraparticle strategy of RNA synthesis helps orchestrate the concerted packaging and replication of the viral genome. Here, we review our current understanding of rotavirus RNA synthetic mechanisms... - Culturing, storage, and quantification of rotavirusesMichelle Arnold
Laboratory of Infectious Diseases, NIAID NIH, Bethesda, Maryland, USA
Curr Protoc Microbiol . 2009..This unit describes easily applicable procedures for the culturing, storage, and quantification of RVs... - Molecular characterization of a subgroup specificity associated with the rotavirus inner capsid protein VP2Sarah M McDonald
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Dr MSC 8026, Rm 6314, Bethesda, MD 20892 8026, USA
J Virol 82:2752-64. 2008..This study reveals the extent of genetic variation among group A rotavirus VP2 proteins and illuminates the molecular basis for a previously described SG specificity associated with the rotavirus inner capsid protein...