Sarah M McDonald

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. doi request reprint RNA synthetic mechanisms employed by diverse families of RNA viruses
    Sarah M McDonald
    Virginia Tech Carilion Research Institute and School of Medicine, Roanoke, VA, USA
    Wiley Interdiscip Rev RNA 4:351-67. 2013
  2. pmc Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics
    Sarah M McDonald
    Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA
    J Virol 86:9148-62. 2012
  3. pmc Intra-genotypic diversity of archival G4P[8] human rotaviruses from Washington, DC
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Genet Evol 11:1586-94. 2011
  4. pmc Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype
    Allison F Dennis
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 88:3789-801. 2014
  5. pmc Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000634. 2009
  6. doi request reprint Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles
    Crystal E Boudreaux
    Virginia Tech Carilion Research Institute, Roanoke, VA, USA
    J Gen Virol 94:1818-26. 2013
  7. pmc Rotavirus VP2 core shell regions critical for viral polymerase activation
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6311, Bethesda, MD 20892 8026, USA
    J Virol 85:3095-105. 2011
  8. ncbi request reprint PCR-based approach to distinguish group A human rotavirus genotype 1 vs. genotype 2 genes
    Allison O McKell
    Virginia Tech Carilion Research Institute, Roanoke, VA 24016, USA Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA
    J Virol Methods 194:197-205. 2013
  9. pmc Shared and group-specific features of the rotavirus RNA polymerase reveal potential determinants of gene reassortment restriction
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20826 8026, USA
    J Virol 83:6135-48. 2009
  10. pmc Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116E
    Christine M Rippinger
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virology 405:201-13. 2010

Collaborators

  • Daniel C Payne
  • Philippe Lemey
  • Shiliang Wang
  • Marc Van Ranst
  • Jelle Matthijnssens
  • John T Patton
  • Brian L Gilmore
  • Allison F Dennis
  • Allison O McKell
  • Crystal E Boudreaux
  • Deborah F Kelly
  • Justin R Tanner
  • Shane D Trask
  • Kristen M Guglielmi
  • Christine M Rippinger
  • Michelle Arnold
  • Erica M Heiman
  • Slavica Mijatovic-Rustempasic
  • Mathew D Esona
  • Kathryn M Edwards
  • James D Chappell
  • Joshua C Nichols
  • Shannon P Showalter
  • Andrew C Demmert
  • Donald C Vile
  • Madeline J Dukes
  • Mario Barro
  • Tamara Bar-Magen
  • Zenobia F Taraporewala

Detail Information

Publications18

  1. doi request reprint RNA synthetic mechanisms employed by diverse families of RNA viruses
    Sarah M McDonald
    Virginia Tech Carilion Research Institute and School of Medicine, Roanoke, VA, USA
    Wiley Interdiscip Rev RNA 4:351-67. 2013
    ..Combined with elegant biochemical studies, such structures are providing a scientific platform for the rational design of antiviral agents aimed at preventing and treating RNA virus-induced diseases...
  2. pmc Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics
    Sarah M McDonald
    Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA
    J Virol 86:9148-62. 2012
    ..Thus, this large-scale, comparative genomic study of modern human RVs provides significant insight into how this pathogen evolves during its spread in the community...
  3. pmc Intra-genotypic diversity of archival G4P[8] human rotaviruses from Washington, DC
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Genet Evol 11:1586-94. 2011
    ..Thus, archival human RVs sequenced in this study might represent evolutionary precursors to modern-day strains...
  4. pmc Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype
    Allison F Dennis
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 88:3789-801. 2014
    ..The ongoing evolution of G2 VP7 lineages may give rise to antigenic changes that undermine vaccine effectiveness in the long term...
  5. pmc Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000634. 2009
    ..Elucidation of the selective pressures that favor maintenance of RVs with certain sets of genes may be necessary to anticipate future vaccine needs...
  6. doi request reprint Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles
    Crystal E Boudreaux
    Virginia Tech Carilion Research Institute, Roanoke, VA, USA
    J Gen Virol 94:1818-26. 2013
    ..When combined with previous work, the results of this study support the notion that the same VP2 regions that engage VP1 during activation are also involved in packaging the enzyme into the core. ..
  7. pmc Rotavirus VP2 core shell regions critical for viral polymerase activation
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6311, Bethesda, MD 20892 8026, USA
    J Virol 85:3095-105. 2011
    ..Based on these findings, we predict that several regions of VP2 engage the polymerase during the concerted processes of rotavirus core assembly and genome replication...
  8. ncbi request reprint PCR-based approach to distinguish group A human rotavirus genotype 1 vs. genotype 2 genes
    Allison O McKell
    Virginia Tech Carilion Research Institute, Roanoke, VA 24016, USA Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061, USA
    J Virol Methods 194:197-205. 2013
    ..As such, primer sets now exist for all eleven genes of common human RVs, allowing for the identification of reassortant strains with mixed constellations of both genotype 1 and 2 genes using a rapid and economical RT-PCR/PCR method. ..
  9. pmc Shared and group-specific features of the rotavirus RNA polymerase reveal potential determinants of gene reassortment restriction
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20826 8026, USA
    J Virol 83:6135-48. 2009
    ..Together, the results of this study provide unprecedented insight into the structure and function of RV RdRps and support the notion that VP1 interactions may influence the emergence of reassortant viral strains...
  10. pmc Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116E
    Christine M Rippinger
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Virology 405:201-13. 2010
    ..The results of this study enhance our understanding of the molecular determinants of RV3 and 116E attenuation and are expected to aid in the ongoing development of these vaccine candidates...
  11. pmc Structural insights into the coupling of virion assembly and rotavirus replication
    Shane D Trask
    Rotavirus Molecular Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 10:165-77. 2012
    ..In this Review, we explore the current understanding of rotavirus replication and how it compares to replication of other Reoviridae family members...
  12. pmc The ins and outs of four-tunneled Reoviridae RNA-dependent RNA polymerases
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
    Curr Opin Struct Biol 19:775-82. 2009
    ..This intra-particle mechanism of RNA synthesis coordinates genome packaging with replication during the infectious cycle...
  13. pmc Assortment and packaging of the segmented rotavirus genome
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
    Trends Microbiol 19:136-44. 2011
    ..However, as reviewed here, recent insights gained from the study of RV and two other segmented RNA viruses, influenza A virus and bacteriophage Φ6, reveal potential mechanisms of RV assortment and packaging...
  14. doi request reprint Visualizing viral assemblies in a nanoscale biosphere
    Brian L Gilmore
    Virginia Tech Carilion Research Institute, Virginia Tech, Roanoke, Virginia 24016, USA
    Lab Chip 13:216-9. 2013
    ..Images of DLPs were used to calculate the first 3D view of macromolecules in solution. We refer to this new fluidic visualization technology as in situ molecular microscopy...
  15. pmc Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions
    Erica M Heiman
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8026, Room 6314, Bethesda, MD 20892 8026, USA
    J Virol 82:11106-16. 2008
    ..The results of this study provide evidence that group A HRV gene constellations exist and may be influenced by interactions among viral proteins during replication...
  16. pmc Mechanism of intraparticle synthesis of the rotavirus double-stranded RNA genome
    Kristen M Guglielmi
    Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:18123-8. 2010
    ..This intraparticle strategy of RNA synthesis helps orchestrate the concerted packaging and replication of the viral genome. Here, we review our current understanding of rotavirus RNA synthetic mechanisms...
  17. pmc Culturing, storage, and quantification of rotaviruses
    Michelle Arnold
    Laboratory of Infectious Diseases, NIAID NIH, Bethesda, Maryland, USA
    Curr Protoc Microbiol . 2009
    ..This unit describes easily applicable procedures for the culturing, storage, and quantification of RVs...
  18. pmc Molecular characterization of a subgroup specificity associated with the rotavirus inner capsid protein VP2
    Sarah M McDonald
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Dr MSC 8026, Rm 6314, Bethesda, MD 20892 8026, USA
    J Virol 82:2752-64. 2008
    ..This study reveals the extent of genetic variation among group A rotavirus VP2 proteins and illuminates the molecular basis for a previously described SG specificity associated with the rotavirus inner capsid protein...