Valeria R Mas

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 84:1262-71. 2007
  2. pmc Proteomic analysis of HCV cirrhosis and HCV-induced HCC: identifying biomarkers for monitoring HCV-cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 87:143-52. 2009
  3. pmc Evaluation of gene panel mRNAs in urine samples of kidney transplant recipients as a non-invasive tool of graft function
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Med 13:315-24. 2007
  4. ncbi request reprint Study of mRNA growth factors in urinary cells of kidney transplant recipients as predictors of chronic allograft nephropathy
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0057, USA
    Transplantation 80:1686-91. 2005
  5. ncbi request reprint Molecular and clinical response to angiotensin II receptor antagonist in kidney transplant patients with chronic allograft nephropathy
    Valeria R Mas
    Department of Pathology and Surgery, Virginia Commonwealth University, MCV Campus, West Hospital, Ninth Floor, South Wing, P O Box 980057, 23298 0057, Richmond, VA, USA
    Transpl Int 17:540-4. 2004
  6. ncbi request reprint Establishing the molecular pathways involved in chronic allograft nephropathy for testing new noninvasive diagnostic markers
    Valeria Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 83:448-57. 2007
  7. doi request reprint Gene expression patterns in deceased donor kidneys developing delayed graft function after kidney transplantation
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 85:626-35. 2008
  8. doi request reprint Distinctive gene expression profiles characterize donor biopsies from HCV-positive kidney donors
    Valeria R Mas
    Virginia Commonwealth University, Richmond, VA
    Transplantation 90:1172-9. 2010
  9. pmc Molecular pathways involved in loss of kidney graft function with tubular atrophy and interstitial fibrosis
    Daniel G Maluf
    Department of Surgery, Division of Transplant, Virginia Commonwealth University, Richmond, Virginia 23298 0057, United States of America
    Mol Med 14:276-85. 2008
  10. ncbi request reprint Genes associated with progression and recurrence of hepatocellular carcinoma in hepatitis C patients waiting and undergoing liver transplantation: preliminary results
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0057, USA
    Transplantation 83:973-81. 2007

Detail Information

Publications36

  1. ncbi request reprint Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 84:1262-71. 2007
    ..We aimed to evaluate the expression of angiogenic factors in hepatitis C virus (HCV)-HCC tissues and the utility of angiogenesis soluble factors as noninvasive markers of HCC and tumor growth...
  2. pmc Proteomic analysis of HCV cirrhosis and HCV-induced HCC: identifying biomarkers for monitoring HCV-cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 87:143-52. 2009
    ..We evaluated global protein expression in plasma samples of HCV-cirrhotic and HCV-cirrhotic-HCC patients...
  3. pmc Evaluation of gene panel mRNAs in urine samples of kidney transplant recipients as a non-invasive tool of graft function
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Med 13:315-24. 2007
    ..A characteristic pattern of mRNA levels in the different KTP groups was observed indicating that the mRNA levels in Ur cells might reflect allograft function...
  4. ncbi request reprint Study of mRNA growth factors in urinary cells of kidney transplant recipients as predictors of chronic allograft nephropathy
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0057, USA
    Transplantation 80:1686-91. 2005
    ..Current diagnostic methods for CAN are inadequate, and noninvasive assays for detecting allograft dysfunction/rejection and predicting long-term outcomes are a priority in transplantation...
  5. ncbi request reprint Molecular and clinical response to angiotensin II receptor antagonist in kidney transplant patients with chronic allograft nephropathy
    Valeria R Mas
    Department of Pathology and Surgery, Virginia Commonwealth University, MCV Campus, West Hospital, Ninth Floor, South Wing, P O Box 980057, 23298 0057, Richmond, VA, USA
    Transpl Int 17:540-4. 2004
    ..2+/-377 mg/24 h, P=0.001. Intra-graft expression of TGF-beta1 was decreased after treatment. In conclusion, losartan significantly decreases the intra-graft expression of TGF-beta1 and proteinuria in KTPs with CAN...
  6. ncbi request reprint Establishing the molecular pathways involved in chronic allograft nephropathy for testing new noninvasive diagnostic markers
    Valeria Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 83:448-57. 2007
    ..The multistage processes that result in CAN are poorly understood. Noninvasive assays for detecting allograft dysfunction and predicting long-term outcomes are a priority in transplantation (Tx)...
  7. doi request reprint Gene expression patterns in deceased donor kidneys developing delayed graft function after kidney transplantation
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 85:626-35. 2008
    ..The mechanisms leading to DGF deserve special interest because DGF exerts negative influences on long-term outcomes. We studied gene expression profiles in deceased donor kidney (DDK) biopsies with and without DGF...
  8. doi request reprint Distinctive gene expression profiles characterize donor biopsies from HCV-positive kidney donors
    Valeria R Mas
    Virginia Commonwealth University, Richmond, VA
    Transplantation 90:1172-9. 2010
    ..Frequently, donors infected with hepatitis C virus (HCV) are used. To elucidate an initial compromise of molecular pathways in HCV graft, gene expression profiles were evaluated...
  9. pmc Molecular pathways involved in loss of kidney graft function with tubular atrophy and interstitial fibrosis
    Daniel G Maluf
    Department of Surgery, Division of Transplant, Virginia Commonwealth University, Richmond, Virginia 23298 0057, United States of America
    Mol Med 14:276-85. 2008
    ..The top-scored networks were related to immune response, inflammation, and cell-to-cell interaction, showing the importance of chronic inflammation in progressive graft deterioration...
  10. ncbi request reprint Genes associated with progression and recurrence of hepatocellular carcinoma in hepatitis C patients waiting and undergoing liver transplantation: preliminary results
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0057, USA
    Transplantation 83:973-81. 2007
    ..Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence...
  11. doi request reprint Molecular pathways involved in loss of graft function in kidney transplant recipients
    Valeria R Mas
    Molecular Transplant Research Laboratory, Transplant Division, Department of Surgery, Molecular Medicine Research Building, Virginia Commonwealth University, Richmond, VA 23298, USA
    Expert Rev Mol Diagn 10:269-84. 2010
    ..A major challenge in the future of kidney transplantation includes the study of chronic allograft dysfunction pathogenesis to identify early markers of disease progression, as well as potential therapeutics pathways...
  12. ncbi request reprint Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation: genes involved in tumor progression
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond 23298, USA
    Liver Transpl 10:607-20. 2004
    ....
  13. doi request reprint Identification of biomarkers to assess organ quality and predict posttransplantation outcomes
    Mariano J Scian
    Division of Transplantation, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908 0679, USA
    Transplantation 94:851-8. 2012
    ..The increased disparity between organ supply and need has led to the use of extended criteria donors and donation after cardiac death donors with other comorbidities...
  14. ncbi request reprint Molecular techniques for identifying HCC origin and biology after orthotopic liver transplantation
    Valeria R Mas
    Division of Transplant Surgery, Department of Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, PO Box 980254, Richmond, VA 23298, USA
    Diagn Mol Pathol 15:90-4. 2006
    ..These techniques provided consistent evidence that the second HCC was a recurrence of the primary tumor...
  15. pmc Identifying genes for establishing a multigenic test for hepatocellular carcinoma surveillance in hepatitis C virus-positive cirrhotic patients
    Kellie J Archer
    Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298 0032, USA
    Cancer Epidemiol Biomarkers Prev 18:2929-32. 2009
    ....
  16. doi request reprint Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation
    Ricardo C Gehrau
    1 Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA 2 Department of Pathology, Virginia Commonwealth University, Richmond, VA 3 Address correspondence to Daniel G Maluf, M D, Liver Transplant Program, Transplant Division, Department of Surgery, University of Virginia, 1300 Jefferson Park Avenue, Barringer 5, Room 5417, Charlottesville, VA
    Transplantation 96:926-34. 2013
    ..Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regulation results critical in several biological processes...
  17. pmc Pretransplant transcriptome profiles identify among kidneys with delayed graft function those with poorer quality and outcome
    Valeria R Mas
    Department of Surgery, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
    Mol Med 17:1311-22. 2011
    ..In conclusion, DGF is a poor marker for organ quality and transplant outcome. In contrast, preimplant gene expression profiles identify "poor quality" grafts and may eventually improve organ allocation...
  18. ncbi request reprint Apolipoprotein E genotypes as predictors of high-risk groups for developing hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment
    Daniel G Maluf
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 80:1705-11. 2005
    ..Apoliprotein E (Apo E) polymorphism is an established genetic risk factor for hyperlipidemia. We studied the association between Apo E gene polymorphisms and lipids after kidney transplantation in patients undergoing sirolimus treatment...
  19. pmc Differentially expressed genes between early and advanced hepatocellular carcinoma (HCC) as a potential tool for selecting liver transplant recipients
    Valeria R Mas
    Division of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Mol Med 12:97-104. 2006
    ..Whether gene expression profiling of HCC will be refined to the point of predicting potential metastatic biologic behavior to predict post-LT recurrence will require longitudinal prospective study of this gene array technology...
  20. pmc Molecular mechanisms involved in the interaction effects of alcohol and hepatitis C virus in liver cirrhosis
    Valeria R Mas
    Hume Lee Transplant Center, Division of Transplant, Department of Surgery, Virginia Commonwealth University Health System, Richmond, Virginia 23298 0057, USA
    Mol Med 16:287-97. 2010
    ..Alcohol*HCV in the cirrhotic tissues resulted in a strong negative regulation of the apoptosis pattern with concomitant positive regulation of cellular division and proliferation...
  21. pmc Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Med 15:85-94. 2009
    ..Characteristic gene signatures were identified at different stages of HCV-HCC progression. A set of genes were identified to predict whether the cirrhotic tissue was associated with HCC...
  22. pmc Identifying genes progressively silenced in preneoplastic and neoplastic liver tissues
    Kellie J Archer
    Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298 0032, USA
    Int J Comput Biol Drug Des 3:52-67. 2010
    ..9% of the remaining genes examined. Our results indicate that further high-throughput methylation studies to more fully characterize molecular events involved in hepatocarcinogenesis are warranted...
  23. ncbi request reprint Hepatitis C virus infection and kidney transplantation: predictors of patient and graft survival
    Daniel G Maluf
    Department of Surgery, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 83:853-7. 2007
    ..This study aimed to evaluate the outcomes of our HCV+/end-stage renal disease (ESRD) patient population based on the therapeutic option including KTx or continuation in dialysis...
  24. doi request reprint Hepatic disease biomarkers and liver transplantation: what is the potential utility of microRNAs?
    Ricardo C Gehrau
    Department of Surgery, University of Virginia, Transplant Division, PO Box 800625, 409 Lane Rd, Charlottesville, VA 22908 0625, USA
    Expert Rev Gastroenterol Hepatol 7:157-70. 2013
    ..The present review aims to provide an overview of recent achievements in research on the potential applicability of miRNAs as biomarkers in liver disease and liver transplantation...
  25. doi request reprint MiRNAs in kidney transplantation: potential role as new biomarkers
    Mariano J Scian
    University of Virginia, Department of Surgery, PO Box 800679, Charlottesville, VA, USA
    Expert Rev Mol Diagn 13:93-104. 2013
    ....
  26. pmc Molecular profiles of HCV cirrhotic tissues derived in a panel of markers with clinical utility for hepatocellular carcinoma surveillance
    Ricardo C Gehrau
    University of Virginia, Department of Surgery, Transplant Division Charlottesville, Virginia, United States of America
    PLoS ONE 7:e40275. 2012
    ..Early hepatocellular carcinoma (HCC) detection is difficult because low accuracy of surveillance tests. Genome-wide analyses were performed using HCV-cirrhosis with HCC to identify predictive signatures...
  27. pmc High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma
    Kellie J Archer
    Department of Biostatistics, Virginia Commonwealth University, 730 East Broad Street, P O Box 980032, Richmond, VA 23298 0032, USA
    Mol Genet Genomics 283:341-9. 2010
    ..Our study demonstrates that high-throughput methylation technologies may be used to identify differentially methylated CpG sites that may prove to be important molecular events involved in carcinogenesis...
  28. doi request reprint The urine microRNA profile may help monitor post-transplant renal graft function
    Daniel G Maluf
    Translational Genomics Transplant Laboratory, Transplant Division, Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Kidney Int 85:439-49. 2014
    ..Thus, a panel of urine miRNAs was identified as potential biomarkers for monitoring graft function and anticipating progression to CAD in kidney transplant patients. ..
  29. ncbi request reprint Evaluation of quality-control criteria for microarray gene expression analysis
    Catherine I Dumur
    Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Chem 50:1994-2002. 2004
    ..Development of quality-control criteria to ensure reproducibility of microarray results for potential clinical application is still in its infancy...
  30. pmc Identifying biomarkers as diagnostic tools in kidney transplantation
    Valeria R Mas
    Molecular Transplant Research Laboratory, Transplant Division, Department of Surgery, Molecular Medicine Research Building, Virginia Commonwealth University, 1220 East Broad Street, Richmond, VA 23298, USA
    Expert Rev Mol Diagn 11:183-96. 2011
    ..This article will discuss the existing gap between biomarker discovery and clinical application in the kidney transplant setting. Approaches to implementing biomarker monitoring into clinical practice will also be discussed...
  31. doi request reprint Proteomics and liver fibrosis: identifying markers of fibrogenesis
    Valeria R Mas
    Transplant Molecular Laboratory, Transplant Division, Department of Surgery, Molecular Medicine Research Building, Virginia Commonwealth University, 1220 E Broad Street, Richmond, VA 23298, USA
    Expert Rev Proteomics 6:421-31. 2009
    ..This review aims to provide an overview of the possibilities that proteome technology can offer to the knowledge, diagnosis and prognosis of liver fibrosis...
  32. ncbi request reprint Engraftment measurement in human liver tissue after liver cell transplantation by short tandem repeats analysis
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Cell Transplant 13:231-6. 2004
    ....
  33. doi request reprint Cell transplant techniques: engraftment detection of cells
    Robert A Fisher
    Department of Surgery, Transplantation Division, Virginia Commonwealth University, Medical College of Virginia Hospitals, Richmond, Virginia, USA
    Methods Mol Biol 481:97-105. 2009
    ..Radiolabeling and dye labeling techniques, DNA typing of HLA class I alleles, soluble class I HLA ELISA, real-time quantitative PCR techniques including short tandem repeats analysis will be detailed and critiqued...
  34. ncbi request reprint Hepatic artery thrombosis after liver transplantation and genetic factors: prothrombin G20210A polymorphism
    Valeria R Mas
    Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298 0248, USA
    Transplantation 76:247-9. 2003
    ..62%) in 13 patients. Prothrombin G20210A polymorphism was found in the DNA obtained from 2 of 14 liver allograft tissues (14.2%) but not in the DNA from leukocytes obtained from the peripheral blood of recipients with HAT...
  35. ncbi request reprint Liver transplant complications in hepatitis C infected recipients: recurrence versus rejection
    Ricardo C Gehrau
    Department of Surgery, University of Virginia, P O Box 800625, 904 Lane Rd, Charlottesville, VA 22908 0625, USA
    Expert Rev Gastroenterol Hepatol 8:453-6. 2014
    ..This editorial describes and discusses potential biomarkers of disease differentiation including recent reports in the field of genomics, proteomics, immunohistochemistry among other technologies. ..
  36. pmc Quality assessment of microarray data in a multicenter study
    Kellie J Archer
    Virginia Commonwealth University, 730 East Broad Street, Theater Row, Richmond, VA 23298 0032, USA
    Diagn Mol Pathol 18:34-43. 2009
    ..Moreover, evaluation of sample quality at various steps in the data acquisition process is an important component of a multicenter study to ensure all participating centers adhere to established protocols...