A Marmarou

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219 0449, USA
    J Neurosurg 102:987-97. 2005
  2. ncbi Pathophysiology of traumatic brain edema: current concepts
    A Marmarou
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 86:7-10. 2003
  3. ncbi Estimated incidence of normal pressure hydrocephalus and shunt outcome in patients residing in assisted-living and extended-care facilities
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurg Focus 22:E1. 2007
  4. ncbi IMPACT database of traumatic brain injury: design and description
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical School, Richmond, Virginia 23219, USA
    J Neurotrauma 24:239-50. 2007
  5. ncbi The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurgery 57:S17-28; discussion ii-v. 2005
  6. ncbi Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurgery 57:S1-3; discussion ii-v. 2005
  7. ncbi Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219, USA
    J Neurotrauma 24:270-80. 2007
  8. ncbi Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema
    A Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:393-7. 2006
  9. ncbi Traumatic brain edema in diffuse and focal injury: cellular or vasogenic?
    A Marmarou
    Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:24-9. 2006
  10. ncbi Brain tissue water content in patients with idiopathic normal pressure hydrocephalus
    G Aygok
    Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:348-51. 2006

Research Grants

Detail Information

Publications79

  1. ncbi Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219 0449, USA
    J Neurosurg 102:987-97. 2005
    ....
  2. ncbi Pathophysiology of traumatic brain edema: current concepts
    A Marmarou
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 86:7-10. 2003
    ..This article provides an update of our current progress toward supporting this hypothesis and includes an update on the role of aquaporins in traumatic brain edema...
  3. ncbi Estimated incidence of normal pressure hydrocephalus and shunt outcome in patients residing in assisted-living and extended-care facilities
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurg Focus 22:E1. 2007
    ..A secondary objective was to evaluate prospectively the diagnosis and outcome of surgical treatment in a subset of patients residing in healthcare facilities who were at risk for idiopathic NPH...
  4. ncbi IMPACT database of traumatic brain injury: design and description
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical School, Richmond, Virginia 23219, USA
    J Neurotrauma 24:239-50. 2007
    ....
  5. ncbi The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurgery 57:S17-28; discussion ii-v. 2005
    ..This report develops evidence-based guidelines for the use of supplementary tests as an aid in prognosis...
  6. ncbi Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurgery 57:S1-3; discussion ii-v. 2005
    ..The guidelines were to encompass value of clinical presentation, value of supplementary diagnostic tests, surgical management, and outcome assessment...
  7. ncbi Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219, USA
    J Neurotrauma 24:270-80. 2007
    ..0001). Pupil reactivity was more robust between these time points. It is recommended that the study hospital enrollment GCS and pupil reactivity be used for prognostic analysis...
  8. ncbi Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema
    A Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:393-7. 2006
    ..05). Attenuation of the ischemia-induced AQP4 up-regulation by PMA suggests that the reduction in brain edema formation following PMA treatment was at least in part mediated by AQP4 modulation...
  9. ncbi Traumatic brain edema in diffuse and focal injury: cellular or vasogenic?
    A Marmarou
    Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:24-9. 2006
    ..Taking these findings in concert, it is concluded that the predominant form of edema responsible for brain swelling and raised ICP is cellular in nature...
  10. ncbi Brain tissue water content in patients with idiopathic normal pressure hydrocephalus
    G Aygok
    Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:348-51. 2006
    ..To our knowledge, this is the first study to confirm that periventricular lucency seen on MRI represents increased water content in the extracellular space that is markedly elevated prior to shunting...
  11. ncbi Diffuse brain injury complicated by acute subdural hematoma in the rodents: the effect of early or delayed surgical evacuation
    S Sawauchi
    Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA
    Acta Neurochir Suppl 81:243-4. 2002
    ..In absence of secondary insult, rapid evacuation of traumatic SDH limits exposure to high ICP, reduces brain edema and is beneficial...
  12. ncbi Contribution of raised ICP and hypotension to CPP reduction in severe brain injury: correlation to outcome
    A Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Acta Neurochir Suppl 95:277-80. 2005
    ..With use of the CPP concept of treatment, the major contribution to CPP shifted to ICP and arterial hypotension played less of a role. Overall, CPP management has been associated with improved outcome...
  13. ncbi The effect of cyclosporin A on brain edema formation following experimental cortical contusion
    S Fukui
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    Acta Neurochir Suppl 86:301-3. 2003
    ..We therefore suggest that an intravascular route may be better for CsA administration because the intrathecal injection may exacerbate brain edema as found in our previous study...
  14. ncbi Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients
    A Marmarou
    Department of Radiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0508, USA
    J Neurosurg 93:183-93. 2000
    ..The goal of this study was to examine the roles of cerebral blood volume (CBV) and edema in traumatic brain swelling...
  15. ncbi N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury
    S Signoretti
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0508, USA
    J Neurotrauma 18:977-91. 2001
    ..NAA recovers if the degree of injury is moderate and not accompanied by secondary insult. The highly similar time course and correlation between NAA and ATP supports the notion that NAA reduction is related to energetic impairment...
  16. ncbi Contrasting effects of dopamine therapy in experimental brain injury
    A Beaumont
    Division of Neurosurgery, Medical College of Virginia, Richmond 23298, USA
    J Neurotrauma 18:1359-72. 2001
    ..It is possible therefore that subgroups of patients exist who experience adverse effects of vasopressor treatment, and consequently the effects of vasopressor therapy in the clinical setting need to be more carefully evaluated...
  17. ncbi Mitochondrial injury measured by proton magnetic resonance spectroscopy in severe head trauma patients
    A Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Acta Neurochir Suppl 95:149-51. 2005
    ..The prognostic value of NAA/Cr to assist in management and also to serve as a surrogate endpoint for clinical trials appears promising...
  18. ncbi Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat
    A Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:303-6. 2006
    ..This substance offers a new avenue in brain edema treatment and prompts further study into AQP4 modulation...
  19. pmc Effects of Glasgow Outcome Scale misclassification on traumatic brain injury clinical trials
    Juan Lu
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
    J Neurotrauma 25:641-51. 2008
    ..An awareness of this procedural error and methods to reduce misclassification should be incorporated in TBI clinical trials...
  20. ncbi Application of chemical shift imaging for measurement of NAA in head injured patients
    S Signoretti
    Division of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Acta Neurochir Suppl 81:373-5. 2002
    ..NAA decreases and remains low in patients with poor outcome. NAA recovers in patients with favorable outcome, suggesting marginal metabolic impairment and possible re-synthesis of the NAA pool...
  21. ncbi Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group
    A Marmarou
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0508, USA
    J Neurotrauma 16:431-44. 1999
    ..26). The consistent positive trends seen in ICP, TIL, neuropsychological tests, and, most importantly, 3- and 6-month GOS provide supportive evidence that a bradykinin antagonist may play a neuroprotective role in severe brain injury...
  22. ncbi Acute subdural hematoma associated with diffuse brain injury and hypoxemia in the rat: effect of surgical evacuation of the hematoma
    Satoshi Sawauchi
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 21:563-73. 2004
    ..Under this situation, the rapid evacuation exacerbated brain edema. These results have clinical implications for the management of severe traumatic SDH, especially its operative indication and timing...
  23. ncbi Diffuse brain injury complicated by acute subdural hematoma and secondary insults in the rodents: the effect of surgical evacuation
    S Sawauchi
    Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA
    Acta Neurochir Suppl 81:241-2. 2002
    ..Secondary insult after traumatic SDH was associated with significant brain swelling and stimulated refractory rise in ICP. In traumatic SDH complicated by secondary insult, brain swelling is exacerbated by surgical evacuation...
  24. ncbi Continuous negative abdominal pressure device to treat pseudotumor cerebri
    H J Sugerman
    Department of Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    Int J Obes Relat Metab Disord 25:486-90. 2001
    ..To study the effects of an externally applied negative abdominal pressure device designed to lower the effects of intra-abdominal pressure (IAP) on headaches and pulsatile tinnitus in severely obese women with pseudotumor cerebri (PTC)...
  25. ncbi Surgical management of idiopathic normal-pressure hydrocephalus
    Marvin Bergsneider
    Division of Neurosurgery, University of California at Los Angeles Medical Center, Los Angeles, California, USA
    Neurosurgery 57:S29-39; discussion ii-v. 2005
    ..Many earlier studies predated our current understanding of the hydrodynamics of cerebrospinal fluid shunts, and therefore, the conclusions drawn may no longer be valid...
  26. ncbi Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries
    Anthony Marmarou
    Departments of Neurosurgery and Radiology, Virginia Commonwealth University Medical College of Virginia Campus, Richmond, Virginia 23298 0508, USA
    J Neurosurg 104:720-30. 2006
    ..In this study the authors used magnetic resonance (MR) imaging techniques to identify the type of edema that occurs in patients with TBI...
  27. ncbi Assessment of cerebral S100B levels by proton magnetic resonance spectroscopy after lateral fluid-percussion injury in the rat
    Andrea Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurosurg 102:1115-21. 2005
    ..Given that no data exist about the temporal profile of cerebral S100B levels following TBI and their correlation to serum levels, the authors examined whether proton magnetic resonance (MR) spectroscopy is capable of measuring S100B...
  28. ncbi Outcome measures for clinical trials in neurotrauma
    M Ross Bullock
    Division of Neurosurgery, Medical College of Virginia, Richmond, Virgina 23298 0631, USA
    Neurosurg Focus 13:ECP1. 2002
    ....
  29. pmc A method for reducing misclassification in the extended Glasgow Outcome Score
    Juan Lu
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 27:843-52. 2010
    ..The data suggest that a collective effort can be made to minimize inter-rater variation...
  30. ncbi Assessment of mitochondrial impairment and cerebral blood flow in severe brain injured patients
    Gunes A Aygok
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, 1001 East Broad Street, Suite 235, P O Box 980508, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 102:57-61. 2008
    ..The objective of this study was to test this hypothesis in severely injured patients (GCS 8 or less) by obtaining simultaneous measures of CBF and NAA...
  31. doi Assessment of mitochondrial impairment in traumatic brain injury using high-resolution proton magnetic resonance spectroscopy
    Stefano Signoretti
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, 23298 0508, USA
    J Neurosurg 108:42-52. 2008
    ....
  32. ncbi The pathophysiology of brain edema and elevated intracranial pressure
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Cleve Clin J Med 71:S6-8. 2004
  33. ncbi Time to treatment in prolonged seizure episodes
    John M Pellock
    Department of Neurology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA
    Epilepsy Behav 5:192-6. 2004
    ..This baseline study supports the need for patient education regarding seizure emergencies and wider availability of at-home treatment options to shorten time to seizure treatment...
  34. ncbi A review of progress in understanding the pathophysiology and treatment of brain edema
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    Neurosurg Focus 22:E1. 2007
    ..The basic types of edema--vasogenic and cytotoxic--were classified 50 years ago, and their definitions remain intact...
  35. ncbi Zonisamide: physician and patient experiences
    Anthony Marmarou
    International Epilepsy Consortium, Virginia Commonwealth University Medical Center, Old City Hall, 1001 E Broad Street, Suite 235, P O Box 980449, Richmond, VA 23298, USA
    Epilepsy Res 64:63-9. 2005
    ..6% (45/84), 58.8% (50/85), and 62.1% (54/87) of patients, respectively. These patients, most of whom were refractory to other AEDs, generally had positive experiences with zonisamide...
  36. ncbi Misclassification and treatment effect on primary outcome measures in clinical trials of severe neurotrauma
    Sung C Choi
    Department of Biostatistics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0032, USA
    J Neurotrauma 19:17-22. 2002
    ..The results also indicate that the number of categories should be carefully determined using the pilot data or the data from phase II trials...
  37. ncbi Mortality from traumatic brain injury
    J Lu
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Acta Neurochir Suppl 95:281-5. 2005
    ..Factors other than age, motor score and pupil reactivity over time are responsible for this reduction. This reduction over time is an important factor for prognostic modeling of TBI...
  38. ncbi Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat
    A Kleindienst
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 96:258-62. 2006
    ..We conclude that DMSO as a vehicle for drug administration may increase the drug concentration into the extracellular space, but since BBB permeability is increased, it may also provide an avenue for development of vasogenic edema...
  39. ncbi Three-year outcome of shunted idiopathic NPH patients
    G Aygok
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Acta Neurochir Suppl 95:241-5. 2005
    ..5%). With proper diagnosis and management of iNPH, shunting of patients is associated with a favorable risk/benefit ratio that is reasonably long lasting...
  40. ncbi Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date
    A Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, VA 23219, USA
    Acta Neurochir Suppl 95:237-40. 2005
    ..It became clear that more prospective randomized studies are needed to resolve some of the controversial issues such as iNPH classification and sensitivity of diagnostic tests for identifying shunt responsive iNPH...
  41. ncbi A new rat model of diffuse brain injury associated with acute subdural hematoma: assessment of varying hematoma volume, insult severity, and the presence of hypoxemia
    Satoshi Sawauchi
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 20:613-22. 2003
    ..These results suggest that these models may be potentially useful to study the combination of DBI and SDH with or without hypoxemia...
  42. ncbi The importance of translational research in brain injury
    A Marmarou
    Division of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA
    Acta Neurochir Suppl 95:3-5. 2005
    ..Several examples will be given to strengthen the notion that we must not abandon the translational aspect of research but to embrace the process if we are to further improve outcome from brain injury...
  43. ncbi Approximate entropy: a regularity statistic for assessment of intracranial pressure
    A Beaumont
    Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Acta Neurochir Suppl 81:193-5. 2002
    ..This study defines a novel method for application of ApEn to the ICP/mABP waveform, and reports changing ApEn with pathophysiology in the rodent brain...
  44. pmc The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat
    Giovanna Fazzina
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 27:453-61. 2010
    ..021). A downregulation of AQP4 in the ischemic area paralleling the reduction in brain edema formation following PMA treatment suggests that the effect was mediated by AQP4 modulation...
  45. ncbi Secondary ischemia impairing the restoration of ion homeostasis following traumatic brain injury
    Michael F Stiefel
    Department of Neurosurgery, Virginia Commonwealth University Health System, Richmond 23298 0508, USA
    J Neurosurg 103:707-14. 2005
    ..The purpose of this study was to characterize the effects of secondary ischemia following traumatic brain injury (TBI) on the ability to restore ion homeostasis...
  46. ncbi The protective effect of cyclosporin A upon N-acetylaspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury
    Stefano Signoretti
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    J Neurotrauma 21:1154-67. 2004
    ....
  47. doi Xenon-enhanced cerebral blood flow at 28% xenon provides uniquely safe access to quantitative, clinically useful cerebral blood flow information: a multicenter study
    A P Carlson
    Department of Neurosurgery, University of New Mexico, Albuquerque, New Mexico, USA
    AJNR Am J Neuroradiol 32:1315-20. 2011
    ..We sought to better determine the safety profile of this lower concentration through a multicenter evaluation of adverse events reported by all centers currently performing xenon/CT studies in the US...
  48. ncbi Modulation of aquaporin-4 water transport in a model of TBI
    A M Amorini
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 86:261-3. 2003
    ....
  49. ncbi Secondary insults worsen blood brain barrier dysfunction assessed by MRI in cerebral contusion
    A Beaumont
    Division of Neurosurgery, Medical College of Virginia, Richmond, VA, USA
    Acta Neurochir Suppl 81:217-9. 2002
    ..This study non-invasively assesses the influence of hypoxia and hypotension on BBB permeability following experimental cortical contusion...
  50. ncbi Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema
    Keisuke Taya
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, 1101 East Marshall Street, P O Box 980508, Richmond, VA 23298 0508, USA
    Acta Neurochir Suppl 102:425-9. 2008
    ..We, therefore, examined whether the selective V1a receptor antagonist, SR49059, reduces brain edema by modulating AQP4 expression following cortical contusion injury (CCI)...
  51. pmc Effect of secondary insults upon aquaporin-4 water channels following experimental cortical contusion in rats
    Keisuke Taya
    Department of Neurosurgery, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 27:229-39. 2010
    ....
  52. pmc Clinical trials in head injury
    Raj K Narayan
    Department of Neurosurgery, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 19:503-57. 2002
    ..This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research...
  53. ncbi A single dose, three-arm, placebo-controlled, phase I study of the bradykinin B2 receptor antagonist Anatibant (LF16-0687Ms) in patients with severe traumatic brain injury
    Anthony Marmarou
    American Brain Injury Consortium, ABIC Technical Center, Old City Hall Suite 235, 1001 East Broad Street, Richmond, VA 23298 0449, USA
    J Neurotrauma 22:1444-55. 2005
    ..To address this issue, a dose-response trial that would investigate the effects of Anatibant on the incidence of raised ICP and on functional outcome in severe TBI patients is needed...
  54. ncbi Cation dysfunction associated with cerebral ischemia followed by reperfusion: a comparison of microdialysis and ion-selective electrode methods
    Michael F Stiefel
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    J Neurosurg 97:97-103. 2002
    ..The object of this study was to measure [K+]e and [Na+]e by using ion-selective electrodes (ISEs) and to compare these measurements with those obtained using the well-established method of microdialysis...
  55. ncbi The modulation of aquaporin-4 by using PKC-activator (phorbol myristate acetate) and V1a receptor antagonist (SR49059) following middle cerebral artery occlusion/reperfusion in the rat
    Kenji Okuno
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Acta Neurochir Suppl 102:431-6. 2008
    ..To investigate if edema formation is affected by the reduction of AQP4 expression, we utilized PMA and SR49059 following middle cerebral artery occlusion model (MCAo), and measured AQP4 expression by Western-Blot (WB) techniques...
  56. ncbi Differential effects of atrial natriuretic peptide on the brain water and sodium after experimental cortical contusion in the rat
    Shinji Fukui
    Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, 23298, USA
    J Cereb Blood Flow Metab 23:1212-8. 2003
    ..These findings suggest that ANP administration exacerbates brain edema after the experimental cortical contusion in rats, possibly because of an increase in the BBB permeability via cGMP pathway, whereas it reduces brain sodium levels...
  57. ncbi Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT study
    Jackelien G M Van Beek
    Center for Clinical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:315-28. 2007
    ..60-0.78). Higher glucose values were associated with increasing age, but on adjusted analysis, the strength of the association with outcome remained. Whether treatment of abnormal values may improve outcome needs further rigorous study...
  58. ncbi Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:329-37. 2007
    ....
  59. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials...
  60. doi Outcome in 1,000 head injury hospital admissions: the Athens head trauma registry
    George Stranjalis
    Department of Neurosurgery, University of Athens, Evangelismos Hospital, Athens, Greece
    J Trauma 65:789-93. 2008
    ....
  61. ncbi Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:287-93. 2007
    ..The occurrence of secondary insults prior to or on admission to hospital in TBI patients is strongly related to poorer outcome and should therefore be a priority for emergency department personnel...
  62. ncbi Prognostic value of computerized tomography scan characteristics in traumatic brain injury: results from the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:303-14. 2007
    ..We conclude that both the CT classification and individual CT characteristics are important predictors of outcome in TBI. For clinical trials, a central review process is advocated to minimize observer variability in CT assessment...
  63. ncbi Prognostic value of admission blood pressure in traumatic brain injury: results from the IMPACT study
    Isabella Butcher
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:294-302. 2007
    ..Our finding of a smooth relationship with improving outcome as SBP increases up to 135 mm Hg, while not supporting a strong causal inference, does suggest that current guidelines need to be reconsidered...
  64. ncbi Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurosurgery 57:1244-53; discussion 1244-53. 2005
    ..We critically reviewed the use of two types of secondary analyses, covariate adjustment and subgroup analysis, which are common in TBI trials...
  65. ncbi Predicting outcome after traumatic brain injury: development and validation of a prognostic score based on admission characteristics
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    J Neurotrauma 22:1025-39. 2005
    ..The high discriminative ability indicates the potential of this model for classifying patients according to prognostic risk...
  66. ncbi [Increasing cerebral perfusion pressure in serious cranial injury--contradictory effects of dopamine]
    Pal Barzo
    Szent Györgyi Albert Orvostudományi Egyetem, Idegsebészeti Klinika, Szeged
    Ideggyogy Sz 58:233-44. 2005
    ..There are, however, some unresolved issues and potential risks to this therapy...
  67. ncbi Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
    ..A major reduction in sample size can be obtained with covariate adjustment in TBI trials. Covariate adjustment for strong predictors should be incorporated in the analysis of future TBI trials...
  68. ncbi Prognosis and clinical trial design in traumatic brain injury: the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:232-8. 2007
    ....
  69. ncbi Statistical approaches to the univariate prognostic analysis of the IMPACT database on traumatic brain injury
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:251-8. 2007
    ..Many of our approaches are based on simple graphical displays of the data, but, where appropriate, we have also used methods that although established in the statistical literature are relatively novel in their application to TBI...
  70. ncbi Diagnosing idiopathic normal-pressure hydrocephalus
    Norman Relkin
    Department of Neurology and Neuroscience, The New York Presbyterian Weill Cornell Medical College, New York, New York, USA
    Neurosurgery 57:S4-16; discussion ii-v. 2005
    ..This report contains evidence-based guidelines for clinical diagnosis of INPH that are intended to facilitate future epidemiological studies of INPH, promote earlier and more accurate diagnosis, and ultimately improve treatment outcome...
  71. ncbi Prognostic value of demographic characteristics in traumatic brain injury: results from the IMPACT study
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:259-69. 2007
    ..We conclude that outcome following TBI is dependent on age, race, to a lesser extent on education, but not on gender...
  72. ncbi Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study
    Isabella Butcher
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:281-6. 2007
    ..Falls were found to be associated with an older age and with a higher incidence of mass lesions. Following adjustment for age in the analysis, the relationship between cause of injury and outcome was lost...
  73. ncbi Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 22:511-7. 2005
    ..The approach raises issues of clinical, statistical, and regulatory importance, and we initiate what we believe needs to become a widespread debate amongst the community involved in clinical research in head injury and stroke...
  74. ncbi Cerebral oxidative stress and depression of energy metabolism correlate with severity of diffuse brain injury in rats
    Barbara Tavazzi
    Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, Rome, Italy
    Neurosurgery 56:582-9; discussion 582-9. 2005
    ..For this purpose, we studied the time-course changes of parameters reflecting ROS-mediated oxidative stress and modifications of cell energy metabolism determined in rats subjected to cerebral insult of increasing severity...
  75. ncbi A new reproducible model of an epidural mass lesion in rodents. Part I: Characterization by neurophysiological monitoring, magnetic resonance imaging, and histopathological analysis
    Ralf Burger
    Department of Neurosurgery, University of Wurzburg, Germany
    J Neurosurg 97:1410-8. 2002
    ..The goal of this study was to characterize a new model of an epidural mass lesion in rodents by means of neurophysiological monitoring, magnetic resonance imaging, and histopathological analysis...
  76. ncbi Assessment of cerebrospinal fluid outflow resistance
    Anders Eklund
    Department of Biomedical Engineering and Informatics, Umea University Hospital, 90185 Umea, Sweden
    Med Biol Eng Comput 45:719-35. 2007
    ....
  77. ncbi [Cerebral edema and changes of cerebral blood volume in patients with head injuries]
    Pal Barzo
    Szegedi Tudomanyegyetem, Általános Orvostudományi Kar, Szent Györgyi Albert Orvos és Gyógyszerésztudományi Centrum, Idegsebészeti Klinika, Szeged
    Orv Hetil 143:1625-34. 2002
    ..The goal of this study was to examine the roles of cerebral blood volume (CBV) and edema in traumatic brain swelling...
  78. ncbi Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients
    Petra Klinge
    Neurosurgical Department, Medical School Hannover, Hannover, Germany
    Neurosurgery 57:S40-52; discussion ii-v. 2005
    ..Because specific criteria for defining clinical improvement are seldom reported, conclusions drawn about shunt outcome may be subjective...
  79. ncbi Some prognostic models for traumatic brain injury were not valid
    Chantal W P M Hukkelhoven
    Center for Medical Decision Making Sciences, Department of Public Health, Erasmus MC University Medical Center Rotterdam, P O Box 1739, 3000 DR Rotterdam, The Netherlands
    J Clin Epidemiol 59:132-43. 2006
    ..We aimed to determine the validity of six models that used baseline clinical and computed tomographic characteristics to predict mortality or unfavorable outcome at 6 months or later after severe or moderate TBI...

Research Grants1

  1. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
    ..Taken in concert, these studies will provide a more indepth understanding of the role of aquaporins in brain injury and introduce novel therapeutic approaches for treating brain edema. ..