D G Maluf

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi Impact of the donor risk index on the outcome of hepatitis C virus-positive liver transplant recipients
    Daniel G Maluf
    Division of Transplantation Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Liver Transpl 15:592-9. 2009
  2. pmc Molecular pathways involved in loss of kidney graft function with tubular atrophy and interstitial fibrosis
    Daniel G Maluf
    Department of Surgery, Division of Transplant, Virginia Commonwealth University, Richmond, Virginia 23298 0057, United States of America
    Mol Med 14:276-85. 2008
  3. ncbi Hepatitis C virus infection and kidney transplantation: predictors of patient and graft survival
    Daniel G Maluf
    Department of Surgery, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 83:853-7. 2007
  4. ncbi Multimodality therapy and liver transplantation in patients with cirrhosis and hepatocellular carcinoma: 6 years, single-center experience
    D G Maluf
    Virginia Commonwealth University, Department of Surgery, Richmond, VA 23298, USA
    Transplant Proc 39:153-9. 2007
  5. ncbi Utilization of extended donor criteria liver allograft: Is the elevated risk of failure independent of the model for end-stage liver disease score of the recipient?
    Daniel G Maluf
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 82:1653-7. 2006
  6. ncbi Molecular markers in stored kidneys using perfluorocarbon-based preservation solution: preliminary results
    D G Maluf
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia 23298 0248, USA
    Transplant Proc 38:1243-6. 2006
  7. doi Kidney grafts from HCV-positive donors: advantages and disadvantages
    D G Maluf
    Virginia Commonwealth University Medical Center, Richmond, 23298 0057, USA
    Transplant Proc 42:2436-46. 2010
  8. ncbi Apolipoprotein E genotypes as predictors of high-risk groups for developing hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment
    Daniel G Maluf
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 80:1705-11. 2005
  9. doi MicroRNA signature at the time of clinical HCV recurrence associates with aggressive fibrosis progression post-liver transplantation
    R C Gehrau
    Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA, USA
    Am J Transplant 13:729-37. 2013
  10. ncbi Adult living donor versus deceased donor liver transplantation: a 6-year single center experience
    Daniel G Maluf
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University Health System, Richmon, VA, USA
    Am J Transplant 5:149-56. 2005

Collaborators

Detail Information

Publications40

  1. doi Impact of the donor risk index on the outcome of hepatitis C virus-positive liver transplant recipients
    Daniel G Maluf
    Division of Transplantation Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Liver Transpl 15:592-9. 2009
    ..In conclusion, a synergistic interaction between donor DRI and recipient HCV status exists, such that an allograft from a high-DRI donor more adversely affects the outcome of an HCV(+) recipient than that of an HCV(-) recipient...
  2. pmc Molecular pathways involved in loss of kidney graft function with tubular atrophy and interstitial fibrosis
    Daniel G Maluf
    Department of Surgery, Division of Transplant, Virginia Commonwealth University, Richmond, Virginia 23298 0057, United States of America
    Mol Med 14:276-85. 2008
    ..The top-scored networks were related to immune response, inflammation, and cell-to-cell interaction, showing the importance of chronic inflammation in progressive graft deterioration...
  3. ncbi Hepatitis C virus infection and kidney transplantation: predictors of patient and graft survival
    Daniel G Maluf
    Department of Surgery, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 83:853-7. 2007
    ..This study aimed to evaluate the outcomes of our HCV+/end-stage renal disease (ESRD) patient population based on the therapeutic option including KTx or continuation in dialysis...
  4. ncbi Multimodality therapy and liver transplantation in patients with cirrhosis and hepatocellular carcinoma: 6 years, single-center experience
    D G Maluf
    Virginia Commonwealth University, Department of Surgery, Richmond, VA 23298, USA
    Transplant Proc 39:153-9. 2007
    ..Pretransplant HCC understaging contributes to posttransplant HCC recurrence after LTx...
  5. ncbi Utilization of extended donor criteria liver allograft: Is the elevated risk of failure independent of the model for end-stage liver disease score of the recipient?
    Daniel G Maluf
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 82:1653-7. 2006
    ..The goal of this analysis was to determine if outcomes from the use of extended criteria donor (ECD) livers were dependent upon the Model for End-Stage Liver Disease (MELD) score of the recipient...
  6. ncbi Molecular markers in stored kidneys using perfluorocarbon-based preservation solution: preliminary results
    D G Maluf
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia 23298 0248, USA
    Transplant Proc 38:1243-6. 2006
    ..We evaluated histologically and a number of molecular changes induced by ischemia in stored kidneys with University of Wisconsin (UW) and PFC-based preservation solutions (PFC-UW)...
  7. doi Kidney grafts from HCV-positive donors: advantages and disadvantages
    D G Maluf
    Virginia Commonwealth University Medical Center, Richmond, 23298 0057, USA
    Transplant Proc 42:2436-46. 2010
    ..In patients willing to accept HCV-positive grafts (929 [25.6%]), waiting time was significantly shortened (P < .001). However, this benefit was offset by decreased patient survival (P < .001) and graft survival (P = .007)...
  8. ncbi Apolipoprotein E genotypes as predictors of high-risk groups for developing hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment
    Daniel G Maluf
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Transplantation 80:1705-11. 2005
    ..Apoliprotein E (Apo E) polymorphism is an established genetic risk factor for hyperlipidemia. We studied the association between Apo E gene polymorphisms and lipids after kidney transplantation in patients undergoing sirolimus treatment...
  9. doi MicroRNA signature at the time of clinical HCV recurrence associates with aggressive fibrosis progression post-liver transplantation
    R C Gehrau
    Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA, USA
    Am J Transplant 13:729-37. 2013
    ..Seven microRNAs were successfully validated in the validation set using QPCR. We have identified a 9-microRNA signature able to identify early post-LT patients at high risk of severe HCVrec during long-term follow-up...
  10. ncbi Adult living donor versus deceased donor liver transplantation: a 6-year single center experience
    Daniel G Maluf
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University Health System, Richmon, VA, USA
    Am J Transplant 5:149-56. 2005
    ..Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx...
  11. ncbi Polymorphisms in cytokines and growth factor genes and their association with acute rejection and recurrence of hepatitis C virus disease in liver transplantation
    V R Mas
    Department of Pathology, Virginia Commonwealth University, 403 North 13th Street, Richmond, VA 23298 0248, USA
    Clin Genet 65:191-201. 2004
    ..001) compared to patients without AR. There was an association between pro-inflammatory genotypes and HCV recurrence. Our data suggest that cytokine gene polymorphisms might play a role in AR and HCV recurrence in LTxRs...
  12. doi Molecular pathways involved in loss of graft function in kidney transplant recipients
    Valeria R Mas
    Molecular Transplant Research Laboratory, Transplant Division, Department of Surgery, Molecular Medicine Research Building, Virginia Commonwealth University, Richmond, VA 23298, USA
    Expert Rev Mol Diagn 10:269-84. 2010
    ..A major challenge in the future of kidney transplantation includes the study of chronic allograft dysfunction pathogenesis to identify early markers of disease progression, as well as potential therapeutics pathways...
  13. ncbi Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation: genes involved in tumor progression
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond 23298, USA
    Liver Transpl 10:607-20. 2004
    ....
  14. ncbi Molecular techniques for identifying HCC origin and biology after orthotopic liver transplantation
    Valeria R Mas
    Division of Transplant Surgery, Department of Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, PO Box 980254, Richmond, VA 23298, USA
    Diagn Mol Pathol 15:90-4. 2006
    ..These techniques provided consistent evidence that the second HCC was a recurrence of the primary tumor...
  15. doi MicroRNAs as biomarkers in solid organ transplantation
    V R Mas
    Translational Genomics Transplant Laboratory, Transplant Division, Department of Surgery, University of Virginia, Charlottesville, USA
    Am J Transplant 13:11-9. 2013
    ....
  16. pmc Differentially expressed genes between early and advanced hepatocellular carcinoma (HCC) as a potential tool for selecting liver transplant recipients
    Valeria R Mas
    Division of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Mol Med 12:97-104. 2006
    ..Whether gene expression profiling of HCC will be refined to the point of predicting potential metastatic biologic behavior to predict post-LT recurrence will require longitudinal prospective study of this gene array technology...
  17. ncbi Reasons for non-use of recovered kidneys: the effect of donor glomerulosclerosis and creatinine clearance on graft survival
    Erick B Edwards
    Research Department, United Network for Organ Sharing, Richmond, VA 23219, USA
    Transplantation 77:1411-5. 2004
    ..We compared the percentage of glomerulosclerosis (GS) and creatinine clearance (CrCl) of both discarded and transplanted cadaveric kidneys and examined their effect on graft survival and function...
  18. pmc MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA
    M J Scian
    Surgery Biostatistics Human and Molecular Genetics Pathology, Virginia Commonwealth University, Richmond, VA, USA
    Am J Transplant 11:2110-22. 2011
    ..A characteristic miRNA signature for IF/TA that correlates with paired urine samples was identified. These results support the potential use of miRNAs as noninvasive markers of IF/TA and for monitoring graft function...
  19. ncbi Immunobiology and long-term graft function in a transplant heterotopic renal rat model
    D G Maluf
    Medical College of Virginia, Virginia Commonwealth University, Division of Transplant Surgery, and Department of Pathology, Richmond, VA 23298 0254, USA
    Clin Transplant 16:6-14. 2002
    ..In the present study, we investigated the immunobiology of grafts in a long-term follow-up (>350 d)...
  20. pmc Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Med 15:85-94. 2009
    ..Characteristic gene signatures were identified at different stages of HCV-HCC progression. A set of genes were identified to predict whether the cirrhotic tissue was associated with HCC...
  21. doi Incidence of prolonged length of stay after orthotopic liver transplantation and its influence on outcomes
    Jenny O Smith
    Hepatology Section and Liver Transplant Program, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Transpl 15:273-9. 2009
    ..Efforts to modify those factors that contribute to PLOS may reduce this event, improve survival, and reduce OLT-associated costs...
  22. ncbi Genes associated with progression and recurrence of hepatocellular carcinoma in hepatitis C patients waiting and undergoing liver transplantation: preliminary results
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0057, USA
    Transplantation 83:973-81. 2007
    ..Liver transplantation (LT) represents a curative treatment for small hepatocellular carcinoma (HCC). Potentially curable higher-stage HCC patients are denied LT due to the lack of cancer markers that predict progression and recurrence...
  23. ncbi Adult living donor versus deceased donor liver transplantation: a 10-year prospective single center experience
    Robert A Fisher
    Division of Transplantation, Department of Surgery, Virginia Commonwealth, University Health System, Richmond, VA, USA
    Ann Hepatol 8:298-307. 2009
    ..Biliary complications were more common in A2ALLTx but were not associated with increased graft loss compared to ADDLTx...
  24. pmc High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma
    Kellie J Archer
    Department of Biostatistics, Virginia Commonwealth University, 730 East Broad Street, P O Box 980032, Richmond, VA 23298 0032, USA
    Mol Genet Genomics 283:341-9. 2010
    ..Our study demonstrates that high-throughput methylation technologies may be used to identify differentially methylated CpG sites that may prove to be important molecular events involved in carcinogenesis...
  25. ncbi Molecular and clinical response to angiotensin II receptor antagonist in kidney transplant patients with chronic allograft nephropathy
    Valeria R Mas
    Department of Pathology and Surgery, Virginia Commonwealth University, MCV Campus, West Hospital, Ninth Floor, South Wing, P O Box 980057, 23298 0057, Richmond, VA, USA
    Transpl Int 17:540-4. 2004
    ..2+/-377 mg/24 h, P=0.001. Intra-graft expression of TGF-beta1 was decreased after treatment. In conclusion, losartan significantly decreases the intra-graft expression of TGF-beta1 and proteinuria in KTPs with CAN...
  26. pmc Evaluation of gene panel mRNAs in urine samples of kidney transplant recipients as a non-invasive tool of graft function
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Med 13:315-24. 2007
    ..A characteristic pattern of mRNA levels in the different KTP groups was observed indicating that the mRNA levels in Ur cells might reflect allograft function...
  27. doi Hepatitis C virus recurrence after liver transplantation: biomarkers of disease and fibrosis progression
    Daniel G Maluf
    Transplant Division, Virginia Commonwealth University Medical Center, Medical College of Virginia Hospitals, 1200 East Broad Street, West Hospital, 9th Fl, South Wing, PO Box 980254, Richmond, VA 23298, USA
    Expert Rev Gastroenterol Hepatol 4:445-58. 2010
    ..The mechanisms responsible for the accelerated liver damage in HCV-infected orthotopic liver transplantation recipients remain largely unknown...
  28. pmc Identifying genes progressively silenced in preneoplastic and neoplastic liver tissues
    Kellie J Archer
    Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298 0032, USA
    Int J Comput Biol Drug Des 3:52-67. 2010
    ..9% of the remaining genes examined. Our results indicate that further high-throughput methylation studies to more fully characterize molecular events involved in hepatocarcinogenesis are warranted...
  29. ncbi Hepatic artery thrombosis after liver transplantation and genetic factors: prothrombin G20210A polymorphism
    Valeria R Mas
    Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298 0248, USA
    Transplantation 76:247-9. 2003
    ..62%) in 13 patients. Prothrombin G20210A polymorphism was found in the DNA obtained from 2 of 14 liver allograft tissues (14.2%) but not in the DNA from leukocytes obtained from the peripheral blood of recipients with HAT...
  30. pmc Identifying genes for establishing a multigenic test for hepatocellular carcinoma surveillance in hepatitis C virus-positive cirrhotic patients
    Kellie J Archer
    Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia 23298 0032, USA
    Cancer Epidemiol Biomarkers Prev 18:2929-32. 2009
    ....
  31. ncbi Living kidney donors requiring transplantation: focus on African Americans
    Eric M Gibney
    Division of Nephrology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 84:647-9. 2007
    ..Although AAs comprised 14.3% of all living kidney donors, they constituted 44% of donors reaching the waiting list (P<0.001). These data provide indirect evidence that the risk of kidney failure may be exaggerated in AA donors...
  32. ncbi Is hepatic transplantation justified for primary liver cancer?
    Robert A Fisher
    Department of Surgery, Division of Transplant Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Surg Oncol 95:674-9. 2007
    ..The pertinent medical literature and update of an ongoing intent-to-treat HCC with transplant single center randomized control trial are reviewed...
  33. ncbi Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 84:1262-71. 2007
    ..We aimed to evaluate the expression of angiogenic factors in hepatitis C virus (HCV)-HCC tissues and the utility of angiogenesis soluble factors as noninvasive markers of HCC and tumor growth...
  34. doi Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome
    Richard Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Am J Med 121:119-26. 2008
    ..We hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation...
  35. pmc Proteomic analysis of HCV cirrhosis and HCV-induced HCC: identifying biomarkers for monitoring HCV-cirrhotic patients awaiting liver transplantation
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 87:143-52. 2009
    ..We evaluated global protein expression in plasma samples of HCV-cirrhotic and HCV-cirrhotic-HCC patients...
  36. ncbi Study of mRNA growth factors in urinary cells of kidney transplant recipients as predictors of chronic allograft nephropathy
    Valeria R Mas
    Division of Transplant, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0057, USA
    Transplantation 80:1686-91. 2005
    ..Current diagnostic methods for CAN are inadequate, and noninvasive assays for detecting allograft dysfunction/rejection and predicting long-term outcomes are a priority in transplantation...
  37. ncbi Engraftment measurement in human liver tissue after liver cell transplantation by short tandem repeats analysis
    Valeria R Mas
    Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298 0248, USA
    Cell Transplant 13:231-6. 2004
    ....
  38. doi Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
    ..Aims: To assess impact of pretransplant hyponatraemia on post-transplant outcomes...
  39. doi Proteomics and liver fibrosis: identifying markers of fibrogenesis
    Valeria R Mas
    Transplant Molecular Laboratory, Transplant Division, Department of Surgery, Molecular Medicine Research Building, Virginia Commonwealth University, 1220 E Broad Street, Richmond, VA 23298, USA
    Expert Rev Proteomics 6:421-31. 2009
    ..This review aims to provide an overview of the possibilities that proteome technology can offer to the knowledge, diagnosis and prognosis of liver fibrosis...
  40. ncbi Hardikar syndrome: a case requiring liver transplantation
    Daniel G Maluf
    Transplant Surgery, Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Transplantation 74:1058-61. 2002
    ..She received a liver transplant at 24 months of age from a living donor. She has had an excellent clinical outcome in liver function without further decline of growth and development...