Dongmin Liu

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. pmc Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells
    Hongwei Si
    Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA
    Endocrinology 153:3190-8. 2012
  2. pmc Development of a nongenetic mouse model of type 2 diabetes
    Elizabeth R Gilbert
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Exp Diabetes Res 2011:416254. 2011
  3. pmc Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling
    Zhenquan Jia
    Department of Biology, The University of North Carolina at Greensboro, Greensboro, NC 27412, USA
    Endocrinology 154:727-37. 2013
  4. ncbi request reprint Genistein activates the 3',5'-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function
    Dongmin Liu
    Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Endocrinology 146:1312-20. 2005
  5. ncbi request reprint Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway
    Dongmin Liu
    Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Diabetes 55:1043-50. 2006
  6. pmc Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms
    Dongmin Liu
    Division of Endocrinology, Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:889-98. 2008
  7. ncbi request reprint Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression
    Dongmin Liu
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, USA
    Endocrinology 148:3068-76. 2007
  8. pmc Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice
    Zhuo Fu
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Endocrinology 151:3026-37. 2010
  9. ncbi request reprint Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5'-monophosphate-dependent mechanism
    Dongmin Liu
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Endocrinology 145:5532-9. 2004
  10. pmc Epigallocatechin gallate reduces vascular inflammation in db/db mice possibly through an NF-κB-mediated mechanism
    Pon V Anandh Babu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, USA
    Mol Nutr Food Res 56:1424-32. 2012

Research Grants

Detail Information

Publications34

  1. pmc Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells
    Hongwei Si
    Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA
    Endocrinology 153:3190-8. 2012
    ..These findings provide the first evidence to our knowledge that genistein may play a beneficial role in vascular function through targeting the PKA/CREB/eNOS/NO signaling pathway...
  2. pmc Development of a nongenetic mouse model of type 2 diabetes
    Elizabeth R Gilbert
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Exp Diabetes Res 2011:416254. 2011
    ..The combination of HFD and three 40 mg/kg STZ injections induced a model with metabolic characteristics of T2D, including peripheral insulin resistance and reduced β-cell mass...
  3. pmc Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling
    Zhenquan Jia
    Department of Biology, The University of North Carolina at Greensboro, Greensboro, NC 27412, USA
    Endocrinology 154:727-37. 2013
    ..These findings demonstrated that genistein improves thrombin-induced endothelial barrier dysfunction in ECs through PKA-mediated suppression of RhoA signaling...
  4. ncbi request reprint Genistein activates the 3',5'-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function
    Dongmin Liu
    Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Endocrinology 146:1312-20. 2005
    ....
  5. ncbi request reprint Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway
    Dongmin Liu
    Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Diabetes 55:1043-50. 2006
    ....
  6. pmc Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms
    Dongmin Liu
    Division of Endocrinology, Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:889-98. 2008
    ..These data, along with previous findings, define an important vascular endothelial cell signaling pathway that is activated by DHEA and suggest that this steroid may play a role in vascular function...
  7. ncbi request reprint Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression
    Dongmin Liu
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, USA
    Endocrinology 148:3068-76. 2007
    ..This may represent an important mechanism underlying the vascular protective effect of DHEA...
  8. pmc Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice
    Zhuo Fu
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    Endocrinology 151:3026-37. 2010
    ..These results demonstrate that genistein may be a natural antidiabetic agent by directly modulating pancreatic beta-cell function via activation of the cAMP/PKA-dependent ERK1/2 signaling pathway...
  9. ncbi request reprint Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5'-monophosphate-dependent mechanism
    Dongmin Liu
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Endocrinology 145:5532-9. 2004
    ..These effects were mediated by PKA and were unrelated to an estrogenic effect. This cellular mechanism may underlie some of the cardiovascular protective effects proposed for soy phytoestrogens...
  10. pmc Epigallocatechin gallate reduces vascular inflammation in db/db mice possibly through an NF-κB-mediated mechanism
    Pon V Anandh Babu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, USA
    Mol Nutr Food Res 56:1424-32. 2012
    ..We investigated whether epigallocatechin gallate (EGCG), a major catechin found in green tea, reduces vascular inflammation in diabetes...
  11. doi request reprint Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes
    Zhuo Fu
    Department of Human Nutrition, Foods and Exercise, Virginia Tech Blacksburg, VA 24061, USA
    Appl Physiol Nutr Metab 37:480-8. 2012
    ..In conclusion, dietary intake of genistein could prevent T2D via a direct protective action on β-cells without alteration of periphery insulin sensitivity...
  12. pmc Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice
    Pon Velayutham Anandh Babu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, USA
    J Nutr 142:724-30. 2012
    ..We conclude that genistein improves diabetes-caused vascular inflammation, which may be mediated through promoting the cAMP/PKA pathway...
  13. ncbi request reprint Evaluation of a novel photoactive and biotinylated dehydroepiandrosterone analog
    Dongmin Liu
    Research Service, Department of Veterans Affairs Medical Center, Iowa City, IA, USA
    Mol Cell Endocrinol 328:56-62. 2010
    ..These data confirm the successful synthesis of a photoactive, biotinylated DHEA analog which is capable of cross-linking to and identifying plasma membrane DHEA binding sites and which will allow us to further purify this receptor...
  14. ncbi request reprint Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr Biochem 19:216-28. 2008
    ..We provide molecular evidence in vivo demonstrating that ABA improves insulin sensitivity and obesity-related inflammation by inhibiting MCP-1 expression and F4/80(hi) ATM infiltration through a PPARgamma-dependent mechanism...
  15. pmc Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster
    Hongwei Si
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    J Nutr 141:1095-100. 2011
    ..Consistently, epicatechin (0.1-8 mmol/L) also promoted survival and increased mean lifespan of Drosophila. Therefore, epicatechin may be a novel food-derived, antiaging compound...
  16. pmc Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall
    Amir J Guri
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr Biochem 21:1178-85. 2010
    ..This is the first report showing that ABA prevents or ameliorates atherosclerosis-induced hypertension, immune cell recruitment into the aortic root wall and up-regulates aortic eNOS expression in ApoE(-/-) mice...
  17. ncbi request reprint Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor
    Dongmin Liu
    Division of Endocrinology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52246, USA
    Steroids 69:279-89. 2004
    ..The release of NO is independent of intracellular calcium mobilization, but depends on tyrosine- and MAP kinases. This cellular mechanism may underlie some of the cardiovascular protective effects proposed for DHEA...
  18. ncbi request reprint Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3)
    Dongmin Liu
    Division of Endocrinology, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52246, USA
    J Biol Chem 277:21379-88. 2002
    ..These novel findings should allow us to isolate the putative receptor and reevaluate the physiological role of DHEA activity...
  19. pmc Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice
    Zhuo Fu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, Virginia 24061, United States
    J Agric Food Chem 61:4303-9. 2013
    ..These findings demonstrate that EC may be a novel, plant-derived compound capable of preventing T1D by modulating immune function and thereby preserving islet mass...
  20. pmc Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA)
    Horacio F Olivo
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Bioorg Med Chem Lett 20:1153-5. 2010
    ..We detected specific protein bands of approximately 55, 80, and 150 kDa by SDS-PAGE analysis of vascular endothelial cell plasma membranes which had been photoirradiated in the presence of 8...
  21. doi request reprint Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice
    Zhuo Fu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, 1880 Pratt Drive, Corporate Research Center, Blacksburg, VA 24060, USA
    Br J Nutr 105:1218-25. 2011
    ..While EGCG did not modulate insulitis, it elevated the circulating anti-inflammatory cytokine IL-10 level in NOD mice. These findings demonstrate that EGCG may be a novel, plant-derived compound capable of reducing the risk of T1D...
  22. pmc Long-term exposure to genistein improves insulin secretory function of pancreatic beta-cells
    Zhuo Fu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Eur J Pharmacol 616:321-7. 2009
    ..These findings provide evidence that genistein may be a novel bioactive compound that has an anti-diabetic effect by improving insulin secretion from pancreatic beta-cells...
  23. pmc Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase
    Hongwei Si
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Apoptosis 14:66-76. 2009
    ..Preservation of the functional integrity of the endothelial monolayer may represent an important mechanism by which genistein exerts its vasculoprotective effect...
  24. pmc Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats
    Hongwei Si
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 138:297-304. 2008
    ..Our data suggest that genistein has direct genomic effects on the vascular wall that are unrelated to its known actions, leading to increased eNOS expression and NO synthesis, thereby improving hypertension...
  25. doi request reprint Butyrate activates the cAMP-protein kinase A-cAMP response element-binding protein signaling pathway in Caco-2 cells
    Aihua Wang
    Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, USA
    J Nutr 142:1-6. 2012
    ..Overall, this study raises the possibility that some of the regulatory effects of butyrate in animals, including those on the colonocytes, may be mediated by the cAMP-PKA-CREB signaling pathway at the cellular level...
  26. ncbi request reprint Dehydroepiandrosterone inhibits intracellular calcium release in beta-cells by a plasma membrane-dependent mechanism
    Dongmin Liu
    Division of Endocrinology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, 52242, USA
    Steroids 71:691-9. 2006
    ..Furthermore, these data provide evidence consistent with the existence of a specific plasma membrane DHEA receptor, mediating this signal transduction pathway by pertussis toxin-sensitive G-proteins...
  27. pmc Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes
    Zhuo Fu
    Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA 24061, USA
    Curr Diabetes Rev 9:25-53. 2013
    ..In addition, this review presents evidence that genetic and environmental factors can lead to hyperglycemia, dyslipidemia, inflammation, and autoimmunity, resulting in β-cell dysfunction, thereby triggering the pathogenesis of diabetes...
  28. pmc Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function
    Elizabeth R Gilbert
    Departments of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA
    Food Funct 4:200-12. 2013
    ..This review focuses on the anti-diabetic effects of genistein in both in vitro and in vivo models and potential mechanisms underlying its direct effects on β-cells...
  29. pmc Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes
    Elizabeth R Gilbert
    Department of Animal and Poultry Sciences, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, USA
    Epigenetics 7:841-52. 2012
    ..Further studies aimed at better understanding how epigenetic regulation of gene expression controls β-cell function may reveal potential therapeutic targets for prevention and treatment of diabetes...
  30. pmc Green tea catechins and cardiovascular health: an update
    Pon Velayutham Anandh Babu
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Curr Med Chem 15:1840-50. 2008
    ..In addition, the possible structure-activity relationship of catechins is discussed...
  31. ncbi request reprint Phytochemical genistein in the regulation of vascular function: new insights
    Hongwei Si
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Curr Med Chem 14:2581-9. 2007
    ..These new findings reveal the novel roles for genistein in the regulation of vascular function and provide a basis for further investigating its therapeutic potential for inflammatory-related vascular disease...
  32. pmc The flavonoid luteolin induces nitric oxide production and arterial relaxation
    Hongwei Si
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, 24061, USA
    Eur J Nutr 53:269-75. 2014
    ..In the present study, we investigated the hypothesis that luteolin can directly act on vascular endothelial cells (ECs), leading to nitric oxide (NO) production and subsequent vascular relaxation...
  33. ncbi request reprint Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets
    Amir J Guri
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, 319 Wallace Hall, Blacksburg, VA 24061, USA
    Clin Nutr 26:107-16. 2007
    ..We have investigated whether abscisic acid (ABA), a naturally occurring phytochemical with structural similarities to TZDs, could be used as an alternative to TZDs to improve glucose homeostasis...
  34. ncbi request reprint Flavonoids influence epigenetic-modifying enzyme activity: structure - function relationships and the therapeutic potential for cancer
    E R Gilbert
    Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Curr Med Chem 17:1756-68. 2010
    ....

Research Grants1

  1. Genistein and cAMP signaling in vascular endothelium
    Dongmin Liu; Fiscal Year: 2007
    ..The demonstration of the health benefits of soy isoflavones in vasculature is expected to have significant effect on public health since isoflavones are widely used as a dietary supplements. ..