Pin Lan Li

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Lipid rafts and redox signaling
    Pin Lan Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Antioxid Redox Signal 9:1411-5. 2007
  2. pmc Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e45020. 2012
  3. pmc Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes
    Ming Xu
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 8:e71212. 2013
  4. pmc Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis
    Xiang Li
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 9:e87552. 2014
  5. pmc Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease
    Pin Lan Li
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA, 23298, USA
    Handb Exp Pharmacol 216:171-97. 2013
  6. ncbi request reprint Hyperhomocysteinemia: association with renal transsulfuration and redox signaling in rats
    Li Pin-Lan
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Chem Lab Med 45:1688-93. 2007
  7. ncbi request reprint Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Antioxid Redox Signal 9:817-28. 2007
  8. pmc Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells
    Ming Xu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Biol Cell 23:1546-57. 2012
  9. pmc Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, VA 23298, United States
    Cell Signal 20:637-44. 2008
  10. pmc SNARE-mediated rapid lysosome fusion in membrane raft clustering and dysfunction of bovine coronary arterial endothelium
    Wei Qing Han
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 301:H2028-37. 2011

Collaborators

Detail Information

Publications95

  1. ncbi request reprint Lipid rafts and redox signaling
    Pin Lan Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Antioxid Redox Signal 9:1411-5. 2007
    ..We hope that this forum could lead to more studies in this area and enhance our understanding of lipid rafts and redox regulation under physiologic and pathologic conditions...
  2. pmc Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e45020. 2012
    ..In conclusion, Asm gene knockout or corresponding enzyme inhibition protects the podocytes and glomeruli from hHcys-induced oxidative stress and injury...
  3. pmc Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes
    Ming Xu
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS ONE 8:e71212. 2013
    ....
  4. pmc Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis
    Xiang Li
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 9:e87552. 2014
    ..Such novel action of inflammasomes may facilitate entry or retention of macrophages into the arterial wall, where they form foam cells and ultimately induce atherosclerosis...
  5. pmc Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease
    Pin Lan Li
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA, 23298, USA
    Handb Exp Pharmacol 216:171-97. 2013
    ....
  6. ncbi request reprint Hyperhomocysteinemia: association with renal transsulfuration and redox signaling in rats
    Li Pin-Lan
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Clin Chem Lab Med 45:1688-93. 2007
    ....
  7. ncbi request reprint Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Antioxid Redox Signal 9:817-28. 2007
    ..This ASM-mediated feedforwarding mechanism may be critical for an efficient transmembrane signaling through LRs...
  8. pmc Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells
    Ming Xu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Biol Cell 23:1546-57. 2012
    ....
  9. pmc Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, VA 23298, United States
    Cell Signal 20:637-44. 2008
    ..These results provide direct evidence that O2- could be locally produced via NOX on the SR and that this local O2- producing system is controlled by cADPR-RyR/Ca2+ signaling pathway...
  10. pmc SNARE-mediated rapid lysosome fusion in membrane raft clustering and dysfunction of bovine coronary arterial endothelium
    Wei Qing Han
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 301:H2028-37. 2011
    ..VAMP-2 is critical to lysosome fusion in MR clustering, and this VAMP-2-mediated lysosome-MR signalosomes contribute to redox regulation of coronary endothelial function...
  11. pmc Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochim Biophys Acta 1803:482-91. 2010
    ..It is concluded that NADPH oxidase subunits aggregation and consequent activation of this enzyme through LR clustering is an important molecular mechanism triggering oxidative injury of podocytes induced by Hcys...
  12. pmc Membrane raft-lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin
    Min Xia
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298, USA
    Cardiovasc Res 89:401-9. 2011
    ..The present study was designed to test a hypothesis that visfatin causes coronary endothelial dysfunction through lysosome trafficking and fusion to cell membranes, membrane raft (MR) clustering, and formation of redox signalosomes...
  13. pmc Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes
    Su Jie Jia
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Physiol Heart Circ Physiol 295:H1743-52. 2008
    ....
  14. ncbi request reprint Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, USA
    Hypertension 47:74-80. 2006
    ..These results suggest that LR clustering occurs in coronary endothelial cells. The formation of redox signaling platforms on the cell membrane mediates transmembrane signaling of death receptors, resulting in endothelial dysfunction...
  15. ncbi request reprint Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 288:H686-94. 2005
    ..production through activation of NAD(P)H oxidase. This ceramide-O2*-. signaling pathway may contribute importantly to endostatin-induced endothelial dysfunction...
  16. pmc NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice
    Ming Xu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Free Radic Biol Med 52:357-65. 2012
    ....
  17. ncbi request reprint Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes
    Jing Xiong
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    J Cell Mol Med 17:1598-607. 2013
    ..These results indicate that CD38 importantly control lysosomal function and influence autophagy at the maturation step in podocytes. ..
  18. ncbi request reprint Role of cyclic ADP-ribose in Ca2+-induced Ca2+ release and vasoconstriction in small renal arteries
    Eric G Teggatz
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Microvasc Res 70:65-75. 2005
    ..6) from ryanodine receptors was induced by CaCl2. We conclude that cADPR importantly contributes to CICR and vasomotor responses of small renal arteries through enhanced dissociation of ryanodine receptors from their accessory protein...
  19. ncbi request reprint Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscle
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Vasc Res 40:28-36. 2003
    ..These results suggest that the cADPR signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors...
  20. pmc Lysosome fusion to the cell membrane is mediated by the dysferlin C2A domain in coronary arterial endothelial cells
    Wei Qing Han
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cell Sci 125:1225-34. 2012
    ..We conclude that dysferlin determines lysosome fusion to the plasma membrane through its C2A domain and it is therefore implicated in membrane-raft-mediated signaling and regulation of endothelial function in coronary circulation...
  21. pmc NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Antioxid Redox Signal 13:975-86. 2010
    ..These results support the view that the NMDA receptor may mediate Nox activation in the kidney during hHcys and thereby play a critical role in the development of hHcys-induced glomerulosclerosis...
  22. pmc Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction
    Si Jin
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th, Richmond, VA 23298, USA
    Arterioscler Thromb Vasc Biol 28:485-90. 2008
    ..The present study tested whether EST stimulates clustering of ceramide-enriched lipid rafts (LRs), which assembles and activates NADPH oxidase to form redox signaling platforms...
  23. pmc Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Pathol 179:2210-9. 2011
    ..In conclusion, our observations reveal that Asm plays a pivotal role in mediating podocyte injury and glomerular sclerosis associated with NADPH oxidase-associated local oxidative stress during hHcys...
  24. pmc TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice
    Xiang Li
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Mol Med (Berl) 91:25-36. 2013
    ....
  25. pmc Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cell Mol Med 16:1674-85. 2012
    ....
  26. pmc Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells
    Jun Xiang Bao
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 North 12th, Richmond, VA 23298, USA
    Antioxid Redox Signal 12:703-12. 2010
    ..It is concluded that lysosome-targeted ASM, through sortilin, is able to traffic to and expose to cell-membrane surface, which may lead to LRs clustering and NOX activation in CAECs...
  27. pmc Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats
    Qing Zhu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hypertension 58:657-64. 2011
    ....
  28. ncbi request reprint Cyclic ADP ribose-mediated Ca2+ signaling in mediating endothelial nitric oxide production in bovine coronary arteries
    Guo Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, Virginia 23298, USA
    Am J Physiol Heart Circ Physiol 290:H1172-81. 2006
    ..In conclusion, these results suggest that cADPR importantly contributes to BK- and A-23187-induced NO production and vasodilator response in coronary arteries through its Ca2+ signaling mechanism in CAECs...
  29. pmc NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia
    Justine M Abais
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Antioxid Redox Signal 18:1537-48. 2013
    ....
  30. pmc Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298, USA
    Hypertension 60:154-62. 2012
    ..In conclusion, NALP3 inflammasome formation and activation on stimulation of homocysteine are important molecular mechanisms triggering podocyte injury and ultimately resulting in glomerulosclerosis in hHcys...
  31. pmc Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts
    Fan Zhang
    Dept of Pharmacology and Toxicology, Virginia Commonwealth Univ, Richmond, 23298, USA
    Am J Physiol Cell Physiol 298:C1209-16. 2010
    ....
  32. pmc Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes
    Ming Xu
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochim Biophys Acta 1833:3228-36. 2013
    ....
  33. ncbi request reprint Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 66:1977-87. 2004
    ....
  34. pmc Epithelial-to-mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298, USA
    Pflugers Arch 462:455-67. 2011
    ..These results suggest that hHcys induces EMT of podocytes through activation of Nox, which represents a novel mechanism of hHcys-associated podocyte injury...
  35. pmc Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells
    Zhengchao Wang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Kidney Int 79:300-10. 2011
    ..We propose that redox regulation of prolyl-PHD2 plays a critical role in angiotensin II-induced activation of HIF-1α in renal cells...
  36. pmc Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells
    Si Jin
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Arterioscler Thromb Vasc Biol 28:2056-62. 2008
    ....
  37. ncbi request reprint Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats
    Ningjun Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hypertension 47:1094-100. 2006
    ..We conclude that hyperhomocysteinemia is associated with a decreased activity and expression of CBS in renal PTs because of the defect of chromosome 13 in SS rats...
  38. pmc Protective role of growth hormone against hyperhomocysteinemia-induced glomerular injury
    Caixia Li
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Commonwealth University, 410 N, 12th Street, Richmond, VA 23298, USA
    Naunyn Schmiedebergs Arch Pharmacol 386:551-61. 2013
    ..All these results support the view that GH ameliorates hHcys-induced glomerular injury by reducing Nox-dependent O2 (.-)/HIF-1α signal pathway and EMT...
  39. ncbi request reprint Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 284:H605-12. 2003
    ..We conclude that NADPH oxidase-mediated superoxide production and subsequent peroxynitrite formation mediate ceramide-induced endothelial dysfunction in small coronary arteries...
  40. ncbi request reprint Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 283:H1785-94. 2002
    ..We conclude that TNF-alpha inhibits NO-mediated endothelium-dependent vasorelaxation in small coronary arteries via sphingomyelinase activation and consequent superoxide production in endothelial cells...
  41. pmc Attenuation by statins of membrane raft-redox signaling in coronary arterial endothelium
    Yu Miao Wei
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 345:170-9. 2013
    ....
  42. pmc Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 410 N, 12th St, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 334:839-46. 2010
    ..In conclusion, our results reveal a pivotal role for ceramide biosynthesis in obesity, metabolic syndrome, and associated kidney damage...
  43. pmc Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries
    Jun Xiang Bao
    Dept of Pharmacology and Toxicology, Virginia Commonwealth Univ, Richmond, 23298, USA
    Am J Physiol Heart Circ Physiol 298:H992-H1002. 2010
    ....
  44. pmc TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    J Cell Mol Med 13:3174-85. 2009
    ..0 +/- 4.4% of control). These results for the first time provide direct evidence that an NAADP-sensitive Ca(2+) release channel is characteristic of TRP-ML1 channels...
  45. pmc Formation of lipid raft redox signalling platforms in glomerular endothelial cells: an early event of homocysteine-induced glomerular injury
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, VA, USA
    J Cell Mol Med 13:3303-14. 2009
    ....
  46. pmc Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension
    Qing Zhu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cell Mol Med 16:2701-7. 2012
    ....
  47. pmc Regulation of renin release via cyclic ADP-ribose-mediated signaling: evidence from mice lacking CD38 gene
    Jing Xiong
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Physiol Biochem 31:44-55. 2013
    ....
  48. pmc A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate
    Qing Zhu
    Dept of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298, USA
    Am J Physiol Renal Physiol 301:F35-41. 2011
    ..It is concluded that S1P is a novel diuretic factor in the renal medulla and may be an important regulator of sodium homeostasis...
  49. ncbi request reprint Contribution of lysosomal vesicles to the formation of lipid raft redox signaling platforms in endothelial cells
    Si Jin
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Antioxid Redox Signal 9:1417-26. 2007
    ....
  50. pmc Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes
    Yu Miao Wei
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Physiol Biochem 31:925-37. 2013
    ..The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes (CAMs) to thereby exert their beneficial effects in atherosclerosis...
  51. ncbi request reprint Protein methylation activates reconstituted ryanodine receptor-ca release channels from coronary artery myocytes
    Ya Fei Chen
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Vasc Res 41:229-40. 2004
    ....
  52. pmc Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing
    Krishna M Boini
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA Electronic address
    Biochim Biophys Acta 1843:836-45. 2014
    ..In conclusion, activation and formation of inflammasomes in podocytes are importantly implicated in the development of obesity-associated glomerular injury...
  53. ncbi request reprint Role of cyclic ADP-ribose-Ca2+ signaling in mediating renin production and release in As4.1 cells
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Cell Physiol Biochem 19:293-302. 2007
    ..These results indicate that cADPR-mediated Ca(2+) signaling pathway is present in As4.1 cells and that this signaling pathway may play a contributing role in the regulation of renin production and release...
  54. ncbi request reprint Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle
    Xiu Yu Yi
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, USA
    Am J Physiol Heart Circ Physiol 290:H1136-44. 2006
    ..These results suggest that a local NAD(P)H oxidase system on SR from CASM regulates RyR/Ca2+ channel activity and Ca2+ release from SR by producing O2-*...
  55. ncbi request reprint Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys
    Ningjun Li
    Dept of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth Univ, PO Box 980613, Richmond, VA 23298, USA
    Am J Physiol Renal Physiol 292:F207-16. 2007
    ..These results indicate that highly expressed PHDs in the renal medulla make an important contribution to the control of renal Na(+) excretion through regulation of HIF-1alpha and its targeted genes...
  56. ncbi request reprint Role of renal medullary heme oxygenase in the regulation of pressure natriuresis and arterial blood pressure
    Ningjun Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Hypertension 49:148-54. 2007
    ....
  57. pmc Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes
    Ming Xu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Cell Physiol 304:C458-66. 2013
    ..These results suggest that TRP-ML1 channel-mediated lysosomal Ca(2+) bursts upon FasL stimulation promote lysosome trafficking and interactions with the SR, leading to apoptosis of CAMs via a Ca(2+)-dependent mechanism...
  58. pmc Production and actions of the anandamide metabolite prostamide E2 in the renal medulla
    Joseph K Ritter
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1217 E Marshall St, Medical Sciences Bldg, Room 531, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 342:770-9. 2012
    ..These results suggest that AEA and/or its prostamide metabolites in the renal medulla may represent medullipin and function as a regulator of body fluid and MAP...
  59. pmc Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
    Qing Zhu
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richnond VA 23298, USA
    Biochim Biophys Acta 1822:936-41. 2012
    ....
  60. ncbi request reprint Calcium-induced calcium release and cyclic ADP-ribose-mediated signaling in the myocytes from small coronary arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Microvasc Res 64:339-48. 2002
  61. ncbi request reprint Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Physiol Biochem 20:909-18. 2007
    ..These results suggest that Vav2 importantly contributes to Hcys-induced increase in Rac1 activity and consequent activation of NADPH oxidase in RMCs via ceramide-associated tyrosine phosphorylation...
  62. pmc Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla
    Zhengchao Wang
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298, USA
    Hypertension 55:1129-36. 2010
    ..The lack of PHD-mediated response to high salt may represent a pathogenic mechanism producing salt-sensitive hypertension...
  63. pmc Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells
    Krishna M Boini
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biochim Biophys Acta 1801:1294-304. 2010
    ....
  64. ncbi request reprint Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Basic Res Cardiol 97:312-9. 2002
    ..These results suggest that myocardial ischemia and reperfusion decrease cADPR in the myocardium by increasing its hydrolysis. Tissue hypoxia may be one of the important mechanisms to activate cADPR hydrolase...
  65. ncbi request reprint Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial myocytes
    Guo Zhang
    Dept of Pharmacology and Toxicology, Medical College of Virginia, 410 North 12th St, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 292:H483-95. 2007
    ..It is concluded that the outward production of O(2)(*-) via NAD(P)H oxidase in CAMs may represent an important producing pattern for its autocrine or paracrine actions...
  66. pmc Contribution of acid sphingomyelinase in the periaqueductal gray region to morphine-induced analgesia in mice
    Joseph K Ritter
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0613, USA
    Neuroreport 23:780-5. 2012
    ..These data provide evidence that ASM activation and ceramide generation in the periaqueductal gray region play a major role in the antinociceptive mechanism of morphine...
  67. ncbi request reprint Podocyte injury and glomerulosclerosis in hyperhomocysteinemic rats
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Nephrol 27:262-8. 2007
    ..The present study was to observe when glomerular injury happens during hHcys and to explore the possible role of podocyte injury in the progression of glomerulosclerosis associated with hHcys...
  68. ncbi request reprint Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 282:25259-69. 2007
    ....
  69. pmc Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
    Wei Qing Han
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    Biochim Biophys Acta 1833:1454-62. 2013
    ..The present study suggests that PHD2/HIF-1α is a novel signaling pathway mediating the fibrogenic effect of TGF-β1, and may be a new therapeutic target in chronic kidney diseases...
  70. pmc Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Cell Physiol 301:C421-30. 2011
    ..Failure of NAADP-TRP-ML1 signaling may be one of the important mechanisms resulting in intracellular lipid trafficking disorder and consequent mucolipidosis...
  71. ncbi request reprint 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels
    William B Campbell
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H1656-64. 2002
    ..14,15-DHET relaxes coronary arteries through activation of K(Ca) channels. Endothelial cells, but not smooth muscle cells, convert EETs to DHETs, and this conversion results in a loss of vasodilator activity...
  72. ncbi request reprint Activation of NAD(P)H oxidase by outward movements of H+ ions in renal medullary thick ascending limb of Henle
    Ningjun Li
    Dept of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Renal Physiol 289:F1048-56. 2005
    ..This H(+) outflow-associated activation of NAD(P)H oxidase importantly contributes to tissue levels of reactive oxygen species in the renal medulla...
  73. pmc Lipid raft-redox signaling platforms in plasma membrane
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    Methods Mol Biol 580:93-107. 2009
    ..It is expected that information provided here will help readers to design necessary experiments in their studies on LR signaling platforms and redox regulation of cell function...
  74. ncbi request reprint Lipid raft redox signaling platforms in endothelial dysfunction
    Pin Lan Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Antioxid Redox Signal 9:1457-70. 2007
    ....
  75. pmc Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla
    Ningjun Li
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298, USA
    Circ Res 102:1101-8. 2008
    ..In conclusion, HIF-1alpha-mediated gene activation importantly participates in the regulation of renal medullary function and long-term arterial blood pressure...
  76. pmc Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298, USA
    Hypertension 53:90-6. 2009
    ..We concluded that Vav2-mediated activation of NADPH oxidase is an important initiating mechanism resulting in hyperhomocysteinemic glomerular injury through enhanced local oxidative stress...
  77. pmc Role of CD38, a cyclic ADP-ribosylcyclase, in morphine antinociception and tolerance
    Lynn C Hull
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    J Pharmacol Exp Ther 334:1042-50. 2010
    ..These results indicate that cADRP-ryanodine receptor Ca(2+) signaling associated with CD38 plays an important role in morphine tolerance...
  78. pmc Reversal by growth hormone of homocysteine-induced epithelial-to-mesenchymal transition through membrane raft-redox signaling in podocytes
    Cai xia Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Cell Physiol Biochem 27:691-702. 2011
    ..It is concluded that Hcys-induced podocyte EMT is associated with transmembrane membrane raft-redox signaling and that GH reverses this Hcys-induced EMT protecting podocytes from functional disturbance...
  79. pmc Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Free Radic Biol Med 48:1109-17. 2010
    ..These results suggest that the functional integrity of NADPH oxidase is essential for hyperhomocysteinemia-induced podocyte injury and glomerulosclerosis...
  80. pmc Docosahexanoic acid-induced coronary arterial dilation: actions of 17S-hydroxy docosahexanoic acid on K+ channel activity
    Xiang Li
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 336:891-9. 2011
    ....
  81. ncbi request reprint 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines
    Clint Mitchell
    Department of Biochemistry, Massey Cancer Center, Box 980035, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 6:618-32. 2007
    ....
  82. pmc Mechanisms of homocysteine-induced glomerular injury and sclerosis
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Nephrol 28:254-64. 2008
    ....
  83. pmc Membrane raft redox signalosomes in endothelial cells
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Free Radic Res 44:831-42. 2010
    ..This may increase enthusiasm of the scientific community for further studies on the molecular mechanisms and the functional significance of forming such MR redox signalosomes...
  84. ncbi request reprint Enhanced production and action of cyclic ADP-ribose during oxidative stress in small bovine coronary arterial smooth muscle
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Microvasc Res 67:159-67. 2004
    ..We conclude that superoxide activates cADPR production, and thereby mobilizes intracellular Ca2+ from the SR and produces vasoconstriction in coronary arteries...
  85. pmc Telemetric signal-driven servocontrol of renal perfusion pressure in acute and chronic rat experiments
    Min Xia
    Dept of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth Univ, PO Box 980613, Richmond, VA 23298, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1494-501. 2008
    ..This system provides a powerful tool and may greatly facilitate the studies in pressure-dependent/-independent effects of a variety of cardiovascular factors...
  86. pmc Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys
    Min Xia
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 329:1056-62. 2009
    ..These results suggest that H(2)S participates in the control of renal function and increases urinary sodium excretion via both vascular and tubular actions in the kidney...
  87. ncbi request reprint Vascular physiology of a Ca2+ mobilizing second messenger - cyclic ADP-ribose
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 23298, USA
    J Cell Mol Med 10:407-22. 2006
    ..Given the importance of Ca(2+) in the regulation of vascular function, the results summarized in this brief review will provide new insights into vascular physiology and circulatory regulation...
  88. pmc Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th, Richmond, VA 23298, USA
    Microvasc Res 78:45-50. 2009
    ....
  89. ncbi request reprint Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 291:H274-82. 2006
    ..26 +/- 4.42% to 51.80 +/- 4.36%. Our results suggest that a lysosome-mediated Ca2+ regulatory mechanism via NAADP contributes to ET-1-induced Ca2+ mobilization in CASMCs and consequent vasoconstriction of coronary arteries...
  90. ncbi request reprint Simultaneous in situ monitoring of intracellular Ca2+ and NO in endothelium of coronary arteries
    Fu Xian Yi
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 283:H2725-32. 2002
    ....
  91. ncbi request reprint Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells
    Zhi Zhang Yang
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 284:F1207-15. 2003
    ..NAD(P)H oxidase activity may importantly contribute to this posttranscriptional regulation of HIF-1alpha in these cells under physiological conditions...
  92. ncbi request reprint Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney
    Andrew Y Zhang
    Deptartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 285:F792-8. 2003
    ..These results indicate that UII produces vasodilator and natriuretic effects in the kidney and that UII-induced vasodilation is associated with increased endothelial NO in the RA...
  93. ncbi request reprint Role of FKBP12.6 in cADPR-induced activation of reconstituted ryanodine receptors from arterial smooth muscle
    Wang xian Tang
    Research Institute of Liver Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Am J Physiol Heart Circ Physiol 282:H1304-10. 2002
    ..We conclude that FKBP12.6 plays a critical role in mediating cADPR-induced activation of RyR/Ca(2+) release channels from the SR of BCASM...
  94. ncbi request reprint Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function
    Ya Fei Chen
    Departments of Physiology and Pharmacology Toxicology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circulation 106:1275-81. 2002
    ..Because Hcys and adenosine (Ado) are simultaneously produced via hydrolysis of S-adenosylhomocysteine (SAH), we hypothesized that hHcys may produce its pathogenic effects by decrease in plasma or tissue Ado concentrations...
  95. ncbi request reprint The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:43079-86. 2005
    ..These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution...

Research Grants31

  1. Ceramide Signaling in Coronary Endothelial Dysfunction
    Pin Lan Li; Fiscal Year: 2010
    ....
  2. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2006
    ..Understanding of this interaction will help develop new therapy for heart diseases since blockade of this interaction may open coronary arteries and increase blood flow to the heart. ..
  3. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  4. Ceramide Signaling in Coronary Endothelial Dysfunction
    Pin Lan Li; Fiscal Year: 2005
    ....
  5. Glomerular Injury Associated with Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2004
    ..abstract_text> ..
  6. Ceramide Signaling in Coronary Endothelial Dysfunction
    Pin Lan Li; Fiscal Year: 2004
    ....
  7. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2003
    ..abstract_text> ..
  8. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2007
    ..Understanding of this interaction will help develop new therapy for heart diseases since blockade of this interaction may open coronary arteries and increase blood flow to the heart. ..
  9. Hypertension and Glomerular Injury in Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2009
    ..Clarification of the action of this protein will help develop new therapeutic strategy for prevention and treatment of Hcys-induced chronic renal failure. ..
  10. Ceramide Signaling in Coronary Endothelial Dysfunction
    Pin Lan Li; Fiscal Year: 2007
    ....
  11. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2010
    ..Understanding of this interaction will help develop new therapy for heart diseases since blockade of this interaction may open coronary arteries and increase blood flow to the heart. ..
  12. Hypertension and Glomerular Injury in Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2009
    ..Clarification of the action of this protein will help develop new therapeutic strategy for prevention and treatment of Hcys-induced chronic renal failure. ..
  13. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2009
    ..Understanding of this interaction will help develop new therapy for heart diseases since blockade of this interaction may open coronary arteries and increase blood flow to the heart. ..
  14. Hypertension and Glomerular Injury in Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2010
    ..Clarification of the action of this protein will help develop new therapeutic strategy for prevention and treatment of Hcys-induced chronic renal failure. ..
  15. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2002
    ..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..
  16. Glomerular Injury Associated with Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  17. Hypertension and Glomerular Injury in Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2009
    ..Clarification of the action of this protein will help develop new therapeutic strategy for prevention and treatment of Hcys-induced chronic renal failure. ..
  18. Glomerular Injury Associated with Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2004
    ..abstract_text> ..
  19. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2004
    ..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..
  20. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2005
    ..abstract_text> ..
  21. Ceramide Signaling in Coronary Endothelial Dysfunction
    Pin Lan Li; Fiscal Year: 2006
    ....
  22. Glomerular Injury Associated with Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2005
    ..abstract_text> ..
  23. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2004
    ..abstract_text> ..
  24. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2004
    ..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..
  25. NAADP-Sensitive Lysosomal Ca2+ Release Channels-TRP-ML1 in Arterial Myocytes
    Pin Lan Li; Fiscal Year: 2010
    ....
  26. NAADP-Sensitive Lysosomal Ca2+ Release Channels-TRP-ML1 in Arterial Myocytes
    Pin Lan Li; Fiscal Year: 2009
    ....
  27. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2003
    ..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..
  28. Glomerular Injury Associated with Hyperhomocysteinemia
    Pin Lan Li; Fiscal Year: 2003
    ..abstract_text> ..
  29. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2001
    ..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..