Po Hsiu Kuo

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Cohort trends in prevalence and spousal concordance for smoking
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219, USA
    Drug Alcohol Depend 88:122-9. 2007
  2. ncbi request reprint A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007
  3. ncbi request reprint The temporal relationship of the onsets of alcohol dependence and major depression: using a genetically informative study design
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:1153-62. 2006
  4. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
  5. pmc The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
    Brien Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 115:245-53. 2009
  6. pmc Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)
    Laura M Hack
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:376-85. 2011
  7. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
  8. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
  9. pmc AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families
    Dawn L Thiselton
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
    Biol Psychiatry 63:449-57. 2008
  10. pmc A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts
    Gursharan Kalsi
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Hum Mol Genet 19:2497-506. 2010

Detail Information

Publications23

  1. pmc Cohort trends in prevalence and spousal concordance for smoking
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23219, USA
    Drug Alcohol Depend 88:122-9. 2007
    ..19-0.49). Despite using a simplified smoking assessment, findings in this study demonstrated changes of lifetime smoking patterns across birth cohorts and the presence of assortative mating for smoking behavior...
  2. ncbi request reprint A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007
    ..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study...
  3. ncbi request reprint The temporal relationship of the onsets of alcohol dependence and major depression: using a genetically informative study design
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 36:1153-62. 2006
    ..In this longitudinal study, we used a genetically informative population-based twin sample to examine the age-at-onset distributions and the temporal relationship of AD and MD...
  4. ncbi request reprint Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence
    Po Hsiu Kuo
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Alcohol Clin Exp Res 30:1807-16. 2006
    ..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits...
  5. pmc The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
    Brien Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 115:245-53. 2009
    ..DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples...
  6. pmc Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)
    Laura M Hack
    Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
    Alcohol Clin Exp Res 35:376-85. 2011
    ..Many linkage and association studies have examined these relationships with inconsistent results, possibly because of low power, poor marker coverage, and/or an inappropriate correction for multiple testing...
  7. ncbi request reprint A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder
    Kenneth S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Alcohol Clin Exp Res 30:1972-7. 2006
    ..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?..
  8. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
    ..Several possibilities, such as differing risk haplotypes, may explain this finding...
  9. pmc AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families
    Dawn L Thiselton
    Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0424, USA
    Biol Psychiatry 63:449-57. 2008
    ..The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients...
  10. pmc A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts
    Gursharan Kalsi
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Hum Mol Genet 19:2497-506. 2010
    ..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings...
  11. pmc Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
    Biol Psychiatry 70:888-96. 2011
    ....
  12. doi request reprint Candidate genes for schizophrenia: a survey of association studies and gene ranking
    Jingchun Sun
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1173-81. 2008
    ..The evaluation of this candidate gene set against sets selected by other methods suggested its utility in follow-up association studies and in further bioinformatics analysis. We also examined the functional biases of the selected genes...
  13. doi request reprint Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
    Edwin J C G van den Oord
    Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, PO Box 980533, Richmond, VA 23298 0533, USA
    Arch Gen Psychiatry 65:1062-71. 2008
    ..It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, and it accounts for much of the substantial comorbidity seen between these disorders...
  14. pmc ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure
    Jingchun Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e28790. 2011
    ..The independent associations of this locus with schizophrenia and with numCIG in non-schizophrenic subjects suggest that this locus may be a common liability to both conditions...
  15. pmc Efficient calculation of empirical P-values for genome-wide linkage analysis through weighted permutation
    Sarah E Medland
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Behav Genet 39:91-100. 2009
    ..We demonstrate the validity of this approach through simulation...
  16. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  17. ncbi request reprint Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15
    Lisa J Martin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Genet Epidemiol 31:S124-31. 2007
    ..We show that while each approach may have certain advantages, adequate error control is largely dependent upon the question under consideration and often requires the use of multiple analytic strategies...
  18. pmc Genomewide linkage survey of nicotine dependence phenotypes
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Drug Alcohol Depend 93:210-6. 2008
    ..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses...
  19. ncbi request reprint The Taipei Adolescent Twin/sibling Family Study I: behavioral problems, personality features, and neuropsychological performance
    Chaucer C H Lin
    Department of Psychiatry, Buddhist Tzu Chi General Hospital and University, Hualien, Taiwan
    Twin Res Hum Genet 9:890-4. 2006
    ..The Mx program was used to estimate parameters for the full model and its reduced models. The recruitment, measurements, data managements, and published results are described in this article...
  20. ncbi request reprint A twin study of competence and behavioral/emotional problems among adolescents in taiwan
    Po Hsiu Kuo
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Behav Genet 34:63-74. 2004
    ..Gender differences in heritability exist for various CBCL-based competence and behavioral/emotional problems...
  21. ncbi request reprint Genetic and environmental influences on schizotypy among adolescents in Taiwan: a multivariate twin/sibling analysis
    Chaucer C H Lin
    Department of Psychiatry, Buddhist Tzu Chi General Hospital and University, Hualien, Taiwan
    Behav Genet 37:334-44. 2007
    ..We concluded that there exist both common and specific genetic factors between the various dimensions of schizotypy, and at least half of their correlations were genetic in nature...
  22. ncbi request reprint Using the CES-D in a two-phase survey for depressive disorders among nonreferred adolescents in Taipei: a stratum-specific likelihood ratio analysis
    Hao Jan Yang
    Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road, Sec 1, Taipei 100, Taiwan
    J Affect Disord 82:419-30. 2004
    ..We examined whether the Center for Epidemiologic Studies Depression Scale (CES-D) is an appropriate instrument for screening depressive disorders among adolescents in Taipei, an ethnic group whose depression is little known of...
  23. ncbi request reprint Substance use among adolescents in Taiwan: associated personality traits, incompetence, and behavioral/emotional problems
    Po Hsiu Kuo
    Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road, Sec 1, Taipei 100, Taiwan
    Drug Alcohol Depend 67:27-39. 2002
    ..We aimed to examine personality traits, incompetence, and behavioral/emotional problems in relation to adolescent substance use and possible interactions between these factors...