John F Kuemmerle

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. request reprint
    Kuemmerle J. Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2000;278:G710-7 pubmed
    ..Regulation of IGFBP production by IGF-I is mediated by activation of distinct MAP kinase and PI 3-kinase pathways, the same pathways through which IGF-I stimulates growth...
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    Kuemmerle J, Teng B. Regulation of IGFBP-4 levels in human intestinal muscle by an IGF-I-activated, confluence-dependent protease. Am J Physiol Gastrointest Liver Physiol. 2000;279:G975-82 pubmed
    ..We conclude that in human intestinal smooth muscle cells levels of secreted IGFBP-4 are determined by the confluence-dependent production of a cation-dependent serine protease that is activated by endogenous IGF-I...
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    Kuemmerle J, Murthy K. Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth. J Biol Chem. 2001;276:7187-94 pubmed
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    Kuemmerle J, Zhou H. Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates growth and IGF-I secretion in human intestinal smooth muscle by Ras-dependent activation of p38 MAP kinase and Erk1/2 pathways. J Biol Chem. 2002;277:20563-71 pubmed
    ..A positive feedback mechanism therefore links IGFBP-5 and IGF-I secretion that reinforces their individual effects on growth. ..
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    Kuemmerle J, Murthy K, Bowers J. IGFBP-3 activates TGF-beta receptors and directly inhibits growth in human intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2004;287:G795-802 pubmed
    ..We conclude that endogenous IGFBP-3 directly inhibits proliferation of human intestinal smooth muscle cells by activation of TGF-betaRI and Smad2, an effect that is independent of its effect on IGF-I-stimulated growth. ..
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    Kuemmerle J. Occupation of alphavbeta3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1194-202 pubmed

Collaborators