THOMAS KRAHE

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Activation of NMDA receptors is necessary for the recovery of cortical binocularity
    Thomas E Krahe
    Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0709, USA
    J Neurophysiol 103:2700-6. 2010
  2. ncbi request reprint Protein synthesis-independent plasticity mediates rapid and precise recovery of deprived eye responses
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, 1101 East Marshall Street, Richmond, Virginia 23298, USA
    Neuron 48:329-43. 2005
  3. pmc Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders
    Arco P Paul
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neurosci 30:2513-20. 2010
  4. ncbi request reprint Early alcohol exposure induces persistent alteration of cortical columnar organization and reduced orientation selectivity in the visual cortex
    Alexandre E Medina
    Deptartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Box 0709, 1101 East Marshall St, Rm 12 042, Richmond, VA 23298 0709, USA
    J Neurophysiol 93:1317-25. 2005
  5. ncbi request reprint Neonatal alcohol exposure induces long-lasting impairment of visual cortical plasticity in ferrets
    Alexandre E Medina
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neurosci 23:10002-12. 2003
  6. doi request reprint Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disorders
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0709, USA
    Alcohol Clin Exp Res 34:493-8. 2010
  7. pmc Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    PLoS ONE 4:e6643. 2009
  8. ncbi request reprint Neocortical plasticity deficits in fetal alcohol spectrum disorders: lessons from barrel and visual cortex
    Alexandre E Medina
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neurosci Res 86:256-63. 2008
  9. ncbi request reprint Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure
    Alexandre E Medina
    Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 26:1057-60. 2006
  10. pmc Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation
    Claudio C Filgueiras
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298 0709, United States
    Neurosci Lett 473:202-7. 2010

Research Grants

  1. MECHANISMS OF VISUAL PLASTICITY
    THOMAS KRAHE; Fiscal Year: 2004

Collaborators

Detail Information

Publications13

  1. pmc Activation of NMDA receptors is necessary for the recovery of cortical binocularity
    Thomas E Krahe
    Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0709, USA
    J Neurophysiol 103:2700-6. 2010
    ..These findings provide an important new insight for a specific role of NMDARs in the recovery of cortical binocularity from the effects of MD...
  2. ncbi request reprint Protein synthesis-independent plasticity mediates rapid and precise recovery of deprived eye responses
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, 1101 East Marshall Street, Richmond, Virginia 23298, USA
    Neuron 48:329-43. 2005
    ....
  3. pmc Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders
    Arco P Paul
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neurosci 30:2513-20. 2010
    ..This finding suggests that overexpression of SRF in astrocytes may reduce the deficits in neuronal plasticity seen in models of FASD...
  4. ncbi request reprint Early alcohol exposure induces persistent alteration of cortical columnar organization and reduced orientation selectivity in the visual cortex
    Alexandre E Medina
    Deptartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Box 0709, 1101 East Marshall St, Rm 12 042, Richmond, VA 23298 0709, USA
    J Neurophysiol 93:1317-25. 2005
    ..These findings indicate that alcohol exposure during a brief period of development disrupts cortical processing of sensory information at a later age and suggest a neurobiological substrate for some types of sensory deficits in FAS...
  5. ncbi request reprint Neonatal alcohol exposure induces long-lasting impairment of visual cortical plasticity in ferrets
    Alexandre E Medina
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neurosci 23:10002-12. 2003
    ..This model provides a novel approach to investigate the consequences of fetal alcohol exposure and should contribute to elucidate how alcohol disrupts neural plasticity...
  6. doi request reprint Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disorders
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0709, USA
    Alcohol Clin Exp Res 34:493-8. 2010
    ..This disruption can be reversed, however, by treating animals with a Phosphodiesterase (PDE) type 1 inhibitor long after the period of alcohol exposure...
  7. pmc Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disorders
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    PLoS ONE 4:e6643. 2009
    ..There is growing evidence that some of these sensory processing problems may be related to altered cortical maps caused by impaired developmental neuronal plasticity...
  8. ncbi request reprint Neocortical plasticity deficits in fetal alcohol spectrum disorders: lessons from barrel and visual cortex
    Alexandre E Medina
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neurosci Res 86:256-63. 2008
    ..In this Mini-Review, we discuss the effects of ethanol exposure during development on neuronal plasticity and suggest environmental and pharmacological approaches to ameliorate these problems...
  9. ncbi request reprint Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure
    Alexandre E Medina
    Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 26:1057-60. 2006
    ..Our finding should contribute to a better understanding and treatment of cognitive deficits associated with mental disorders, such as FAS...
  10. pmc Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation
    Claudio C Filgueiras
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298 0709, United States
    Neurosci Lett 473:202-7. 2010
    ..Our results show that inhibition of PDE1 improves learning and memory deficits in rats early exposed to alcohol and provide evidence for the potential therapeutic use of vinpocetine in FASD...
  11. ncbi request reprint Recovery of cortical binocularity and orientation selectivity after the critical period for ocular dominance plasticity
    David S Liao
    Dept of Anatomy and Neurobiology, Virginia Commonwealth Univ School of Medicine, 1101 E Marshall St, Sanger Hall Rm 12 042, Richmond VA 23298 0709, USA
    J Neurophysiol 92:2113-21. 2004
    ..Collectively, these results indicate that there is potential for recovery of cortical binocularity and deprived eye orientation selectivity after the end of the critical period for ocular dominance plasticity...
  12. ncbi request reprint Neonatal transection of the corpus callosum affects paw preference lateralization of adult Swiss mice
    Alex C Manhães
    Laboratorio de Neurofisiologia, Departamento de Ciencias Fisiologicas, IBRAG, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 87, fundos, 5 andar, Vila Isabel, Rio de Janeiro, RJ 20 551 030, Brazil
    Neurosci Lett 348:69-72. 2003
    ..These results lend support to the hypothesis that the development of the CC plays a role in the establishment of the normal pattern of behavioral lateralization...
  13. ncbi request reprint Effects of rotational side preferences on immobile behavior of normal mice in the forced swimming test
    Thomas E Krahe
    Laboratório de Neurofisiologia e Avaliação Neurocomportamental, Universidade do Estado do Rio de Janeiro UERJ, RJ, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 26:169-76. 2002
    ..These results reinforce the idea that side preferences of spontaneous rotational behavior may account for interindividual differences in animal models of depression...

Research Grants1

  1. MECHANISMS OF VISUAL PLASTICITY
    THOMAS KRAHE; Fiscal Year: 2004
    ..A better understanding of these mechanisms should provide specific targets to develop novel therapeutic approaches in the treatment of amblyopia. ..