D J Kopacz

Summary

Affiliation: Virginia Mason Medical Center
Country: USA

Publications

  1. ncbi Effect of clonidine on lidocaine clearance in vivo: a microdialysis study in humans
    D J Kopacz
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesthesiology 95:1371-6. 2001
  2. ncbi A comparison of levobupivacaine 0.125%, fentanyl 4 microg/mL, or their combination for patient-controlled epidural analgesia after major orthopedic surgery
    D J Kopacz
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesth Analg 89:1497-503. 1999
  3. ncbi A comparison of epidural levobupivacaine 0.5% with or without epinephrine for lumbar spine surgery
    D J Kopacz
    Departments of Anesthesiology and Neurosurgery, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesth Analg 93:755-60. 2001
  4. ncbi A model to evaluate the pharmacokinetic and pharmacodynamic variables of extended-release products using in vivo tissue microdialysis in humans: bupivacaine-loaded microcapsules
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Clinic, Seattle, Washington 98111, USA
    Anesth Analg 97:124-31, table of contents. 2003
  5. ncbi The dose response and effects of dexamethasone on bupivacaine microcapsules for intercostal blockade (T9 to T11) in healthy volunteers
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Clinic, Seattle, Washington, 98111 USA
    Anesth Analg 96:576-82, table of contents. 2003
  6. ncbi Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans
    C M Bernards
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 91:962-8. 1999
  7. ncbi Hospital discharge after ambulatory knee arthroscopy: A comparison of epidural 2-chloroprocaine versus lidocaine
    J M Neal
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington, USA
    Reg Anesth Pain Med 26:35-40. 2001
  8. ncbi Accuracy of laser Doppler capillary flow measurements for predicting blood loss from skin incisions in pigs
    R L Carpenter
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA 98111
    Anesth Analg 68:308-11. 1989
  9. ncbi Spinal 2-chloroprocaine: the effect of added clonidine
    Brad R Davis
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98111, USA
    Anesth Analg 100:559-65. 2005
  10. ncbi Spinal 2-chloroprocaine for surgery: an initial 10-month experience
    Jessica R Yoos
    Department of Anesthesiology, Virginia Mason Clinic, 1100 Ninth Avenue, Seattle, WA 98111, USA
    Anesth Analg 100:553-8. 2005

Collaborators

Detail Information

Publications24

  1. ncbi Effect of clonidine on lidocaine clearance in vivo: a microdialysis study in humans
    D J Kopacz
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesthesiology 95:1371-6. 2001
    ..By directly measuring lidocaine tissue concentrations at the site of injection in the presence and absence of clonidine, this study was designed to address this question...
  2. ncbi A comparison of levobupivacaine 0.125%, fentanyl 4 microg/mL, or their combination for patient-controlled epidural analgesia after major orthopedic surgery
    D J Kopacz
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesth Analg 89:1497-503. 1999
    ..Patients in this study began demand-dosing later, reported lower pain scores, and had no greater risk of adverse events than those who were given either levobupivacaine or fentanyl alone...
  3. ncbi A comparison of epidural levobupivacaine 0.5% with or without epinephrine for lumbar spine surgery
    D J Kopacz
    Departments of Anesthesiology and Neurosurgery, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesth Analg 93:755-60. 2001
    ..Epinephrine 1:400,000 is as effective as 1:200,000 in reducing the resultant serum levobupivacaine levels after epidural anesthesia...
  4. ncbi A model to evaluate the pharmacokinetic and pharmacodynamic variables of extended-release products using in vivo tissue microdialysis in humans: bupivacaine-loaded microcapsules
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Clinic, Seattle, Washington 98111, USA
    Anesth Analg 97:124-31, table of contents. 2003
    ..Systemic absorption of bupivacaine produces higher peak plasma levels after aqueous injection than after microcapsule injection, despite the injection of a threefold larger load of bupivacaine in the latter...
  5. ncbi The dose response and effects of dexamethasone on bupivacaine microcapsules for intercostal blockade (T9 to T11) in healthy volunteers
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Clinic, Seattle, Washington, 98111 USA
    Anesth Analg 96:576-82, table of contents. 2003
    ..03). We conclude that bupivacaine/dexamethasone microcapsules are well tolerated and demonstrate a dose-related effect in onset and duration of intercostal blockade. Inclusion of dexamethasone increases intercostal block anesthesia...
  6. ncbi Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans
    C M Bernards
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Anesthesiology 91:962-8. 1999
    ..This study was designed to address this issue...
  7. ncbi Hospital discharge after ambulatory knee arthroscopy: A comparison of epidural 2-chloroprocaine versus lidocaine
    J M Neal
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington, USA
    Reg Anesth Pain Med 26:35-40. 2001
    ..We hypothesized that 2-chloroprocaine would facilitate earlier discharge than lidocaine...
  8. ncbi Accuracy of laser Doppler capillary flow measurements for predicting blood loss from skin incisions in pigs
    R L Carpenter
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA 98111
    Anesth Analg 68:308-11. 1989
    ..69, P less than 0.001). We conclude that the laser Doppler is a useful tool for evaluating the ability of subcutaneously injected local anesthetics (vasodilators) or vasoconstrictors to alter bleeding from skin incisions...
  9. ncbi Spinal 2-chloroprocaine: the effect of added clonidine
    Brad R Davis
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98111, USA
    Anesth Analg 100:559-65. 2005
    ..We conclude that small-dose clonidine increases the duration and improves the quality of 2-CP spinal anesthesia without systemic side effects...
  10. ncbi Spinal 2-chloroprocaine for surgery: an initial 10-month experience
    Jessica R Yoos
    Department of Anesthesiology, Virginia Mason Clinic, 1100 Ninth Avenue, Seattle, WA 98111, USA
    Anesth Analg 100:553-8. 2005
    ..2-CP spinal anesthesia has proven to be a safe and effective alternative to lidocaine and procaine for ambulatory surgical procedures of < or =1 h, with a predictable regression of block height. No patients reported TNS after surgery...
  11. ncbi Spinal 2-chloroprocaine: a comparison with small-dose bupivacaine in volunteers
    Jessica R Yoos
    Department of Anesthesiology, Virginia Mason Clinic, 1100 Ninth Avenue, Seattle, WA 98111, USA
    Anesth Analg 100:566-72. 2005
    ..We conclude that spinal 2-CP provides adequate duration and density of block for ambulatory surgical procedures, and has significantly faster resolution of block and return to ambulation compared with 7.5 mg of bupivacaine...
  12. ncbi Spinal 2-chloroprocaine: a comparison with procaine in volunteers
    Aaron F Gonter
    Department of Anesthesiology, Virginia Mason Clinic, 1100 Ninth Avenue, Seattle, WA 98111, USA
    Anesth Analg 100:573-9. 2005
    ....
  13. ncbi Spinal 2-chloroprocaine: minimum effective dose
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA 98111, USA
    Reg Anesth Pain Med 30:36-42. 2005
    ..Recent studies using preservative-free 2-chloroprocaine (2-CP) for spinal anesthesia have shown it to be a reliable short-acting agent in the 30-mg to 60-mg range. Investigations of doses below this range have not been performed...
  14. ncbi The training and careers of regional anesthesia fellows--1983-2002
    Joseph M Neal
    Department of Anesthesiology, Virginia Mason Medicl Center, Seattle, WA, USA
    Reg Anesth Pain Med 30:226-32. 2005
    ..The education and subsequent careers of regional anesthesia fellows have not been examined but may provide insight into improving future fellowship training and/or the future of the subspecialty...
  15. ncbi Parasternal block and local anesthetic infiltration with levobupivacaine after cardiac surgery with desflurane: the effect on postoperative pain, pulmonary function, and tracheal extubation times
    Susan B McDonald
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Ave, PO Box 900, Mailstop B2 AN, Seattle, WA 98111, USA
    Anesth Analg 100:25-32. 2005
    ....
  16. ncbi Prospective comparison of continuous femoral nerve block with nonstimulating catheter placement versus stimulating catheter-guided perineural placement in volunteers
    Francis V Salinas
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 9th Avenue, B2 AN, Seattle, WA 98101, USA
    Reg Anesth Pain Med 29:212-20. 2004
    ..Stimulating catheter-guided perineural placement may potentially increase the success rate and quality of continuous femoral nerve block as compared with a nonstimulating catheter technique. These hypotheses have not been rigorously tested...
  17. ncbi Spinal 2-chloroprocaine: the effect of added dextrose
    Daniel T Warren
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2 AN, Seattle, WA 98111, USA
    Anesth Analg 98:95-101, table of contents. 2004
    ..Adding dextrose does not significantly alter spinal block characteristics but increases residual bladder dysfunction. Therefore, the addition of glucose to 2-chloroprocaine for spinal anesthesia is not necessary...
  18. ncbi Spinal 2-chloroprocaine: the effect of added fentanyl
    Julie S Vath
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2 AN, Seattle, WA 98111, USA
    Anesth Analg 98:89-94, table of contents. 2004
    ..The addition of fentanyl lengthens regression to L1 and tourniquet tolerance while minimally lengthening block duration...
  19. ncbi Spinal 2-chloroprocaine: a dose-ranging study and the effect of added epinephrine
    Kristin N Smith
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2 AN, Seattle, WA 98111, USA
    Anesth Analg 98:81-8, table of contents. 2004
    ..Preservative and antioxidant free 2-CP can be used effectively for spinal anesthesia in doses of 30-60 mg. Epinephrine is not recommended as an adjunct because of the frequent incidence of side effects...
  20. ncbi Spinal 2-chloroprocaine: a comparison with lidocaine in volunteers
    Mary E Kouri
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2 AN, Seattle, WA 98111, USA
    Anesth Analg 98:75-80, table of contents. 2004
    ..Reliable sensory and motor blockade with predictable duration and minimal side effects make chloroprocaine an attractive choice for outpatient spinal anesthesia...
  21. ncbi Spinal chloroprocaine solutions: density at 37 degrees C and pH titration
    Kimberly B Na
    Department of Anesthesiology, Virginia Mason Medical Center, 1100 Ninth Avenue, B2 AN, Seattle, WA 98111, USA
    Anesth Analg 98:70-4, table of contents. 2004
    ..0), but the pH can be increased to more than 7.0 with a small amount of bicarbonate (0.25-0.33 mL/10 mL). The increased density of plain chloroprocaine makes it a useful hyperbaric spinal drug without the addition of dextrose...
  22. ncbi Regional anesthesia and pain medicine: residency training--the year 2000
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Reg Anesth Pain Med 27:9-14. 2002
    ..This manuscript reports the impact these changes have had on the use of regional anesthesia techniques in residency training programs in the year 2000...
  23. ncbi Hyperbaric spinal levobupivacaine: a comparison to racemic bupivacaine in volunteers
    Elizabeth A Alley
    Department of Anesthesiology, Virginia Mason Medical Center, Seattle, Washington 98111, USA
    Anesth Analg 94:188-93, table of contents. 2002
    ..Hyperbaric spinal levobupivacaine has equivalent clinical efficacy to racemic bupivacaine for spinal anesthesia in doses from 4 to 12 mg...
  24. ncbi Extended-duration analgesia: update on microspheres and liposomes
    Julie S Rose
    Virginia Mason Medical Center, Seattle, WA, USA
    Reg Anesth Pain Med 30:275-85. 2005