Adam P Klausner

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Antimuscarinics for the treatment of overactive bladder: a review of central nervous system effects
    Adam P Klausner
    Division of Urology, Virginia Commonwealth University School of Medicine, PO Box 980118, Richmond, VA 23298, USA
    Curr Urol Rep 8:441-7. 2007
  2. doi request reprint A new and automated method for objective analysis of detrusor rhythm during the filling phase
    Adam P Klausner
    Department of Surgery Division of Urology, Virginia Commonwealth University School of Medicine, PO Box 980118, Richmond, VA, 23298 0118, USA
    World J Urol 32:85-90. 2014
  3. doi request reprint Does oxybutynin alter plaques, amyloid beta peptides and behavior in a mouse model of Alzheimer's disease?
    Adam P Klausner
    Department of Neuroscience, University of Virginia Health System, Charlottesville, Virginia, USA
    J Urol 179:1173-7. 2008
  4. doi request reprint A survey of ethically challenging issues in urological practice
    Adam P Klausner
    Virginia Commonwealth University Health System, Richmond, Virginia, USA
    J Urol 185:1407-11. 2011
  5. doi request reprint The neurogenic bladder: an update with management strategies for primary care physicians
    Adam P Klausner
    Division of Urology, Department of Surgery, Virginia Commonwealth University School of Medicine, PO Box 980118, Richmond, VA 23298 0118, USA
    Med Clin North Am 95:111-20. 2011
  6. doi request reprint The influence of psychiatric comorbidities and sexual trauma on lower urinary tract symptoms in female veterans
    Adam P Klausner
    Division of Urology, Virginia Commonwealth University School of Medicine and the Hunter Holmes McGuire Veterans Affairs Hospital, Richmond, Virginia 23298 0118, USA
    J Urol 182:2785-90. 2009
  7. doi request reprint Elevated steady-state bladder preload activates myosin phosphorylation: detrusor smooth muscle is a preload tension sensor
    Jordan B Southern
    Virginia Commonwealth Univ School of Medicine, Depts of Biochemistry and Molecular Biology and Pediatrics, Richmond, VA 23298 0614, USA
    Am J Physiol Renal Physiol 303:F1517-26. 2012
  8. pmc Rhythmic contraction generates adjustable passive stiffness in rabbit detrusor
    Atheer M Almasri
    Department of Mechanical Engineering, Richmond, Virginia Commonwealth University, VA 23284 3015, USA
    J Appl Physiol (1985) 108:544-53. 2010
  9. doi request reprint Carbachol-induced volume adaptation in mouse bladder and length adaptation via rhythmic contraction in rabbit detrusor
    John E Speich
    Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, 23284 3015, USA
    Ann Biomed Eng 40:2266-76. 2012
  10. ncbi request reprint Prostaglandin E₂mediates spontaneous rhythmic contraction in rabbit detrusor muscle
    Adam P Klausner
    Department of Surgery Division of Urology, Virginia Commonwealth University, Richmond, VA 23298 0118, USA
    Can J Urol 18:5608-14. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Antimuscarinics for the treatment of overactive bladder: a review of central nervous system effects
    Adam P Klausner
    Division of Urology, Virginia Commonwealth University School of Medicine, PO Box 980118, Richmond, VA 23298, USA
    Curr Urol Rep 8:441-7. 2007
    ....
  2. doi request reprint A new and automated method for objective analysis of detrusor rhythm during the filling phase
    Adam P Klausner
    Department of Surgery Division of Urology, Virginia Commonwealth University School of Medicine, PO Box 980118, Richmond, VA, 23298 0118, USA
    World J Urol 32:85-90. 2014
    ..Therefore, the purpose of this study was to develop an automated computer algorithm to analyze rat detrusor rhythm in a quick, accurate, and reproducible manner...
  3. doi request reprint Does oxybutynin alter plaques, amyloid beta peptides and behavior in a mouse model of Alzheimer's disease?
    Adam P Klausner
    Department of Neuroscience, University of Virginia Health System, Charlottesville, Virginia, USA
    J Urol 179:1173-7. 2008
    ....
  4. doi request reprint A survey of ethically challenging issues in urological practice
    Adam P Klausner
    Virginia Commonwealth University Health System, Richmond, Virginia, USA
    J Urol 185:1407-11. 2011
    ..We surveyed ethical attitudes among urological and nonurological practitioners, allowing for thought and discussion regarding ethical issues in a larger audience...
  5. doi request reprint The neurogenic bladder: an update with management strategies for primary care physicians
    Adam P Klausner
    Division of Urology, Department of Surgery, Virginia Commonwealth University School of Medicine, PO Box 980118, Richmond, VA 23298 0118, USA
    Med Clin North Am 95:111-20. 2011
    ..This article describes the indications and technique of urodynamic testing and the interpretation of the results of such testing. The management of patients with neurogenic bladder dysfunction is also discussed...
  6. doi request reprint The influence of psychiatric comorbidities and sexual trauma on lower urinary tract symptoms in female veterans
    Adam P Klausner
    Division of Urology, Virginia Commonwealth University School of Medicine and the Hunter Holmes McGuire Veterans Affairs Hospital, Richmond, Virginia 23298 0118, USA
    J Urol 182:2785-90. 2009
    ..We characterized the association of psychiatric comorbidities and sexual trauma with lower urinary tract symptoms in women...
  7. doi request reprint Elevated steady-state bladder preload activates myosin phosphorylation: detrusor smooth muscle is a preload tension sensor
    Jordan B Southern
    Virginia Commonwealth Univ School of Medicine, Depts of Biochemistry and Molecular Biology and Pediatrics, Richmond, VA 23298 0614, USA
    Am J Physiol Renal Physiol 303:F1517-26. 2012
    ....
  8. pmc Rhythmic contraction generates adjustable passive stiffness in rabbit detrusor
    Atheer M Almasri
    Department of Mechanical Engineering, Richmond, Virginia Commonwealth University, VA 23284 3015, USA
    J Appl Physiol (1985) 108:544-53. 2010
    ..Most importantly, rhythmic contraction (RC) generated APS, and because RC occurs spontaneously in human bladder, a physiological role for RC was potentially identified...
  9. doi request reprint Carbachol-induced volume adaptation in mouse bladder and length adaptation via rhythmic contraction in rabbit detrusor
    John E Speich
    Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, 23284 3015, USA
    Ann Biomed Eng 40:2266-76. 2012
    ..The present data identify a potential physiological role for SRC in bladder adaptation and motivate the investigation of a potential link between short-term volume adaptation and OAB with impaired contractility...
  10. ncbi request reprint Prostaglandin E₂mediates spontaneous rhythmic contraction in rabbit detrusor muscle
    Adam P Klausner
    Department of Surgery Division of Urology, Virginia Commonwealth University, Richmond, VA 23298 0118, USA
    Can J Urol 18:5608-14. 2011
    ..The purpose of this investigation was to determine if prostaglandin E₂(PGE₂) is produced by rabbit detrusor free of urothelium and demonstrate that PGE₂ is responsible for the generation of spontaneous rhythmic contraction (SRC)...
  11. doi request reprint Fourier transform analysis of rabbit detrusor autonomous contractions reveals length dependent increases in tone and slow wave development at long lengths
    Michael D Byrne
    Division of Urology, Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 0118, USA
    J Urol 190:334-40. 2013
    ..In this in vitro study we used fast Fourier transforms to assess the length dependence of low amplitude rhythmic contraction components...
  12. doi request reprint Potential for control of detrusor smooth muscle spontaneous rhythmic contraction by cyclooxygenase products released by interstitial cells of Cajal
    Clinton Collins
    Department of Surgery, Urology Division, Virginia Commonwealth University School of Medicine, VA 23298 0614, USA
    J Cell Mol Med 13:3236-50. 2009
    ..Additional studies on prostaglandin-dependent SRC may generate opportunities for the application of novel treatments for disorders leading to overactive bladder...
  13. pmc Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction
    John E Speich
    Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 West Main St, Richmond, VA 23284 3015, USA
    Am J Physiol Renal Physiol 302:F967-76. 2012
    ..The presence of APS in mouse bladder will permit future studies of APS regulatory pathways and potential alterations of APS in disease models using knockout transgenetic mice...
  14. pmc Adaptation of the length-active tension relationship in rabbit detrusor
    John E Speich
    Department of Mechanical Engineering, Virginia Commonwealth University, 401 W Main St, PO Box 843015, Richmond, VA 23284 3015, USA
    Am J Physiol Renal Physiol 297:F1119-28. 2009
    ..In addition, our findings demonstrate that preconditioning, APS and adaptation of the active L-T curve can each impact the maximum total tension observed at a particular DSM length...
  15. ncbi request reprint Increased expression of heat shock protein 20 and decreased contractile stress in obstructed rat bladder
    Timothy W Batts
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908 1395, USA
    J Urol 176:1679-84. 2006
    ..Heat shock protein 20 is the proposed mediator of force suppression in vascular smooth muscle. We investigated whether heat shock protein 20 could also mediate the decreased contractility observed in partially obstructed rat bladders...
  16. pmc Potentiation of carbachol-induced detrusor smooth muscle contractions by beta-adrenoceptor activation
    Adam P Klausner
    Department of Surgery Division of Urology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298 0614, United States
    Eur J Pharmacol 606:191-8. 2009
    ..Moreover, beta-adrenoceptor stimulation changed the cellular mechanism by which carbachol produced contraction. The potential significance of multi-receptor and multi-cell crosstalk is discussed...
  17. ncbi request reprint Tadalafil increases Akt and extracellular signal-regulated kinase 1/2 activation, and prevents apoptotic cell death in the penis following denervation
    Jeffrey J Lysiak
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    J Urol 179:779-85. 2008
    ..We also determined whether treatment with the phosphodiesterase-5 inhibitor tadalafil prevents apoptosis as well as the specific mechanisms involved...
  18. doi request reprint Expert training with standardized operative technique helps establish a successful penile prosthetics program for urologic resident education
    Ashley B King
    Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0118, USA
    J Sex Med 8:2726-32. 2011
    ..Specifically, in the area of prosthetic urology, only a small proportion of programs have full-time faculty available to train residents in this discipline...
  19. ncbi request reprint The role of corticotropin releasing factor and its antagonist, astressin, on micturition in the rat
    Adam P Klausner
    Department of Urology, University of Virginia Health System, Charlottesville, 22908 0422, USA
    Auton Neurosci 123:26-35. 2005
    ..Further studies are needed to explore the possibility whether CRF antagonists are effective for detrusor overactivity and the overactive bladder syndrome...
  20. doi request reprint Vaginal symptoms and sexual function after tension-free vaginal tape-obturator placement: minimum 12-month follow-up
    Ashley B King
    Virginia Commonwealth University School of Medicine, Richmond, Virginia 23223, USA
    Urology 81:50-4. 2013
    ....
  21. ncbi request reprint Association of bladder sensation measures and bladder diary in patients with urinary incontinence
    Ashley B King
    Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Can J Urol 19:6183-7. 2012
    ..We previously reported urodynamic derivatives that may be useful in assessing bladder sensation. We sought to further investigate these derivatives by assessing for a relationship with 3-day bladder diary...
  22. ncbi request reprint Audience response system: a new learning tool for urologic conferences
    Cynthia P Leung
    Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Can J Urol 20:7042-5. 2013
    ..In this study, we explore the utility of an ARS as an educational tool in the setting of a large urology conference...
  23. ncbi request reprint Is cystoscopy indicated for incidentally identified bladder wall thickening?
    Daniel S McPartlin
    Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0118, USA
    Can J Urol 20:6615-9. 2013
    ..The purpose of this study was to evaluate the yield of cystoscopy in detecting bladder malignancy following incidentally identified bladder wall thickening observed on computed tomography (CT) scans...
  24. ncbi request reprint Corticotropin releasing factor: a mediator of emotional influences on bladder function
    Adam P Klausner
    Department of Urology, University of Virginia Health System, Charlottesville, Virginia, USA
    J Urol 172:2570-3. 2004
    ..We review evidence linking overactive bladder (OAB) and interstitial cystitis with anxiety and depression, and highlight the importance of corticotropin releasing factor (CRF) as a potential mediator of these conditions...
  25. doi request reprint A case of potential treatment of remote pain after sacral nerve stimulation for chronic urinary retention
    Jennifer R Hoyt
    Department of Surgery, Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Clin J Pain 28:539-41. 2012
    ..A case is presented in which a 58-year-old man developed a potential unintended and durable treatment of pain at remote sites (cervical region and low back) after sacral nerve stimulation for chronic urinary retention...
  26. ncbi request reprint Long term prostate-specific antigen trends following subcapsular prostatectomy
    Adam P Klausner
    Dept of Surgery Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0118, USA
    Can J Urol 17:5442-6. 2010
    ..The purpose of this study was to evaluate the utility of prostate-specific antigen (PSA) screening for prostate cancer after subcapsular prostatectomy...
  27. ncbi request reprint Research frontiers in the treatment of urinary incontinence
    Adam P Klausner
    Department of Urology, University of Virginia Health System, Charlottesville, Virginia, USA
    Clin Obstet Gynecol 47:104-13. 2004
  28. ncbi request reprint In vivo detection of apoptotic cells in the testis using fluorescence labeled annexin V in a mouse model of testicular torsion
    Sang Kuk Yang
    Department of Urology, Konkuk University School of Medicine, Chungju Hospital, Korea
    J Urol 176:830-5. 2006
    ..In vivo detection of apoptotic cells with fluorescently labeled annexin V is an emerging technique that we evaluated for detecting apoptotic germ cells in a mouse model of testicular torsion...
  29. ncbi request reprint Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine
    Kyu Sung Lee
    Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Urol 170:2067-71. 2003
    ..We examined a rat model of endogenous depression caused by lowering 5-HT for effects on voiding frequency (VF) and awake cystometry (CMG), and examined the effect of reversal using the selective serotonin reuptake inhibitor fluoxetine...
  30. ncbi request reprint Urinary incontinence in the geriatric population
    Adam P Klausner
    Department of Urology, Box 1272, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 70:54-61. 2003
    ..Urinary incontinence is a widespread, yet potentially treatable, problem in the geriatric population...
  31. ncbi request reprint Effect of catheter size on urodynamic assessment of bladder outlet obstruction
    Adam P Klausner
    Department of Urology, Mount Sinai Medical Center, New York, New York 10029, USA
    Urology 60:875-80. 2002
    ..To examine the effect of cross-sectional catheter diameter on urodynamic measurement of bladder outlet obstruction as predicted by the Abrams-Griffiths nomogram...