TODD O KITTEN

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc The Streptococcus sanguinis competence regulon is not required for infective endocarditis virulence in a rabbit model
    JILL E CALLAHAN
    VCU Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e26403. 2011
  2. pmc Oral streptococcal bacteremia in hospitalized patients: taxonomic identification and clinical characterization
    Todd Kitten
    The Philips Institute of Oral and Craniofacial Molecular Biology, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Clin Microbiol 50:1039-42. 2012
  3. pmc Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans streptococci
    Todd Kitten
    The Philips Institute of Oral and Craniofacial Molecular Biology, Department of Adult Health Nursing, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 70:422-5. 2002
  4. pmc Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesis
    Sehmi Paik
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, 521 North 11th Street, Richmond, VA 23298 0566, USA
    Infect Immun 73:6064-74. 2005
  5. pmc The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor
    Sehmi Paik
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Bacteriol 185:5967-75. 2003
  6. pmc Genome of the opportunistic pathogen Streptococcus sanguinis
    Ping Xu
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284 2030, USA
    J Bacteriol 189:3166-75. 2007
  7. pmc Identification of Streptococcus sanguinis genes required for biofilm formation and examination of their role in endocarditis virulence
    Xiuchun Ge
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298 0566, USA
    Infect Immun 76:2551-9. 2008
  8. pmc Comprehensive evaluation of Streptococcus sanguinis cell wall-anchored proteins in early infective endocarditis
    Lauren Senty Turner
    The Philips Institute of Oral and Craniofacial Molecular Biology, Richmond, VA 23298 0566, USA
    Infect Immun 77:4966-75. 2009
  9. pmc Contribution of lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus sanguinis
    Sankar Das
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0566, USA
    J Bacteriol 191:4166-79. 2009
  10. pmc Development of genetic tools for in vivo virulence analysis of Streptococcus sanguinis
    Lauren Senty Turner
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Microbiology 155:2573-82. 2009

Collaborators

  • C N Cornelissen
  • Hui Wu
  • Cindy L Munro
  • Xiuchun Ge
  • Ping Xu
  • Lauren Senty Turner
  • Sehmi Paik
  • Sankar Das
  • Taisei Kanamoto
  • JILL E CALLAHAN
  • Takeshi Unoki
  • Zhenming Chen
  • Arunsri Brown
  • Daniel H Conrad
  • Sehmi P Lee
  • Michael D Chaplin
  • Luiz S Ozaki
  • Joao M Alves
  • Francis L Macrina
  • Stephanie Hendricks
  • Doruk Akan
  • Yingping Wang
  • Patricio Manque
  • Myrna G Serrano
  • Darrell L Peterson
  • Daniela Puiu
  • Gregory A Buck
  • Lauren Senty
  • Jody C Noe

Detail Information

Publications11

  1. pmc The Streptococcus sanguinis competence regulon is not required for infective endocarditis virulence in a rabbit model
    JILL E CALLAHAN
    VCU Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e26403. 2011
    ..We propose that the different roles of the S. sanguinis, S. pneumoniae, and S. mutans com regulons in virulence can be understood in relation to the pathogenic mechanisms employed by each species...
  2. pmc Oral streptococcal bacteremia in hospitalized patients: taxonomic identification and clinical characterization
    Todd Kitten
    The Philips Institute of Oral and Craniofacial Molecular Biology, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Clin Microbiol 50:1039-42. 2012
    ..Together, Streptococcus mitis and Streptococcus oralis were significantly more likely than the 12 combined remaining species to be isolated from neutropenic patients...
  3. pmc Vaccination with FimA from Streptococcus parasanguis protects rats from endocarditis caused by other viridans streptococci
    Todd Kitten
    The Philips Institute of Oral and Craniofacial Molecular Biology, Department of Adult Health Nursing, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Infect Immun 70:422-5. 2002
    ..mitis, S. mutans, and S. salivarius. FimA thus has promise as a vaccinogen to control infective endocarditis caused by oral streptococci...
  4. pmc Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesis
    Sehmi Paik
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, 521 North 11th Street, Richmond, VA 23298 0566, USA
    Infect Immun 73:6064-74. 2005
    ..The results suggest that housekeeping functions such as cell wall synthesis, amino acid and nucleic acid synthesis, and the ability to survive under anaerobic conditions are important virulence factors in S. sanguinis endocarditis...
  5. pmc The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor
    Sehmi Paik
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Bacteriol 185:5967-75. 2003
    ..Finally, a sloA mutant demonstrated loss of virulence in a rat model of endocarditis, suggesting that metal transport is required for endocarditis pathogenesis...
  6. pmc Genome of the opportunistic pathogen Streptococcus sanguinis
    Ping Xu
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284 2030, USA
    J Bacteriol 189:3166-75. 2007
    ..In particular, S. sanguinis possesses a remarkable abundance of putative surface proteins, which may permit it to be a primary colonizer of the oral cavity and agent of streptococcal endocarditis and infection in neutropenic patients...
  7. pmc Identification of Streptococcus sanguinis genes required for biofilm formation and examination of their role in endocarditis virulence
    Xiuchun Ge
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298 0566, USA
    Infect Immun 76:2551-9. 2008
    ..This result indicates that the ability to form biofilms in vitro is not associated with endocarditis virulence in vivo in S. sanguinis...
  8. pmc Comprehensive evaluation of Streptococcus sanguinis cell wall-anchored proteins in early infective endocarditis
    Lauren Senty Turner
    The Philips Institute of Oral and Craniofacial Molecular Biology, Richmond, VA 23298 0566, USA
    Infect Immun 77:4966-75. 2009
    ..sanguinis infective endocarditis, strategies designed to interfere with individual cell wall-anchored proteins or sortases would not be effective for disease prevention...
  9. pmc Contribution of lipoproteins and lipoprotein processing to endocarditis virulence in Streptococcus sanguinis
    Sankar Das
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0566, USA
    J Bacteriol 191:4166-79. 2009
    ....
  10. pmc Development of genetic tools for in vivo virulence analysis of Streptococcus sanguinis
    Lauren Senty Turner
    The Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Microbiology 155:2573-82. 2009
    ..Thus, the chromosomal site utilized is a good candidate for further manipulations of S. sanguinis. In addition, the resistant strains developed may be further applied as controls to facilitate screening for virulence factors in vivo...
  11. pmc Pooled protein immunization for identification of cell surface antigens in Streptococcus sanguinis
    Xiuchun Ge
    Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 5:e11666. 2010
    ..We developed an approach to identify surface antigens rapidly in Streptococcus sanguinis, a common infective endocarditis causative species...

Research Grants9

  1. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2001
    ..It is anticipated that the characterization of mutants with altered virulence will result in a better understanding of the pathogenesis of endocarditis and will identify promising novel targets for vaccine or therapeutic development. ..
  2. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2002
    ..It is anticipated that the characterization of mutants with altered virulence will result in a better understanding of the pathogenesis of endocarditis and will identify promising novel targets for vaccine or therapeutic development. ..
  3. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2003
    ..It is anticipated that the characterization of mutants with altered virulence will result in a better understanding of the pathogenesis of endocarditis and will identify promising novel targets for vaccine or therapeutic development. ..
  4. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2005
    ..We also expect the study to examine virtually all potential vaccine candidates in S. sanguis and to identify those that are most promising. ..
  5. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2006
    ..We also expect the study to examine virtually all potential vaccine candidates in S. sanguis and to identify those that are most promising. ..
  6. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2007
    ..We also expect the study to examine virtually all potential vaccine candidates in S. sanguis and to identify those that are most promising. ..
  7. Streptococcal genomics and pathogenesis
    Todd Kitten; Fiscal Year: 2007
    ..abstract_text> ..
  8. Streptococcal virulence factors in extra-oral disease
    Todd Kitten; Fiscal Year: 2009
    ..We also expect the study to examine virtually all potential vaccine candidates in S. sanguis and to identify those that are most promising. ..